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PubMed1980

Prostatic induction: interaction of epithelium and mesenchyme from normal wild-type mice and androgen-insensitive mice with testicular feminization.

The prostate gland develops from the urogenital sinus as epithelial buds projecting into the surrounding mesenchyme. The role of the mesenchyme in this process was determined using sinuses from normal and androgen-insensitive Tfm mice which are deficient in androgen receptors. Epithelium and mesenchyme from both types of sinus were separated and recombined and the recombinants grown in organ culture in the presence of testosterone. Recombinants consisting of normal epithelium and normal mesenchyme developed epithelial buds projecting into the surrounding mesenchyme but no buds were formed in recombinants of epithelium and mesenchyme from mutant mice. In recombinants of epithelium from mutant mice with normal mesenchyme the epithelium developed prostatic buds and the number was similar to that found if normal epithelium was associated with normal mesenchyme. In contrast, normal epithelium combined with mesenchyme from mutant mice failed to form prostatic buds. The results suggested that the mesenchyme determines the development of prostatic buds and that the lack of inductive capacity of the mesenchyme from mutant mice may be due to a deficiency of mesenchymal androgen receptors.

Androgen-Insensitivity Syndrome↗
PubMedDate not supplied

Dis-ease between nursing and feminism: nurses caring for one another within a feminist framework.

Mental health professionals have the experience and skills necessary to provide care and support to colleagues and peers in these troubled and stressful times. Yet, traditionally nurses have not been supportive of one another. Not receiving much interest from the feminist movement and not willingly to embrace feminist social activism, the nursing profession has suffered as it continues to embrace racist, classist, sexist, and homophobic outdated theories and research practices. Without a collective voice which unites all nurses in a common struggle, issues related to mental health nursing will continue to be viewed in a fragmented way. Until feminist research, theory, and practice become central to the profession's ideology, nurses will continue to be divided among themselves, unable to provide the necessary caring for one another.

Female↗