[Respiration, 24-hour catecholamine excretion and serum concentration of 11-hydroxycorticosteroids in patients with chronic nonspecific lung diseases].
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The effect of fat composition with a different ratio of polyunsaturated fatty acids of families omega 3 and omega 6 on expression of experimental dietary anaphylaxis, liver monooxygenase system and metabolism of 17-oxycorticosteroides (17-OCS) in guinea-pig have been investigated. Fat components in experimental diets were presented by sunflower, ichthyene oils and mix of these oils in the ratio 1:1. A ratio of PUFA of a family omega 6 to omega 3 in diets were 64,0; 0,13 and 2,64. It was shown that a burden of dietary anaphylaxis were reduced significantly at the introduction in diets of sunflower oil.ulakcuu is authentically reduced. Simultaneously a marked increase of a ratios P-450B to P-450L and b5 to P-450 and reduction of a hexenal sleep duration were determined. The amount of excreted polar 17-OCS was also decreased in animals fed sunflower oil. Probable mechanisms of hypoallergenic action of dietary sunflower oil were conditioned by reorganization of liver cytochrome P-450 system and respective alterations of 17-OCS metabolism are discussed.
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The circadian rhythm of hydrocortisone and ACTH in plasma and 17-OCS in the urine were registered in 10 patients with bronchial asthma and 5 healthy subjects. It was found that maximal concentrations of hydrocortisone occurred in the day time whereas those of ACTH at nights in moderate asthma. In its severe forms neither hydrocortisone nor ACTH followed circadian rhythms. It is recommended to treat patients with severe bronchial asthma on the individual basis selecting glucocorticosteroid doses with reference to plasma fluctuations of hydrocortisone.
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