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PubMed1984

Use of the SADS diagnostic interview in evaluating legal insanity.

Examined clinical usefulness of the SADS diagnostic interview in evaluations of criminal responsibility. Findings, based on 78 SADS evaluations from a specialized forensic clinic, indicated that SADS successfully differentiated between sane and insane evaluatees. These differences were found primilarily in the severity of psychotic symptoms and overall level of psychological impairment. In addition, preliminary data on institutionalized and outpatient Ss suggested the potential applicability of the SADS for assessing the general psychological functioning of insane patients in treatment.

Adaptation, Psychological↗
PubMed2000

Film-induced sadness as a trigger for disinhibited eating.

OBJECTIVE: We tested whether film-induced sadness enhances food intake in restrained eaters. METHOD: Female participants scoring either high or low on a measure of dietary restraint viewed two film segments in counterbalanced order on successive days: an emotionally neutral travelogue and a sad film depicting the death of the young female protagonist. RESULTS: Contrast analyses revealed that film-induced sadness significantly reduced food intake in low-restraint individuals, but only nonsignificantly increased it in high-restraint individuals. DISCUSSION: When sadness is induced without an apparent ego threat, high-restraint participants may not exhibit as much disinhibited eating as when they are exposed to mood inductions that threaten their self-esteem.

Adult↗
PubMed2006

The relation of ANS and HPA activation to infant anger and sadness response to goal blockage.

This study examined the relation of anger and sadness to heart rate and cortisol in 4-month-old infants' (n = 56) response to a goal blockage. The blockage occurred during a contingency learning procedure where infants' response no longer produced a learned interesting event. Anger and sadness were the major emotional expressions to the blockage. The two emotional expressions were differentially related to heart rate and cortisol. Anger was related to increased heart rate, but not cortisol, whereas sadness was related to increased cortisol, but not heart rate. Along with other work, the present results support the view that infant anger in response to goal blockage involves autonomic as opposed to adrenocortical activation as a consequence of an expectation of control over the event. In contrast, sadness in response to goal blockage involves adrenocortical as opposed to autonomic activation stemming from the absence of an expectation of control.

Affect↗
PubMed1999

Characteristics of eating in anger, fear, sadness and joy.

The influences of emotions on eating were investigated. One-hundred and seven female and 103 male subjects were asked to report how various characteristics of eating could change during the emotions of anger, fear, sadness and joy. Subjects completed a questionnaire of 33 items for each emotion and a food deprivation condition. A factor analysis of the items answered with respect to food deprivation yielded four factors which were labelled hunger, impulsive eating, sensory eating and hedonic eating. ANCOVAs showed main effects of emotions upon each factor. Single comparisons showed that: (1) subjects reported to experience higher levels of hunger during anger and joy than during fear and sadness; (2) impulsive eating and sensory eating were rated higher during anger than during the other emotions; and (3) hedonic eating was rated higher during joy than during the other emotions. Results did not indicate any differential influences upon eating between fear and sadness. Women reported to experience higher tendencies of impulsive eating and sensory eating than men during anger and sadness. Eating scores of negative emotions correlated low and positive with body mass index, low and negative with dietary restraint. The differential effects of emotions on characteristics of eating may be due to differences of the examined emotions in frequency of occurrence, physiological correlates and motivational properties.

Adult↗
PubMed1999

All Negative Moods Are Not Equal: Motivational Influences of Anxiety and Sadness on Decision Making.

Affective states of the same valence may have distinct, yet predictable, influences on decision processes. Results from three experiments show that, in gambling decisions, as well as in job-selection decisions, sad individuals are biased in favor of high-risk/high-reward options, whereas anxious individuals are biased in favor of low-risk/low-reward options. We argue that these biases occur because anxiety and sadness convey distinct types of information to the decision-maker and prime different goals. While anxiety primes an implicit goal of uncertainty reduction, sadness primes an implicit goal of reward replacement. We offer that these motivational influences operate through an active process of feeling monitoring, whereby anxious or sad individuals think about the options and ask themselves, "What would I feel better about ellipsis?" Copyright 1999 Academic Press.

Journal Article↗
PubMed2001

Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness.

RATIONALE: Noradrenergic processes within the amygdala have been implicated in the modulation of memory for emotional material. The amygdala has also been associated with the processing of facial expressions of emotion, particularly those of fear and sadness. However, the role of noradrenaline in the latter process is unknown. OBJECTIVE: Therefore the present study examined the effect of an oral beta-blocker (propranolol, 80 mg) upon facial expression recognition in healthy volunteers. METHODS: Facial expressions of six basic emotions, which had been "morphed" between neutral and each emotional standard, were used in the recognition task. Subjects completed this task both before and 1 h following either propranolol or a placebo. Control measures of choice reaction time and vigilance performance were also included to assess any non-specific effects of the drug upon alertness and speed. RESULTS: The administration of propranolol, relative to placebo, specifically increased reaction time to identify facial expressions of sadness correctly, in the absence of changes in speed to recognise other facial expressions of emotion. Subjective ratings of mood and alertness as well as speed in the two control tasks were not altered by propranolol, arguing against an account in terms of general sedation. CONCLUSIONS: These data suggest that noradrenergic processes are not only involved in memory for emotional material but also in the evaluation of sadness from facial expression. The selective nature of this effect adds to evidence suggesting that the recognition of different expressions of emotion depends upon at least partly separable neural processes. A role for noradrenaline in recognising sadness in others has potential relevance for our understanding of disorders characterised by disturbances in emotional processing.

Administration, Oral↗
PubMed2006

Hot cognition in investigative judgments: the differential influence of anger and sadness.

The authors predicted that the cognitive appraisal tendencies associated with sadness and anger would exert different influences on investigators' crime-related judgments. Supporting evidence was found in an experiment with 61 experienced criminal investigators. First, when judging the reliability of a witness statement, sad participants relied on their perception of both witness and situational variables, whereas angry participants relied only on their perception of witness variables. This corresponds to the emphasis placed on situational and individual control in the appraisals associated with sadness and anger, respectively. Second, when making judgments of the case, sad participants were sensitive to the consistency of a witness statement with the central hypothesis of the investigation, indicating substantive processing, whereas angry participants were unaffected by statement-hypothesis consistency, indicating heuristic processing. The findings suggest that the process of reliability assessment can be better understood by consulting theories of attribution and information processing.

Adult↗
PubMed1982

Small mammal studies in a SAD baiting area.

Studies in the laboratory or in the field on the effect of SAD virus on small rodents are reported. Laboratory experiments by oral inoculation of SAD strain in a wide variety of small mammals led to the conclusion that spontaneous SAD transmission from rodent to rodent is a rare event. Field experiments were conducted by live-trapping, sacrifice and analysis of 192 Apodemus sylvaticus, 28 Clethrionomys glareolus and 48 Crocidura russula. They gave no indication that SAD virus became established in this small animal community on an island after a single exposure to a high density (300 sites on 10 hectares) of vaccine baits.

Administration, Oral↗
PubMed2005

A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder.

BACKGROUND: Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS: Using event-related functional magnetic resonance imaging (fMRI), neural responses to happy and sad facial expressions were measured in 14 healthy individuals and 16 individuals with major depressive disorder. RESULTS: Healthy but not depressed individuals demonstrated linear increases in response in bilateral fusiform gyri and right putamen to expressions of increasing happiness, while depressed individuals demonstrated linear increases in response in left putamen, left parahippocampal gyrus/amygdala, and right fusiform gyrus to expressions of increasing sadness. There was a negative correlation in depressed individuals between depression severity and magnitude of neural response within right fusiform gyrus to happy expressions. CONCLUSIONS: Our findings indicate preferential increases in neural response to sad but not happy facial expressions in neural regions involved in the processing of emotional stimuli in depressed individuals. These findings may be associated with the above pattern of implicit and explicit attentional biases in these individuals and suggest a potential neural basis for the negative cognitions and social dysfunction in major depression.

Adult↗
PubMed2006

On the measurement of rumination: a psychometric evaluation of the ruminative response scale and the rumination on sadness scale in undergraduates.

Rumination is considered a specific cognitive vulnerability factor that is thought to play a prominent role in the maintenance of depressive symptoms. The present study investigated the psychometric properties of two measures of rumination, the ruminative response scale (RRS) and the rumination on sadness scale (RSS) in undergraduates (N=331). A joint factor analysis yielded three factors, 'rumination on causes of sadness', 'symptom-based rumination', and 'rumination on sadness'. The internal consistency of the rumination factors was good and the test-retest stability over a 6-month period of time was moderate. Support was also found for the construct validity of the rumination factors. Finally, the 'rumination on the causes of sadness' factor was found to moderate the relation between depression measured at baseline and at 6-month follow-up. More specifically, baseline depression was a strong predictor of future depression but this was particularly true for high ruminating individuals. Implications of the results and directions for future research are provided.

Adolescent↗
PubMed2004

Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces.

Previous functional neuroimaging studies have demonstrated that the amygdala activates in response to fearful faces presented below the threshold of conscious visual perception. Using a backward masking procedure similar to that of previous studies, we used functional magnetic resonance imaging (fMRI) to study the amygdala and anterior cingulate gyrus during preattentive presentations of sad and happy facial affect. Twelve healthy adult females underwent blood oxygen level dependent (BOLD) fMRI while viewing sad and happy faces, each presented for 20 ms and "masked" immediately by a neutral face for 100 ms. Masked happy faces were associated with significant bilateral activation within the anterior cingulate gyrus and amygdala, whereas masked sadness yielded only limited activation within the left anterior cingulate gyrus. In a direct comparison, masked happy faces yielded significantly greater activation in the anterior cingulate and amygdala relative to identically masked sad faces. Conjunction analysis showed that masked affect perception, regardless of emotional valence, was associated with greater activation within the left amygdala and left anterior cingulate. Findings suggest that the amygdala and anterior cingulate are important components of a network involved in detecting and discriminating affective information presented below the normal threshold of conscious visual perception.

Adult↗
PubMed2004

Decreasing TSH levels in patients with Seasonal Affective Disorder (SAD) responding to 1 week of bright light therapy.

BACKGROUND: Seasonal Affective Disorder (SAD) is characterised by lowered mood and atypical depressive symptoms such as hypersomnia, weight gain and fatigue. These symptoms seem associated with hypothyroidism, but the results of evaluations of the thyroid function in SAD patients have been conflicting, most likely due to the very small number of observations. METHODS: In total, 83 patients fulfilling the DSM-III-R criteria for SAD were treated with bright light for 1 week in an open trial. Thyroid function was evaluated by TSH (thyroid-stimulating hormone), T(4) (thyroxine) and T(3) (triiodthyronine) levels at baseline and after 1 week of bright light treatment. RESULTS: The response rate in terms of a 50% reduction of pre-treatment scores on the Hamilton Depressions Rating Scale (HAM-D(17)) was 61%. The TSH levels in all 83 patients decreased significantly from 1.57 at baseline to 1.30 at endpoint. In the group of responders (n=52) the TSH levels decreased significantly from 1.71 to 1.37, while in the group of non-responders (n=31) the decrease in TSH levels was not statistically significant. CONCLUSIONS: During 1 week of bright light therapy the TSH levels in SAD patients were reduced, with the highest reduction in the group of patients responding to light therapy.

Adult↗
PubMed2004

Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania.

BACKGROUND: The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying negative emotions. There are sparse data to suggest there may be an analogous, state-related negative recognition bias for negative emotions in mania. We used functional magnetic resonance imaging (fMRI) to investigate the behavioural and neurocognitive correlates of happy and sad facial affect recognition in patients with mania. METHOD: Functional MRI and an explicit facial affect recognition task were used in a case-control design to measure brain activation and associated behavioural response to variable intensity of sad and happy facial expressions in 10 patients with bipolar I mania and 12 healthy comparison subjects. RESULTS: The patients with mania had attenuated subjective rating of the intensity of sad facial expressions, and associated attenuation of activation in the subgenual anterior cingulate and bilateral amygdala, with increased activation in the posterior cingulate and posterior insula. No behavioural or neurocognitive abnormalities were found in response to presentation of happy facial expressions. CONCLUSIONS: Patients with mania showed a specific, mood-congruent, negative bias in sad facial affect recognition, which was associated with an abnormal profile of brain activation in paralimbic regions implicated in affect recognition and mood disorders. Functional imaging of facial emotion recognition may be a useful probe of cortical and subcortical abnormalities in mood disorders.

Adult↗
PubMed1999

An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.

SAD B19 is an attenuated vaccine virus for oral vaccination of carnivores against rabies. The safety of SAD B19 was investigated in 16 animal species by different routes of administration. During the observation period all animals given the vaccine virus, irrespective of the route of administration, did not show any clinical signs of rabies, with the exception of certain rodent species. In these animals a low residual pathogenicity was observed, however transmission of the vaccine virus to control animals was not demonstrable. No vaccine virus could be detected in the saliva of the six mammal species examined. Furthermore, the genetical stability was shown for SAD B19 through passaging in neural tissue of dogs, foxes and mice. From the results presented here on innocuity and stability, it can be concluded that SAD B19 rabies vaccine is suitable for oral vaccination campaigns for carnivores against rabies.

Administration, Oral↗
PubMed1991

The relationship between coping style and loneliness in adolescents: can "sad passivity" be adaptive?

The authors' purpose in this paper was to examine how the use of the "sad passive" coping style may be related to adolescent self-reported loneliness. Subjects were asked to complete the revised UCLA Loneliness Scale (Russell, Peplau, & Cutrona, 1980) to determine self-reported loneliness and the Coping with Loneliness Questionnaire (CLQ; Rubenstein & Shaver, 1980) in order to examine coping styles. We hypothesized that those adolescents whose coping strategies fell into the category of sad passivity described by Rubenstein and Shaver would indicate greater loneliness than those adolescents whose coping strategies fell into other categories. Results indicated that sad passivity was used by both lonely and nonlonely adolescents, but that nonlonely youngsters resorted to this method only temporarily and in preparation for a more active coping style. Lonely teens, on the other hand, appeared to remain in the sad-passive mode to a maladaptive degree. These results were discussed in terms of their importance for theories of adolescent loneliness and for possible intervention strategies.

Adaptation, Psychological↗
PubMed1999

Dissociable neural responses to facial expressions of sadness and anger.

Previous neuroimaging and neuropsychological studies have investigated the neural substrates which mediate responses to fearful, disgusted and happy expressions. No previous studies have investigated the neural substrates which mediate responses to sad and angry expressions. Using functional neuroimaging, we tested two hypotheses. First, we tested whether the amygdala has a neural response to sad and/or angry facial expressions. Secondly, we tested whether the orbitofrontal cortex has a specific neural response to angry facial expressions. Volunteer subjects were scanned, using PET, while they performed a sex discrimination task involving static grey-scale images of faces expressing varying degrees of sadness and anger. We found that increasing intensity of sad facial expression was associated with enhanced activity in the left amygdala and right temporal pole. In addition, we found that increasing intensity of angry facial expression was associated with enhanced activity in the orbitofrontal and anterior cingulate cortex. We found no support for the suggestion that angry expressions generate a signal in the amygdala. The results provide evidence for dissociable, but interlocking, systems for the processing of distinct categories of negative facial expression.

Adult↗
PubMed2006

SAD phasing by OASIS-2004: case studies of dual-space fragment extension.

The principle of dual-space phasing is used in dealing with protein SAD data. Four programs are involved in iterative dual-space fragment extension to improve automatic model building. OASIS-2004 is used to break the phase ambiguity intrinsic in the SAD experiment. In the initial cycle, discrimination of SAD phase doublets is performed by the direct method incorporating the known anomalous-scattering substructure. In subsequent cycles, discrimination is performed by the direct method incorporating both the known anomalous-scattering substructure and the partial protein structure obtained from model building in the preceding cycle. DM is used to improve direct-method phases via density modification. RESOLVE is used for initial model building and ARP/wARP is used to complete the structure. Case studies with three sets of difficult SAD data showed that the procedure is beneficial to high-throughput protein-structure determination and all of the four programs involved make their unique contribution to the process.

Models, Molecular↗
PubMed2006

A comparison of SAD and two-wavelength MAD phasing for radiation-damaged Se-MET crystals.

Although a case has been made that single-wavelength anomalous dispersion (SAD) is the optimal strategy for data collection in the presence of radiation damage, two-wavelength MAD experiments at the inflection and a high-energy remote point of the absorption edge have been shown to be a potentially successful alternative method. In order to further investigate the performance of both data collection strategies, a comparison of SAD and MAD phasing was carried out for increasingly damaged data sets from three different seleno-methionine protein samples collected under similar experimental conditions. In all but one example the MAD phases appeared to be less affected than SAD phases with increasing exposure to X-rays, and had a better overall success rate, indicating that this method should be given serious consideration when dealing with radiation-sensitive crystals. Simultaneous data collection in wedges at all wavelengths seems to be a very important factor in the success of MAD experiments; the decreased absorbed dose resulting from eschewing data collection at the maximum f '' wavelength may play a less important role. Specific radiation damage to the selenium atoms is found to be a minor effect compared with the effect on the anomalous dispersion signal, although potentially large enough to be a useful contribution to phasing in both SAD and MAD experiments.

Computer Simulation↗