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Ethics and the psychiatric determination of competency to be executed.

For the last several centuries, most jurisdictions using capital punishment have had formal or informal rules that prohibit the execution of the mentally ill. In this article, the procedures for such exclusions in Florida are examined. The article begins by attempting to answer the question of why legislators and judges, at least nominally, have prohibited the execution of the mentally ill. Next, Florida's criteria for defining and procedures for excluding mentally ill prisoners are examined and found to be vague. We then turn attention to the ethical problems created by the statute and its implementation that face the participating psychiatrists and the profession. These problems are compounded because the physician's findings are not acted upon by politically neutral authorities and the inmate has no opportunity to challenge the findings with his own panel of experts. Finally, since any exclusion of the mentally ill from execution is temporary and the patient will be executed if he recovers, the dilemmas facing the treatment staff if the death sentence is not commuted to life imprisonment before treatment are discussed.

Capital Punishment↗

[Communication-promoting exercise therapy in a closed male psychiatric ward].

The use of the communication-promoting gesture therapy in a locked psychiatric men's ward led to the result, that a part of the restlessness and aggression potential of the patients could be commuted into a constructive social behaviour. Simultaneous increased frankness and confidence of patients in physicians and male nurses. A tied group doesn't seem to be a condition for that.

Combined Modality Therapy↗

Production and certification of secondary enzyme reference materials (ERMs). Part 1: Preparation of the sera and some of their properties.

We produced three batches of a human-serum-based enzyme reference material (ERM) enriched with human aspartate aminotransferase (EC 2.6.1.1), alanine aminotransferase (EC 2.6.1.2), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27). The added enzymes were not exhaustively purified; thus the final ERMs contained some enzymes as contaminants, of which only glutamate dehydrogenase activity might interfere. The stability during storage and after reconstitution was good. The commutability of the four enzymes in the three ERM batches was also good, except when German or Scandinavian methods for aminotransferases were involved. The temperature-conversion factors for the ERMs were equivalent to those for patients' sera. Reactivation after reconstitution was complete within 5 min and was independent of the temperature of the reconstitution fluid. We believe that these secondary ERMs will aid in the transfer of accuracy between well-defined reference methods and daily working methods so that clinical enzymology results will become more comparable from laboratory to laboratory.

Alanine Transaminase↗

Service areas for ambulatory medical care.

This article evaluates three alternative definitions of physician service areas using data from the 1978 National Health Interview Survey. The three types of areas are county aggregations based on different data sources: the Bureau of Economic Analysis Economic Areas (BEAAs), Ranally Basic Trading Areas (RBTAs), and Health Care Commuting Areas (HCCAs). The three types of areas differ substantially in size, population, urbanization, and the availability of physicians. The overall percentage of physician visits outside each of the three areas was small, ranging from 3 percent for BEAAs to 5 percent for RBTAs and HCCAs. Visits by nonmetropolitan residents were about four times as likely as those by metropolitan residents to occur outside of each area. The results suggest that HCCAs are the most appropriate primary care physician service areas because they are the smallest in size and population and have the greatest variability in physician supply, yet they exhibit an amount of outside-area travel for care similar to that of the two larger types of areas.

Ambulatory Care↗

A method to provide secure attachment of miniature electric connectors in free-moving animals.

A connection assembly for miniature electric plug and socket systems used in the recording and stimulation of the brain in free-moving animals was constructed from sew-on dress snaps. Two male portions of the snaps were cemented to the miniature electric socket or the dental acrylic mound that attached the socket to the skull. The female portions of the snaps were sewn to the ends of an elastic band. The wires that lead to the commutator passed through a hole in the elastic band. The plug and socket were securely attached to one another by snapping the elastic band to the skull.

Animals↗

Characterization and intermethod relationships of materials containing purified human pancreatic and salivary amylase.

We describe the preparation and characterization of materials containing human pancreatic and salivary alpha-amylase (EC 3.2.1.1) and examine their relationship to endogenous amylase in human serum. Amylase was purified from human pancreas and saliva by solvent- and salt-fractionation and column chromatography to specific activities of 63 and 279 kU/g, respectively. Four liquid pools, differing only in activity, were prepared from each source of amylase, each in a matrix containing, per liter: 30 g of human albumin, 50 mmol of sodium chloride, 1 mmol of calcium chloride, and 50 mmol of Tris hydrochloride buffer, pH 7.4. Characterization of the pools showed that the amylase activity in the materials was stable for at least six months at 25 degrees C; among-vial variability of amylase activity was less than or equal to 0.5% (2 CV); and the pools were free from eight possible contaminating enzymes. Plots of salivary vs pancreatic amylase activity measure in our materials with eight commercially available methods showed least-squares slopes ranging from 0.51 to 1.0. The intermethod "commutability" of the materials (i.e., how closely they mimic endogenous serum amylase) was examined in relationship to approximately 100 human sera.

Amylases↗

[Incidence of previous engagement in sports among patients with symptomatic arthrosis. Controlled study].

The authors investigated sports-related precedents in two groups of male subjects, aged 40 years and over, of French nationality. One group had consulted for a degenerative, chronic rheumatic disorder, and the control group showed no signs of this type of disorder. Care was taken to verify that the two groups did not differ in terms of profession, means of commuting from home to work, and non-sporting leisure physical activities. The authors observed that the subjects of the first group (chronic degenerative rheumatic disease) more frequently engaged in a sports activity, and in a significant manner, than did the control subjects. A separate study of the certain kinds of sports and the various arthritic localisations also revealed significant correlations. Although this involved a retrospective enquiry, the authors feel that the results provide arguments in favor of the pathogenic role of sports activity, with regard to peripheral joints and the spine. However, this role of sports is probably only partial and irregular. The risks of sports activity must be put in perspective and balanced with the various advantages afforded by the practice of sports.

Adult↗

Stable, highly immunogenic mutants of "Salmonella" with two independent, attenuating markers as potential live vaccine and their validity for "Shigella" and other bacteria.

This paper presents for Salmonella sp. an easily realizable principle to develop high-immunogenic, stable live vaccines with two independent attenuating mutations, which is valid for Shigella sp. and Pasteurella s. too. To avoid overattenuation by the stepwise introduction of two attenuating markers, only those mutations are suitable which do not suppress pathogenic structures or essential metabolic functions, but only transduce them into a leaky function, as e.g.: mutagen induced auxotrophic phenotypes with diminished virulence by commutation; purine dependent strains, which hitherto erroneously were regarded as non-immunogenic and particularly distinct chromosomal resistant genotypes, in which the conformational change of the drug target simultaneously causes resistance and changes virulence behaviour (pathwaydrift-mutants). Moreover, in Salmonella, an additional high sensitivity marker against ten sides and drugs possessing a permeation barrier in the outer membrane diminishes--without influence on virulence and immunogenicity--surviving in intestine (bile) and (detergent contaminated) environment. Therefore this hst-marker confers antiepidemic quality to vaccine strains and increases safety. To meet security demands for such vaccines with laboratory methods some easy and practicable tests for standardization are suggested, which include estimation of reversion frequency of pur- and hst marker and the proof of immunogenicity for mice. The safety and efficacy of such vaccine strains are pointed out by veterinarians in live-stock.

Animals↗

[Feasibility of increasing the high-speed response of the electromechanical drive in assisted circulation devices].

The conditions in assisted circulation, especially with ballooned aorta, place high demands on the speed of the intraortal pump-balloon response. The salient feature of the described assisted circulation unit consists in that the intraortal pump-balloon is connected to the pneumotract via a commutative air-operated valve. A block diagram of the assisted circulation unit "Biopulso-4" based on the use of the electric drive, designed at the All-Union Scientific-Research Institute of Medical Equipment and Instruments, stress diagrams and a scheme explaining the operation of the apparatus, are described. The results obtained show the possibility of the balloon's resetting and opening in 70 ms, with the triggering synchronous pulse delay of 10 ms prior to response (with air use as power gas). These results are not any worse than those obtained with the pneumatic drive-based assisted circulation apparatus.

Assisted Circulation↗

[Calibration and standardization in enzyme immunoassay].

Calibration is performed using multipoints of the calibrator in enzyme immunoassay (EIA). Calibration curves in EIA are frequently represented by non-linearity. Therefore, calibration in EIA is fitted with suitable functions. These functions are demonstrated with logistic curve, logit-log conversion, spleen function, etc. Consequently, the calibration procedure is indicated for the manufacturer's instruction, and also the calibrator is prepared as a commercial available reagent kit. To minimize EIA measurements among laboratories, and among methods, standardization with a common suitable reference material is needed. Reference materials for EIA, international standards are prepared by the expert committee of WHO. These standards must be transferred to national standards, manufacturer's standards and calibrators of commercial available reagent kits. Finally, the measured value from the routine method is maintained with commutability and traceability.

Calibration↗

[Improvement of result coherence in clinical enzymology: multicenter study of gamma-glutamyltransferase, alkaline phosphatase and amylase activities].

We report here on the results of a multicenter study of three enzyme activities (gamma-glutamyltransferase, alkaline phosphatase and amylase). For each activity, measurements were performed in two laboratories on different series of patients' specimens under routine conditions, at 30 and 37 degrees C, with techniques frequently used in France and with the IFCC reference method, when it exists. For each technique, precision was acceptable, but results differed considerably according to the technique used. The study also showed that for different techniques it is not possible to use a single transformation factor for activities between 30 and 37 degrees C. Patients' results determined by two techniques often showed a constant relationship. Groups of techniques that determined the same catalytic activity in patients' specimens were identified, whereas other techniques did not have this property. Several preparations, including reference materials produced by the Community Bureau of Reference (European Community, Brussels) and ten commercial secondary materials were tested for similar behaviour as compared to patients' samples. Results show the commutability of reference materials within a group of techniques indicating that they can be used as calibrators. This was seldom the case for the commercial secondary materials and we did not find any such material suitable for calibration of the three enzymatic activities. The present study demonstrates that with defined techniques and validated calibrators it is possible to reduce considerably differences between results obtained with different techniques at different temperatures and in different laboratories.

Alkaline Phosphatase↗

Behavior of frozen serum pools and lyophilized sera in an external quality-assessment scheme.

To further improve analytical accuracy in clinical chemistry, proficiency testing needs amelioration in the quality of materials tested and in target value assignment. To obtain information on the actual state-of-the-art in the Lombardy region of Italy, and to examine the behavior of different types of control materials (fresh-frozen human sera and lyophilized materials), we developed the following experimental design. Two human serum pools and two lyophilized sera were distributed to 32 laboratories for determination of glucose, creatinine, cholesterol, sodium, potassium, and gamma-glutamyltransferase (gamma-GT). Each analyte was measured in triplicate on each of 3 days. Target values for the controls were obtained with Reference Methods. The results show a good intralaboratory precision for every component but some accuracy problems for glucose, creatinine, cholesterol, and gamma-GT. Lyophilized materials showed some commutability problems for glucose, electrolytes, and gamma-GT, mainly with dry chemistry technology.

Blood↗

Street food vending in Latin America.

Despite occasional attempts to repress it, street food vending in Latin America appears to be on the rise--encouraged by growing marginal urban populations, the unemployed status of innumerable potential street vendors, lengthening commutes for workers, public demand for cheap and culturally appropriate food near workplaces, and a shortage or absence of regular establishments serving such food. Besides placing a hidden burden on public services, the generally unregulated and quasi-clandestine street food industry tends to observe poor hygienic practices and to pose significant public health problems. Within this context, Latin America's cholera epidemics have drawn increasing attention to street food's potential for disease transmission and have created growing support for attempts to resolve these troubles. What appears needed at this point, rather than futile attempts at abolition, is a new and more positive approach wherein countries change their regulations so as to permit peaceful and constructive adaptation of street food vending to a new style of Latin American social life. This implies legal reorganization directed at structurally developing street food vending and permitting application of measures--especially provision and use of safe water--that will foster good hygiene and safe foods. It also implies creating programs to provide appropriate training for inspectors as well as health education for both vendors and consumers of street food; and it implies promoting and adopting improved methods for preparing and selling such food. There is no reason to suppose these measures will provide an immediate panacea for the street food vending problem; but there is good reason to think they can immensely improve the situation that exists today.

Food Handling↗

[A proposal to convert our view from precision into accuracy in routine analysis].

Recently, measurement systems in clinical chemistry have been improved to be more precise in analysis than those in 1980s. As a result, several advances in instruments and reagents have been brought such as incorporating microprocessors into hardwares of instruments and developing ready-to-use reagents, and the precision level of measurement systems is now sufficient for routine analysis. In the near future, however, we will have to focus on the accuracy of measurement systems to obtain accurate and commutable laboratory data. We report a present status of the precision in routine analysis and our activity in data maintenance for accurate analysis by reference methods.

Chemistry, Clinical↗

Changes in the telephone calling patterns of adolescent girls.

It is commonly believed that adolescent girls now call adolescent boys on a regular basis and this represents a change in behavior from previous generations. The purpose of this study was to test the hypothesis that during the last 40 years the incidence has increased. A sample of current students from a Southern urban commuter university was interviewed to determine their telephone use patterns. The changes in calling behavior among this sample indicates a transition period between a time when adolescent girls perceived their parents as disapproving of their calling boys (they placed few calls) to a time when adolescent girls perceived their parents as approving (they evidenced many such calls). Based on the current age of respondents, the transition period was calculated to be from 1964 to 1981. The results are discussed in relation to changes in adolescent female gender roles in the United States beginning in 1964.

Adolescent↗

Residential preferences and migration.

For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities. However, as Fuguitt and Zuiches (1975) have reported, the majority of people also want these places to be within commuting distance of a large metropolitan city. This research tests the hypothesis that size-of-place and urban proximity preferences are factors in the dispersal of population through migration. A one-year panel survey of Pennsylvania households indicates that only about one household in ten that moved actually attained its preference for a smaller-sized place or a location more distant from a large city. Preferences for smaller-sized places and proximity to a city were not correlated with where people actually moved when the size and proximity of the previous residence were taken into consideration.

Attitude↗

[Device for determining oxygen tension in biological objects using a pulse method].

An apparatus designed by the authors for measuring oxygen tension in biological objects is described. An electronic commutator allows it to close the inlet of the recording system at the instant of interval, to accomplish separate and smooth adjustment of the pulse and interval duration within a wide range. This makes it possible to electively establish the electrodes polarization and depolarization conditions depending upon the electrochemical characteristics of the electrodes, the nature of the biological object and the purposes of investigations, which represents the advantage of the unit over the other known apparatus.

Oxygen↗

Interests, obligations, and justice: some notes toward an ethic of managed care.

In their commentary on the recent report on the ethics of managed care by the American Medical Association's (AMA) Council on Ethical and Judicial Affairs, Miles and Koepp offer two salient criticisms: For one thing, they fault the Council for not disclosing how intellectual, legal, and financial conflicts of interest may have influenced the Council's ethical opinions. Specifically, they point to the AMA's customary interest in preserving the fee-for-service system and in avoiding potential litigation that might arise from strictures imposed on rulings of the Council on Ethical and Judicial Affairs by the Federal Trade Commission (FTC). For another, Miles and Koepp decry the Council's focus on the ethical obligations of individual physicians to their own patients to the neglect of their obligations to the healthcare plan, the other patients in the plan, and to society at large. Specifically, they lament the lack of a well-developed ethic of distributive justice and collective governance suitable to the economic exigencies of allocating resources. In this commentary, I wish to examine more closely two issues raised by Miles and Koepp's critique. The first issue is the assumption that the existence of interests--and, therefore, the possibility of conflicts of interest--is relevant in assigning validity to the conclusions of an ethical deliberation and that full disclosure is helpful in determining that validity. The second issue is the proper ethical relationship that should obtain between the obligations of physicians, to their own patients with whom they have a covenant of trust, and the obligations they incur to a health plan or to society when they sign a contract as a participating physician. This is part of the more general question of the proper relationship between commutative and distributive justice when they are in conflict. A third issue, which neither Miles and Koepp nor I address is the ethical propriety or moral legitimacy of restraints imposed by the FTC on the ethical guidelines of a profession. Should the FTC's legal hegemony over competition overrule the integrity of professional ethics? Should it make any difference in the Council's ethical opinions? This is a subject for more extended treatment than I can give it here. Suffice it to say that the rulings of the FTC are legal, not ethical, rulings. As such, their validity must be subjected to the same critical examination as other ethical statements. The mere existence of an FTC ruling, its practical consequences notwithstanding, is no warrant for abandoning an ethical principle. This is particularly the case since the FTC has made the protection of competition its icon and endowed it with a quasi-ethical authority. My commentary is not an item-by-item apologia for the Council's report. I do agree with, and wish to defend, its emphasis on the primacy of the physician's obligation to his or her patient even in a managed-care system. But I also agree with Miles and Koepp that a fuller development of an ethic of distributive justice is in order. I suspect they would frame their ethic differently than would I. I do not agree with them, however, that disclosure of interests would help to judge the ethical validity of the Council's opinions, except in a limited way. Lest I be suspected of a conflict of interest, I must state at the outset that I had no part in drafting the Council's report and that I have no personal or intellectual commitment to fee-for-service per se. The report did cite a work of mine, however, and I do have an interest in clarifying its relevance to the issues in question.

American Medical Association↗