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PubMed1999

[Collagen expression of intra-acinar pulmonary arteries and right ventricle and intervention of Radix Astragali in rats with hypoxic pulmonary hypertension].

OBJECTIVE: To investigate the collagen expression effect of intra-acinar pulmonary arteries and the right ventricle and to observe the intervention effect of Radix Astragali in rats with hypoxic pulmonary hypertension. METHODS: Wistar male rats were divided into three groups: hypoxia group, which was fed in hypoxic environment (oxygen concentration was 9%-12%) under normal atmospheric pressure for three weeks (12 hours every day); intervention group, which was abdomenly injected with Radix Astragali and fed in the same environment as hypoxia group; and control group, which was fed in normal environment. Pulmonary artery pressure and cardiac output of the right ventricle were measured with catheterization and Fick's method. Protein expression of collagen in intra-acinar pulmonary arteries was assessed with histopathologic method. mRNA expressions of collagen in the right ventricle, and endothelin-1 and nitric oxide synthase in lung tissue were evaluated by RT-PCR technique. RESULTS: Compared with those in control group, pulmonary artery pressure and protein expression of collagen in intra-acinar pulmonary arteries and mRNA expression of type I collagen in the right ventricle and endothelin-1 in lung tissue were obviously increased in hypoxia group (mean pulmonary artery pressure: (24.8 +/- 3.6) mm Hg vs (18.8 +/- 1.7) mm Hg, P < 0.01; protein expression of collagen: (20.4 +/- 4.5) AU vs (3.4 +/- 1.1) AU (P < 0.01), but mRNA expression of nitric oxide synthase in lung tissue was declined. Compared with the data obtained in hypoxia group, cardiac output and mRNA expression of nitric oxide synthase in lung tissue were raised in intervention group (cardiac output: [(141 +/- 20) ml/min vs (118 +/- 40) ml/min, P < 0.01], but protein expression of collagen in intra-acinar pulmonary arteries and mRNA expression of type I collagen in the right ventricle and endothelin-1 in lung tissue were markedly decreased (protein expression of collagen: [(5.6 +/- 1.2) AU vs (20.4 +/- 4.5) AU, P < 0.001]. CONCLUSION: Changes of collagen expression in intra-acinar pulmonary arteries and right ventricle are one of the most important features in remodeling of pulmonary arteries and right ventricle in hypoxic pulmonary hypertension. Radix Astragali can partly inhibit the remodeling of pulmonary arteries and right ventricle, and regulate mRNA expression of endothelin-1, nitric oxide synthase, and collagen, thus contributing to the treatment of hypoxic pulmonary hypertension.

Animals↗

PubMed2001

Effects of huangqi jianzhong tang on hematological and biochemical parameters in judo athletes.

AIM: The purpose of the study was to investigate the effects of Huangqi Jianzhong Tang (HQJZT) on hematological and biochemical parameters in judo athletes. METHODS: Sixteen male and eight female judo athletes in Hsin-Ming senior high school were randomly and stratified divided into control and experimental group, which received placebo and HQJZT respectively during the five-week training program. The measurement of the hematological and biochemical parameters was performed twice, just before and after the training. The data was analyzed with paired-t test and ANOVA. RESULTS: The values of RBC, Hb, and Hct were obvious decreased after intervention, while the value of GOT, GPT, BUN, and CK was elevated. CONCLUSION: The results indicated the hematological and biochemical changes were caused by the physical training but not the effects of HQJZT. The HQJZT had no adverse effects on the judo athletes in our study.

Adolescent↗

PubMed2000

[Determination of astragaloside IV in radix Astragali by HPLC with evaporative light scattering detector].

OBJECTIVE: To develop a new method for the determination of astragaloside IV in Radix Astragali. METHOD: A HPLC-ELSD method was set up, using Hypersil C18 column (150 mm x 4.6 mm), acetonitrile-water(1:2) as mobile phase with a flow rate of 1.0 ml.min-1. The parameters of drift tube and gas flow rate of the detector were set at 105 degrees C and 2.96 L.min-1 respectively. RESULT: The calibration curve was linear in the range of 2.02-10.12 micrograms. The average recovery was 100.5%. CONCLUSION: The active constituent astragaloside IV in Radix Astragali can be separated effectively. ELSD detection is appropriate for the determination of constituents with end absorption at low ultra-violet wavelengths.

Astragalus propinquus↗

PubMed1999

[Antiviral action of combined use of rhizoma Polygoni cuspidati and radix Astragali on HSV-1 strain].

OBJECTIVE: The clinical action of combined use of Rhizoma Polygoni Cuspidati and Radix Astragali on HSV-1 was investigated with a view to developing a new antiviral drug. METHOD: The action was analyzed by way of plaque reduction assay and median-effect principle. RESULTS: In the HEp-2 cell system, if the combination ratio of Rhizoma Polygoni Cuspidati and Radix Astragali was 1(ED50):1(ED50) then, (1) In directly annihilating HSV-1 F strain, when the plaque reduction rate was 20%-80%, and the combination index was < 1.0, there was synergism. (2) In inhibiting the multiplication of HSV-1 F strain, when the plaque reduction rate was 20%-60%, and the combination index was < 1.0, there was also synergism. (3) In blockading HSV-1 F strain infection, when the plaque reduction rate was 20%-90% and the combination index was < 1.0, there was synergism. So this ratio of 1(ED50):1(ED50) should be the first choice for combination. CONCLUSION: The treatment index of the above two Chinese medicinal herbs equals 10(3), and the cytotoxicity is not potentiated, indicating that the combination is helpful as a virucide for HSV-1 F strain.

Antiviral Agents↗

PubMed2002

[Detection report on noxious elements in Radix astragli].

OBJECTIVE: The contents and dissolution rates of As, Hg, Cd and Pb including 44 batches of Astragali samples from major habitats were analysed. METHOD: As was determined by hydride generation-AFS. Hg was determined by cold vapour-ASS. Cd and Pb were determined by ICP-ES. RESULTS: The contents of As, Hg, Cd, Pb were 0.018-0.617 microgram/g, 0.004-0.181 microgram/g, 0.029-0.168 microgram/g, and 0.290-5.501 micrograms/g respectively. The As, Hg, Cd, Pb dissolution rates were 30.2%-54.2%, 4.9%-9.8%, 50.%-87.9%, and 12.6%-27.8% respectively. CONCLUSION: The contents of As, Hg and Cd were very low and below the limitation of national food and hygiene standard, but that of Pb was high in Astragali and its extracts.

Arsenic↗

PubMed2001

[Effect of danggui buxue decoction on proliferation and expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells].

OBJECTIVE: To investigate the effect of Danggui Buxue Decoction (DBD) on proliferation and expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs). METHODS: After treating HUVECs with various concentrations of DBD, we analyzed the proliferation phase of HUVECs and the expression of ICAM-1 using flow cytometry. RESULTS: It was found that DBD could promote the proliferation of HUVECs and the expression of ICAM-1. The expression of CD54 (ICAM-1) was significantly increased in the experiment groups as compared with that in the control group (P < 0.05). In addition, cell cycle analysis revealed more synthetic period cells in the experiment groups than in control group (P < 0.05). CONCLUSION: DBD can promote the proliferation of HUVECs and Increase the expression ICAM-1.

Angelica sinensis↗

PubMed2002

[The pharmacological studies of yifuzhixue pill].

OBJECTIVE: To investigate the pharmacological effect of Yifuzhixue Pill (YFZXP). METHODS: PPT, RT, PT, platelet counts and platelet adhesive rate were examined after administration of YFZXP. In other hand, the functions of isolated rabbit's uteri were also examined to determine whether they were responsible to the administration of YFZXP. RESULTS: YFZXP could enhance the intrinsic blood coagulating function and stimulate the contraction of smooth muscles of uterus including increasing the rhythms and strength. The stimulation effect of YFZXP on smooth muscles of uterus exhibited no selections between the uteri treated with or without estradiol. It was speculated that the increased intrinsic blood coagulating and uterus' contraction induced by YFZXP were contributed to its anti-bleeding effect in uterus.

Animals↗

PubMed2003

Anti-aging effect of astragalosides and its mechanism of action.

AIM: To study the anti-aging effect of astragalosides (AST) and its mechanism of action. METHODS: Rotating rod test and step-down type passive avoidance test were performed to determine the effects of AST on motor and memory of D-galactose (D-gal)-induced senescent mice and the middle-aged mice. The proliferative response of splenocytes induced by Con A or LPS, IL-2 production of splenocytes induced by ConA of D-gal-treated mice and the middle-aged mice were also measured. RESULTS: AST (40 mg.kg(-1).d(-1), ig, for 10 weeks) was found to ameliorate age-related alternations in both motor response and memory, enhance the deteriorated cellular immunity in D-gal-treated mice and the pre-aged (17-month-old) mice. CONCLUSION: AST has an anti-aging effect on D-gal-induced senescent mice and has the effect of delaying senility of the middle-aged mice, which was related to its improvement of brain function and immunomodulatory effects.

Aging↗

PubMed2002

[Effect of components of dang-gui-bu-xue decoction on hematopenia].

OBJECTIVE: To investigate the effects and the related mechanisms of the components of Dang-Gui-Bu-Xue decoction (DGBXD) on improving blood deficiency. METHOD: The effects of promoting hematopoietic function were observed with the blood difficient model mice, by giving components of DGBXD. RBC, WBC, reticulocytes and bone marrow nucleated cells (BMNC) were determined. The components of DGBXD on proliferation of BMNC and on clony forming unit (CFU) were also determined. RESULT: The components of DGBXD remarkably increased the quantity of RBC, WBC, and BMNC. Some of the components promoted the proliferation of BMNC and increased the quantity of CFU-Mix. Among them, polysaccharide of angelica was most potent. CONCLUSION: The studies show that the extracts and some components of DGBXD can promote the hemopoietic function system of the model mice, and they exert the effects in a comprehensive way.

Angelica sinensis↗

PubMed2001

[Effect of satragaloside IV on the increase of microvascular permeability induced by histamine in pial microvessels of rat].

OBJECTIVE: To study the effect of satragaloside IV on the microvascular permeability induced by histamine in pial microvessels. METHOD: The microvascular permeability was expressed by changes in the transendothelial electrical resistance which was measured with technique using microelectrode impaled into the vascular lumen and based on cable analysis of vessels in rat. RESULT: The transendothelial electrical resistance of microvessels superfused with artificial cerebrospinal fluid was about 2500 omega.cm2, indicating a tight barrier with extremely low ion permeability, and application of 10(-4) mol.L-1 histamine in superfusate caused a rapid and reversible decrease in transendothelial electrical resistance. In paired experiment, the decrease of transendothelial electrical resistance induced by 10(-4) mol.L-1 histamine was inhibited by adding 0.8 x 10(-4) mol.L-1 satragaloside IV in superfusate. CONCLUSION: The results indicated that increases in the microvascular permeability induced by histamine, and satragaloside IV can inhibit the increases in the microvascular permeability induced by histamine. It is necessary that the cellular mechanism of permeability response induced by satragaloside IV be further elucidated.

Animals↗

PubMed2001

[The protective effects of yi-xin-kang capsule on the structure and function of rat myocardial mitochondria].

OBJECT: To observe the injury induced by Isoproterenol (ISO) on the structure and function of rat myocardial mitochondria and the protective effects of Yi-Xin-Kang Capsule (H303). METHOD: After injection of ISO, rat myocardial mitochondria were isolated. The activities of phospholipidase A2(PLA2) and Ca(2+)-ATPase, the content of phospholipids (PL) and high-energy phosphates, membrane lipid fluidity (LFU) and respiration function were determined respectively. RESULT: ISO induced severe injury to myocardial mitochondria. The activity of PLA2 was significantly activated. The intensity of LFU, the activity of Ca(2+)-ATPase, respiration function of mitochondria and the contents of PL and high-energy phosphates of myocardium tissue were significantly decreased. Oral administration of H303 significantly decreased the activity of PLA2. The contents of PL and LFU, the activity of Ca(2+)-ATPase were significantly increased. The respiration function of mitochondria was protected by accelerating III state respiration rate, improving ADP/O ratio and recovering the depressed respiration control rate. CONCLUSION: H303 possessed protective effect on structural and functional injury of mitochondria induced by ISO.

Animals↗

PubMed2002

[Depressive effect of total flavonoid fraction of Asttragalus complanatus R. Br and its influence upon hemodynamics in SHR].

OBJECTIVE: To investigate effects of total flavonoid fraction of Asttragalus complanatus on blood pressure in conscious spontaneously hypertensive rats(SHR) and hemodynamics in anesthetized SHR. METHOD: Blood pressure was recorded with tail-culf method and hemodynamics was recorded with polygraph after administration of total flavonoid fraction of Asttragalus complanatus. RESULT: Total flavonoid fraction of Asttragalus complanatus (100, 200 mg.kg-1) could decrease blood pressure of conscious SHR(decreasing 7.1%, P < 0.05 and 9.3%, P < 0.01 respectively). Meanwhile, there was no significant change in heart rate(HR). R Br (200 mg.kg-1) could decrease total peripheral resistance (TPR) (decreasing 20%, P < 0.05) but did not influence the cardiac output(CO) and heart rate in anesthetized SHR. CONCLUSION: Total flavonoid fraction of Asttragalus complanatus possesses obvious hypotensive effect, mainly by means of decreasing the TPR.

Animals↗

PubMed2002

[Study on the effect of zhimu combined huangqi on improving renal hypertension rat's cardiac dysfunction].

OBJECTIVE: To observe the effect of Zhimu and Huangqi used singly or combinatively on improving experimental cardiac dysfunction, and mainly to observe zhimu's effect on restraining sympathetic nerve and blocking beta-adrenergic-recepter and huangqi's effect of improving hemodynamics on heart failure. METHOD: Two-clib one kidney operation was done to make renal hypertension rat model, 8 weeks after operation, rats were divided into groups and medicated for 6 weeks, and then their heart rate and blood pressure were measured, left ventricle was cannulated to estimate heart function, and heart-weight-index and left-ventricle-weight-index were measured. RESULT: Zhimu could slow rats heart rate obviously, prevent cardiac remodeling, but did not affect cardiac function remarkably; Huangqi could reduce blood pressure, heighten +dp/dtmax and -dp/dtmax remarkably; the combined use of the two drugs could decrease plasma catecholamine concentration, adjust myocardium cAMP content, and improve heart function obviously. CONCLUSION: Zhimu and Huangqi can protect experimental cardiac dysfunction, and the combined use is better than the single use, which shows it better to use the two drugs combinatively in treating heart dysfunction.

Anemarrhena↗

PubMed2003

[Protective effect of ganmeiling injection on chronic hepatic injury in rats].

OBJECTIVE: To study protective effect of Injection Ganmeiling on chronic hepatic injury. METHODS: The activity of AST, ALT and ALP in serum and histopathological change were determined in hepatic injury rats induced by CCl4. RESULTS: Ganmeiling obviously inhibited the rising of AST, ALT and ALP in serum. The histopathological examination showed that Ganmeiling could alleviate the condition of necrosis and the degeneration of hepatic cells. CONCLUSION: The results suggested that Ganmeiling could protect liver from hepatic injury induced by CCl4.

Animals↗

PubMed1999