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PubMed2006

Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women.

The intake of long-chain n-3 PUFA, including DHA (22 : 6n-3), is associated with a reduced risk of CVD. Schizochytrium sp. are an important primary source of DHA in the marine food chain but they also provide substantial quantities of the n-6 PUFA docosapentaenoic acid (22 : 5n-6; DPA). The effect of this oil on cardiovascular risk factors was evaluated using a double-blind randomised placebo-controlled parallel-design trial in thirty-nine men and forty women. Subjects received 4 g oil/d for 4 weeks; the active treatment provided 1.5 g DHA and 0.6 g DPA. Active treatment increased plasma concentrations of arachidonic acid, adrenic acid, DPA and DHA by 21, 11, 11 and 88 mg/l respectively and the proportions of DPA and DHA in erythrocyte phospholipids by 78 and 27 % respectively. Serum total, LDL- and HDL-cholesterol increased by 0.33 mmol/l (7.3 %), 0.26 mmol/l (10.4 %) and 0.14 mmol/l (9.0 %) compared with placebo (all P < or =0.001). Factor VII (FVII) coagulant activity increased by 12 % following active treatment (P = 0.006). There were no significant differences between treatments in LDL size, blood pressure, plasma glucose, serum C-reactive protein, plasma FVII antigen, FVII activated, fibrinogen, von Willebrand factor, tocopherol or carotenoid concentrations, plasminogen activator inhibitor-1, creatine kinase or troponin-I activities, haematology or liver function tests or self-reported adverse effects. Overall, the oil was well tolerated and did not adversely affect cardiovascular risk.

Adult↗
PubMed2004

Food safety: current situation, unaddressed issues and the emerging priorities.

This paper reviews the topic of food safety with reference to the Eastern Mediterranean Region. The differing views of food safety and the current situation with regard to ensuring food safety are presented. Also discussed are some of the unaddressed issues and challenges related to food safety. The new conditions that have arisen in the modern world which have facilitated the emergence of pathogens are presented, such as changes in animal husbandry, changes in international trade and travel, lifestyle and consumer changes. The urgent need for action in order to reduce the risk of microbiological and chemical foodborne diseases is emphasized. The food chain starts from farm and ends at fork; controlling this complex process requires an integrated approach and a responsible authority to oversee it in order to protect and promote food safety.

Animal Feed↗
PubMed2005

Molecular mechanisms of resistance in multidrug-resistant serovars of Salmonella enterica isolated from foods in Germany.

OBJECTIVES: The objectives of this study were to determine antimicrobial susceptibility and to characterize the molecular mechanisms of multidrug resistance among German food-borne Salmonella isolates of different serovars. METHODS: A total of 319 epidemiologically independent multidrug-resistant isolates from German foodstuffs comprising 25 different serovars were tested for their antimicrobial susceptibility by broth microdilution. The presence of antimicrobial resistance genes, integrons of classes 1 and 2 and their integrated resistance gene cassettes as well as the Salmonella genomic island 1 (SGI1) was investigated by PCR and DNA sequencing. Localization of integrons and relevant resistance genes was done by Southern hybridization. Sequence analysis revealed mutations in the quinolone resistance-determining region of the gyrA gene. RESULTS: The most prevalent resistances found in the multidrug-resistant serovars of Salmonella enterica from foods were to streptomycin (94%), sulfamethoxazole (92%), tetracycline (81%), ampicillin (73%), spectinomycin (72%), chloramphenicol (48%) and trimethoprim (27%). Twenty-four resistance genes covering six antimicrobial families (beta-lactams, aminoglycosides, phenicols, sulphonamides, tetracycline, and trimethoprim) were identified in the food isolates, many of them integrated as gene cassettes in class 1 and class 2 integrons. Class 1 integrons were detected in 65% of the multidrug-resistant Salmonella isolates comprising 16 different serovars, while class 2 integrons were found in 10% of the isolates belonging to two serovars only. The results demonstrate a clear predominance of both SGI1-borne resistance genes and class 1 integrons in Salmonella serovar Typhimurium DT104 and of class 2 integrons in Salmonella serovar Paratyphi B (d-tartrate positive). Nalidixic acid resistance found in 15% of the isolates was associated with single mutations in the gyrA gene. CONCLUSIONS: This study confirms the role of foods of animal and other origin as a reservoir of multidrug-resistant Salmonella and underlines the need for continuing surveillance of food-borne zoonotic bacterial pathogens along the food chain.

Anti-Bacterial Agents↗
PubMed2005

Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China.

Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) were studied monthly in a large shallow, eutrophic lake of the subtropical China during June-November, 2003. Microcystins (MCs) were quantitatively determined by High-Performance Liquid Chromatography (HPLC) with a qualitative analysis by a Finnigan LC-MS system. On the average of the study period, hepatopancreas was the highest in MC contents (mean 4.14 and range 1.06-7.42 microg g(-1)DW), followed by digestive tracts (mean 1.69 and range 0.8-4.54 microg g(-1)DW) and gonad (mean 0.715 and range 0-2.62 microg g(-1)DW), whereas foot was the least (mean 0.01 and range 0-0.06 microg g(-1)DW). There was a positive correlation in MC contents between digestive tracts and hepatopancreas. A constantly higher MC content in hepatopancreas than in digestive tracts indicates a substantial bioaccumulation of MCs in the hepatopancreas of the snail. The average ratio of MC-LR/MC-RR showed a steady increase from digestive tracts (0.44) to hepatopancreas (0.63) and to gonad (0.96), suggesting that MC-LR was more resistant to degradation in the snail. Since most MCs were present in the hepatopancreas, digestive tracts and gonad with only a very small amount in the edible foot, the risk to human health may not be significant if these toxic parts are removed prior to snail consumption. However, the possible transference of toxins along food chains should not be a negligible concern.

Animals↗
PubMed1999

[Dioxins and furans: origins and risks].

A bibliographic review is presented with the objective of describing the origin and the risks to the public health of dioxins and furans and getting familiar with some research areas about these compounds. The review has considered 16 selected references covering a period of approximately twelve years (1986 to 1997). The main conclusions were: a) These compounds are from nonnatural origin, considered highly toxic, extremely persistent in the environment, and they have been detected in all environmental matrices like: soil, sediments, air, water, animals and plants; b) emissions of these compounds to the atmosphere come primarily from combustion processes; c) atmospheric dispersion, deposition and subsequent accumulation in the food chain seem to be the major exposure pathway to the general population; d) due to their lipophilic characteristic and persistence in the environment, these compounds accumulate in adipose tissues, being food of animal origin those which present higher concentrations; e) in Brazil, the few studies conducted, with the measurement of concentrations of these compounds in the environment have showed levels comparable to those obtained in Germany. The authors recommend the development of further studies about these compounds in Brazil, specially about their accumulation in food and in human tissue

Animals↗
PubMed2004

Epidemiological and epizootological aspects of salmonellosis.

In their case report, most of the patients with salmonellosis mentioned consumption of meals containing poultry products, primarily eggs and egg products as a source of their disease. Microbiological analysis of samples showed that in more than 88 % of cases the infection agent was identified as Salmonella enteritidis. This serovar is the most frequent pathogen isolated at poultry farms. In the period of the past five years, 171 outbreaks of salmonellosis were recorded in Slovakia. However, within the group of animal tenders at these farms, no case of salmonellosis was confirmed. The alimentary character of salmonellosis led us to check results of analyses of samples of food and foodstuff of animal origin examined for Salmonella spp. performed during the past five years. The control of results indicated that out of these 228 545 samples of food and foodstuff of animal origin only 0.21% were confirmed as being Salmonella positive and the average ratio of Salmonella enteritidis occurrence in samples was 0.1% per year. A higher incidence (1.43 %) was recorded only in eggs and egg products. Our observations indicated that there was a change in tenacity of Salmonella enteritidis due to its increased resistance, primarily against elevated temperatures including that of pasteurization. An everyday requirement for decreasing the incidence of salmonellosis is based on strict hygienic behaviour "from stable to table". The objective of salmonellosis elimination strongly depends on amending the current legislation as to the establishment of hygienic conditions in complete food chains. (Tab. 4, Ref. 21.)

Animals↗
PubMed2004

Influence of processing on trichothecene levels.

Trichothecene mycotoxins frequently occur in cereal grains that are intended for food production. The process of converting grains into food and drinks for consumers has significant effects on the levels of toxins in the final food. Surveillance of retail food and drinks of cereal origin demonstrates that trichothecenes do survive the production processes employed. Trichothecenes are relatively heat stable chemicals, with high water solubility, properties that affect their processing fate. It is known that the extent of transmission into final food products is dependent on the pattern of Fusarium infection in the grains. For dry-milled products, the most highly contaminated fractions are those that contain the whole or the outer portions of the grain. For wet milling, the trichothecenes primarily transfer to the aqueous fractions, the most contaminated streams enter the animal food chain, although there is no evidence of significant trichothecenes transmission into animal products. However, anomalies remain in the understanding of the processing effects of several major cereal processes used in European food production (e.g. baking and brewing).

Edible Grain↗
PubMed1986

Food, nutrition, and agriculture: a liaison for world development.

In spite of larger worldwide food harvests in recent years, the number of people in underdeveloped countries without enough food to eat is increasing. Those most likely to suffer from undernutrition are the traditionally vulnerable groups, especially the rural poor. In many underdeveloped countries, the average farm size is smaller, the number of landless farm workers is larger, and the number of rural poor families without land on which to grow food or money to buy it for home consumption is greater than ever before. Undernutrition is often viewed as a family health problem only. Thus, education in nutrition is generally directed toward home economists, health workers, and primary school teachers. Since unavailability of food is usually the most limiting factor in improving nutritional status of the poor, all agencies dealing with the food chain from production to consumption should be involved. An educational partnership between health, nutrition, and agriculture may be the most important alliance that could be brought into being to ensure enough food for the nutritional well-being of the world's population. This article presents the rationale for education in nutrition in the preparation of agriculturalists and reviews some of the past efforts and present activities of national and international organizations to meld nutrition into agricultural world development programs.

Agriculture↗
PubMed1994

Cumulation NOx in foodstuffs and raw materials of animal origin.

In recent years quality of all raw materials processed by agricultural-food industry complex has been influenced by penetration of contaminating hazardous substances into the food chain as a result of high chemization, as well as by the exhalation fall-outs of industrial enterprises. In our study we followed the cumulation of nitrates and nitrites in food and raw materials of animal origin in the exposed industrial area of East Slovak Ironworks in Kosice. Determined were the residual levels of nitrates and nitrites in meat and organs of slaughterhouse cattle, milk and water from individual agricultural enterprises. Consistent control of the content of these hazardous substances in foodstuffs of vegetable and animal origin, water, soil and air represents a considerable contribution from viewpoint of consumer protection.

Air Pollutants↗
PubMed2005

Antimicrobial resistance of Salmonella spp. from pigs at slaughter in Spain in 1993 and 2001.

AIM: To compare the incidence of antimicrobial resistance among Salmonella serotypes isolated in a pig slaughterhouse in Zaragoza (Spain) during 1993 and 2001. METHODS AND RESULTS: A total of 168 isolates representing 10 serotypes were examined by disc diffusion method using 17 antibiotics. Data showed that the majority of the strains were resistant to streptomycin (97%), sulfadiazine (93.4%) and tetracycline (83.3%). A large proportion of the collection was multidrug resistant (MDR, resistance to four or more antibiotics) with a greater incidence in 2001. The findings imply an increasing incidence of MDR amongst S. Typhimurium, and all S. Typhimurium-definitive phage type (DT) 104 isolates were resistant to ampicillin, chloramphenicol, streptomycin, sulphonamide and tetracycline (R-ACSSuT). This resistance phenotype had spread among other phage and serotypes. Salmonella Ohio was also a MDR serotype and this is not a serotype normally associated with drug resistance. CONCLUSIONS: A large proportion of the strains were MDR and this showed that pork products could be a potential vehicle of MDR Salmonella food-borne infections. SIGNIFICANCE AND IMPACT OF THE STUDY: The findings may have significant public health consequences and could contribute to the development of useful practices aimed at limiting the transmission of MDR Salmonella serotypes through the food chain.

Abattoirs↗
PubMed2006

Characterization of antimicrobial resistance and class 1 and 2 integrons in Salmonella enterica isolates from different sources in Portugal.

OBJECTIVES: The antimicrobial resistance profiles of 1183 Salmonella isolates collected during 2002-2003 from several sources (human, food products and environment) were evaluated. The occurrence, distribution and cassette content of class 1 and 2 integrons among the sulphonamide-resistant population, as well as the role of particular clones to the spread of these genetic elements, were investigated. METHODS: The isolates were examined for susceptibility to antimicrobial agents. The characterization of class 1 and 2 integrons was investigated using PCR, PCR-RFLP (restriction fragment length polymorphism) and sequencing in the sulphonamide-resistant isolates. Conjugation assays and clonality analysis by PFGE were performed. RESULTS: The most common resistance phenotypes were to nalidixic acid, tetracycline, streptomycin, sulfamethoxazole and ampicillin (ranging from 31% to 17%). Resistance to sulphonamides (n=200) was associated with resistance to other antimicrobial agents, with 75% of the isolates carrying one or two class 1 integrons while only 3% simultaneously carried class 1 and 2 integrons. Integrons were observed among at least 11 serotypes (mainly Typhimurium) and in a reduced number of PFGE clones (20). Eight class 1 integron types were found, with the aadA genes (aadA1, aadA2 and aadA5) alone or downstream of a trimethoprim (dfrA1, dfrA12 and dfrA17) or a beta-lactamase resistance gene (blaoxa-30) and the blaPSE-1 gene alone. Most of the class 1 integron types were shared by several clones from the same or different serotypes obtained either from humans or food products of animal origin, especially pork products. However, some Typhimurium-specific integrons were found: aadA2 plus blaPSE-1 and blaoxa-30-aadA1. CONCLUSIONS: Apart from the hypothetical contribution of the conjugative transfer of integrons, the incidence of Salmonella carrying these genetic units seems to rely on the ability of certain clones to spread or persist in particular animal niches. Our data suggest that food-producing animals might be simultaneously considered as a reservoir of clones and integrons carrying antibiotic resistance genes, thus making the food chain, especially pork products, a possible source of multidrug-resistant isolates in humans.

Anti-Bacterial Agents↗
PubMed1998

A database for environmental contaminants in traditional food in northern Canada.

The potential health effects of environmental contaminants in traditional food on indigenous peoples in Northern Canada have been a growing concern. We have conducted an extensive literature review on contaminant levels in Northern Canada through searches of commercial, private, and government databases for the years 1986-1995, including MEDLine, Agricola, Biological Abstracts, Current Contents, Applied Science and Technology, Biosis, CABCD, Aquatic Sciences and Fisheries Abstracts, CRIS/ICAR, and the Northern Aquatic Food Chain Contaminant Database. More than 20,000 data items were identified in over 50 published articles, unpublished data, government reports, and review articles. Ranges of levels of 13 contaminants in major traditional food groups collected from four geographical regions (Yukon, MacKenzie, Keewatin, Baffin and Northern Quebec) were calculated. Exposure levels, particularly according to different dietary patterns, were estimated and discussed in relation to guideline levels.

Animals↗
PubMed1989

Risk assessment of the mycotoxin ochratoxin A.

Ochratoxin A (OA) is a mycotoxin which has been found to occur in foods of plant origin, in edible animal tissues, as well as in human blood sera and tissues. The ability of OA to move up the food chain is aided by its long half-life in certain edible animal species. In this report, an evaluation of the health risks to Canadians due to the presence of OA in food products is presented. The first part of the report deals with the physicochemical aspects, mycology, laboratory production, analytical methods, and natural occurrence in plant products, animal products, and human tissues. The stability of OA in foods and feeds, the effects of food processing, and the removal from foods and feeds by physiochemical means are also discussed. From these data, the worst case estimate for the daily exposure of Canadians to OA, from the consumption of pork-based food products and cereal foods, is approximately 5 ng OA/kg body wt (mean of eaters) for young children, the highest consumption group on a body weight basis. The second part of the report deals with the metabolic disposition as well as the available toxicity database for OA in laboratory animals, farm animals, and humans. The major target for OA toxicity in all mammalian species tested is the kidney, and endemic nephropathies affecting livestock as well as humans have been attributed to OA. OA is also teratogenic, and in the fetus the major target is the developing central nervous system. Recent studies have provided "clear evidence" of the carcinogenicity of OA in two rodent species. OA was found to be nonmutagenic in various microbial and mammalian gene mutation assays, but weak genotoxic activity to mammalian cells was noted. In addition, OA was found to suppress immune function. Based on the NTP carcinogenicity study with OA in rats, the estimated tolerable daily intake in humans ranges from 0.2 to 4.2 ng OA/kg body wt, depending on the method of extrapolation used. In view of the toxic properties of OA, it is recommended that exposure to OA be kept to a minimum. In Canada, further monitoring programs are required to better define the overall residue profile of OA in cereal grains, animal feeds, animal food products, and human blood. Such data are required to better assess dietary exposure and to ascertain the need for regulatory controls or other control mechanisms.

Abnormalities, Drug-Induced↗
PubMed1989

Uncertainty in predictions of fallout radionuclides in foods and of subsequent ingestion.

Uncertainty in predictions from the PATHWAY food-chain model was estimated using Monte Carlo simulation. Uncertainty estimates, measured by the geometric standard deviation (GSD), were obtained for median values of time-integrated concentrations of 131I, 136Cs, and 137Cs in foods and for the corresponding time-integrated intakes resulting from ingestion of all foods. The GSDs associated with a given food for the two short-lived radionuclides, 131I and 136Cs, were not significantly different, but they differed from the GSDs for the longer-lived radionuclide. The GSDs for integrated concentrations of radionuclides in milk varied with the time of year fallout was deposited, but uncertainty for nondairy products was relatively independent of the date of fallout deposition. The estimated GSDs were applied to other radionuclides of interest based on physical half-life and ranged from 1.7 to 2.7 for time-integrated intake across all foods for radionuclides with physical half-lives less than 30 d, from 1.8 to 2.3 for half-lives ranging from 30 to 500 d, and from 1.9 to 2.1 when half-lives were greater than 500 d.

Animal Feed↗
PubMed1991

Effect of dietary intake on the 137Cs retention model.

Whole-body counting measurements were conducted to monitor the 137Cs biological half-life of 14 individuals in Athens during the period June 1988 to June 1989. The results and the solution of a 137Cs retention model showed that the individuals examined were receiving 0-3.7 Bq d-1 of 137Cs through the food chain during the period investigated.

Adult↗
PubMed2006

Antimicrobial resistance in Campylobacter isolated from food animals and humans in northern Thailand.

A study was conducted to determine the prevalence of Campylobacter with antimicrobial resistance from chickens, pigs, dairy cows, healthy farm workers, and children hospitalized with diarrhea in northern Thailand. Resistance was highest in pig samples and lowest in healthy farm workers. Resistance to fluoroquinolones and tetracycline was high in all study populations. The increased prevalence of resistant isolates from meat samples collected at markets, compared to isolates collected from animals on the farm or the slaughterhouse, suggests that contamination after carcasses leave the slaughterhouse is an important factor in the spread of resistant bacteria into the human food chain.

Animal Diseases↗
PubMed2003

Assessment of dietary exposure to some persistent organic pollutants in the Republic of Karakalpakstan of Uzbekistan.

A 1999 study heightened long-standing concerns over persistent organic pollutant contamination in the Aral Sea area, detecting elevated levels in breast milk and cord blood of women in Karakalpakstan (western Uzbekistan). These findings prompted a collaborative research study aimed at linking such human findings with evidence of food chain contamination in the area. An international team carried out analyses of organochlorine and organophosphate pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) on samples of 12 foods commonly produced and consumed in Karakalpakstan. Analysis consistently detected long-lasting organochlorine pesticides and their metabolites in all foods of animal origin and in some vegetables such as onions and carrots--two low-cost components of many traditional dishes. Levels of PCBs were relatively low in all samples except fish. Analyses revealed high levels of PCDDs and PCDFs (together often termed "dioxins") in sheep fat, dairy cream, eggs, and edible cottonseed oil, among other foodstuffs. These findings indicate that food traditionally grown, sold, and consumed in Karakalpakstan is a major route of human exposure to several persistent toxic contaminants, including the most toxic of dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). Intake estimations demonstrate that consumption of even small amounts of locally grown food may expose consumers to dioxin levels that considerably exceed the monthly tolerable dioxin intake levels set by the World Health Organization. Data presented in this study allow a first assessment of the risk associated with the consumption of certain food products in Karakalpakstan and highlight a critical public health situation.

Dioxins↗
PubMed1999

Campylobacter jejuni.

Campylobacter jejuni is the most frequently diagnosed bacterial cause of human gastroenteritis in the United States. The emergence of antimicrobial-resistant and, in particular, of fluoroquinolone-resistant C. jejuni infections in Europe and the United States, temporally associated with the approval of use of fluoroquinolones in veterinary medicine, is an important public health concern. Recent research has provided strong evidence for an association between Campylobacter infection and Guillain-Barr Syndrome (GBS), and Campylobacter is the most frequent antecedent infection in GBS. The consumption of undercooked poultry and cross-contamination of other foods with uncooked meat products are leading risk factors for human campylobacteriosis. Reinforcing hygienic practices at each link in the food chain, from producer to consumer, is critical in preventing the disease.

Animals↗