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PubMedDate not supplied

Parachordoma of the sacrococcygeal region--a neuroepithelial tumor.

The parachordoma is a seldom, benign tumor of uncertain histogenesis. A case in a 25-year-old man is presented. The parachordoma in the present study reacted with antibodies to GFA, S-100, NSE and vimentin, but not with antibodies to EMA, keratin and NF. Differential diagnoses are the chordoma, the extraskeletal myxoid chondrosarcoma and the subcutaneous sacrococcygeal myxopapillary ependymoma. The immunohistochemical reactions of these tumors were compared and we found that the parachordoma had an immunologically different staining pattern. The parachordoma is thus immunologically different from the chordoma, the extraskeletal myxoid chondrosarcoma and the subcutaneous sacrococcygeal myxopapillary ependymoma. We conclude that the parachordoma is an entity of its own. The immunohistochemical reactions indicate that the parachordoma is a neuroepithelial tumor with glial differentiation.

Adult↗
PubMed1982

[Congenital cysts and teratomas in the sacrococcygeal region. Report of 2 cases].

Developmental abnormalities in the embryo may lead to tumours in the sacro-coccygeal area, so-called sacral cysts and the teratomas (5, 7). At birth they are caudal tumours of variable size covered with thin, stretched skin. Blood vessels can be seen through the skin, particularly in the mid-line. One gains the impression that the stretched skin could burst at any moment. It is assumed that these teratomas derive from the pluripotent cells of Hensen's node and then grow in front of the coccyx (2). They grow and spread in various directions, particularly in a dorsal and caudal direction extra-rectally and, to a lesser extent, into the pelvis in a pre-sacral position. The classification of these tumours depends on their spread. The spread and localisation of these tumours may cause stenosis of elongation of the rectum and displacement of small and large bowel and of the bladder.

Cysts↗
PubMed1989

Extraspinal ependymoma in the sacrococcygeal region. A case report with ultrastructural, immunohistochemical and cytophotometric studies.

We describe on a primary, subcutaneous sacrococcygeal ependymoma presenting in a young female patient. Detailed immunohistochemical and electron microscopic examinations were performed. Out of the 40 similar cases reported in literature this is the first in which the determination of DNA content was also used to predict biological behaviour. The tumour proved to be aneuploid with low proliferative capacity in spite of absent histological signs of malignancy. It is suggested that DNA determination may be helpful in establishing prognosis and that it may contribute to a better understanding of the biological behaviour of this tumour.

Adult↗
PubMed1984

Myxopapillary ependymoma of the cauda equina with extension to the skin of the sacrococcygeal region.

Cutaneous involvement by myxopapillary ependymoma of the cauda equina is described clinically and morphologically. The patient, a young woman, was 12 years old at the time that the neoplasm was diagnosed. Skin involvement developed 12 1/2 years following the initial diagnosis of the primary neoplasm and after the third attempt at surgical extirpation. Involvement of the skin preceded the death of the patient by 11 months.

Adolescent↗
PubMed1990

The projection of spinocerebellar neurons from the sacrococcygeal region of the spinal cord in the cat. An experimental study using anterograde transport of WGA-HRP and degeneration.

The projection from the sacro-coccygeal region of the spinal cord to the cerebellum was studied by two different techniques in the cat. In five cats wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) was injected caudal to a preceding unilateral cordotomy at the sacral level, aimed at interrupting the spinocerebellar tracts on one side completely, and the distribution of WGA-HRP labeled mossy fibers and mossy fiber terminals was studied in the cerebellum. In three additional cats, degenerating fibers were examined in Fink-Heimer stained sections following unilateral transection of the lateral and ventral funiculi at L7 or S3 level. In the WGA-HRP experiments the labeled mossy fiber terminals were located bilaterally in lobules I-V. Most of them were found in the anterior part of lobule II. In addition, labeled terminals were observed in sublobule VIIIB and in pars copularis of the paramedian lobule, contralateral to the cordotomy. The terminals in the anterior lobe were concentrated in longitudinal zones parallel to the mid sagittal plane. In lobule II, the terminals were most abundant in the superficial, apical parts of the folia. Some presumed terminals were also seen in the cerebellar nuclei. Labeled fibers were found contralateral, but not ipsilateral to the cordotomy in the superior and inferior cerebellar peduncles, as well as in the spinal cord rostral to the cordotomy. The results of the degeneration experiments were the same as those of the WGA-HRP experiments with regard to the detailed projections in the cerebellar cortex. This is strong support against the possibility that WGA-HRP labeled cerebellar mossy fiber terminals, following WGA-HRP injections in the spinal cord, would represent terminals of collaterals of retrogradely labeled neurons. It also lends strong support in favour of WGA-HRP as a reliable anterograde tracer for studying cerebellar cortical projections of spinocerebellar neurons in the cat.

Animals↗