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PubMed2001

Amygdala response to fearful faces in anxious and depressed children.

BACKGROUND: Alterations in amygdala function have been implicated in the pathophysiological characteristics of adult anxiety and depressive disorders. Studies with healthy adults and children, as well as with adults who have amygdala lesions, have found facial expressions of emotion to be useful probes of amygdala activity. Our study examined the amygdala response to fearful and neutral facial expressions in healthy, anxious, and depressed children. We hypothesized that children with anxiety and depression may show atypical amygdala responses to emotional stimuli. METHODS: Twelve children (8-16 years of age) with generalized anxiety or panic disorder and 12 healthy comparison children underwent noninvasive functional magnetic resonance imaging while viewing photographs of fearful and neutral facial expressions. In a second comparison, 5 girls with major depressive disorder were compared with 5 anxious and 5 healthy girls from the previous sample. RESULTS: Children with anxiety disorders showed an exaggerated amygdala response to fearful faces compared with healthy children, whereas depressed children showed a blunted amygdala response to these faces. In addition, the magnitude of the amygdala's signal change between fearful and neutral faces was positively correlated with the severity of everyday anxiety symptoms. CONCLUSIONS: Our results suggest that amygdala function is affected in both anxiety and depression during childhood and adolescence. Moreover, this disruption appears to be specific to the child's own rating of everyday anxiety.

Adolescent↗
PubMed2006

Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers.

RATIONALE: The serotonin precursor L-tryptophan (TRP) is available as a nutritional supplement and is licensed as an antidepressant in a number of countries. However, evidence of its efficacy as the primary treatment for depression is limited, and the direct action of TRP on the symptoms of depression and anxiety has not been well-characterised. OBJECTIVES: The present study assessed whether TRP induces cognitive changes opposite to the negative biases found in depression and characteristic of those induced by serotonergic antidepressants in healthy volunteers. MATERIALS AND METHODS: Thirty eight healthy volunteers were randomised to receive 14 days double-blind intervention with TRP (1 g 3x a day) or placebo. On the final day, emotional processing was assessed using four tasks: facial expression recognition, emotion-potentiated startle, attentional probe and emotional categorisation and memory. RESULTS: TRP increased the recognition of happy facial expressions and decreased the recognition of disgusted facial expressions in female, but not male, volunteers. TRP also reduced attentional vigilance towards negative words and decreased baseline startle responsivity in the females. CONCLUSIONS: These findings provide evidence that TRP supplementation in women induces a positive bias in the processing of emotional material that is reminiscent of the actions of serotonergic antidepressants. This highlights a key role for serotonin in emotional processing and lends support to the use of TRP as a nutritional supplement in people with mild depression or for prevention in those at risk. Future studies are needed to clarify the effect of tryptophan on these measures in men.

Adolescent↗
PubMed2005

Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndrome.

The amygdala is preferentially activated by facial expressions of fear. Right and left amygdala are hypothesized to play distinct, but complementary, roles that influence somatic and cognitive responses to facial expressions. Right amygdala activation is linked to autonomic arousal, and thus indirectly influences left hemisphere cognitive processing centres. Left amygdala activation is more closely associated with cognitive processing and differentiation of facial emotions. A double-dissociation between the functions of left and right amygdala is implied by lesion studies but supportive evidence is inconsistent, partly because patients with structural anteromedial temporal anomalies have experienced variable surgical procedures. A functional dissociation can be demonstrated between arousal and the cognitive appraisal of fearful faces in the condition of X-monosomy or Turner syndrome. Previous research found Turner syndrome women of normal verbal intelligence are seriously impaired in their ability cognitively to differentiate fearful from other facial expressions but they acquire fear conditioning normally, with enhanced autonomic responses. These findings supported the dissociation hypothesis, which was formally tested in a study of 12 X-monosomic and 12 control females who participated in functional magnetic resonance imaging during which simultaneous skin conductance recordings were acquired. Faces depicting fear or neutral emotions were presented to both case and control subjects in random order. Arousal to (fearful-neutral) faces was associated with transiently increased skin conductance responses and bilateral amygdala activation in both groups, but X-monosomic females had proportionately greater--and more persistent--right amygdala activation than controls. In both groups, cognitive accuracy correlated positively with differential activity of left fusiform gyrus. There was a significant correlation between the left fusiform and left medial amygdala activation only in normal females, and only in them did differential SCRs (to fearful-neutral faces) correlate positively with left fusiform responses. Arousal and cognitive appraisal functions of the amygdala can thus be functionally dissociated. X-monosomy selectively impairs explicit recognition of fearful faces in the presence of normal or enhanced autonomic reactivity, and is associated with a functional dissociation of activity in left amygdala and left fusiform gyrus. These findings imply X-linked genes are essential for binding somatic responses to the cognitive appraisal of emotional stimuli.

Adult↗
PubMed2004

Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.

OBJECTIVE: Antidepressants that inhibit the reuptake of serotonin (SSRIs) or norepinephrine (SNRIs) are effective in the treatment of disorders such as depression and anxiety. Cognitive psychological theories emphasize the importance of correcting negative biases of information processing in the nonpharmacological treatment of these disorders, but it is not known whether antidepressant drugs can directly modulate the neural processing of affective information. The present study therefore assessed the actions of repeated antidepressant administration on perception and memory for positive and negative emotional information in healthy volunteers. METHOD: Forty-two male and female volunteers were randomly assigned to 7 days of double-blind intervention with the SSRI citalopram (20 mg/day), the SNRI reboxetine (8 mg/day), or placebo. On the final day, facial expression recognition, emotion-potentiated startle response, and memory for affect-laden words were assessed. Questionnaires monitoring mood, hostility, and anxiety were given before and after treatment. RESULTS: In the facial expression recognition task, citalopram and reboxetine reduced the identification of the negative facial expressions of anger and fear. Citalopram also abolished the increased startle response found in the context of negative affective images. Both antidepressants increased the relative recall of positive (versus negative) emotional material. These changes in emotional processing occurred in the absence of significant differences in ratings of mood and anxiety. However, reboxetine decreased subjective ratings of hostility and elevated energy. CONCLUSIONS: Short-term administration of two different antidepressant types had similar effects on emotion-related tasks in healthy volunteers, reducing the processing of negative relative to positive emotional material. Such effects of antidepressants may ameliorate the negative biases in information processing that characterize mood and anxiety disorders. They also suggest a mechanism of action potentially compatible with cognitive theories of anxiety and depression.

Adrenergic Uptake Inhibitors↗
PubMed2006

Impaired sadness recognition is linked to social interaction deficit in autism.

Can autistic individuals use motion cues to identify simple emotions from 2D abstract animations? We compared emotion recognition ability using a novel test involving computerised animations, and a more conventional emotion recognition test using facial expressions. Adults with autism and normal controls, matched for age and verbal IQ, participated in two experiments. First, participants viewed a series of short (5s) animations. These featured an 'emotional' triangle, interacting with a circle. They were designed to evoke an attribution of emotion to the triangle, which was rated both in terms of anger, happiness, sadness or fear from its pattern of movement, and how animate ("living") it appeared to be. Second, emotion recognition was tested from standardised photographs of facial expressions. In both experiments, adults with autism were significantly impaired relative to comparisons in their perception of sadness. This is the first demonstration that, in autism, individuals can have difficulties both in the interpretation of facial expressions and in the recognition of equivalent emotions based on the movement of abstract stimuli. Poor performance in the animations task was significantly correlated with the degree of impairment in reciprocal social interaction, assessed by the Autism Diagnostic Observation Schedule. Our findings point to a deficit in emotion recognition in autism, extending beyond the recognition of facial expressions, which is associated with a functional impairment in social interaction skills. Our results are discussed in the context of the results of neuroimaging studies that have used animated stimuli and images of faces.

Adult↗
PubMed2006

An analysis of categorical perception of facial emotion in schizophrenia.

BACKGROUND: Emotion perception deficits have been extensively documented in schizophrenia and are associated with poor social functioning. Yet fundamental questions about the nature and scope of these impairments remain unanswered from commonly used experimental tasks. An alternative categorical perception paradigm that focuses on distinguishing boundaries between emotions was used to evaluate whether schizophrenia patients demonstrate atypical patterns of categorical perception and a negativity bias in the identification of ambiguous facial expressions. METHOD: 47 schizophrenia outpatients and 31 nonpsychiatric controls completed a forced-choice emotion identification task. Stimuli consisted of a series of digitized facial images that were morphed in 10% signal intensity increments along continua between pairs of emotions (happy-sad; fearful-happy; angry-fearful; angry-sad) and presented in a random order. For each emotion continuum, measures of the response slope and the location of the boundary shift point between emotions were calculated for each group. RESULTS: The schizophrenia group demonstrated significantly shallower response curves than controls across all emotion continua. Despite these generally less precise demarcations between emotions, patients did not significantly differ from controls in the location of the shift point between emotions on any of the continua. CONCLUSIONS: Schizophrenia patients demonstrated impaired categorical perception of facial expressions with generally less sharp categorizations of ambiguous stimuli to one emotion category or another. However, patients did not demonstrate a negativity bias in their processing of ambiguous facial expressions. The emotional continuum paradigm can help to clarify the nature and boundaries of affect perception deficits in schizophrenia.

Adolescent↗
PubMed2004

What makes Mona Lisa smile?

To study the ability of humans to read subtle changes in facial expression, we applied reverse correlation technique to reveal visual features that mediate understanding of emotion expressed by the face. Surprising findings were that (1) the noise added to a test face image had profound effect on the facial expression and (2) in almost every instance the new expression was meaningful. To quantify the effect, we asked naïve observers to rank the face of Mona Lisa superimposed with noise, based on their perception of her emotional state along the sad/happy dimension. Typically, a hundred trials (with 10 or more samples for each rank category) were sufficient to reveal areas altering the facial expression, which is about two orders of magnitude less than in the other reverse correlation studies. Moreover, the perception of smiling in the eyes was solely attributable to a configurational effect projecting from the mouth region.

Emotions↗
PubMed2000

Emotion space as a predictor of binocular rivalry.

In our 1999 report, we examined robustness of a two-dimensional structure of facial expressions of emotion under the condition of some perceptual ambiguity, using a stereo-scope. The current study aimed to replicate and extend the previous work by adding facial photographs of different persons and by measuring participants' perception of stereoscopically presented faces. Multidimensional scaling provided a two-dimensional configuration of facial expressions comparable with the previous studies. Although binocular rivalry was a less frequent phenomenon, it was suggested that the distances between facial expressions in the derived space were a contributing factor in eliciting binocular rivalry.

Emotions↗
PubMed2004

Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania.

BACKGROUND: The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying negative emotions. There are sparse data to suggest there may be an analogous, state-related negative recognition bias for negative emotions in mania. We used functional magnetic resonance imaging (fMRI) to investigate the behavioural and neurocognitive correlates of happy and sad facial affect recognition in patients with mania. METHOD: Functional MRI and an explicit facial affect recognition task were used in a case-control design to measure brain activation and associated behavioural response to variable intensity of sad and happy facial expressions in 10 patients with bipolar I mania and 12 healthy comparison subjects. RESULTS: The patients with mania had attenuated subjective rating of the intensity of sad facial expressions, and associated attenuation of activation in the subgenual anterior cingulate and bilateral amygdala, with increased activation in the posterior cingulate and posterior insula. No behavioural or neurocognitive abnormalities were found in response to presentation of happy facial expressions. CONCLUSIONS: Patients with mania showed a specific, mood-congruent, negative bias in sad facial affect recognition, which was associated with an abnormal profile of brain activation in paralimbic regions implicated in affect recognition and mood disorders. Functional imaging of facial emotion recognition may be a useful probe of cortical and subcortical abnormalities in mood disorders.

Adult↗
PubMed2003

Attentionally modulated effects of cortisol and mood on memory for emotional faces in healthy young males.

Heightened cortisol levels due to stress or acute administration seem to enhance memory for emotional material, independently of emotional valence. An arousal-driven neurobiological mechanism involving the amygdala has been proposed. The relation between pre-task salivary measures of cortisol (by convention named 'basal levels') and emotionally modulated memory has not been investigated yet. Given the association between higher basal levels of cortisol and indices of low mood, valence-specific effects on emotionally modulated memory could be expected (e.g. mood-congruent or stimulus-specific forms of processing). This study was designed to investigate the relationship between basal levels of salivary cortisol, self-reported mood and spatial memory for neutral, happy and angry facial expressions in healthy young volunteers (N=31). Memory performance was indexed using a modified version of a computerized object-relocation task, using emotional facial expressions as stimuli. Results showed a significant relation between cortisol and depressive mood. More importantly, both the levels of cortisol and depressive mood were inversely related to the memory performance for the happy facial expressions, while a similar relationship between cortisol and memory performance on angry faces neared significance. An explanation in terms of the down-regulation of social behavior by elevated basal cortisol levels is postulated.

Adult↗
PubMed2006

Normal standards of fetal behavior assessed by four-dimensional sonography.

OBJECTIVE: In this prospective randomized study, fetal behavior was investigated in order to determine the standard parameters of fetal movements and facial expressions in all three trimesters of normal pregnancy. METHODS: Sixty-three pregnant women with singleton pregnancies in all trimesters were included in the investigation. Four-dimensional (4D) ultrasound was performed for each patient over a 30-minute period. Variables of maternal and fetal characteristics including gestational age, eight fetal movement patterns in the first trimester, and sixteen parameters of fetal movement and fetal facial expression patterns in the second and third trimesters were recorded for the construction of fetal neurological charts. RESULTS: In the first trimester, a tendency towards an increased frequency of fetal movement patterns with increasing gestational age was noticed. Only the startle movement pattern seemed to occur stagnantly during the first trimester (p > 0.05). At the beginning of the second trimester, the frequency of fetal movement patterns tended to increase. During the second and third trimester, multiple regression and polynomial regression revealed statistically significant changes in tongue expulsion (p < 0.05), smiling (p < 0.05), grimacing (p < 0.05), swallowing (p < 0.05), eye blinking (p < 0.01), head movements, and all hand to body contact movements (p < 0.01), except for head anteflexion (p > 0.05). There were no statistically significant changes during the second and third trimesters in mouthing, yawning, and sucking (p > 0.05). At the middle of the third trimester, the fetuses displayed decreasing or stagnant incidence of fetal facial expressions except for eye blinking, which showed increased frequency with increasing gestational age. A statistically significant correlation was found between all head movements and hand to body contact patterns during the second and third trimesters except for head anteflexion (r = -0.231; p > 0.05). CONCLUSIONS: The full range of quantitative fetal facial expressions and fetal movement patterns can be assessed successfully by 4D sonography. It is important to be able to assess normal fetal behavior throughout gestation to identify abnormal behavior before birth.

Female↗
PubMed2001

A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies.

The processing of emotional expressions is fundamental for normal socialisation and interaction. Reduced responsiveness to the expressions of sadness and fear has been implicated in the development of psychopathy (R. J. R. Blair, 1995). The current study investigates the sensitivity of children with psychopathic tendencies to facial expressions. Children with psychopathic tendencies and a comparison group, as defined by the Psychopathy Screening Device (PSD; P. J. Frick & R. D. Hare, in press), were presented with a cinematic display of a standardised set of facial expressions that depicted sadness, happiness, anger, disgust, fear, and surprise. Participants observed as these facial expressions slowly evolved through 20 successive frames of increasing intensity. The children with psychopathic tendencies presented with selective impairments; they needed significantly more stages before they could successfully recognise the sad expressions and even when the fearful expressions were at full intensity were significantly more likely to mistake them for another expression. These results are interpreted with reference to an amygdala and empathy impairment explanation of psychopathy.

Adolescent↗
PubMed2005

The relation of facial affect recognition and empathy to delinquency in youth offenders.

Associations among facial affect recognition, empathy, and self-reported delin-quency were studied in a sample of 29 male youth offenders at a probation placement facility. Youth offenders were asked to recognize facial expressions of emotions from adult faces, child faces, and cartoon faces. Youth offenders also responded to a series of statements on emotional empathy, and provided self-reported acts of delinquency. Findings revealed a moderate positive relationship between ability to recognize the expression, angry, in adult faces, and self-reported acts of delinquent behavior, which included physical violence, theft, and vandalism. Findings revealed a moderate inverse relationship between ability to recognize facial expressions of emotions in child faces and self-reported acts of physical violence. With respect to specific facial expressions of emotions in child faces, a moderate inverse relationship was found between ability to recognize the expression, fearful, and self-reported acts of physical violence. A moderate positive relationship was found between ability to recognized the expression, fearful, in child faces, and ability to empathize with the emotional experiences of others. Strong and moderate links were found between the negative expressions, fearful and sad, and angry and sad, respectively. Additionally, a strong inverse relationship was found between ability to emphathize with the emotional experiences of others and self-reported acts of delinquent behavior. Lastly, a strong positive relationship was found between covert and overt self-reported acts of delinquent behavior. Results from this exploratory investigation suggest a link between facial affect recognition, empathy, and delinquency. Findings have important implications for educators and counselors who work with youth offenders within probation placement facilities.

Adolescent↗
PubMed1994

Movement, face processing and schizophrenia: evidence of a differential deficit in expression analysis.

Three dynamic face-processing tasks based on the Bruce & Young (1986) functional model of face processing were presented to 10 schizophrenic and 10 depressed inpatients and to 10 non-patient subjects. Familiar face recognition, facial expression recognition and unfamiliar face matching were examined. Schizophrenic patients' performance was significantly poorer than that of depressed patients and non-patient controls. Significantly lower scores were obtained on the facial expression recognition task than on the familiar face recognition task. There was a differential pattern of group performance on each of the three tasks: schizophrenic and depressed patients were as accurate as non-patient controls on the familiar face recognition task, but significantly less accurate than non-patient controls on the unfamiliar face-matching task. Schizophrenic patients were significantly less accurate than depressed patients and non-patient controls on the facial expression recognition task. The results are contrasted with an analogous static face-processing study.

Adolescent↗
PubMed1988

Differential facial responses to four basic tastes in newborns.

The distinctiveness and recognizability of taste-elicited facial expressions in newborns were examined in 2 studies. Sucrose, sodium chloride, citric acid, and quinine hydrochloride solutions were presented to 12 infants at 2 hours of age. In Study 1, the anatomically based Facial Action Coding System adapted for infants (Baby FACS) was used to obtain detailed, objective descriptions of the infants' videotaped facial responses to each solution. Facial responses to sucrose were characterized primarily by facial relaxation and sucking. The responses to salty, sour, and bitter solutions shared the same hedonically negative upper- and midface components but differed in the accompanying lower-face actions: lip pursing in response to sour and mouth gaping in response to bitter. There was no distinctive facial expression for sodium chloride. These findings demonstrate that newborns differentiate sour and bitter from each other and from salt, as well as discriminating sweet versus nonsweet tastes. In Study 2, untrained adults viewing videotapes of the infants' facial reactions made forced-choice judgments identifying the stimuli presented and rated the hedonic tone of the infants' responses. While the judges accurately identified the newborns' responses to sucrose, there were systematic errors in their judgments of the 3 nonsweet stimuli. The judges' hedonic ratings, on the other hand, clearly differentiated between the infants' responses to the bitter stimulus and the other 3 tastes. The findings are discussed in terms of the possible functional origins and communicative value of taste-elicited facial expressions in infants.

Discrimination Learning↗
PubMed1984

Lateral asymmetry of positive and negative emotions.

This reaction time study examined whether the left and right hemispheres are differentially specialized to process positive and negative affect respectively in adult females and males. Either happy or sad facial expressions of emotion were presented simultaneously with neutral facial expressions to the two visual fields. Happy faces were responded to more rapidly in the left visual field-right hemisphere with no visual field differences for sad faces. Females were superior to males when emotional facial stimuli were presented to the left visual field and were more accurate in recognizing sad faces compared to happy ones.

Adult↗
PubMed2003

Matching expression variant faces.

Several models have been proposed that attempt to explain how the brain identifies people by looking at their faces. However, to date, it is still not clear by which mechanism the brain successfully accomplishes the matching of two or more face images when differences in facial expression make the (local and global) appearance of these images different from one another. There seems to be a consensus that faces are processed holistically rather than locally, but there is not yet consensus on whether information on facial expression is passed to the identification process to aid recognition of individuals or not. Models have been proposed that exploit each of these two views, and psychophysical data exist in favor of and against each view. In this article, we show how the experimental data of these two opposite views can be explained by incorporating a key process of motion estimation in the classical feedforward model of face processing. This new model will then lead us to hypothesize that to successfully match expression variant faces, it is convenient to use the information supplied by this motion estimation process within the matching task. We will show experimental results in favor of this hypothesis. Finally, we will show how we can also use the same motion estimator to recognize facial expressions.

Computer Simulation↗
PubMed1987

Anhedonia and emotional responses to affect evoking stimuli.

The purpose of the present study was to determine whether individuals with unusually high scores on the Scale for Physical Anhedonia (Chapman et al. 1976) would differ from average scorers in their emotional responses to affect-evoking stimuli. Ten male and ten female anhedonics, as well as ten male and ten female control subjects, were each shown brief filmclips that were expected to elicit emotional responses. The subjects' facial expressions were videotaped while they watched the filmclips, and they also completed adjective checklists describing how they felt while watching them. The anhedonics and nonanhedonics did not differ in their self-reports of emotional experience, nor did they differ in their facial expressions of emotion while viewing the filmclips. Compared to men, women reported experiencing more emotion, and their facial expressions also indicated greater responsiveness.

Affective Symptoms↗