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PubMed1990

Risks of developing an otogenic intracranial abscess.

One-and-a-half per cent of adults have active chronic otitis media and its management to prevent complications is a considerable workload. The risks of developing these complications is relatively unknown but because of its mortality, intracranial abscess is the most relevant. A 10-year review of all otogenic intracranial absesses in Scotland was carried out. A 15 per cent allowance was made for missing records. The annual risk in an adult with active chronic otitis media of developing an abscess is about one in 10,000 but its development is three times more likely in males. This risk might appear low but the lifetime expectancy of an individual aged 30 years with active chronic otitis media developing an abscess is one in 200. However, as yet, there is no evidence that surgery reduces this risk. Unfortunately, because of the duration of follow-up needed and the size of the sample required, scientific evidence would be difficult to obtain. However, 5 per cent of abscesses currently occur in the immediate post-operative period following mastoid surgery.

Adolescent↗
PubMed1991

Elective coronary artery bypass surgery without homologous blood transfusion. Early results with an inexpensive blood conservation program.

Restriction of donor blood transfusions in cardiac surgery should reduce risks of infective contamination and antigenicity. We report a systemic, simple and inexpensive blood conservation program used for 121 consecutive patients who underwent elective coronary artery bypass surgery without need for homologous blood transfusion. The left internal mammary artery was grafted in all cases, in addition to saphenous vein grafts. Autologous, heparinized blood was removed intraoperatively, pre-bypass, and returned to the patient at conclusion of the extracorporeal circulation. The volume remaining in the oxygenator and the tubing set was returned without cell processing or hemofiltration. Using the hard-shell cardiotomy reservoir from the heart-lung machine, autotransfusion of the shed mediastinal blood was continued hourly up to 18 hours after surgery. The mean postoperative mediastinal bleeding was 551 +/- 206 ml, of which 505 +/- 218 ml was autotransfused. No re-exploration for bleeding was required and no homologous red-cell transfusions were given. Five patients each received 1-2 units of fresh frozen plasma because of prolonged bleeding time. Morbidity was low and mortality nil. At discharge the mean hemoglobin was 12.0 +/- 1.4 g/dl and the hematocrit 36.0 +/- 4.2%.

Adult↗
PubMed1999

[Anterior cruciate ligament injuries--still an enormous challenge. Life style-related surgery likely to be used more widely].

Anterior cruciate ligament (ACL) injuries still constitute the greatest single problem in orthopaedic sports medicine. The natural history is not well known. Conservative treatment is appropriate in cases where there are no instability problems, and where activity modifications are acceptable to the patient. However, there is an increased risk of meniscus and cartilage injuries, and thus of arthrosis. The indication for surgery depends on the level of activity, and on whether instability symptoms are present. Arthroscopic surgery of the ACL seems to yield good short-term results in 80-90 per cent of cases. Out-patient ACL surgery is becoming increasingly common. Rehabilitation is often vigorous, with early mobilisation and weight-bearing. Functional range-of-motion and closed kinetic chain exercises predominate. Successful surgical outcome often allows former levels of activity to be resumed. There is still uncertainty as to whether surgery reduces the risk of arthrosis. The nature of the original trauma, and continued top level sports activity may be factors of importance. Further research is needed to elucidate the natural history, and determine the long-term effects of modern ACL surgery.

Anterior Cruciate Ligament↗
PubMed2004

Carotid endarterectomy, carotid artery shunting and outcome: an historical perspective.

PURPOSE OF REVIEW: Carotid endarterectomy is now celebrating its 50th anniversary! Yet, despite millions of these operations having been performed, there is little agreement about the best methods of surgical technique, cerebral protection, anesthetic technique and monitoring methods. In this time of evidence-based medicine, carotid endarterectomy fares badly, with only the indications for the surgery having been subjected to the appropriate methodology of clinical trials and biostatistics for proper evaluation. This review is designed to look back over the history of carotid endarterectomy in order to understand the evolution of current practices. RECENT FINDINGS: Within the past 5 years, despite the publication of many papers dealing with issues surrounding carotid shunting, no randomized controlled trials evaluating this aspect of carotid artery surgery have appeared. One must probe further into the past to understand how so much can be written yet so little learned! SUMMARY: Current evidence is not able to support the hypothesis that shunting during carotid artery surgery reduces the risk of perioperative stroke or death or that its use is associated with an increase in perioperative or long-term complications. Routine, selective or no shunting protocols during carotid artery surgery remain a matter of local custom and tradition.

Journal Article↗
PubMed1992

The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection.

BACKGROUND: Randomized, controlled trials have shown that prophylactic antibiotics are effective in preventing surgical-wound infections. However, it is uncertain how the timing of antibiotic administration affects the risk of surgical-wound infection in actual clinical practice. METHODS: We prospectively monitored the timing of antibiotic prophylaxis and studied the occurrence of surgical-wound infections in 2847 patients undergoing elective clean or "clean-contaminated" surgical procedures at a large community hospital. The administration of antibiotics 2 to 24 hours before the surgical incision was defined as early; that during the 2 hours before the incision, as preoperative; that during the 3 hours after the incision, as perioperative; and that more than 3 but less than 24 hours after the incision, as postoperative. RESULTS: Of the 1708 patients who received the prophylactic antibiotics preoperatively, 10 (0.6 percent) subsequently had surgical-wound infections. Of the 282 patients who received the antibiotics perioperatively, 4 (1.4 percent) had such infections (P = 0.12; relative risk as compared with the preoperatively treated group, 2.4; 95 percent confidence interval, 0.9 to 7.9). Of 488 patients who received the antibiotics postoperatively, 16 (3.3 percent) had wound infections (P less than 0.0001; relative risk, 5.8; 95 percent confidence interval, 2.6 to 12.3). Finally, of 369 patients who had antibiotics administered early, 14 (3.8 percent) had wound infections (P less than 0.0001; relative risk, 6.7; 95 percent confidence interval, 2.9 to 14.7). Stepwise logistic-regression analysis confirmed that the administration of antibiotics in the preoperative period was associated with the lowest risk of surgical-wound infection. CONCLUSIONS: We conclude that in surgical practice there is considerable variation in the timing of prophylactic administration of antibiotics and that administration in the two hours before surgery reduces the risk of wound infection.

Adult↗
PubMed2005

The impact of epilepsy surgery on mortality.

Patients with refractory epilepsy suffer from an increased risk of death, primarily due to seizure-related fatalities including sudden unexpected death (SUDEP), which could be conceivably avoided by surgical cure of the epilepsy. Several series have addressed this issue by comparing the mortality rate between medically and surgically treated drug resistant populations, as well as between patients, seizure free and non seizure free post-operatively. Results from some studies suggest that successful temporal lobe surgery reduced the risk of death to that observed in the normal population, whereas patients who continue to suffer recurrent seizures still present an increased standardized mortality ratio (SMR). However, other series have failed to replicate this finding, or found no difference in the overall mortality and SUDEP rates between operated and medically treated patients. All the above studies suffer various types of methodological limitations, hampering any definite conclusion regarding the impact of epilepsy surgery on mortality. However, part of the apparently discordant reported findings might be reconciled through the following framework. Patients who will eventually respond favourably or unfavourably to an anterior temporal lobectomy might already differ in the risk of seizure-related death, pre-operatively. Specifically, patients whose temporal lobe epileptogenic network extends to the perisylvian region (temporal plus epilepsy) appear to be at higher risk of failed TLE surgery, secondary generalised tonic-clonic seizures, ictal apnoea or insula-driven severe cardiac arrhytmias. This population might carry most of the SUDEP burden, both pre- and post-operatively, accounting for the lack of an obvious net reduction of seizure related deaths after temporal lobe surgery. A multicentric study has recently been launched in order to test this hypothesis, and will hopefully help to conclude on the impact of epilepsy surgery on mortality outcome.

Cause of Death↗
PubMed2001

[Surgery for a recently symptomatic severe carotid stenosis, indicated or not? Clinical application of 'evidence-based' medicine].

Two trials have shown that carotid surgery reduced the risk of stroke or death for patients with a recently symptomatic severe carotid stenosis. Nevertheless, it remains difficult to advise in individual cases. The risk of a stroke is about 20% in the next 3 years on medical treatment alone. This means that surgery is of no value in about 80% of the patients. With the help of prediction rules (developed by Rothwell and Warlow) it is possible to further individualize the decision whether or not to operate, by incorporating factors such as the angiographic roughness of the stenosis lining, the time since the cerebrovascular symptoms appeared, the extent of the stenosis, increased operation risk, sex, peripheral vascular disease and systolic blood pressure. If these prediction rules prove to be correct, doctors will be able to better advise their individual patients.

Carotid Stenosis↗
PubMed2006

Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery: a guideline from the American College of Physicians.

Postoperative pulmonary complications play an important role in the risk for patients undergoing noncardiothoracic surgery. Postoperative pulmonary complications are as prevalent as cardiac complications and contribute similarly to morbidity, mortality, and length of stay. Pulmonary complications may even be more likely than cardiac complications to predict long-term mortality after surgery. The purpose of this guideline is to provide guidance to clinicians on clinical and laboratory predictors of perioperative pulmonary risk before noncardiothoracic surgery. It also evaluates strategies to reduce the perioperative pulmonary risk and focuses on atelectasis, pneumonia, and respiratory failure. The target audience for this guideline is general internists or other clinicians involved in perioperative management of surgical patients. The target patient population is all adult persons undergoing noncardiothoracic surgery.

Adult↗
PubMed2006

Symptomatic and asymptomatic carotid stenosis: how, when, and who to treat?

Carotid stenosis is an important cause of ischemic stroke. Large randomized trials of endarterectomy have shown that surgery reduces the risk of stroke in patients with recently symptomatic carotid stenosis of 50% or greater, and to a lesser extent in patients with asymptomatic carotid stenosis of 60% or greater. More recent research has gone some way in identifying which patients benefit most and when intervention is most effective. Individual risk modeling has been shown to be useful in selecting patients with the most to gain from endarterectomy for symptomatic stenosis, although timely surgery and optimal medical treatment are of equal importance. Further research is required in order to determine the role of carotid stenting and to identify those individuals with asymptomatic stenosis who have the most to gain from intervention.

Carotid Stenosis↗
PubMed2006

Alfuzosin 10 mg once daily prevents overall clinical progression of benign prostatic hyperplasia but not acute urinary retention: results of a 2-year placebo-controlled study.

OBJECTIVES: To evaluate the effect of alfuzosin 10 mg once daily administered for 2 years on progression events in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). PATIENTS AND METHODS: In all, 1522 men at risk of having progression events from LUTS/BPH were randomized to receive alfuzosin 10 mg once daily (759) or placebo (763) for 2 years. Endpoints assessed were the occurrence of a first episode of acute urinary retention (AUR; primary) and the need for BPH-related surgery. Post hoc analyses included a deterioration in the International Prostate Symptom Score (IPSS) of > or = 4 points and overall clinical progression of BPH (occurrence of AUR and/or surgery and/or symptom deterioration). RESULTS: Over 2 years, symptom deterioration was the most common progression event (14.3%), followed by BPH-related surgery (5.8%) and AUR (2.0%). Alfuzosin did not reduce the risk of AUR (alfuzosin 2.1% vs placebo 1.8%, P = 0.82) but tended to reduce the risk of surgery (5.1% vs 6.5%, P = 0.18); the reduction in risk (RR) and 95% confidence interval with alfuzosin was 22 (-18 to 48)%; and significantly reduced the risk of symptom deterioration (11.7% vs 16.8%; P = 0.0013); the RR was 30 (10-46)%. The overall clinical progression of BPH was significantly lower with alfuzosin than with placebo (16.3% vs 22.1%, P < 0.001); RR 26 (9-40)%. Alfuzosin also significantly improved the IPSS (P = 0.017), quality of life (P < 0.001) and peak flow rate (P = 0.001) compared with placebo. Baseline levels of prostate-specific antigen (PSA) predicted both AUR and BPH-related surgery events, while the baseline postvoid residual urine volume predicted symptom deterioration. The incidence of adverse events with alfuzosin was comparable to that with placebo. CONCLUSIONS: Alfuzosin 10 mg once daily prevents the overall clinical progression of BPH, defined by the occurrence of a deterioration in IPSS of > or = 4 points and/or AUR and/or BPH-related surgery, but does not reduce the primary occurrence of AUR. Alfuzosin significantly improves LUTS and quality of life over 2 years, and is well tolerated.

Adrenergic alpha-Antagonists↗
PubMed2000

Laparoscopic cholecystectomy in cirrhosis: contraindication or privileged indication?

Until recently, cirrhosis has been considered to be an absolute or relative contraindication of laparoscopic cholecystectomy. An evaluation of benefits and risks of laparoscopic cholecystectomy in the treatment of gall bladder lithiasis in cirrhotic patients is presented. Thirty-three consecutive laparoscopic cholecystectomies in patients with cirrhosis were performed between March 1990 and March 1997. During the same period, no open cholecystectomy was performed in patients with cirrhosis. There was no morbidity or mortality; the conversion rate was 6% (2/33). No patient received blood transfusion, and the mean hospital stay was 2.8 days. These results favorably compare with the results of open cholecystectomy. Specific advantages of laparoscopic cholecystectomy in patients with cirrhosis include the absence of wound infection and a lower rate of postoperative hepatic failure. Finally, laparoscopic surgery reduces the risk of viral contamination (the hepatitis B virus, the hepatitis C virus, or the human immunodeficiency virus) of the surgical staff.

Adult↗
PubMed2004

Selective use of off-pump coronary bypass surgery reduces mortality and neurologic morbidity associated with high-risk coronary bypass surgery: a 400-case comparative experience.

The frequency of use of off-pump coronary artery bypass (CAB) surgery to surgically treat coronary artery disease has varied greatly from center to center and from surgeon to surgeon because of preference, training, and experience. We report an experience with 400 consecutive isolated CAB procedures selectively managed with on-pump or off-pump surgery, according to the perceived potential for aortic embolization or stroke as determined by clinical and imaging determinations. The off-pump CAB group (46 patients) was 7.1 years older (P < .05) and had an 11% lower ejection fraction (P < .03) than the on-pump group. There was no difference in gender, urgency of surgery, hemodynamic stability, angina class, or incidence of prior myocardial infarction. All 400 patients underwent intraoperative transesophageal echocardiography, and many underwent an epiaortic study to supplement image quality. Patients without palpable or imaged advanced aortic disease or deemed to be at clinically high risk for stroke (advanced age, prior strokes, or advanced cerebrovascular or peripheral vascular disease) underwent on-pump procedures requiring 55 minutes of aortic ischemia and 97 minutes of high-flow, high-pressure bypass on average. All others underwent off-pump procedures. The numbers of grafts per patient were similar (3.2 on-pump, 2.8 off-pump; = ns). There was no in-hospital or 30-day mortality in either group. Using the New York State risk-adjustment algorithm, we found the predicted mortality rate for the off-pump group was higher (2.24% on-pump versus 5.54% off-pump, P = .008). The postoperative length of stay was longer in the off-bypass group (3.67 days versus 4.31 days, P = .003). The frequencies of hospital readmission and perioperative complications (renal, pulmonary, infection, bleeding, cardiac, neurologic) were similar, and there were no postoperative strokes in either group. The selective use of off-pump surgery safely managed patients at higher risk for perioperative stroke and associated embolic multisystem organ failure and death. Individual surgeon and center-wide use of a selective approach is recommended as an alternative to a single-procedure nonselective approaches.

Aged↗
PubMed1995

[The effect of surgical antibiotic prophylaxis and the timing of its administration on the risk of surgical wound infection].

BACKGROUND: Clinical trials have demonstrated the efficacy of surgical prophylaxis (SP). Nevertheless, how the timing of antibiotic administration influences the risk of infection in clinical praxis has scarcely been studied. In this study an assessment was made of whether the non administration of antibiotic, or its administration longer than 2 hours preoperatively, or only postoperatively, are associated with a higher rate of infection of the surgical wound (SWI) compared with antibiotic administration within the two hours prior to surgery in our setting. METHODS: Observational, longitudinal, pseudoretrospective study. It included 2,483 patients undergoing surgery in 1992, with clean-contaminated, contaminated and clean with prophylaxis indication, and without previous infection surgeries. Information on variables potentially associated with SWI and incidence of infection was monitored. A multivariate analysis was made by means of the logistic regression method to evaluate the association of prophylaxis and time of administration, controlling for the remaining variables. RESULTS: 754 patients received appropriate prophylaxis (within 2 hours prior to surgery); 28 of these patients (3.7%) developed SWI. Twenty-four of the 107 who received prophylaxis longer than 2 hours prior to surgery developed infection (22.4%; p < 0.001 compared with the first group; OD: 7.5, 95% CI: 3.94-14.1); in the group of patients non receiving preintervention doses 94 patients developed infection (7.7%; p = 0.001; OR: 2.16, 95% IC: 1.38-3.41). Among patients who did not receive prophylaxis 24 infections were detected (6%; p = 0.10; OR: 1.66, 95% CI: 0.91-2.99). In the multivariate analysis the administration of prophylaxis longer than 2 hours prior to surgery or postoperatively was confirmed to be associated with a higher SWI rate, as in the non-administration situation, controlling for the remaining variables (OR for longer than 2 hours: 5.82; for postoperative administration: 3.23, and for non-administration: 2.68). CONCLUSIONS: The administration of SP is inappropriate in a high percentage of cases. The administration of SP within the 2 hours prior to surgery reduces the risk of SWI, compared with the administration 2 hours or longer prior to intervention or only postoperatively.

Adolescent↗
PubMed2000

Reduced risk of coronary artery bypass surgery for unstable angina during a 6-year period.

OBJECTIVE: To assess the risk of early death or acute myocardial infarction in patients undergoing isolated coronary artery bypass surgery for unstable coronary artery disease. METHODS: Retrospective observational study of 853 patients operated on because of unstable coronary artery disease during 1990-1995. RESULTS: There were 5.9% deaths and 13.0% nonfatal infarctions < or =30 days. These figures declined during the observation period and were 2.6% and 6.2%, respectively, in 1995. The relative risk of early death or myocardial infarction was 50% less during 1994-1995 than during 1990-1991, after multivariate adjustment for several patient risk factors. The risk of death or infarction was almost twice as high in patients > or =50 years than in those < 50 years of age. Multivariate analysis showed that aortic-cross-clamp time > or =60 min, previous bypass surgery, pre-operative heart failure, emergency surgery, worse Braunwald class and non-use of an internal mammary artery graft were associated with an increased risk of death or infarction. Early mortality was 3.4% (24/702) in unstable patients without symptoms of congestive heart failure, who were not operated on emergently after failed percutaneous coronary intervention and had not had previous cardiac surgery. CONCLUSIONS: We observed a marked reduction of the risk of early death or myocardial infarction after surgery for unstable angina during the 6-year period 1990-1995. The risk reduction was not explained from operations performed on patients with less risk and indicates improved peri-operative patient management.

Adult↗
PubMed2005

Adjuvant therapy of stage II and III colon cancer.

Up to 50% of patients who undergo curative resection for colon cancer relapse and ultimately die of metastatic disease. Adjuvant chemotherapy given after surgery reduces the risk of disease recurrence in patients with stage II/III disease, and considerable progress of adjuvant chemotherapy in these patients has been reported. Clinical studies evaluating chemotherapy regimens continue, as do trials that use specific, molecularly targeted agents that have shown promising results in patients with advanced colon cancer. Ongoing important issues to be addressed relate to the optimal schedule and/or choice of chemotherapeutic regimens, and the efficacy of the combination of molecular agents with conventional chemotherapy.

Chemotherapy, Adjuvant↗