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PubMed2006

Chemical sensors based on micromachined transducers with integrated piezoresistive readout.

We demonstrate an approach for the development of chemical sensors utilizing silicon micromachined physical transducers with integrated piezoresistive readout. Originally, these transducers were developed and optimized as sensitive accelerometers for automotive applications. However, by applying a chemically responsive layer onto the transducer, we convert these transducers into chemical sensors. These transducers are attractive for chemical sensing applications for several key reasons. First, the required sensitivity of the chemical sensor can be achieved by choosing the right spring constant of the transducer. Second, the integrated piezoresistive readout of the transducer is already optimized and is very straightforward, providing a desired reproducibility in measurements, while not requiring bulky equipment. Third, chemically responsive film deposition is simple due to the ease of access to the transducer's surface. Fourth, such transducers are already available for another (automotive) application, making these sensors very cost-effective. The applicability of this approach is illustrated by the fabrication of highly sensitive CO2 sensors. To study hysteresis effects, we selected high CO2 concentrations (10-100% CO2) to provide the worst-case scenario for the sensor operation. These sensors demonstrate a hysteresis-free performance over the concentration range from 10 to 100% vol CO2, have detection limits of 160-370 ppm of CO2, and exhibit a relatively rapid response time, T(90) = 45 s. Importantly, we demonstrate a simple method for cancellation of vibration effects when these physical transducers, initially developed as accelerometers, are applied as chemical sensors.

Journal Article↗
PubMed1997

Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.

Dendritic cells (DCs) are bone marrow-derived leukocytes that function as potent antigen presenting cells capable of initiating T cell-dependent responses from quiescent lymphocytes. DC pulsed with tumor-associated antigen (TAA) peptide or protein have recently been demonstrated to elicit antigen-specific protective antitumor immunity in a number of murine models. Transduction of DCs with TAA genes may allow stable, prolonged antigen expression as well as the potential for presentation of multiple, or unidentified, epitopes in association with major histocompatibility complex class I and/or class II molecules. To evaluate the potential efficacy of retrovirally transduced DCs, bone marrow cells harvested from BALB/c mice were transduced with either a model antigen gene encoding beta-galactosidase (beta-gal) or a control gene encoding rat HER-2/neu (Neu) by coculture with irradiated ecotropic retroviral producer lines. Bone marrow cells were differentiated into DC in vitro using granulocyte/macrophage colony-stimulating factor and interleukin-4. After 7 d in culture, cells were 45-78% double positive for DC phenotypic cell surface markers by FACS(R) analysis, and DC transduced with beta-gal were 41-72% positive for beta-gal expression by X-gal staining. In addition, coculture of beta-gal transduced DC with a beta-gal-specific T cell line (CTLx) resulted in the production of large amounts of interferon-gamma, demonstrating that transduced DCs could process and present endogenously expressed beta-gal. DC transduced with beta-gal and control rat HER-2/neu were then used to treat 3-d lung metastases in mice bearing an experimental murine tumor CT26.CL25, expressing the model antigen, beta-gal. Treatment with beta-gal-transduced DC significantly reduced the number of pulmonary metastatic nodules compared with treatment with Hank's balanced salt solution or DCs transduced with rat HER-2/neu. In addition, immunization with beta-gal-transduced DCs resulted in the generation of antigen-specific cytotoxic T lymphocytes (CTLs), which were significantly more reactive against relevant tumor targets than CTLs generated from mice immunized with DCs pulsed with the Ld-restricted beta-gal peptide. The results observed in this rapidly lethal tumor model suggest that DCs transduced with TAA may be a useful treatment modality in tumor immunotherapy.

Animals↗
PubMed1983

Limited homology between trg and the other transducer proteins of Escherichia coli.

Transducers are transmembrane proteins that are central to the chemotactic system of Escherichia coli. The proteins transduce ligand recognition into an excitatory signal and function in adaptation as methyl-accepting proteins. The transducer genes tsr, tar, and tap have extensive homology with each other. However, previous studies revealed little indication of homology between those three transducer genes and a fourth gene, trg. We investigated the relationship between trg and the other genes by blot-hybridization experiments and the relationship between Trg and the other transducer proteins by immune precipitation and experiments with an antiserum raised to purified Trg protein. In experiments in which 35% mismatch would be tolerated, weak hybridization of trg was detected to a DNA fragment containing tar and tap but not to a fragment containing tsr. In experiments in which only 30% mismatch would be tolerated, no trg hybridization was apparent either to total chromosomal DNA or to DNA from hybrid plasmids carrying the other transducer genes. An anti-Trg serum formed immune precipitates with the Tsr and Tar proteins as well as with the Trg protein to which it was raised. We conclude that there is homology between Trg and the other transducer, but the homology is more limited than that shared among the other transducers. Furthermore, we found no indication of additional transducer genes closely related to trg. Thus, the trg gene is a somewhat distant cousin within a single transducer gene family of E. coli.

Bacterial Proteins↗
PubMed1996

A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients.

Corrective gene transfer for therapeutic intervention in metabolic and hematopoietic disorders has been hampered by the relatively inefficient transduction of human hematopoietic stem cells. To overcome this, a bicistronic recombinant retrovirus has been generated that delivers both a therapeutic glucocerebrosidase (GC) cDNA for the treatment of Gaucher disease, and a small murine cell surface antigen (heat-stable antigen [HSA]) as a selectable marker. An amphotropic retroviral-producing cell clone was created, and filtered supernatant was used to transduce NIH 3T3 cells. Sorting of transduced cells by flow cytometry enabled separation into populations based on cell surface fluorescence intensity derived from the expressed HSA. Significant increases in GC enzyme activity were seen for the transduced and especially the transduced and sorted cells. Similarly, increases in GC specific activity were seen in transduced and sorted skin fibroblasts from a patient with Gaucher disease. To streamline future transfer and sorting protocols for hematopoietic cells, transformed B-cell lines from Gaucher patients were created. Type I B cells were transduced and sorted, and large increases in GC specific activity occurred with concomitant increases in integrated retroviral copy numbers. In addition, toward the goal of using this selectable approach for corrective gene transfer to bone marrow stem cells, CD34+ cells were isolated from normal BM donors, transduced, and sorted based on cell surface expression of HSA. Proviral DNA was detected in approximately 40% of clonogenic progenitor colonies derived from unsorted, transduced CD34+ cells, demonstrating the high titer of the vector. However, after sorting, 100% of the colonies had the corrective GC cDNA, demonstrating the efficiency of this selective system for human hematopoietic progenitors. It is expected that strategies based on this approach will allow sorting of transduced cells of many types before implantation of transduced cells to animals or patients. This vector system may also be used to simplify manipulations and studies on retroviral-mediated gene delivery in vitro and for in vivo models.

3T3 Cells↗
PubMed1997

Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

A retroviral gene therapy approach was developed to protect early hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, and O6-benzylguanine (BG), an inhibitor of a key BCNU resistance protein, O6-alkylguanine DNA alkyltransferase (AGT). The retroviral vector MFG was used to transfer the G156A MGMT (deltaMGMT) cDNA, encoding a mutant AGT that is resistant to inhibition by BG, into murine bone marrow-derived hematopoietic progenitors. Following transplantation into lethally irradiated mice, the transduced cells were subjected to in vivo BG and BCNU treatment to examine the ability to enrich for transduced cells expressing deltaAGT. Transplantation of deltaMGMT-transduced cells resulted in deltaAGT expression in 30% of bone marrow nucleated cells 13 weeks after transplantation. After one cycle of BG and BCNU, deltaAGT expression was observed in 60% of bone marrow cells, and the percentage of colony-forming units (culture; CFU-C) containing proviral sequence increased from 67 to 100%. CFU-C obtained from BG and BCNU-treated deltaMGMT animals up to 23 weeks after transplantation were more resistant to combination BG and BCNU than CFU-C from mice transplanted with lacZ-transduced cells and treated with BG and BCNU or from mice transplanted with deltaMGMT-transduced cells and left untreated. The degree of drug resistance in deltaMGMT-transduced hematopoietic progenitors to BG and BCNU was much greater than we observed previously with wild-type MGMT gene transfer and treatment with BCNU alone. Furthermore, whereas 21 of 22 mice transplanted with deltaMGMT-transduced cells survived in vivo BG and BCNU administration, only 3 of 13 mice transplanted with lacZ-transduced progenitors survived similar drug treatment. Thus, deltaMGMT-transduced murine bone marrow cells selectively survive in vivo BG and BCNU exposure, resulting in prolonged enrichment for the transduced cells and protection from mortality induced by this drug combination.

Animals↗
PubMed2005

A multicentered comparison of measurements obtained with microtip and external water pressure transducers.

This study compared simultaneous intravesical pressure readings obtained with catheter-mounted microtip transducers and external water pressure transducer catheters during filling cystometry. Women undergoing multichannel urodynamic testing were randomly assigned to one of three groups: two microtip catheters, two external water pressure transducer catheters, or one of each type. Intravesical pressure was measured simultaneously for each transducer combination in each subject for minimal and maximal Valsalva effort and minimal, moderate, and maximal cough effort at two sequential bladder volumes (150 and 300 ml). Paired t tests were used to compare the means of the intravesical pressure obtained by the two types of catheters. The largest mean differences were observed when comparing microtip and water pressure transducers. Correlations of maximum pressure were consistently high between two microtip transducers and two water pressure transducers but lower for the microtip-water combination. Excellent reproducibility was demonstrated with transducers of similar types for intravesical pressures recorded during Valsalva and cough in women without prolapse. However, considerable variability was seen in pressures recorded by different transducers, particularly dependent on the water catheter manufacturer, indicating that intravesical pressure recordings from microtip and water-based systems are not interchangeable.

Adult↗
PubMed1985

Acoustic impedance matching of medical ultrasound transducers.

Ultrasonic transducers for pulse-echo systems are studied both theoretically and experimentally. For the theoretical calculations the Mason model for thickness-mode disc transducers with and without backing and matching layers is used. By building several of the theoretically investigated transducer configurations it is shown that theory and experiment agree well. Thus the properties of a transducer can be predicted to a good approximation before its experimental realization. To find transducers with good sensitivity and short pulses, the pulse shape and frequency response for the following classes of transducers were studied both theoretically and experimentally: transducers with backing only, transducers with heavy backing and front matching layers, and air-backed transducers with front matching layers.

Humans↗
PubMed2004

Strain and force transducers used in human and veterinary tendon and ligament biomechanical studies.

Biomechanical studies often aim at determining the contribution (in terms of load or strain) of a tendon or ligament in posture, gesture or locomotion. To this end, many transducers have been developed since 30 years. These devices implanted within or attached to the inside of the tendon or ligament must be compliant enough to measure in vivo the tissue load or strain without interfering with the movement of man or animals. They can be transducers with variation of electrical resistance (liquid metal strain gauge, buckle transducer, implantable force transducer and pressure transducer), variation of magnetic field (Hall effect transducer) and variation of light flow (optic fibre). Their use requires surgery in order to implant them and it is limited in time because of their invasive character and the development of fibrous healing reactions. Besides, the transducer dimensions and its position in the tendon can influence the transducer output signal. Moreover, the latter may not reflect the behaviour of the tendon as a whole but only locally. In addition, a calibration is required in order to convert the output signal into a strain or a force. In animals, this calibration is generally made by a post-mortem procedure on dissected anatomical specimens; in man, an indirect calibration procedure using inverse dynamic calculations is generally performed. However, the calibration conditions cannot reproduce exactly the in vivo conditions. So far, only invasive transducers have allowed to measure strain or force in tendons with all constraints and limits mentioned above.

Animals↗
PubMed2006

High-frequency ultrasonic imaging of the anterior segment using an annular array transducer.

OBJECTIVE: Very high-frequency ultrasound (VHFU; >35 megahertz [MHz]) allows imaging of anterior segment structures of the eye with a resolution of less than 40 microm. The low focal ratio of VHFU transducers, however, results in a depth of field (DOF) of less than 1 mm. The aim was to develop a high-frequency annular array transducer for ocular imaging with improved DOF, sensitivity, and resolution compared with conventional transducers. DESIGN: Experimental study. PARTICIPANTS: Cadaver eyes, ex vivo cow eyes, in vivo rabbit eyes. METHODS: A spherically curved annular array ultrasound transducer was fabricated. The array consisted of 5 concentric rings of equal area, had an overall aperture of 6 mm, and a geometric focus of 12 mm. The nominal center frequency of all array elements was 40 MHz. An experimental system was designed in which a single array element was pulsed and echo data were recorded from all elements. By sequentially pulsing each element, echo data were acquired for all 25 transmit-and-receive annuli combinations. The echo data then were focused synthetically and composite images were produced. Transducer operation was tested by scanning a test object consisting of a series of 25-microm diameter wires spaced at increasing range from the transducer. Imaging capabilities of the annular array were demonstrated in ex vivo bovine, in vivo rabbit, and human cadaver eyes. MAIN OUTCOME MEASURES: Depth of field, resolution, and sensitivity. RESULTS: The wire scans verified the operation of the array and demonstrated a 6.0-mm DOF, compared with the 1.0-mm DOF of a conventional single-element transducer of comparable frequency, aperture, and focal length. B-mode images of ex vivo bovine, in vivo rabbit, and cadaver eyes showed that although the single-element transducer had high sensitivity and resolution within 1 to 2 mm of its focus, the array with synthetic focusing maintained this quality over a 6-mm DOF. CONCLUSIONS: An annular array for high-resolution ocular imaging has been demonstrated. This technology offers improved DOF, sensitivity, and lateral resolution compared with single-element fixed focus transducers currently used for VHFU imaging of the eye.

Animals↗
PubMed2006

A KLM-circuit model of a multi-layer transducer for acoustic bladder volume measurements.

In a preceding study a new technique to non-invasively measure the bladder volume on the basis of non-linear wave propagation was validated. It was shown that the harmonic level generated at the posterior bladder wall increases for larger bladder volumes. A dedicated transducer is needed to further verify and implement this approach. This transducer must be capable of both transmission of high-pressure waves at fundamental frequency and reception of up to the third harmonic. For this purpose, a multi-layer transducer was constructed using a single element PZT transducer for transmission and a PVDF top-layer for reception. To determine feasibility of the multi-layer concept for bladder volume measurements, and to ensure optimal performance, an equivalent mathematical model on the basis of KLM-circuit modeling was generated. This model was obtained in two subsequent steps. Firstly, the PZT transducer was modeled without PVDF-layer attached by means of matching the model with the measured electrical input impedance. It was validated using pulse-echo measurements. Secondly, the model was extended with the PVDF-layer. The total model was validated by considering the PVDF-layer as a hydrophone on the PZT transducer surface and comparing the measured and simulated PVDF responses on a wave transmitted by the PZT transducer. The obtained results indicated that a valid model for the multi-layer transducer was constructed. The model showed feasibility of the multi-layer concept for bladder volume measurements. It also allowed for further optimization with respect to electrical matching and transmit waveform. Additionally, the model demonstrated the effect of mechanical loading of the PVDF-layer on the PZT transducer.

Animals↗
PubMed2004

The effect of transducer characteristics on the estimation of Nakagami paramater as a function of scatterer concentration.

The effect of transducer characteristics on the sensitivity of the Nakagami parameter to detect the variation of scatterer concentrations was studied. The rationale for this study stems from our pilot results which showed that the Nakagami parameters, estimated using a nonfocused transducer were not as sensitive as those of measurements using a commercial ultrasonic scanner in previous reports. This discrepancy may be attributed to the effects of transducer characteristics relative to the size of the resolution cell as verified by measurements of phantoms and 2-D computer simulations. The Nakagami parameter as a function of scatterer concentration was calculated using backscattered signals acquired from the scattering medium of different scatterer concentrations ranging from 2 to 32 scatterers/mm(3) using both 5 MHz nonfocused and focused transducers. Experimental and simulation results obtained from the nonfocused transducer represent that their respective Nakagami parameters increased from 1.17 to 1.31 and from 0.82 to 1.01 corresponding to the increase of scatterer concentrations. For the results obtained from the focused transducer, their average Nakagami parameters increased from 0.27 to 0.72 and from 0.33 to 0.81. These consistent results demonstrated that Nakagami parameter estimated using a focused transducer tends to be more sensitive than that by a nonfocused transducer to detect the variation of low scatterer concentration. This difference is fully due to the effect of transducer characteristics associated with the effective number of scatterers in the resolution cell.

Computer Simulation↗
PubMed2006

The use of a segmented transducer for rib sparing in HIFU treatments.

The use of focused ultrasound as a minimally invasive treatment for tumours is rapidly expanding. Target organs include the liver and kidneys. Both single element and phased array transducers may be used in the clinic. The presence of the rib cage presents a problem in high intensity focused ultrasound (HIFU) treatment planning, due to its high attenuation of the HIFU beam resulting in a loss of power at the focus as well as an increase in the risk of damage at the rib and to overlying tissues, including the skin. In this paper, a linearly segmented transducer, in which all active elements are driven in phase, has been investigated. The aim of the study was to investigate how a beam with a clinically useful profile could be achieved by removing the contribution of edge segments from one side of the transducer to the field. We have considered the case in which the HIFU beam approaches the rib cage during a treatment and investigated configurations of the transducer for which up to three segments on the edge are switched off. This problem has been studied initially using a linear acoustic field program to model the segmented transducer's acoustic beam profile. Experimental measurements of the transducer's acoustic field were performed using an automated beam plotting system. Temperature measurements were made on a rib surface for two transducer configurations using a fine wire thermocouple. A thermochromic liquid crystal material was used to assess qualitatively the heating pattern generated by the ultrasound beam. We show the rib sparing potential of the segmented transducer during HIFU treatment by demonstrating a reduction in the prefocal width of the ultrasound beam when edge segments are switched off. This has been predicted with the acoustic field model and demonstrated experimentally by acoustic field measurements and observations of the heating pattern generated by the ultrasound beam. A significant decrease in the temperature rise on a rib was observed in the case for which three edge segments were switched off compared with when all segments were active. We conclude that a segmented transducer extends the potential for treating liver tumours. In the case where the tumour lies behind, but close to the edge of, the ribs, energy loss at the focus and excessive heating in the rib and overlying tissue can be avoided by switching off edge segments.

Acoustics↗
PubMedDate not supplied

Improved echocardiographic detection and characterization of left ventricular apical thrombi with a 5.0 MHz short-focus transducer.

Transthoracic echocardiography is a frequently used technique for detecting ventricular thrombi. This study compares the usefulness of a 5.0 MHz short focal length transducer (5-short) with standard frequency (2.5 or 3.5 MHz) transducers for the detection of left ventricular thrombi. In addition, the effect of body habitus on study quality was evaluated. A consecutive series of 101 patients sent for echocardiographic imaging with the diagnosis of myocardial infarction, dilated cardiomyopathy, or recent suspected embolic event were imaged in the apical four-chamber, apical long-axis, and apical two-chamber views with a standard transducer and also with the 5-short. Out of this group, 16 apical thrombi were identified, six with the 5-short only, three with standard transducers only, and seven by both techniques. The areas of the seven thrombi detected by both transducers were consistently larger when measured on 5-short images compared with standard transducer images (4.6 +/- 2.3 vs 3.7 +/- 2.3 cm2, p = 0.02). In the three studies positive only with the standard transducers, the 5-short demonstrated only prominent trabeculae but no thrombus. The studies positive only with the 5-short had significantly smaller calculated thrombi areas than those visualized by the standard transducers (1.6 +/- 1.2 vs 4.2 +/- 2.1 cm2, p = 0.02). No thrombus was detected by either technique in a normally contracting left ventricular apex. There were significantly fewer studies having near-field artifact when performed by the 5-short compared with those performed with standard transducers (14/101 vs 40/101, p = 0.00004).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1996

Microbiologic assessment of the transabdominal ultrasound transducer head.

The objectives of this study were to determine (1) the rate of bacterial isolation from the abdomen of women having obstetric ultrasonography, (2) the rate of bacterial transmission to the transducer head, and (3) the eradication rate after routine wiping of the transducer head. A total of 191 obstetric patients participated in this study. At the start of each day, the transducer head and the coupling gel were cultured. Aerobic cultures were obtained from each patient's periumbilical and suprapubic areas before the transabdominal scan and from the transducer head before and after wiping off the gel with a dry cloth. Daily transducer head and gel cultures were negative. Of the abdominal skin cultures, 175 (92%) were positive; 35 (18%) were positive for serious organisms, and 140 (74%) were positive for organisms of low virulence. Sixty percent of the transducer head cultures from women with abdominal skin pathogens were positive before the gel was wiped off. None of the cultures from the transducer head were positive after removal of the gel. We conclude that many women carry potentially virulent pathogens on the abdominal skin and that transmission of these organisms to the transducer head commonly occurs. Physical removal of the gel from the transducer head effectively eradicates these microorganisms, minimizing patient-to-patient transmission.

Abdomen↗
PubMed2001

The influence of roughness, angle, range, and transducer type on the echo signal from planar interfaces.

The received electrical echo signal from a pulse-echo system insonifying a planar interface was measured for varying degrees of rms roughness [0 to 0.29 mm (0 to 1.7 lambda)], angles of incidence, theta, (-7 degrees to 7 degrees), and ranges to a planar or focused transducer. The effect of varying theta is quantified in terms of the energy of the received signal, E(theta), and the normalized spectrum of the received signal. E(theta) is approximately Gaussian when using a planar transducer or a focused transducer with the reflecting interface located at or beyond the focal point. For focused transducers with the interface located closer than the geometrical point of focus, two maxima can sometimes be observed when varying the incident angle. As is generally known, the width of E(theta) is strongly dependent on transducer type, e.g., for a smooth interface, the -3 dB width for a 25.4 mm diameter 5-MHz planar and focused transducer was approximately 0.5 degree and 4 degrees (at the focal point), respectively. E(0 degree) as a function of surface roughness, Rq, was nearly linear on a decibel scale, with a slope of -109 dB/(Rq/lambda) and -61 dB/(Rq/lambda) for planar and focused transducers, respectively. The characteristic nulls present in the normalized spectra of the echo signal at non-normal incidence tend to vanish with increasing Rq when using planar transducers. For focused transducers, the normalized spectra change from relatively flat to monotonically decreasing as Rq increases, and they exhibit reduced amplitude with increased incident angle.

Acoustics↗
PubMed2002

Damping, amplitude, aging tests of stacked transducers for shock wave generation.

New clinical concepts in lithotripsy demand small shock heads. Reducing the size of piezoelectric shock heads will be possible only if the pressure generated at the surface of each transducer can be increased so that the total pressure at the focus remains the same. To solve this problem, different solutions were proposed. For example, it has been demonstrated that piezocomposite material, as opposed to piezoceramic material, allows the generation of a higher surface pressure before breaking, mainly because radial modes are dramatically reduced. In addition, in a previous paper, we showed the feasibility of generating high-pressure pulse waves without increasing the transducer voltage by using sandwiched transducers, which are a stack of two or more transducers. Some discrepancies appeared, however, between the pressure measured at the surface of the front transducer and the arithmetic sum of the pressures generated by each transducer constituting the stack. In fact, development of such stacked transducers capable of generating surface pressures in the range of 2 to 5 MPa is very complex, which may explain why no aging tests have been reported in the literature thus far. In the first part of this paper, we theoretically determine the importance of the electroacoustical coupling between the two transducers on the generated surface pressure. We show that pressure losses due to these electroacoustical couplings are less than 5%. Experimental measurements done on a stacked transducer assembled and tightened in a castor oil-filled tank are in excellent accordance with the theoretical measurements. Using this assembly technique, it was possible to obtain, on average, out of four elements, a pressure of 7.5 MPa for the duration of 4 million shocks, which would allow the treatment of approximately 1000 patients.

Computer Simulation↗
PubMed2005

Stress field forming of sector array transducers for vibro-acoustography.

This paper presents a study of the stress field forming of sector array transducers for vibro-acoustography applications. The system point-spread function (PSF) is given in terms of the dynamic radiation stress exerted on a point target by a dual ultrasound beam with slightly different frequencies. The radiation stress is calculated by assuming that the resulting ultrasound beam is a plane wave. The stress is proportional to the product of the velocity potential of each incident ultrasound beam. The beamforming and stress field forming of sector array transducers are analyzed through linear acoustics. An expression for the velocity potential produced by sector array transducers is derived. The vibro-acoustography PSF is evaluated numerically. A comparison between the PSF of a sector array and a confocal transducers is presented. The compared characteristics of the PSF are sidelobe levels, transverse, and in-depth spatial resolution. Indeed, one motivation to study sector transducers is the fact the depth-of-field of these transducers should be smaller than that of same size confocal transducers. An experimental setup was used to validate the theoretical PSF of sector array transducers. Results show that the measured PSF is in good agreement with the theoretical predications. Vibro-acoustography images of a breast-phantom by both transducers are presented and discussed.

Acoustics↗
PubMed1989

Surface heating of diagnostic ultrasound transducers.

Surface temperatures of a variety of transducers used with common commercial ultrasonic diagnostic equipment have been measured. Transducers operating in imaging mode, in both continuous and pulsed Doppler modes, and in mixed modes were investigated. A total of 30 transducers and scan-heads used with equipment from 10 manufacturers were examined, including a range of array types, mechanical sectors and continuous-wave Doppler transducers. Measurements were made using an infrared radiometer, or a thermocouple probe, with the transducers operating in air. Surface temperatures of 13 transducers operating in imaging mode were found to be in the range 0.0-13.1 degrees C above ambient after 5 min operation. Some transducers operating in pulsed Doppler mode reached considerably higher temperatures. The most extreme example increased the surface temperature by 36.5 degrees C after 1 min and reached a steady-state temperature of almost 80 degrees C. Transducers operating at these temperatures cannot be retained on the skin of a conscious subject without pain, and will cause skin burns within a brief period of time. A linear relationship has been demonstrated between temperature increase and spatial-average acoustic intensity. The rate of increase in air was found to be about 10 times greater for pulsed arrays than for continuous-wave Doppler transducers.

Hot Temperature↗