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[Peri-implantation enzymes and mineralization in bone tissue after implantation of bioactive vitroceramic material--a method for biomaterial testing for hard tissue substitutes. 2. Results of studies of vitroceramics and their modification by the admixture of metal oxides].

The activities of the alkaline and the acid bone phosphatases as well as the concentrations of calcium and phosphorus were measured in the periimplantal tissue of the rat femur bone after implantation of the vitroceramic Ap 40, the metal oxide stabilized vitroceramics Ap 40 A and Ap 40 Z, as well titanium after 2, 10, and 15 weeks. The incorporation of the vitroceramic Ap 40 turns out like a primary bone fracture healing. The implants Ap 40 A and Ap 40 Z are a compromise with a higher stability and the osteogenesis induced effect is preserved, but is belated in contrast to Ap 40.

Acid Phosphatase↗

Handling antineoplastic-drug admixtures at cancer centers: practices and pharmacist attitudes.

Results of a 1986 national survey of handling practices for antineoplastic drugs at cancer centers and pharmacists' attitudes toward the importance of recommended practices are reported. A sample of 323 hospitals representing the 27 comprehensive cancer centers (CCCs) and 296 member institutions of the Association of Community Cancer Centers (ACCC) was selected for participation in the survey. Respondents were asked to rate the importance of a recommendation using a five-point scale. Data were analyzed according to hospital bed capacity (small, medium, and large). A total of 175 usable questionnaires were returned, yielding a response rate of 54%. Overall, 99.6% and 94.7% of CCCs and ACCC member institutions, respectively, used vertical-laminar-airflow containment h oods. Personnel used in antineoplastic-drug preparation varied according to hospital size, with CCCs using technicians more frequently than ACCC members. Training methods for personnel were similar among hospitals, although CCCs reported using written testing during training more often than ACCC members. Concern about the safety of the pregnant or breast-feeding woman and of the fetus or infant has led to precautionary policies and procedures in many hospitals. Most hospitals handled antineoplastic waste separately from other waste and regarded this as extremely important. Incineration of antineoplastic waste was used by most hospitals. Antineoplastic-drug-handling precautions taken at CCCs and ACCC member institutions have improved during recent years; pharmacists' perceptions of the importance of various recommendations for handling antineoplastic agents may be helpful in analyzing and developing relevant guidelines.

Antineoplastic Combined Chemotherapy Protocols↗

[Are any drug admixtures except iron preparations required in the treatment of iron deficiency anemia?].

The aim was to estimate the efficacy of multimodality therapy of iron deficiency anemia with vitamins combined with iron salts and to compare the results of this therapy with that including iron salts only. Besides the results of therapy using iron preparations administered per os and in injections were compared. Altogether 250 women were entered in this study. Chronic posthemorrhagic iron deficiency anemia was diagnosed in 175 patients, in 75 iron deficiency anemia developed against a background of pregnancy 250 women were divided into 10 groups. The last 3 groups included pregnant women. The selection in the first 7 and last 3 groups was randomized. The rate of increment of hemoglobin, erythrocytes and serum iron did not differ in the groups of patients receiving in addition to iron vitamins B12 and B6, copper sulfate, the combination of iron with the vitamin B group and copper sulfate. In the group receiving iron for injection the rate of increment of hemoglobin did not almost differ from that in the study groups, however it was slightly higher. Similar results were obtained for the pregnant women. Subsequent therapy after hemoglobin normalization was shown to make therapeutic results more stable. A conclusion was made of inappropriateness of the use of iron combined with other preparations in view of numerous cases of side-effects and danger of the development of siderosis of internal organs as a result of erroneous drug administration. The use of iron preparations for injections was recommended only in disturbed intestinal absorption of iron.

Adolescent↗