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Report of the ad hoc task force on circumcision.
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Cathepsin B and complement C3 are major comigrants in the estrogen-induced peroxidase fraction of rat uterine fluid.
The luminal fluid of estrogen or DES-stimulated uterus of immature rats contains 10-12 isoforms of peroxidase between pI 4.5-6.0. N-terminal amino acid sequencing of diaminobenzidine-peroxidase bands eluted from IEF and SDS-PAGE gels showed the presence of cathepsin B and the complement family of proteins as the major comigrants. Sequential treatment of uterine fluid by cation, anion, and size exclusion chromatography resulted in a five-fold purification of peroxidase having a specific activity of 273 units/mg. Mass spectrometric studies of bands isolated from SDS-PAGE gels from the size-exclusion purified peroxidase fraction showed the presence of complement C3 along with novel previously uncharacterized proteins. Two dimensional electrophoresis followed by N-terminal amino acid sequencing confirmed the presence of cathepsin B isoforms and isoforms of a novel protein at approximately 87 kDa. Identification by mass spectrometry from the database for this novel protein was inconclusive but could most likely be a candidate for estrogen-induced peroxidase. Results conclusively prove that cathepsin B and complement C3 are major proteins in the estrogen-induced peroxidase fraction of uterine fluid.
[Lichen sclerosus et atrophicus penis].
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[Chlamydia, herpes, chancre,gonorrhea, syphilis. Are you familiar with the therapy?].
Sexually transmitted diseases (STDs) which today are taken to cover all genital contact infections including the classical venereal diseases, have increased appreciably in recent years. With regard to the penis, STDs may manifest as papules, pustules and ulcers including urethral discharge and swelling of regional lymph nodes. Possible causes may be bacterial, viral or fungal. Depending on the pathogens involved, local or hematogeneous dissemination may occur. Treatment of infectious penile diseases follows the recommendations contained in the guidelines of the German Society for STD.
[Genital pustules and skin papules].
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Knowledge-based approaches in the design and selection of compound libraries for drug discovery.
In the past decade, the pharmaceutical industry has realized the increasing significance of impacting the early phase hit-to-lead development in the drug discovery process. In particular, knowledge-based approaches emerged and evolved to address a multitude of issues such as absorption, distribution, metabolism and excretion (ADME), potency, toxicity and overall drugability. Each of these approaches seeks to bring together all relevant pieces of information and create a knowledge-oriented process to deploy such information in drug discovery. This review focuses on work relating to drugability, which aims at obtaining hits (or leads) that have enhanced likelihoods of leading to successful clinical candidates by medicinal chemistry efforts. The period covered in this review is from 1997 (since the publication of Lipinski's rule of 5) to March 2002.
Pancreatic enzymes replacement therapy in chronic pancreatitis: an update.
Chronic pancreatitis is the major cause of exocrine pancreatic insufficiency which should be compensated by pancreatic enzyme replacement therapy. There are now available a great number of pancreatic enzyme preparations, but encapsulated enteric-coated microspheres and minimicrospheres are considered the enzyme treatment of choice. However, full compensation of pancreatic exocrine insufficiency with enzyme replacement therapy cannot be obtained in all patients with chronic pancreatitis.
[Some enzymological and immunological shifts following prolonged occupational exposure to the effects of alpha-methylstyrene and divinyl].
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[Dry method of treatment of balanoposthitis].
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Marriage process and household formation in Bolivia and Argentina: the impact of migration in a peasant society.
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Therapeutic challenge of premalignant and malignant skin lesions.
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[Agricultural structures and internal migration in a historical perspective: Latin American case studies].
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[Household economy and gender differences in international migration: a case study of Bolivians in Argentina].
The author analyzes household economy and sex differentials among Bolivian immigrants in Argentina. "While male Bolivian (mainly from Cochabamba) immigrants come to Argentina in search of better job opportunities, female immigration does not result generally from an individual decision, but from the adjustment to family, implying a loss in status and independence as compared to their place of origin. Job opportunities for Bolivian female workers are reduced mainly on account of their poor literacy levels; thus they often work for very low wages, deprived of any social benefits." (SUMMARY IN ENG)
Sentinel lymph node biopsy in breast cancer--is lymphoscintigraphy really necessary?
The role of lymphoscintigraphy in sentinel node biopsy in breast cancer remains debatable. This study assesses the value of lymphoscintigraphy in axillary sentinel node biopsy in women undergoing surgery for breast cancer. Sixty-two patients underwent sentinel node biopsy using a combination of technetium-labelled nanocolloid, lympho-scintigraphy and patent blue dye. Lymphoscintigraphy was successful in 84% of patients. Axillary sentinel nodes were identified intraoperatively in all these patients. Internal mammary nodes were identified on lymphoscintigraphy in 19%. Despite lymphoscintigraphy being unsuccessful in 10 patients, axillary sentinel nodes were found intraoperatively in eight of these patients. Lymphoscintigraphy did not increase the detection rate of axillary sentinel nodes and a negative scan did not preclude identification of an axillary sentinel node intraoperatively. This study questions the contribution of lymphoscintigraphy in axillary sentinel node biopsy, however its value may lie in the detection of extra-axillary nodes.
[Etiology of acute purulent balanopostitis in children].
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Cutting Balloon angioplasty for underexpanded stent deployed through struts of previously implanted stent.
We describe a case in which stenting through the struts of a previously deployed stent resulted in stent underexpansion despite 25 atm inflation pressure. Four months later, follow-up angiography demonstrated in-stent restenosis. It was successfully expanded with a Cutting Balloon.