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Interventional sialography: a single-center experience.

PURPOSE: To evaluate interventional sialography for the treatment of chronic recurrent sialadenitis due to calculus and/or stricture. METHODS: We performed a retrospective review and follow-up of 12 patients treated over a 3-year period. The techniques for calculus extraction by papillotomy and basket extraction, and stricture dilatation by a combination of predilation with lacrimal dilators and then angioplasty balloons are described and the literature is reviewed. RESULTS: Follow-up of 1-40 months (mean 14.6 months) showed that 7 of 12 patients remained symptom free and 2 others became asymptomatic after an interval. There were no major complications from the procedure. CONCLUSION: Interventional sialography is a safe and acceptable alternative to surgery and can be considered as first-line therapy for symptomatic salivary duct calculus and stricture.

Catheterization↗

Simultaneous computed tomography and sialography of the parotid and submandibular glands.

A technique of simultaneous computed tomography and sialography of the parotid and submandibular glands is described and the examination of 14 patients reported. Tumours were diagnosed in six cases and in the remaining eight cases inflammatory lesions were found. Sialographic enhancement offered definite advantages in localisation of lesions and examination of the tumour-normal tissue interface compared with either C.T. or sialography alone.

Humans↗

Combined CT scanning and sialography in the management of parotid tumors.

In the diagnosis of parotid gland tumors, three major questions need to be answered. First, is the mass intra glandular or extraglandular? Second, is it benign or malignant? Third, does it lie deep to or superficial to the facial nerve? Computerized tomography is a relatively new diagnostic technique and when used in conjunction with sialography can provide very useful preoperative information about parotid lesions. A case is presented in which computerized tomography sialography was performed preoperatively in a patient with a parotid gland swelling and greatly assisted in the diagnosis and operative treatment. The technique is described in detail and previous reports of the procedure are reviewed.

Adenolymphoma↗

Digital subtraction sialography: technique, advantages and results in 107 cases.

Sialographic examinations with the digital subtraction technique were performed in 107 salivary glands (90 parotid and 17 submandibular) of 99 patients. Diagnostic and technical advantages of the digital imaging and subtraction for sialography were investigated. Superior quality enabled detailed imaging of the entire ductal system. Reduced radiation exposure, short examination time and almost painless examinations with good patient tolerance proved to be the major advantages of digital subtraction sialography as a diagnostic tool.

Adolescent↗

The functional evaluation of salivary glands using dynamic MR sialography following citric acid stimulation: a preliminary study.

OBJECTIVE: We introduce a new technique for the functional evaluation of the salivary glands using continuous magnetic resonance (MR) sialography before and after citric acid stimulation. METHODS: In 10 volunteers, the time-dependent changes in the maximum area of the detectable parotid gland ducts on MR sialographic images taken every 30 seconds before and after citric acid stimulation were analyzed. The time period to the occurrence of the maximum duct area poststimulation was noted, and then the time for the area to return to its 50% value pre-citric acid stimulation was also observed. This new technique was clinically applied in 1 patient with an excessive supply impression of saliva and in 1 patient with a short supply impression with saliva. RESULTS: In all volunteers after citric acid stimulation, the maximum area of the detectable salivary gland ducts first increased and then decreased. A strong relationship was found between the maximum area of the detectable salivary gland ducts before citric acid stimulation and total saliva volume (Pearson r = 0.672, P = .031). Compared with all the volunteers, the ratio of change in the detectable ducts was the highest in the patient with an excessive supply impression of saliva, but lowest in the patient with a short supply impression with saliva. CONCLUSIONS: This initial study suggests that dynamic MR sialography allows for functional and morphological evaluation of the salivary glands. This technique appears to have many possible applications and further investigation in this field is necessary.

Adult↗

Contrast media in sialography: a comparison of Lipiodol Ultra Fluid and Urografin 290.

A prospective, randomized study of 60 patients undergoing sialography was conducted to compare Lipiodol Ultra Fluid (UF) (Ethyl diiodostearate, May & Baker Ltd), with Urografin 290 (meglumine diatrizoate 52.1% w/v and sodium diatrizoate 7.9% w/v, Schering). The quality of the images, the clinical tolerance and the side-effects of contrast were compared. Both agents produced adequate opacification of ducts but poor intra-gland duct filling was seen in two patients examined with Lipiodol UF. There were significantly more side-effects (which were also more severe) in the Lipiodol group. It is concluded that Urografin 290 is the better contrast agent for sialography because of better filling of intra-gland ducts and greater clinical tolerance.

Adolescent↗

Magnetic resonance sialography.

To evaluate a new noninvasive sialographic technique, we applied a new magnetic resonance technique to 10 healthy volunteers and 21 patients with lesions of the parotid gland. In addition to the usually performed T(1) and T(2) cross-sectional sequences, a heavily T(2)-weighted sequence (TR = 3600 msec, TE = 800 msec) was performed that allowed depiction of the fluid-filled parotid duct system. Twenty-one patients with benign as well as malignant parotid gland pathologies were examined: sialadenitis (n = 6), sicca syndrome (n = 2), pleomorphic adenoma (n = 4), carcinoma of the parotid gland (n = 2), lymphoepithelial carcinoma (n = 1), cystadenolymphoma (n = 3), non-Hodgkin's lymphoma (n = 2), and congenital duct dilatation (n = 1). Stenseńs duct was reliably depicted in all volunteers and patients. The primary branching ducts were reliably depicted in all normal cases. Intraglandular and extraglandular duct dilatations and duct strictures were well depicted in patients with chronic sialadenitis. Sialolithiasis with a calculus obstructing the duct was demonstrated in 2 cases. In conclusion, Initial experience indicates that magnetic resonance sialography can be applied successfully to investigate the duct system of the parotid gland. The usually performed cross-sectional MRI (T(1)- and T(2)-weighted images, gadolinium-DTPA) depicts the internal architecture of the parotid gland with high reliability. Magnetic resonance sialography with heavily T(2)-weighted images adds important information about the ductal system. Because it is completely noninvasive, the only contraindications are the ones generally accepted for MRI.

Adult↗

[Sensitivity and specificity of sonography and sialography in relation to the diagnosis of parotid tumors].

The results of parotid sialography from a group of patients between 1980 and 1982, were subjected to retrospective evaluation, and compared with sonographic results from another group between 1983 and 1985. In the first period studied sialography showed 75% sensitivity and 100% specificity. Both sensitivity and specificity of sonography were 100% in the second group. Thus, sonography appears superior with regard to diagnosis of intraglandular tumours of the parotid.

Humans↗

Computed tomography and sialography: 1. Normal anatomy.

Computed tomography (CT) has made it possible to identify soft tissue structures not visible by sialography. This paper reviews the normal anatomy in the region of the parotid and submandibular glands in the axial transverse and coronal planes as imaged by CT before and after sialography. A clear understanding of the normal structures is important before undertaking an evaluation of disease.

Humans↗

Computed tomography and sialography: 2. Pathology.

Computed tomography (CT) has added a significant amount of diagnostic information to the imaging of the salivary glands. Two groups of patients were evaluated at two institutions to determine the impact of CT on the diagnosis of various diseases and to evaluate the contribution of CT versus conventional sialography, respectively. Patients were studied by each modality alone and in combination. Emphasis has been placed on the group that had CT combined with sialography, since benign and malignant tumors were found to be better evaluated by the two techniques together.

Female↗

Analysis of the diagnostic process in sialography.

The diagnostic process in sialography was evaluated using the mouse parotid gland as a model. The relative significance of each of the three diagnostic phases, psychophysical, psychological and nosological, was determined by analysing observer accuracy in detecting sialoadenitis and sialodochitis on digital and analogue microsialograms. Automated diagnosis based on parametric values of the digitized image was compared with the human system using ROC analysis. The overall accuracy of automated diagnosis was superior to that of an observer with analogue images. It is concluded that if observers were to be given the same quantitative information and informed of its diagnostic value in the psychological phase, then variation in the detection of the abnormalities could be reduced and the overall diagnostic accuracy in sialography improved.

Animals↗

Radiographic quality and patient discomfort in sialography: comparison of iohexol with iothalamate.

We have compared the usefulness of a newly developed, low osmolality contrast medium, Omnipaque 350 (75.49% iohexol, 350 mgI ml-1), for sialography with one of the established, Angioconray (80% sodium iothalamate, 480 mgI ml-1), in a double-blind, prospective randomized clinical trial in 80 patients. The diagnostic quality of the sialograms, pain during the procedure and discomfort subsequently were investigated. There was no difference in either group between the number of sialograms judged as diagnostically useful, although those of excellent quality were significantly more frequent in the Angioconray group. The level of pain on injection of the medium was significantly lower in the Omnipaque group. Eighteen per cent of the patients with Omnipaque had severe or moderate pain on injection of the contrast medium, while 63% had such pain with Angioconray. There was no difference in postprocedural discomfort between the two contrast media. We concluded that the low osmolality contrast medium is more favourable for sialography despite its lower iodine content.

Adult↗

An adverse reaction following sialography.

Reactions following the administration of iodine are well documented in general radiography, but are unusual following sialography. A patient who experienced an adverse reaction following sialography with an iodine-based, low osmolar, contrast medium, Hexabrix 320, is presented. The reaction consisted of severe shoulder and back pain 24 h after the procedure. A skin rash was identified involving the right axilla, groin and elbow, with swelling visible around the right elbow joint. It was not possible to distinguish, on the basis of the available evidence, between an anaphylactoid and idiosyncratic allergic reaction.

Aged↗

[Histological examination in Sjögren's syndrome. Relationship between sialography and histological examination].

Although the etiology of Sjögren's syndrome (SJS) remains unknown, Sjögren's syndrome can be diagnosed by means of clinical features and sialographic and histopathological examinations. In this study of 35 patients with primary SJS and 21 with secondary SJS, two parameters, (the findings of sialography of parotid gland and the histopathology of labial minor salivary gland), were evaluated. Then it was concluded that grade of lesion in sialography was parallel to infiltrative grade of round cells around labial salivary gland in primary SJS but not in secondary SJS. Using monoclonal antibodies to cell surface antigens, lymphocyte subsets in 16 patients with primary SJS and 4 patients with secondary SJS were studied. A predominance of T cells was found and there was no definitive characterization of lymphocyte subset infiltration, between CD4 positive cell and CD8 positive cell. This result was different from the previous reports, and needs further studies.

Humans↗

Sjögren's syndrome: comparison of assessments with quantitative salivary gland scintigraphy and contrast sialography.

UNLABELLED: This study compared the quantitative parameters of salivary gland scintigraphy and the sialographic stages in patients with Sjögren's syndrome. METHODS: One hundred sixteen patients suspected of having Sjögren's syndrome were examined with salivary gland scintigraphy and contrast sialography. When contrast sialography was used as the gold standard, Sjögren's syndrome was diagnosed in 50 of these 116 patients; Sjögren's syndrome was not seen in the other 66 patients. After injection of 370 MBq 99mTc-sodium pertechnetate, dynamic salivary gland scintigraphy with lemon juice stimulation was performed for 50 min. Functional parameters for the parotid and submandibular glands were calculated, and scintigraphic and sialographic results were compared. RESULTS: With the progression of sialographic stages from 0 to 4, the quantity of tracer accumulation decreased in the submandibular gland (P < 0.0001), and the quantity of tracer secretion decreased in the parotid gland (P < 0.0001). The sialographic stage in patients with Sjögren's syndrome was correlated with these scintigraphic parameters (P < 0.0001): sialographic stage = 3.243 - 0.337 x (submandibular gland uptake ratio) - 0.026 x (parotid gland maximum secretion). CONCLUSION: The decreased accumulation in the submandibular gland and the decreased secretion in the parotid gland were highly sensitive indicators of salivary gland disease in Sjögren's syndrome. The sialographic stage was correlated with these scintigraphic parameters.

Adult↗

Parotid sialography; roentgenologico-surgical correlation in a series of 70 cases.

A study was made of the correlation of sialographic, clinical and surgical observations in a series of 70 cases. Sialography is a useful tool in the differentiation between extrinsic and intrinsic space-occupying masses in the parotid region. It permits differentiation between inflammatory lesions and neoplasms, thus eliminating needless surgical explorations. It alerts the surgeon to masses involving the deep lobe. It can be easily performed and causes little discomfort. Bearing in mind its limitations, sialography is an important diagnostic and preoperative aid in the management of parotid lesions.

Humans↗

[Functional digital subtraction sialography in the diagnosis of salivary gland diseases].

Functional digital subtraction sialography with a water soluble radiopaque agent (verografin) made it possible to investigate the structure and functional changes in the salivary glands of 26 patients with a minimum injury of the glands. The method permitted a decrease in a dose of the agent 4 times as compared to routine sialography; the consumption of x-ray film was decreased 5-fold. Digital processing of images helped avoid superimposing of the cranial bone components, improving the quality of images of the salivary glands. The method is indispensable during differential diagnosis, especially at early stages of diseases of the salivary glands.

Adult↗

[The significance of sialography in tumors of the parotid gland (author's transl)].

The significance of sialography in diagnosis of parotid gland tumors is based on the differentiation of chronic inflammatory, benign and malignant lesions. This method combined with history and physical findings will establish the diagnosis in 80% of cases with parotid gland tumors. Water-soluble contrast media are most useful for ductography. It provides good contrast, stays in the duct system for a sufficient period of time and will not cause inconvenience to the patient. Tomograms are particularly valuable in addition to the standard a.p. and lateral standard views. Chronic inflammation causes alterations with small paraductal contrast accumulations throughout the entire efferent duct system. Benign tumors may be recognized by straight ducts and interlobular paravasates. In malignant neoplasms filling defects are more characteristic than parenchymal staining. Peracute and subacute inflammations as well as tuberculosis are difficult to diagnose by sialography.

Adenocarcinoma↗