[Sulfonamides. 7. Sulfonamide derivatives of 1-phenyl-3,4-dimethylpyrazol-5-one and 1-phenyl-3,4-dimethyl-5-chloropyrazole].
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Methods↗
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Results for “SULFONAMIDES”
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[Sulfonamides. IV. Sulfonamide derivatives of 1-(chlorophenyl)-and 1-(dichlorophenyl)-3-methylpyrazolone 5].
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Chemical Phenomena↗
Recently discovered sulfonamide-, acyl sulfonamide- and carboxylic acid-based endothelin antagonists.
Endothelins (ET-1, 2 and 3) are 21-residue peptides with two disulfide bridges and a highly conserved carboxy terminal. ET-1, the most significant isoform, is a potent vasoconstrictor and mitogen that exerts its biological effects through binding to its two G protein-coupled receptors: ET(A) and ET(B). ET(A) receptors are expressed on vascular smooth muscle cells and mediate vasoconstrictive and proliferative responses to ET-1. ET(B) receptors are mainly located on endothelial cells where they clear ET-1 from circulation and mediate vasodilation via the release of nitric oxide. ET-1 has been associated with a variety of serious diseases such as pulmonary hypertension, heart failure, prostate cancer and renal dysfunction.
Animals↗
[Studies on the therapeutic use of sulfonamides. IV. Experimental investigation of the local therapeutic use of sulfonamides in eye diseases].
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Eye Diseases↗
[Experimental studies on sensitization of guinea pigs with sulfonamide and sulfonamide compounds. II].
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Animals↗
[Examination of sulfonamide sensitivity of coliform strains during intermediate influence of sulfonamide solution].
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Escherichia coli↗
[A case of human glanders treated by sulfonamides: development of resistance of the glanders bacillus to sulfonamides during the treatment].
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Animals↗
[Biochemical studies on cyanosis following sulfonamides; distribution of sulfonamides in the blood].
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Blood↗
[Sulfonamide concentration in serum after administration of combined sulfonamides].
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Blood↗
[Oral hypoglycemic sulfonamides in the treatment of pancreatic diabetes; study of a patient hospitalized and treated with 2259 R P (Personal case report) and a brief comparison between the hypoglycemic sulfonamides 2259 R P, 2254 R P and D 860].
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Diabetes Mellitus↗
[Relations between sulfonamides and sugar in blood and behavior of sulfonamides in normal anddiabetic subjects after administration of carbutamide].
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Blood Glucose↗
[New sulfonamides and delayed action sulfonamides].
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Delayed-Action Preparations↗
[Comparison between a sulfonamide-sensitive Escherichia coli strain & a sulfonamide-resistant strain: composition of proteins & amino acids].
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Amino Acids↗
[Studies on the drug resistance of enteric bacteria. 8. Comparison of the sulfonamide resistance in strains resistant to single and multiple sulfonamides obtained from nature].
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Biochemical Phenomena↗
[Comparison of a sulfonamide-sensitive and a sulfonamide-resistant strain of Escherichia coli: study of the minimum requirement of sulfur and nitrogen].
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Biochemical Phenomena↗
[Binding of sulfonamides to proteins. I. Paper electrophoretic studies on the binding of some sulfonamides to the protein fraction of normal human plasma in vitro].
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Blood Proteins↗
[Studies on the sulfonamide content in bile after administration of depot sulfonamides].
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Bile↗
[Vitamins and metabolism of sulfonamides. I. Behavior of the sulfonamide levels in the body fluids and tissues of guinea pigs after loading with B complex vitamins and vitamin C].
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Animals↗