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PubMed2006

Giant cell fibroma: a case report.

This article describes a case of giant cell fibroma in a 3-year-old boy, which is an uncommon age for this lesion. The cause of this pathology has not been determined. The lesion was excised by electro surgery and submitted to a histological exam, which confirmed the diagnosis. No recurrence was observed. Pediatric dentists should be capable to diagnose and treat this kind of lesion despite this lesion being an unusual pathology among children.

Child, Preschool↗
PubMed1992

Recurrent peripheral odontogenic fibroma of the attached gingiva: a case report.

Peripheral odontogenic fibroma is an uncommon, benign, unencapsulated, exophytic gingival mass of fibrous connective tissue covered with a surface epithelium. Odontogenic epithelium and mineralized material may be found in the mass. A case is reported of a lesion that recurred in the attached gingiva following initial excision. Differential diagnosis of exophytic gingival lesions and post-operative management are also discussed.

Connective Tissue↗
PubMed2001

Excision and repair of the peripheral ossifying fibroma: a report of 3 cases.

BACKGROUND: The peripheral ossifying fibroma (POF), one of the most common gingival lesions, has a recurrence rate of nearly 20%. To minimize the reappearance of this lesion, it must be completely excised. In the maxillary anterior region, total excision of a POF can result in an unsightly gingival defect. METHODS: Three cases are presented in which a POF was excised from the gingiva facial to a maxillary central incisor. One of these lesions had previously undergone 2 cycles of conservative excision and recurrence. In all cases, the lesions were excised down to bone. Each of the resulting gingival defects was repaired by a distinct plastic surgery procedure, including a laterally positioned flap, a subepithelial connective tissue graft, and a coronally positioned flap. RESULTS: The defects resulting from the biopsies were satisfactorily repaired. The patients were followed over postsurgical intervals of 10 to 30 months. None of the lesions recurred. CONCLUSIONS: It is customary to manage POF by aggressive excisional biopsy. Several different surgical approaches may potentially be used to repair the resultant gingival defect and minimize patient esthetic concerns.

Adult↗
PubMed1994

An adult case of cardiac fibroma.

The patient, a 48-year-old woman with cardiac fibroma, is the second oldest patient with this disease in Japan. Her electrocardiogram showed findings compatible with old high lateral, posterior and possibly lateral myocardial infarction, regions which corresponded to the tumor site. In patients whose electrocardiogram suggests a previous myocardial infarction (pseudo myocardial infarction), the possibility of intramyocardial tumor should be taken into consideration.

Diagnosis, Differential↗
PubMed1991

[Ossifying fibroma in the cranial vault. Case report].

Ossifying fibroma is relatively common in the maxilla, but rare in the cranial vault. A 10-year-old girl was referred for painful swelling of the left temporal region. On admission, she presented no abnormal physical and neurological findings except for the painful swelling. Plain skull X-ray films showed a radiolucent lesion of the left temporal bone about 4 cm in diameter, with a hyperostotic area of the parietal side. Computed tomography scan using bone window level also showed an abnormal density lesion in the same site. Curettage of this tumor was performed from a cosmetic point of view and at the family's petition. Histological examination showed vascular fibrous tissue in which lamellar bone was surrounded by osteoblasts.

Child↗
PubMed1985

Sonography of ovarian fibromas.

Sonographic findings are described in four women with ovarian fibromas. Three of the four women were postmenopausal. Three had only minimal symptoms; the other presented with acute right lower quadrant pain caused by torsion of the tumor. The tumors were large, ranging from 9 to 16 cm in diameter. A distinctive sonographic appearance was found, with a predominantly hypoechoic, solid mass producing striking sound attenuation.

Adult↗
PubMedDate not supplied

[Fibroma of the root of small intestine mesentery].

Fibromas are rarely localized in the abdomen, but almost always in the mesentery or omentum. We present a 63-year old woman in whom the examination of the upper abdominal pain showed a well distinct abdominal mass at the level of the lower edge of the pancreas. During the operation a tumour, 100 x 87 x 70 mm in size, from the radix of small bowel mesentery, was excised. Seven months later the patient is symptom-free with normal ultrasonographic and CT findings.

Female↗
PubMed2006

Multicentric peripheral ossifying fibroma.

Peripheral ossifying fibroma (POF) is a common solitary gingival growth thought to arise from the periodontal ligament. Though the etiology of POF remains unknown, some investigators consider it an inflammatory or reactive process, while others suggest it is a neoplastic process. In this report, we present and discuss a unique case of multicentric POF, affecting the maxillary and mandibular gingiva of a 49-year-old Caucasian female with meticulous oral hygiene and routine dental care. Though biopsy samples from multiple sites revealed similar histopathologic features, consistent with POF, the fact that there was a multicentric presentation is a unique phenomenon for this lesion. Multicentric lesions presenting in the oral and maxillofacial region are not typical, but have been observed in conditions associated with known genetic mutations, such as nevoid basal cell carcinoma syndrome (multiple odontogenic keratocysts), multiple endocrine neoplasia type II (multiple neuromas), neurofibromatosis (multiple neurofibromas) and Gardner syndrome (multiple neoplasms). This case is the first one to demonstrate that there may be a multicentric variant of POF that has not been previously recognized, and given the clinical presentation and multifocal nature of disease, the lesions in this patient are likely the result of genetic mutation(s) that predisposes to gingival soft tissue overgrowths containing mineralized product.

Female↗
PubMed1990

A clinicopathological study of so-called denture fibroma.

We investigated 60 cases of so-called denture fibroma, most of which occurred in women in their 50s to 70s. The most commonly affected areas were the upper alveolar ridge and the bottom of the alveolabial sulcus, and most of the prostheses responsible were complete dentures. Elevated and tumor-like lesions were most frequent. Histopathologically, about 60% of the lesions were of the fibromatous type. Degeneration and inflammation of the salivary glands were identified in one third of cases.

Adult↗
PubMed1995

The giant cell fibroma. A review of 103 cases with immunohistochemical findings.

This article reports a series of 103 cases of giant cell fibromas occurring in the oral mucosa. The commonest location was the gingiva, followed by the tongue and the buccal mucosa. The mean age of the patients was 27.7 years, and the median age 21 years. Microscopically, the tumors were characterized by the presence of large stellate or angular cells, which occasionally contained several nuclei. Immunohistochemical stains showed that the cells were vimentin-positive but negative for S-100 protein, cytokeratin, leukocyte common antigen, and neurofilament.

Adolescent↗
PubMed1987

Desmoplastic fibroma of bone.

A 5-year-old Chinese boy had dull pain in his right knee for about one year. An intraosseous osteolytic lesion in the metaphysis of the right lower femur was curetted. The diagnosis of desmoplastic fibroma, possibly the first in a Hong Kong Chinese, was based on the clinical, radiological and histological findings. About one year later the only abnormality was a small rounded radiological lucency, static for 4 months. The fibroblastic nature of the lesion and its tendency to local recurrence support a fibromatosis of intraosseous origin.

Bone Neoplasms↗
PubMed1983

Juvenile aponeurotic fibroma: an ultrastructural study.

The light and electron microscopic findings in a case of juvenile aponeurotic fibroma are described. The tumor was composed of fibromatosislike areas and cartilagelike islands with characteristic calcification. The ultrastructural study verified the cartilaginous nature of this tumor. The cartilagelike islands were made up of chondrocytic cells embedded in an abundant intercellular matrix containing fine fibrils, spherical granules, and pleomorphic membrane-bound vesicles. The chondrocytic cells had many microvilli, a well-developed granular endoplasmic reticulum, and a prominent Golgi complex. In the periphery of each cartilagelike island was a perichondriumlike structure exhibiting transitional features from fibroblastic cells to chondrocytic cells. The fibromatosislike areas consisted of spindle-shaped fibroblastic cells and occasional myofibroblasts. The morphologic pattern of the tumor somewhat mimics embryonal chondrogenesis, and the fibromatosislike areas may represent an overgrowth of the fibrous layer of the perichondrium. It is possible to regard this tumor as an organoid tumor having a capacity for bidirectional differentiation into cartilage and fibrous tissue.

Adult↗
PubMed1984

Inclusion body myofibroblasts other than those seen in recurring digital fibroma of childhood.

Four patients of the toxic oil epidemic syndrome (TOES), which took place in Spain in 1981, showed a dermohypodermal fibroblastic process with round eosinophilic cytoplasmic inclusions (ECI) in the proliferating cells. Light and electron microscopic studies revealed that those cells had myofibroblastic features and that the ECI were identical to those seen in recurring digital fibroma of childhood (RDFC). Two cases of RDFC, involving the fingers of 6-month-old and 2-year-old patients, were examined by light and electron microscopy for comparative study. The 4 patients of TOES, aged 14 to 46 years, showed generalized sclerodermalike skin changes, and skin biopsies were obtained from the anterior wall of the abdomen and retromaleolar region of the left leg. The ultrastructural study of the ECI and the initiating changes leading to them allowed us to suggest a cytoskeletal origin for these inclusions.

Adolescent↗
PubMed1992

Calcifying aponeurotic fibroma. A case of multiple primary tumours. Case report.

A 20 year old man had had three subcutaneous tumours on his left forefinger for 15 years. After operation they were found to be infiltrating into the surrounding tissue, and histological examination showed them to be calcifying aponeurotic fibromas. To the knowledge of the author this is the first reported case of multiple primary tumours of this kind.

Adult↗
PubMed2005

Juvenile psammomatoid ossifying fibroma of the neurocranium. Report of four cases.

Juvenile psammomatoid ossifying fibroma (JPOF) is a benign fibroosseous lesion predominantly arising within the paranasal sinuses in children and young adults. Neurocranial occurrence is exceedingly rare and a location within the neurocranial portion of the temporal bone has not been described. The authors report on one case of sinonasal JPOF secondarily extending into the cranial cavity and three cases primarily affecting the neurocranial bones to increase clinical awareness of this uncommon tumor, which may be easily mistaken for meningioma. Moreover, the absence of activating missense mutations of the GNAS1 gene in two cases strongly argues against a relationship between JPOF and fibrous dysplasia.

Adolescent↗