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[Intramural gravidity - case report and account of literature (author's transl)].

Reference is made to a report on intramural pregnancy, the twelfth case so far described in accessible literature, and the authors' own views on the possible origin of this extremely rare location of pregnancy are added to other assumptions so far made on the pathogenesis. The hypothetical proposition made by the author's is based on the assumption of transperitoneal penetration of the uterine wall by the spermovium via a focus of endometriosis. Described are case histories, symptoms, tentative diagnoses, and surgical approach in the cases so far observed.

Adult↗

Rupture of a gravid bicornuate uterus in a primigravida associated with clostridial and bacteroides infection.

The case is presented of a primigravid patient with spontaneous rupture of a bicornuate uterus associated with significant anaerobic infection. Thinning of the myometrium at the site of the rupture was noted in the pathologic specimen. The anaerobic infection, primarily contained in the intact amniotic sac, resolved with total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic drainage and antibiotic therapy.

Adult↗

[Studies about the exposure to radiation of the fetus in case of X-ray examination during gravidity (author's transl)].

In the second communication (Strahlentherapie 156 (1980), 776-785), we discussed the estimation of the exposure to radiation of the fetus by means of tube related data (product of area/surface dose or time/tube current). In this final communication, we present method and problems of the estimation based on the sensitivity of the picture-producing system. In order to apply this method, one must know several factors characterizing the attenuation of X-radiation between the point of incidence and the picture carrier. A detailed report is given on the results of measurements effected on a water phantom in order to find out these factors of attenuation. Then the estimated surface doses are compared to the values determined by thermoluminescence dosimetry. We come to the conclusion that the estimation of the exposure to radiation by means of tube related data will generally involve a lower deviation from the actual value than the estimation based on the dose required by the receiving system.

Female↗

[Observations on prostaglandin effects with myometrium strips of human gravid uterus in vitro. Influence of diclofenac on contractions induced by prostaglandin (author's transl)].

The effect of Diclofenac (Voltaren) was studied on PGE2- and PGF2alpha-induced contractions of pregnant human myometrium in vitro. Tests to establish experimental conditions revealed that PGE2 and PGF2alpha affect the myometrium differently from I. and IInd trimenon uteri. PGF2alpha always induced contractions in corpus uteri as well as cervix strips. PGE2 relaxed myometrium strips obtained from superficial muscle layers and from cervix tissue and caused contractions in the myometrium from the central parts of the corpus uteri. Diclofenac (Voltaren) at concentrations of 10(-5) to 10(-4) M inhibited PGE2 and PGF2alpha-induced contractions. The inhibition was demonstrated by planimetric evaluation of the contractions curves. Contraction activity of I. and IInd trimenon myometrium strips was reduced by Diclofenac but not completely inhibited. From uteri at term, three contraction curves showed complete cessation of PGE2-and PGF2alpha-induced contractions by Diclofenac (10(-4) M). The dose-dependent reduction of myometrial contractions induced by exogen prostaglandins indicates that Diclofenac possesses a direct effect on PGE2 and PGF2alpha-induced contractile activity of the uterus.

Diclofenac↗