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PubMed1981

[Myocardial scintigraphy with Tc-99m-diphosphonate in patients with coronary heart disease: a comparison with ECG and hemodynamic examinations at rest and during exertion].

In 67 patients, 61 of whom underwent a myocardial infarction and 6 suffered from angina pectoris, myocardial scintigraphy was performed using the technetium-99m-diphosphate (Tc-99m-DP). In 51 patients the ECG and left pulmonary end-diastolic pressure (LPEDP) were investigated additionally at rest and during exercise (bicycle ergometre). A significantly higher occurrence of positive scintigrams was found in cases with marked coronary insufficiency, whereas with the normal ECG findings the negative scintigrams were significantly more often. Increased LPEDP values occurred more often with positive than with negative myocardial scintigrams, especially during exercise. The authors recommend the myocardial Tc-99m-DP scintigraphy for the assessment of the activity of pathologic process after acute myocardial infarction.

Angina Pectoris↗
PubMed1993

99mTc-diphosphonate scintigraphy in successful knee arthroplasty and its relation to micromotion.

Nineteen tibial components after successful knee arthroplasty were studied with technetium 99m scintigraphy. All cases were also followed from the operation with roentgen stereophotogrammetric analysis (RSA). All but three cases became stable after an initial period of migration. Scintigraphic uptake was found in all cases, with a ratio as high as seven in the medial compartment and three in the lateral compartment. A group of cases with proven mechanical loosening showed an uptake ratio as high as 6.9 in the medial compartment and 5.5 in the lateral compartment. No correlation was found between scintigraphic uptake and alignment, whether cement was used, or the presence/absence of migration. Technetium 99m scintigraphy is not a useful method for assessing loosening in individual symptomatic cases of knee arthroplasty.

Aged↗
PubMed1977

Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate.

Guanyl-5'-yl-(alpha,beta-methylene)di[gamma-32P]phosphonate (Gp-(CH2)pp) is not hydrolyzed by rat liver membranes under conditions in which GTP and guanyl-5'-yl imidodiphosphate (Gpp(NH)p) are hydrolyzed. Gp(CH2)pp activates adenylate cyclase in hepatic membranes with characteristics similar to those of Gpp(NH)p activation but with lower potency and effectiveness. The analogs, although with lower potency than GTP, also share the ability to change the glucagon receptor from a high to a low affinity state. Both Gp(CH2)pp and Gpp(NH)p stimulate adenylate cyclase activity following a lag period of about 1 min addition of GTP after steady state rates are achieved results in reduction in the rate following a lag period of 6 min from the time of addition of GTP. Pretreatment of the enzyme with Gpp(NH)p or Gp(CH2)pp, followed by washing the membranes, leads to a high activity state of the enzyme which slowly decays in rate unless the analogs are continuously present in the medium. These data suggest that the guanosyl nucleotide analogs act on the enzyme system by a slowly reversible process that possibly reflects slow binding and dissociation from different transition states of the enzyme system and suggest that activation of adenylate cyclase by GTP, Gpp(NH)p, and Gp(CH2)pp does not involve covalent modification of the enzyme.

Adenylyl Cyclases↗