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Results for “INTESTINAL DISEASES”

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PubMed1992

[Coagulation changes in inflammatory intestinal disease].

The aim of the present prospective trial was to study the disorders of blood coagulation in 31 patients diagnosed of inflammatory bowel disease (18 with ulcerative colitis and 13 with Crohn's disease) for assessing the possibility of hypercoagulability state in relation to the grade of activity of the disease. During the acute recurrences we observed an increase of factor VIIIC (65.3%), fibrinogen (57.7%), factor VIIIAg (50%), platelet (30.7%) and factor V (19.2%). In two (7.7%) patients a moderate decrease of antithrombin III was detected during a severe episode of activity. During the periods of inactivity the laboratory values concerning the coagulation were normal. There was a correlation between the blood coagulation alterations and the grade of activity of the inflammatory bowel disease.

Adolescent↗
PubMed1992

[Chronic inflammatory intestinal disease in Catalonia (Barcelona and Gerona)].

We show the results of a retrospective study carried out during ten years (1978-1987), in Catalonia in the provinces of Barcelona and Gerona. The aim of the study was to evaluate the incidence and prevalence of inflammatory chronic bowel disease in our country, its clinical aspects, management and long term survival. An epidemiological inquiry was sent to all the hospitals and gastroenterologists of Catalonia. Nine hundred and seventy six answers were received from 20 Hospitals and four specialists. All of them were revised by the Research Committee, and 761 were validated for their inclusion in the study. The prevalence of the disease was similar both in Barcelona (19 per 100,000) and Gerona (18 per 100,000). The incidence of ulcerative colitis increased during the study, from 0.4 in 1978 to 0.8 in 1987, with a peak of maximum incidence (1.0 per 100,000) in 1985. In the same way, an increase in the incidence of Crohn's disease from 0.2 to 0.7 per 100,000, was observed. The mean incidence per year was 0.6 and 0.4 respectively, similar to the incidence observed in other Spanish regions during the same period of time. Finally we show the most important clinical and therapeutic aspects as well as the survival data.

Actuarial Analysis↗
PubMed2004

[Ischaemic intestinal disease--still opened diagnostic clinical and pathomorphological problem].

Contemporary opinions on etiology and pathogenesis of ischaemic colitis have been presented. Diagnostic difficulties in endoscopic and pathologic examination of colonic ischaemic changes have also been discussed. Some aspects of differential diagnosis of ischaemic colitis has been discussed. The literature opinions and authors own experience indicate that ischaemic colitis is still serious histoclinical problem which could be resolved only if close cooperation of gastrologists and pathologists has been applied.

Algorithms↗
PubMed1991

[New salicylic acid derivatives in the treatment of inflammatory intestinal diseases].

Drug therapy for inflammatory bowel disease was limited for many years to sulfasalazine and some corticosteroids. Since the discovery that 5-aminosalicylic acid (5-ASA) is the active moiety of sulphasalazine in the treatment of chronic inflammatory bowel disease, several new drugs have been developed. These consist either of slow- or delayed-release formulations of plaint 5-ASA (mesalazin) or sulpha-free azo-compounds of 5-ASA. The varying bioavailabilities of the different formulations and compounds make it possible to use them alternatively in different clinical situations. A review of the literature is given and suggestions as to how the new drugs can be used in different diseases.

Aminosalicylic Acids↗
PubMed1991

[Prevalence of large-intestinal diseases in Azerbaijan].

15,000 adults in Azerbaijan have been surveyed. The programme of the survey included interviews with specially designed questionnaires consisting of questions related to working and living conditions, nutritional habits, X-ray and endoscopic examinations of the colon have been conducted. Referrals to polyclinics for colon diseases accounted for 6.0 per 100 inhabitants and after active detection among men--41.5 and among women--45.6 per 100 persons examined. The leading role in the incidence of chronic diseases of colon is played by hemorrhoid (31.0%), chronic colitis (33.6%), colon dyskinesia (13.5%). It has been found that the most significant predisposing causes of colon diseases were: bacillary dysentery, different types of neuroses, milk indigestion, gynaecological and prostatic diseases, and obesity.

Adult↗
PubMed1990

[Drug therapy of chronic inflammatory intestinal diseases].

The therapy of inflammatory bowel diseases (Crohn's disease, ulcerative colitis) has been improved in recent years. This is mainly due to our better understanding of application of aminosalicylates and steroids in regard to localization, activity, and type of chronic inflammatory bowel disease. Newly developed aminosalicylates like mesalazine provoke less side effects. Furthermore, they seem to be effective in the treatment of ileal inflammation of Crohn's disease. Therapy with immunosuppressive drugs like mercaptopurine, azathioprine, and cyclosporin A is justified in case of steroid-resistant Crohn's disease. Alternative therapeutic concepts are at present at the stage of clinical trial.

Aminosalicylic Acids↗
PubMed1990

[Ultrasonography in the diagnosis of chronic inflammatory intestinal disease].

The accuracy of ultrasonography (US) in diagnosing active inflammatory bowel disease (IBD) is assessed on the basis of a randomized prospective study of 61 patients. Twenty-six of the patients were affected with Crohn's disease (CD) and 12 with ulcerative colitis, while the remaining 23 patients were control subjects with no specific chronic IBD. The US signs considered as significant for active CD and UC were: --visualization of a typical target image, that is a hyperechoic center corresponding to luminal bowel content, surrounded by a hypoechoic ring corresponding to loop walls; --at least 2 of the following: solid abdominal mass, distended loops, luminal narrowing, reduced peristalsis, stiff loops, and accumulation of fluid between the loops. US sensitivity and specificity for CD were 77% and 95.6%, respectively. As for UC, no significant results were obtained. In our experience, US is a reliable method for detecting alterations and, especially, complications typical of CD in its active phase. Considering the young age of the patients affected with CD and the number of exams they must undergo, US is considered as a useful tool in disease follow-up.

Adult↗