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PubMed1998

Diltiazem-lidocaine combination for the attenuation of cardiovascular responses to tracheal intubation in hypertensive patients.

PURPOSE: Hypertensive patients are prone to haemodynamic changes after laryngoscopy and tracheal intubation. This study was undertaken to compare the efficacy of a combination of diltiazem and lidocaine with that of each drug alone for suppressing the cardiovascular responses to tracheal intubation. METHODS: Sixty hypertensive patients (ASA II), defined as systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 95 mmHg (World Health Organization), undergoing elective surgery received, in a randomized, double-blind manner, 0.3 mg.kg-1 diltiazem, 1.5 mg.kg-1 lidocaine, or 0.3 mg.kg-1 diltiazem plus 1.5 mg.kg-1 lidocaine i.v. (n = 20 of each) before the initiation of laryngoscopy. Anaesthesia was induced with 5 mg.kg-1 thiopentone i.v., and tracheal intubation was facilitated with 2 mg.kg-1 succinylcholine i.v. after precurarization with 0.02 mg.kg-1 vecuronium i.v. Changes in heart rate (HR), mean arterial pressure (MAP) and rate-pressure product (RPP) were measured before and at immediate, 1, 2, 3, 5 and 10 min after tracheal intubation. RESULTS: The inhibitory effects of diltiazem-lidocaine combination on cardiovascular responses to tracheal intubation was greater than those of diltiazem or lidocaine as a sole medicine (RPP; 10,602 +/- 1448 (combination) vs 11,787 +/- 1345 (diltiazem), 15,428 +/- 1756 (lidocaine), mean +/- SD, P < 0.05). CONCLUSION: Prophylactic therapy with diltiazem-lidocaine combination is more effective than diltiazem or lidocaine alone for attenuating the cardiovascular changes associated with tracheal intubation in hypertensive patients.

Aged↗
PubMed1999

Intubation via LMA in pediatric patients with difficult airways.

PURPOSE: To report two cases of successful tracheal intubation in difficult pediatric airways using a conventional laryngeal mask airway (LMA) with an extended polyvinyl chloride (PVC) tube after laryngeal assessment with a fibreoptic device. CLINICAL FEATURES: Two cases, Dandy-Walker and Pierre Robin syndromes, were scheduled for surgery. They were premedicated with 0.5 mg x kg(-1) promethazine p.o. 90 min before surgery. Both patients arrived in the operating room sedated, with dry mouth, and without evidence of increased intracranial tension or airway obstruction. Inhalational induction with isoflurane 0.5-3% was commenced. Conventional tracheal intubation was impossible in both cases. In each an LMA was inserted to maintain ventilation, anesthesia, and to facilitate intubation. Fibreoptic bronchoscopy was used to assess the larynx, followed by blind intubation via the LMA using extended PVC tracheal tube (TT). Anesthesia was maintained during intubation using Mapleson F anesthesia circuit attached to a connector with fibreoptic bronchoscope adapter. CONCLUSION: This report describes the assessment of the airway with fibreoptic bronchoscopy after LMA insertion facilitated blind tracheal intubation in two children with difficult airways.

Anesthesia, Inhalation↗
PubMed1997

Light-guided retrograde intubation.

PURPOSE: Transillumination of the soft tissues using a lightwand (Trachlight) can guide the endotracheal tube (ETT) into the glottis to facilitate the retrograde intubation. This study evaluated the effectiveness and safety of this intubating technique for patients with cervical spine instability. METHODS: After obtaining institutional approval and informed consent, 27 patients were studied. Light-guided retrograde intubation was performed either awake, or under general anaesthesia. Following cricothyroid membrane puncture using a # 18 i.v. catheter, an epidural catheter was advanced cephalad into the oropharynx. While pulling the epidural catheter taut, the ETT, with the Trachlight in place, was advanced into the glottis. When the tip of the ETT entered the glottis, a bright glow was seen in the anterior neck. The number of attempts, failures, complications, the times required to puncture the cricothyroid membrane, insert the epidural catheter, and insert the ETT into the trachea were recorded. RESULTS: In all patients, the tracheas were successfully intubated. The mean (+/-sd) time to perform cricothyroid puncture, insert the epidural catheter, and place the ETT into the trachea were 66.1 +/- 56.2, 74.0 +/- 25.2, and 72.8 +/- 42.5 sec respectively. The average total-time for this light-guided retrograde intubating technique was 205.8 +/- 78.3 sec. Apart from minor bleeding at the cricothyroid membrane puncture site, there were no major complications. CONCLUSION: In a small number of patients, we have shown that light-guided retrograde intubation is effective and sale for patients with cervical spine instability. This simple and inexpensive technique may prove to be a valuable adjunct in the management of difficult airways.

Humans↗
PubMed1997

Monitoring orbicularis oculi predicts good intubating conditions after vecuronium in children.

PURPOSE: The aim of the study was to compare visual estimation of onset of neuromuscular blockade at both the adductor pollicis (AP) and the orbicularis oculi (OO) in children and to determine if monitoring the OO could predict good intubating conditions during vecuronium-induced neuromuscular blockade. METHODS: Thirty ASAI--II children (1.5-9 yr) were studied. Anaesthesia was induced with 6-8 mg.kg-1 thiopentone. The ulnar nerve at the wrist and the temporal branch of the facial nerve were stimulated every 10 sec using train-of-four (TOF) stimuli. Vecuronium, 0.15 mg.kg-1, was administered as a bolus. The responses at both the OO and the AP were evaluated visually. Patients were randomly divided into two groups. In the AP group (n = 15), the trachea was intubated when the AP was completely blocked. In the OO group (n = 15), intubation was performed when the OO was completely blocked. Intubating conditions were scored on a scale of 1 to 4. RESULTS: All the patients had complete blockade at both the orbicularis oculi and the adductor pollicis. In the two group, time from injection of vecuronium to complete neuromuscular blockade was shorter at the orbicularis oculi than at the adductor pollicis, 1.5 +/- 0.5 min vs 2.3 +/- 0.7 min, respectively, (P < 0.05; mean +/- SD) in the AP group, 1.7 +/- 0.3 min vs 2.3 +/- 0.8 min, respectively in the OO group (P < 0.05). Intubating conditions were excellent in all patient except one, where it was rated as good. They did not differ between groups. CONCLUSION: Following administration of 0.15 mg.kg-1 vecuronium in children, monitoring of the OO can detect good intubating conditions 0.7 min earlier than with monitoring of the AP.

Child↗
PubMed1999

Predictive models for difficult laryngoscopy and intubation. A clinical, radiologic and three-dimensional computer imaging study.

PURPOSE: To identify the variables most useful in predicting difficult laryngoscopy and intubation from various clinical, skeletal (lateral x-rays) and soft tissue (three-dimensional computed tomography imaging) measurements. METHODS: Twenty-four adult patients in whom an unanticipated difficult tracheal intubation was identified according to established criteria were evaluated. Further, a control group of 32 patients in whom tracheal intubation was easily accomplished was studied. We applied multivariate discriminant analysis to clinical and radiological data of all patients to select those variables most useful in predicting difficult laryngoscopy and intubation. The receiver operating characteristic (ROC) curve was used to describe the discrimination abilities and to explore the trade-offs between sensitivity and specificity of the model. RESULTS: With the clinical data alone, discriminant analysis identified four risk factors that correlated with the prediction of difficult laryngoscopy and intubation: thyrosternal distance, thyromental distance, neck circumference and Mallampati classification. With both clinical and radiological data, discriminant analysis identified five risk factors: thyrosternal distance, thyromental distance, Mallampati classification, depth of spine C2 and angle A (the most antero-inferior point of the upper central incisor tooth). The positive predictive value of this combined (clinical and radiological) model was greater than that of the clinical model alone (95.8% vs 87.5%, respectively). The areas under the ROC curves, that measure the probability of the correct prediction of the clinical and the combined models, were found to be 0.933 and 0.973, respectively. CONCLUSIONS: These models can be used for predicting difficult laryngoscopy and intubation in clinical practice.

Adult↗
PubMed1994

Comparison of a rigid laryngoscope with the ultrathin fibreoptic laryngoscope for tracheal intubation in infants.

The flexible ultrathin fibreoptic laryngoscope allows placement of endotracheal tubes as small as 2.5 mm internal diameter. The purpose of this study was to document the safety and efficacy of intubation using an ultrathin fibreoptic laryngoscope. Proved safety and efficacy would justify the routine use of fibreoptic laryngoscopy in normal infants to maintain skills needed for management of the difficult infant airway. In this prospective study, 40 infants < 24 mo of age scheduled for elective surgery were randomly divided into two equal groups. After inhalation induction of anaesthesia, in 20 infants the trachea was intubated using direct rigid laryngoscopy, and in 20 using the ultrathin fibreoptic laryngoscope (size 1.8 mm OD) Olympus LFP. Time to successful intubation was recorded, as well as blood pressure, heart rate, end-tidal CO2 and oxygen saturation. Airway trauma in the operating room, the post-anaesthesia care unit, and on the first postoperative day was recorded. The intubation times using rigid laryngoscopy were less than those using fibreoptic laryngoscopy (13.6 +/- 0.9 sec (mean +/- SEM) vs 22.8 +/- 1.7 sec; P < 0.01). Oxygen saturation and end-tidal CO2 readings were not different between the two groups. After intubation, blood pressure and heart rate increased equally in both groups, returning to normal within one to two minutes. There was no difference in the airway trauma between groups. We conclude that the ultrathin fibreoptic laryngoscope is a safe and effective method for tracheal intubation in infants and may be used routinely in order to maintain fibreoptic airway skills.

Anesthesia, Inhalation↗
PubMedDate not supplied

The LMA Fastrach facilitates fibreoptic intubation in oral cancer patients.

PURPOSE: To compare ease of endotracheal intubation with the Intubating Laryngeal Mask Airway (ILMA) tracheal tube (TT; for LMA-Fastrach) and regular PVC TT (Portex) for nasotracheal fibreoptic intubation in oral cancer patients with a difficult airway. METHODS: 40 patients of physical status ASA I-II with a history of previous oral cancer surgery and/or postoperative radiotherapy scheduled for oral cancer surgery were randomly allocated by sealed envelopes to undergo tracheal intubation with either the ILMA TT or a standard TT. Ease of nasal passage of the TT and ease of tracheal intubation over the fibrescope was assessed. Peak airway pressures were assessed intraoperatively and postoperatively for 12 hr. RESULTS: The use of the ILMA TT increased the ease of nasotracheal intubation by increasing the percentage of successful tube placements at the first attempt (80%) in comparison with standard TT (35%); (P < 0.05). Peak airway pressures were found to remain low with the ILMA TT. None of the patients experienced any airway related complications. CONCLUSIONS: Use of a soft, flexible, nonkinking ILMA TT with a tapered tip design facilitates passage into the trachea over a fibreoptic bronchoscope and allows maintenance of lower airway pressures. The ILMA TT may be a useful adjunct for management of the difficult airway in oral cancer surgery.

Adolescent↗
PubMed2005

[Propofol sedation allows awake intubation of the difficult airway with the Fastrach LMA].

PURPOSE: To evaluate target controlled infusion anesthesia (TCI) with propofol for conscious intubation [(Ramsay score equal to 3 (RS 3)] through the Fastrach laryngeal mask airway (LMA). METHODS: 17 consenting and unpremedicated patients, who showed criteria for difficult intubation (score developed by Arne et al. > or = 11), were monitored and received supplemental oxygen. Propofol was administered by TCI, with successive targets of 0.6 and 1 microg x mL(-1), while the RS was evaluated: if = 3, LMA intubation was attempted, if < 3 the TCI was increased by steps of 0.2 microg x mL(-1) until an RS of 3 was reached. Local anesthesia (lidocaine 5%) of the oropharynx was carried out at 0.6 and 1 microg x mL(-1), together with local anesthesia of the nasopharynx at 1 microg x mL(-1). A standardized questionnaire evaluated memory of and satisfaction with the technique (score/10) on postoperative day 1. RESULTS: The LMA was inserted in 100% of cases and intubation was successful in 16 out of 17 cases (one failure). The propofol target concentration to obtain a RS of 3 was 1.25 +/- 0.07 microg x mL(-1). Amnesia occurred as soon as the target concentration of propofol exceeded 1 microg x mL(-1). The patients found the technique very satisfactory (median satisfaction score = 9.4/10). Incidents of coughing or nausea were observed in 47% and 5% of cases respectively. There was no oesophageal intubation and no desaturation (SpO2 < 95%). CONCLUSION: Propofol administered by TCI to achieve a RS of 3 allows conscious intubation to be performed through a LMA under satisfactory conditions. A LMA could be a possible alternative to a "conscious" fibroscopy.

Aged↗
PubMedDate not supplied

Intubation depth markings allow an improved positioning of endotracheal tubes in children.

OBJECTIVES: To evaluate the position of the new Microcuff pediatric tracheal tube, based upon intubation depth markings. METHODS: With Institutional Ethics Committee approval and informed parental consent, we included patients from birth (> or = 3 kg) to 16 yr undergoing interventional cardiac catheterization requiring general anesthesia with orotracheal intubation. The intubation depth mark of the tracheal tube was placed between the vocal cords by direct laryngoscopy. The distance between tube tip and tracheal carina was measured from routinely taken cardiac catheterization posterior-anterior x-ray computer images with the patient supine and the head in a neutral position. Evaluation was performed for 20 tubes size 3.0 mm internal diameter (ID) and for ten tubes of each size from 3.5 to 7.0 mm ID. RESULTS: 100 patients were studied (47 girls; 53 boys). Tracheal tube tip advancement into the trachea ranged from 40.6% to 68.6% (median 51.4%). The shortest distance from tube tip to the tracheal carina was 15.7 mm using a 3.0 mm ID tube. Using a standard formula for tube insertion in children aged > or = two years [12 cm + (age/2)], in one patient the tube tip would have been below the carina and in seven patients the tube cuffs would have been placed within the larynx. CONCLUSIONS: The intubation depth markings of the new Microcuff pediatric tracheal tube allow safe placement of the tracheal tube with a cuff-free laryngeal zone without the risk for endobronchial intubation. Placement using the intubation depth markings was superior to predicted insertion using a standard formula.

Adolescent↗
PubMed2002

Systolic blood pressure, not BIS, is associated with movement during laryngoscopy and intubation.

OBJECTIVE: To compare bispectral index (BIS) values to hemodynamic variations, in order to evaluate adequacy of anesthesia during orotracheal intubation with muscle relaxants. METHODS: Forty-one patients ASA I-II, scheduled for elective peripheral surgery under general anesthesia with tracheal intubation were enrolled in the study. Fentanyl/thiopental followed by vecuronium were used for induction. Onset of relaxation was monitored at the orbicularis occuli (OO) muscle using train-of-four stimulation. Intubation was performed when no response at the OO was detected visually. Intubating conditions were noted. The "isolated forearm" technique was used to detect movement during laryngoscopy/intubation. BIS values, pulse rate (PR), and systolic pressure were recorded before induction, during laryngoscopy/intubation and 60 sec after intubation. RESULTS: Although intubating conditions were clinically adequate for all patients, ten out of 41 had movement of the isolated arm during laryngoscopy/intubation. BIS values were not significantly different for these patients: 67 (55-83) compared to those who had no movement: 60 (35-80), P = 0.6. During laryngoscopy, PR increased for all patients while systolic pressure increased significantly only in patients who moved: 125 (100-136) mmHg vs those who did not: 108 (67-140), P < 0.05. CONCLUSION: Systolic pressure elevations were associated with inadequate anesthesia as evaluated by the "isolated forearm" technique, during laryngoscopy/intubation. BIS values were not different between groups, suggesting that systolic blood pressure may be a better predictor of inadequate anesthesia under the circumstances described.

Adjuvants, Anesthesia↗
PubMed2004

The McCoy straight blade does not improve laryngoscopy and intubation in normal infants.

PURPOSE: The McCoy curved blade laryngoscope has been demonstrated to improve view at laryngoscopy in adults. A straight-bladed version of this laryngoscope has recently been introduced into pediatric practice. The objective of this prospective, randomized study was to compare the intubating conditions afforded by the McCoy (#1) straight blade laryngoscope with the conventional Miller (#1) blade in neonates and infants. METHODS: Forty patients under six months of age, were randomized into two groups: one group (n = 20) had an initial laryngoscopy with the McCoy blade and then had a laryngoscopy and subsequent intubation using the Miller blade; the second group (n = 20) had an initial laryngoscopy with the Miller blade, followed by laryngoscopy and intubation using the McCoy blade. All intubations were performed by one anesthesiologist familiar with using both blades. RESULTS: The majority of patients (39 out of 40) had a similar or superior view (Cormack and Lehane classification) with the Miller when compared with the McCoy laryngoscope. Mean time to laryngoscopy was 14.9 (12.7) sec with the McCoy and 6.8 (2.07) sec with the Miller blade (P = 0.001), whereas mean time to intubation was 25.13 (10.4) sec with the McCoy and 12 (8.5) sec with the Miller blade (P = 0.014). There was no difference between the groups regarding desaturation and changes in heart rate during laryngoscopy and intubation. CONCLUSION: Our data indicate that the McCoy blade has no advantage over the conventional pediatric Miller blade in normal infants.

Analysis of Variance↗
PubMed2000

Tracheal intubation of outpatients with and without muscle relaxants.

PURPOSE: To compare intubating conditions and postoperative myalgias in outpatients after intubation with propofol/alfentanil compared with propofol/alfentanil/succinylcholine with and without precurarisation with d-tubocurarine. METHODS: 144 ASA I-II ambulatory patients for dental extraction under anesthesia were studied. Subjects received either 3 mg d-tubocurarine (Group II) or saline (Groups I, III) i.v. prior to induction of anesthesia with 20 microg x kg(-1) alfentanil and 2.5 mg x kg(-1) propofol followed by 1.5 mg x kg(-1) succinylcholine (II and III) or saline 0.9% (I) for muscle relaxation. The ease of airway management and the postoperative incidence, severity and distribution of muscle pains were examined. RESULTS: Intubation was successful in all patients and there were no differences in jaw mobility, ease of bag-mask ventilation, visualization of the vocal cords or cord position. Limb movement was more common during intubation in Group I (37.5%) than in Group III (8.3%) or Group II (2%), P < 0.05. At home, VAS scores for myalgia were higher in Group III than in Group I and II. Neck myalgia was more common in Group II (72%) than in Groups II (44%) and I (41%), P < 0.05. Myalgias were also more common in Group III patients (P < 0.05). CONCLUSION: Acceptable intubating conditions were achieved with propofol and alfentanil alone. Succinylcholine reduced limb movement during intubation but was associated with postoperative myalgias for up to five days. Precurarisation with tubocurarine reduced the severity of succinylcholine myalgia.

Adolescent↗
PubMed2002

Oral styletted intubation under video control in a patient with a large mobile glottic tumour and a difficult airway.

PURPOSE: With fibreoptic intubation, advancement of the endotracheal tube (ETT) through the glottis is blind. Thus, in patients with a laryngeal tumour, there is a potential for damage to the tumour. Previously, we proposed the use of a fibreoptic bronchoscope (FOB)-video camera system to permit visualization of tube passage. We used this technique successfully in a patient with a known difficult airway and a large glottic tumour. CLINICAL FEATURES: A 61-yr-old man with a known history of difficult laryngoscopic intubation underwent laryngeal microsurgery for recurrence of a glottic tumour. As preoperative indirect laryngoscopy revealed a large, mobile, and pedunculated glottic lesion obstructing the glottic opening, we planned a conventional awake fibreoptic intubation. Endoscopy showed that the tumour partially obstructed the glottis and the space between the tumour and the glottic opening was very narrow. To avoid damage to the tumour, we changed to an alternative fibreoptic intubation technique. The FOB attached to a video camera was passed nasally and a jaw thrust manoeuver was applied, providing an excellent view of the larynx. An anesthesiologist inserted the ETT with a curved stylet orally, and carefully advanced the tube tip into the space between the tumour and the glottic opening under video control. Absence of damage to the tumour and passage of the tube between the cords were confirmed visually. CONCLUSION: This alternative intubation technique, providing a view of the tube passage into the glottis, was a reasonable method to avoid potential damage to the glottic tumour by blind tube passage during conventional fibreoptic intubation.

Bronchoscopy↗
PubMed2003

Endotracheal suctioning versus minimally invasive airway suctioning in intubated patients: a prospective randomised controlled trial.

STUDY OBJECTIVE: Endotracheal suctioning in intubated patients is routinely applied in most ICUs but may have negative side effects. We hypothesised that on-demand minimally invasive suctioning would have fewer side effects than routine deep endotracheal suctioning, and would be comparable in duration of intubation, length of stay in the ICU, and ICU mortality. DESIGN: Randomised prospective clinical trial. SETTING: In two ICUs at University Hospital Groningen, the Netherlands. PATIENTS: Three hundred and eighty-three patients requiring endotracheal intubation for more than 24 h. INTERVENTIONS: Routine endotracheal suctioning (n=197) using a 49-cm suction catheter was compared with on-demand minimally invasive airway suctioning (n=186) using a suction catheter only 29 cm long. MEASUREMENTS AND RESULTS: No differences were found between the routine endotracheal suctioning group and the minimally invasive airway suctioning group in duration of intubation [median (range) 4 (1-75) versus 5 (1-101) days], ICU-stay [median (range) 8 (1-133) versus 7 (1-221) days], ICU mortality (15% versus 17%), and incidence of pulmonary infections (14% versus 13%). Suction-related adverse events occurred more frequently with RES interventions than with MIAS interventions; decreased saturation: 2.7% versus 2.0% (P=0.010); increased systolic blood pressure 24.5% versus 16.8% (P<0.001); increased pulse pressure rate 1.4% versus 0.9% (P=0.007); blood in mucus 3.3% versus 0.9% (P<0.001). CONCLUSIONS: This study demonstrated that minimally invasive airway suctioning in intubated ICU-patients had fewer side effects than routine deep endotracheal suctioning, without being inferior in terms of duration on intubation, length of stay, and mortality.

Cost-Benefit Analysis↗
PubMed1982

Continuous monitoring of left ventricular performance with the computerized nuclear probe during laryngoscopy and intubation before coronary artery bypass surgery.

Left ventricular performance was monitored serially in 25 patients during laryngoscopy and intubation in the anesthetic induction period before elective coronary artery bypass surgery using the labeled equilibrium blood pool and the computerized nuclear probe. Left ventricular ejection fraction was obtained preoperatively, after induction of anesthesia but before endotracheal intubation, immediately after intubation, and at 1 minute intervals thereafter for 10 minutes. In all patients, there was an immediate decrease (mean 16%) in left ventricular ejection fraction accompanying the reflex hypertension and tachycardia occurring during laryngoscopy and endotracheal intubation; it was significantly depressed for 3 minutes with the concomitant hemodynamic changes. Seven patients did not demonstrate a recovery of left ventricular ejection fraction to the preintubation value. In 10 healthy noncardiac patients undergoing orthopedic surgery, after an identical anesthetic induction sequence and intubation, there was a similar decrease in ejection fraction, but of shorter duration. In these patients the recovery of left ventricular performance preceded the recovery of blood pressure and heart rate. This study demonstrates that profound decreases in left ventricular performance accompany the reflex hypertension and tachycardia occurring during endotracheal intubation and that there is persisting depression of left ventricular function in some patients with coronary artery disease. These findings indicate the potential utility of the computerized nuclear probe for monitoring ventricular performance during this critical period.

Adult↗
PubMed1975

Surface alterations due to endotracheal intubation.

The varied complication of prolonged endotracheal intubation, including tracheal stenosis, stricture and tracheomalacia, are thought to be directly related to lateral tracheal wall pressure. To investigate the initiation, relevance and duration of these changes, studies were undertaken to assess the effects of intubation on the surface anatomy of the trachea by scanning electron microscopy. Tracheal mucosal morphology was studies in (1) anesthetized "normal" dogs; (2) d-ogs sacrificed 2 hours after intubation with cuff deflated or inflated to the "just seal" point using a cuff system producing the lowest tracheal wall pressure; and (3) dogs intubated for 2 hours and then examined at 2 and 7 days after extubation. Intubation without cuff inflation resulted in distinct linear areas of nearly complete ciliary denudation along the tract of tubal insertion within 2 hours. Inflated cuffs produced similar but more widespread changes especially over tracheal rings, indicating that pressure in areas of least resiliency significantly contributes to these alterations. Regeneration of cilia could be seen 2 days after extubation, but many anatomic features remained distorted; at 7 days, regeneration was nearly complete, but isolated areas of denudation could still be identified. Scanning electron micrographs of human tracheas taken at autopsy from patients who had had prolonged intubation with the same cuff system correlated well with those obtained from dogs.

Animals↗
PubMed1992

Placebo-controlled trial of prednisolone in children intubated for croup.

Many studies have attempted to find out whether steroid treatment is beneficial in children with croup, but the results have been inconclusive. We have done a prospective placebo-controlled study of the effect of prednisolone on two clinical endpoints--the duration of intubation and the need for reintubation. Reasons for exclusion were age under 6 months, congenital airway anomalies, and previous intubation. 70 eligible children were randomly assigned treatment with prednisolone 1 mg/kg (n = 38) or placebo (n = 32) every 12 h given by nasogastric tube until 24 h after extubation. 11 (34%) placebo-treated and only 2 (5%) prednisolone-treated patients required reintubation after accidental or elective extubation (p = 0.004, Fisher's exact test; odds ratio 8.9, 95% confidence interval 1.7-59.3). Survival analysis with log-normal regression showed that the duration of intubation was shorter with steroid therapy (p less than 0.003) and increasing age (p less than 0.02), but was not influenced by endotracheal tube size or abnormality on chest radiograph. The median duration of intubation was 138 (95% CI 118-160) h in children who received placebo and 98 (85-113) h in the prednisolone group. Steroid therapy reduces the duration of intubation and the need for reintubation in children intubated for croup.

Age Factors↗
PubMed1995

CT of minor intubation trauma with clinical correlations.

Even when performed by an experienced physician, endotracheal intubation is more traumatic than previously supposed. Following emergency intubation, patients have little probability of having a normal larynx. One-hundred patients underwent CT scan of the larynx 6 months or more following endotracheal intubation of short duration (up to 8 h). Ten patients (Group 1) with respiratory arrest underwent emergency intubation; 90 surgical patients (Group 2) underwent anesthesia with endotracheal intubation. Indirect laryngoscopy was performed in 59 symptomatic patients. Abnormal CT findings were present in 86 out of 100 patients. CT irregularities, which included tears, scars and small laryngoceles, were noted on indirect laryngoscopy in 59 symptomatic patients. The laryngeal damage following endotracheal intubation is surprisingly high.

Adult↗