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At least 91 records · Page 5Linked to original sources
PubMed1988

Early carcinoma of the stomach after gastric surgery: comparison with early carcinoma in the non-operated stomach.

The relationships between the gross and histological types of early gastric carcinoma and non tumorous gastric mucosa were investigated in 12 cases of carcinoma of the stomach after operation and 46 cases of cardiac carcinoma within 5 cm of the squamocolumnar junction. Histological studies were made by examining specimens obtained by gastrectomy. Grossly elevated and histologically differentiated carcinomas were statistically more frequent after gastric surgery, than before. Comparison between cases of elevated and differentiated adenocarcinoma that had undergone gastric surgery with those that had not showed that atrophic gastritis and intestinal metaplasia in the surrounding mucosa of the tumor were significantly slighter after gastric operation than in unoperated cases. Results suggested that early carcinomas developing after gastric surgery are different from those in the upper portion of the unoperated stomach.

Cardia↗
PubMed1986

[Relations between stomach polyps and stomach cancer--results of follow-up after endoscopic polypectomy].

We report on 468 polypectomies on 303 patients in 23,260 gastroscopies. In 230 endoscopic follow-up controls on 129 patients 4 carcinomas are found, and that once after a hyperplastic polyp and thrice after hyperplasiogenic polyps. In comparison to our routine gastroscopies the number of the carcinomas is distinctly lower in the control of polyps, so that the hyperplasiogenic polyps in our gastroscopies do not represent a particular risk group for a carcinoma of the stomach. After polypectomy should be controlled: adenimas, polyps with severe dysplasias, hyperplasiogenic polyposes and stomachs in which polyps remained.

Cell Transformation, Neoplastic↗
PubMed1984

[Hyperplasiogenic gastric polyps and stomach cancer. Endoscopic findings of early stomach cancer in 3 out of 42 biopsies of hyperplasiogenic polyps].

The hyperplasiogenic gastric polyp is an organo-specific polyp and compared to the real adenoma of the stomach and colon is not a neoplasia. The formation of a carcinoma in or on a hyperplasiogenic polyp is extremely rare. Hyperplasiogenic polyps have more of an indicator function, indicating an ill mucous tissue and the possibility of the formation of a carcinoma and a precancerous condition. Three observations of the formation of early carcinoma of the stomach in or on hyperplasiogenic polyps in 42 patients with hyperplasiogenic polyps, which were found in the upper alimentary tract in the course of 4 years and 10.473 endoscopic investigations, are reported here. Due to these observations the endoscopic loop extraction of all polypous protuberances still seems to be necessary.

Adenoma↗
PubMed1983

[Human stomach cancer bearing similarity to experimentally induced stomach cancer in rats].

A periodical and histological study on the histogenesis of experimental stomach carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats suggested that cancer progression occurred from the submucosal focus under the condition of existing adenomatous hyperplasia. This carcinoma manifested particular atypia, combined hyperplasia of the smooth muscle, indistinct borderline from the surrounding normal mucosa. These were considered to be specific histological findings in experimental carcinoma. In 3 of 273 gastrectomized patients with gastric carcinoma the same histological findings were obtained as in experimental gastric carcinoma; 35 patients had submucosal heterotopic glands similar to the experimentally induced rat foci or adenomatous hyperplasias seen in the experimental carcinoma. These results suggest the same histogenesis for human stomach cancer and the experimental carcinoma.

Aged↗
PubMed1983

CT of the stomach and duodenum. Part I: Anatomy and postoperative stomach.

A survey is provided of the CT appearance of the normal and postoperative stomach based on a retrospective study on 262 patients. The results were compared with those of conventional barium meal examination. Detailed understanding of the CT anatomy of the normal and postoperative stomach, as well as familiarity with the usual pitfalls, are imperative to guarantee correct interpretation of pathology.

Duodenum↗
PubMed1982

Converting a stomach to a uterus: the microscopic structure of the stomach of the gastric brooding frog Rheobatrachus silus.

Rheobatrachus silus is a rare aquatic frog of eastern Australia. The female ingests the eggs after fertilization and broods them in the stomach until fully formed. "Gastric brooding" takes place in the fundus and proximal part of the body of the stomach, which dilates to accommodate the growing young. The surface epithelium becomes attenuated and the cells contain fewer mucus droplets. The acini of the glands are less numerous because of stretching, and they contain oxyntic cells that show evidence of profound suppression or regression. Morphometric studies on the limited number of samples show that the oxyntic cells are attenuated with few surface projections, sparse tubulovesicular reticulum, and a few pepsinogen granules and mitochondria. Eight days after ejection of the young, and 4 days after feeding commences, the lining shows a return of gastric pits and glands. The oxyntic cells show many surface projections and a proliferation of the tubulovesicular reticulum and mitochondria. These findings suggest that the eggs, tadpoles, and juvenile frogs release a substance, or substances, that inhibit acid secretion immediately after the eggs are ingested and that persist throughout brooding.

Animals↗
PubMed1994

[Neuroendocrine tumors of the stomach (stomach carcinoid)].

We report about two patients with gastric neuroendocrine tumours (carcinoids) and chronic atrophic gastritis. A 68-year-old woman presented with nonspecific dyspeptic complaints. Gastroscopy revealed a single neuroendocrine tumour of the corpus. 33 months after endoscopic therapy she is free of detectable tumour. As cause of an upper gastrointestinal bleeding in a 75-year-old woman, a small ulcerated fundic neuroendocrine tumour was found together with other multiple tumours. Repeated endoscopic removals of these and further developing similar tumours were necessary during a follow-up of 25 months. Neuroendocrine tumours of the stomach are rare and are potentially malignant. According to their clinical context they can be divided into three subtypes: 1. tumours in chronic atrophic gastritis, 2. tumours in multiple endocrine neoplasia type I, 3. sporadic tumours, not associated with particular diseases. The first two types may be gastrin-promoted; they occur often multifocal only in the nonantral mucosa and seem to behave relatively benign. Metastasis limited to regional lymph nodes has not been described often. The very rare third type appears solitary in the whole stomach and seems to have a higher malignant potential with frequent distant metastasis to the liver. Therapy should be mainly guided by subtype and tumour size.

Aged↗
PubMed1993

[Drug resistance of Helicobacter pylori strains isolated from patients with inflammation of stomach mucous membrane and peptic ulcer of stomach and duodenum].

Twelve strains of H. pylori were tested. They were isolated from biosamples from 23 patients with stomach inflammation (16 persons) and stomach (3) and duodenum peptic ulcer. By application of solid medium dilution of MIC50 and MIC90-16 antibiotics and antimicrobials were tested. Values of MIC50 and MIC90 for antibiotics from the tetracycline group were, respectively 0.25-0.5 microgram/ml and 0.12-1.0 microgram/ml. Similar results were obtained with macrolide antibiotics. All strains were sensitive to penicillin (MIC 0.03-0.12 microgram/ml, ampicillin (MIC 0.06-0.5 microgram/ml) and amoxicillin and rifampicin (MIC 0.07-0.3 microgram/ml). Ten out of 12 investigated strains were resistant to metronidazole (MIC90 = 30 micrograms/ml). Results of this study may be important for etiotropic treatment of infections with H. pylori.

Drug Resistance, Microbial↗
PubMed1993

[UFTPM (UFT + CDDP + MMC) therapy for progressive stomach cancer. Research Association of Progressive Stomach Cancer].

We organized a cooperative research group consisting of 10 institutions and UFTPM therapy was given patients with unresectable and postoperatively relapsed stomach cancer. As the result, 20 cases were registered and the ratio of PR according to the criteria of stomach cancer chemotherapy was 4 out of 17 complete cases (23.5%), excluding 3 incomplete cases. The efficacy for the cases treated with more than 2 courses was 36.4% (4/11) and that for cases with 3 courses was 75% (3/4). One case with 3 courses was resectable and the cancer cells disappeared. Adverse effects of grade 3 or more according to the WHO criteria were observed in 20% of the cases.

Aged↗
PubMed1996

Cytotoxicity of NaCl, a stomach tumor promoter, and prevention by rice extract in stomach mucosa of F344 rats.

Cytotoxicity of NaCl and its prevention by rice extract were studied in the pyloric mucosa of male F344 rat stomach after oral administration of rice extract and 2.6 M NaCl. Effect were observed histologically by hematoxylin and eosin staining and the bromodeoxyuridine method. Replicative DNA synthesis (RDS) was assayed by liquid scintillation counter with [3H]thymidine. NaCl (2.6 M) induced destruction of the surface mucous cells within 1 min. RDS and S-phase cells increased significantly (p < 0.01) and to a maximum at 17 h, and returned to control levels 48 h after exposure. Administration of aqueous rice extract 3 h before NaCl exposure reduced the morphological damage to the mucosa and prevented the increase in RDS dose dependently by up to 65% (p < 0.01). These results showed that NaCl induced rapid mucosal damage and cell proliferation in rat stomach mucosa and that rice extract prevented the damage and reduced the increase in RDS.

Animals↗
PubMed1982

[Cytomorphometric studies on normal stomach mucosa, precancerous diseases and stomach cancer].

By means of a graduated microscope eyepiece-micrometer cytomorphometric investigations have been carried out on paraffin sections from 120 patients with normal gastric mucosa, gastritis, gastric ulcer, polyps and carcinoma of the stomach. In normal mucosa and gastritis, the number of the cell groups is low, the curves are predominantly single peaked, shifted to the left and the sizes of the nuclei are small. In gastric ulcer, polyps and carcinoma the number of the cell groups is high, the curves are multi-peaked, without any well expressed peaks, shifted to the right and the sizes of the nuclei are large.

Flow Cytometry↗
PubMed1996

Cause and effect between concentration-dependent tissue damage and temporary cell proliferation in rat stomach mucosa by NaCl, a stomach tumor promoter.

This study was designed to test whether concentration or dose of NaCl was responsible for the initial tissue damage (after 1 min) and resulting temporary cell proliferation at 17 h in stomach mucosa of male F344 rats after gastric intubation of 0.65, 1.3, 2.6 and 3.7 M NaCl. Histological damage was studied by dual staining combining horseradish peroxidase-labeled Griffonia simplicifolia agglutinin-II staining (HRP-GSA-II) and periodic acid cold thionin-Schiff reaction (PATS). Cell proliferation was studied by measuring replicative DNA synthesis with liquid scintillation counting and by BrdU staining. NaCl at the same overall dose of 0.8 g/kg body weight induced different degrees of response depending on the concentration. For 4 ml of 0.65 M NaCl, there was no tissue damage after 1 min nor any increase in replicative DNA synthesis after 17 h in the pyloric mucosa. Administration of 1.3 M NaCl (2 ml), 2.6 M NaCl (1 ml) and 3.7 M NaCl (0.7 ml) induced concentration-dependent damage of the surface mucous cell layer after 1 min and increased replicative DNA synthesis after 17 h (P<0.05). Concentration-dependent increase in replicative DNA synthesis at 17 h was also induced with the same volume (1 ml) of 1.3, 2.6, and 3.7 M NaCl, while a volume-dependent increase in replicative DNA synthesis at 17 h was induced with 0.4, 0.7 and 1 ml of 3.7 M NaCl. However, a greater increase in replicative DNA synthesis was always observed when using higher NaCl concentrations at the same dose. Liquid scintillation counting was well-correlated with BrdU staining. These results suggest that a high concentration of NaCl is responsible for the initial tissue damage and resulting temporary cell proliferation during stomach tumor promotion.

Animals↗
PubMed1986

[Functional anatomy of stomach circulation: localizing factors in the pathogenesis of stomach ulcer].

Comparative vertebrate anatomy shows that acid secretion and wall stress processes typically occur in different compartments. In the human single-chamber stomach both processes are physiologically separated in time. If both processes take place in one hollow organ at the same time, focal ischemia will occur. Using the microsphere technique a submucous steal-phenomenon, which the effect is due to, has been reproduced experimentally. A network model of the human gastric vascular bed produces borderline infarcts at the preferred sites of human gastric ulcer.

Animals↗
PubMedDate not supplied

[Death caused by stomach rupture due to overinflation during oxygen administration via stomach tube].

Soon after transfer from an intensive care unit to a normal ward within a hospital a 59-year-old female patient died. The investigation revealed that oxygen was insufflated accidentally through a nasogastric tube into the stomach and the intestinum. Autopsy showed a distended abdomen and odorless free gas streaming out of the opened abdomen. In the gastric wall, a 12 cm long rupture and 5 more incomplete ruptures were found. A most possible mechanism of gastric rupture due to overstretching by insufflated gas is presented. Criminal responsibility was excluded as the cause of the death could not be stated without reasonable doubt. The problem of selecting patients for intensive care to the disadvantage of others who also might profit from this special treatment is discussed.

Female↗
PubMed1991

Factors related to and consequences of weight loss in patients with stomach cancer. The Norwegian Multicenter experience. Norwegian Stomach Cancer Trial.

Of 1165 patients with stomach cancer included in a national, prospective multicenter study with 51 surgical units participating, information about weight loss before diagnosis was available for 855 patients (73%). Median weight loss was 5 kg; 259 patients (31%) experienced no weight loss. By logistic regression analysis the authors found that weight loss increased with age and advancing stages of disease (TNM Stage I-IV), with decreasing Karnofsky index, in Lauren's diffuse versus intestinal tumor type, and with tumors located at the cardia/esophagus. Increasing weight loss reduced the resectability rate significantly, but no association between weight loss and postoperative complication rate was found. The odds ratio for postoperative mortality was 2.5 to 1 for the weight loss group 5 to 10kg versus 0 kg. In conclusion, weight loss reflects a less favorable tumor status. Weight loss did not increase postoperative morbidity but did lead Weight to a higher death rate after surgery.

Adult↗
PubMed1994

Human monoclonal antibodies from stomach carcinoma patients react with Helicobacter pylori and stimulate stomach cancer cells in vitro.

BACKGROUND: In recent studies, an increased incidence of gastric adenocarcinomas was observed in patients with Helicobacter pylori infection. However, the extent to which this coincidence is caused by immunologic mechanisms is unknown. METHODS: Two human monoclonal antibodies (MoAbs) from patients with stomach carcinoma and H. pylori-associated gastritis were isolated and established by fusion of spleen cells with the heteromyeloma HAB-1. The reactivity of these human MoAbs was investigated in functional adhesion assays and on Western blots of tissue, tumor cell, and bacterial extracts. Their stimulation and proliferation were tested by the MTT test and 3-H-thymidine incorporation tests. RESULTS: The two monoclonal immunoglobulin-M antibodies, 103/51 and 105/79, inhibited adhesion of tumor cells. On bacterial extracts antibody 103/51 identified protein bands of 55 kilodaltons (kd) and 80 kd, and in tumor cell extracts, a specific protein of approximately about 110 kd and 140 kd. Antibody 105/79 identified a 55 kd protein in bacterial extracts and a 110 kd protein in tumor extracts. In addition, in the 3-H-thymidine incorporation and MTT assay the antibodies showed a stimulatory and growth-enhancing effect on tumor cells in vitro. A similar activity was observed in sera from patients with gastric carcinoma, indicating a physiologic role of such antibodies in vivo. CONCLUSION: The human monoclonal antibodies described here react with H. pylori and cross-react with and stimulate gastric carcinoma cells. It is possible that the production of these antibodies is primarily stimulated by bacterial antigens which cause chronic gastritis and that they might be indirectly responsible for the recently described higher incidence of gastric cancer because of the simultaneous reaction and stimulation of tumor cells they cause.

Adenocarcinoma↗
PubMed2004

Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers.

Cancers induced by different carcinogens show distinct expression profiles. In addition to the specific alterations of tumor-related genes induced by specific carcinogens, it is possible that some initial responses induced by a carcinogen could persist for long periods and are consistently present in the cancers induced. We have analyzed the initial responses in the rat pyloric mucosae after treatment for 2 weeks with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Gene expression was monitored 1 day, 2 weeks and 4 weeks after MNNG treatment by oligonucleotide microarray analysis. Of the differentially expressed genes showing greater than three-fold difference 1 day after MNNG treatment, 143 and 26 genes were up- and down-regulated, respectively, in MNNG-induced stomach cancers. Among these genes, 25 and 6 genes were up- and down-regulated, respectively, in the histologically normal pyloric mucosae, even 4 weeks after cessation of MNNG treatment. Among the up-regulated genes, many genes involved in tissue remodeling (Spi15, Serpine1 and Fst) and cellular growth (Bdnf, Ros1 and Fgf10) were present. The six down-regulated genes included TGF-beta-inducible early growth response gene. These findings demonstrate that some expression changes induced by MNNG persist for a prolonged period and are present in cancers. Persistent expression changes are considered to be important for prediction of past carcinogen exposure, and could provide a molecular environment favorable for malignant transformation.

Animals↗
PubMed2004

Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?

Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger.

Adenosine Diphosphate↗