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At least 91 records · Page 5Linked to original sources
PubMed2003

[Preventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation].

OBJECTIVE: To investigate the possibility of early prevention and treatment of acute lung injury by using composite Rhodiolae (CR) in patients with severe pulmonary hypertension during extracorporeal circulation. METHODS: Seventy-six patients with severe pulmonary hypertension screened out by color 2D-Doppler ultrasonography were randomly divided into the treated group (n = 40) and the control group (n = 36). The general treatment for the two groups, including preoperational preparation, operational procedure and conventional drug therapy, was the same. To the treated group, CR was administered 4 g every day (half the dose in children) at 7-10 day before and 5-7 day after the operation. The life signs, pulmonary ventilation parameters, arterial blood gas analysis were monitored and blood levels of TXB2, 6-keto-PGF1 alpha in both groups were determined in the fixed time points. RESULTS: The various parameters in the treated group were all better than those in the control group (P < 0.05 or P < 0.01), the occurrence rate of acute lung injury and its mortality in the treated group were 7.5% (3/40) and 0% (0/3) respectively, while in the control group were 19.4% (7/36) and 43% (3/7) respectively. CONCLUSION: CR has good preventive and treatment effect in treating complicated acute lung injury during extracorporeal circulation (cardiopulmonary bypass) in patients with pulmonary hypertension.

Adolescent↗
PubMed2004

[Seasonal variations in biomass and salidroside content in roots of Rhodiola sachalinensis as affected by gauze and red film shading].

Rhodiola sachalinensis A. Bor, a perennial herb, belonging to the family Crassulaceae, is mainly distributed in mountains at the altitudes of 1,700-2,500 m. It is a typical alpine plant and a very important medicinal plant with high activities of anti-fatigue, anti-senescence, and anti-radiation, due to the secondary metabolite salidroside in its root. Our previous findings have proven that red light promotes salidroside synthesis remarkably but decreases biomass insignificantly, resulting in a higher yield of salidroside in roots of Rh. sachalinensis in a greenhouse. In order to investigate the influences of shading and red light on seasonal variations in biomass and salidroside content in Rh. sachalinensis roots, the effects on 3 or 4 years old Rh. sachalinensis plants in a nursery in Daxinganling Mountain (124 degrees 02' E, 50 degrees 30' N) were studied in 2001. Compared to the control (CK) of full sunlight, 6 treatments with neutral transparent film and gauze, or red film alone had been conducted for 131 days. In treatment I, Rh. sachalinensis was shaded with neutral transparent film and gauze to achieve an irradiance 51.8% of full sunlight. In treatment II, the plants were shaded by red film alone, but the irradiance was as that in treatment I. In treatments III, IV, V and VI, neutral transparent film and gauze were originally used on May 8, then shifted to red film on Jun 3, July 4, August 4 and September 2, respectively and all experiments stopped on September 16, 2001. Rh. sachalinensis roots were harvested on 2-4th from June to September and finally on September 16, and root-biomass and salidroside content were measured. Root-biomass in plants decreased significantly under shading with neutral transparent film and gauze compared to the control with full sunlight, but little variations in salidroside content and yield. In comparison with shading by neutral transparent film and gauze, root-biomass reduced lightly and salidroside content and yield in roots were increased remarkably under red-film shading. At the end of the season, salidroside content under red light was 163% in 3-year-old and 155% in 4-year-old Rh. sachalinensis roots; whereas salidroside yields were 144% in 3-year-old and 145% in 4-year-old Rh. sachalinensis roots to those in plants under shading. The results also showed that the enhancement in the salidroside content and yield were little related to the duration of red film shading, which implied that in order to increase salidroside content and get higher salidroside yield, but less affect root-biomass, Rh. sachalinensis may be shaded with red film just several days before harvest.

Biomass↗
PubMed2004

[GC-MS analysis of supercritical carbon dioxide extraction products from Rhodiola tibetica].

OBJECTIVE: To analyze the chemical constituents of supercritical carbon dioxide extraction products from Rhodiola tibetica. METHOD: The chemical constituents were separated and identified by gas chromatography-mass spectrometry (GC-MS). RESULT: 26 Components were identified, and their relative contents were determined by normalization method of area. CONCLUSION: This study provides foundation for the exploitation of the resources of R. tibetica.

1-Butanol↗
PubMed2005

[Studies on the chemical constituents from Rhodiola dumulosa (I)].

The rhizoma samples of Rhodiola dumulosa were cut into fragments and extracted by 95% EtOH. This extract was successively extracted with Et2O, EtOAc, n-BuOH. Six compounds were obtained from the Et2O fraction. The structures of six compounds were identified. The compounds are beta-sitosterol (I), herbacetin-8-methyl ether (II), kaemperol (III), kaemperol-7-O-alpha-L-rhamnoside (IV), beta-sitosterol glucoside (V), herbacetin-7-alpha-L-rhamnoside (VI). beta-sitosterol, herbacetin-8-methyl ether and kaemperol of compounds were obtained from this plant for the first time.

Kaempferols↗
PubMed2005

[Effects of plant growth substances on induction and culture of callus from Rhodiola quadrifida].

OBJECTIVE: To investigate the effect of plant growth substances on induction and culture of callus from Rhodiola quadrifida and also to analyze salidroside contents in the callus. METHOD: The optimum combination of plant growth substances in MS solid medium for induction and culture of callus was established using orthogonal design. The contents of salidroside was analyzed by HPLC. RESULT: MS medium containing 2,4-D 1 mg x L(-1), NAA 2 mg x L(-1), 6-BA 0.5 mg x L(-1) and KT 0.1 mg x L(-1) could induce the callus from R. quadrifida most effectively;the induction rate was 83.3%. The optimized combination of plant growth substances for callus subculture was 2,4-D 1 mg x L(-1), 6-BA 0.1 mg x L(-1) and KT 0.5 mg x L(-1). The dry weight could reach 11.77 g x L(-1) when the callus was cultured in the optimum medium for 30 d and salidroside content was 0.28%. CONCLUSION: The quantities of plant growth substances required for induction and culture of callus are different in R. quadrifida. The callus could produce salidroside.

Culture Media↗
PubMed2006

[Study on the extraction process for salidroside and p-tyrosol in Rhodiola crenulata].

OBJECTIVE: To investigate the optimum ethanol extraction process conditions for salidroside and p-tyrosol from Rhodiola crenulata. METHODS: The extraction rate of ethanol extract and content of salidroside and p-tyrosol were chosen as the assessment index by using the orthogonal design. The ethanol content (%), solvent quantum (fold) and extracting time (hour) were reviewed. RESULTS: The optimum ethanol extraction process conditions were as follows: adding 6 fold of 80% ethanol, extracting for 2h and 2 times. CONCLUSION: The optimum extraction process can give a reference to the research of new medicine and production of industry.

Chromatography, High Pressure Liquid↗
PubMed2000

Quantitative determination of salidroside and tyrosol from the underground part of Rhodiola rosea by high performance liquid chromatography.

A reversed-phase high performance liquid chromatographic method was developed to determine salidroside and tyrosol simultaneously in the Rhodiola rosea. The optimum condition was Nova-Pak C18 as stationary phase, 6.5% methanol in water as mobile phase and detection at UV 225 nm. The identification was carried out by comparing the retention time and IC/MS spectrum of the relevant peaks with those of isolated standards. The contents of salidroside and tyrosol in the samples gathered from various area in China were ranged over 1.3-11.1 mg/g and 0.3-2.2 mg/g, respectively.

Chromatography, High Pressure Liquid↗
PubMed2000

Antioxidative phenolic compounds from the roots of Rhodiola sachalinensis A. Bor.

The acetone extract of the roots of Rhodiola sachalinensis has furnished six phenolic compounds which exhibited significant scavenging effects against DPPH free radical. The structures of these compounds were identified and determined as gallic acid (1), (-)-epigallocatechin 3-O-gallate (2), kaempferol (3), kaempferol 7-O-alpha-L-rhamnopyranoside (4), herbacetin 7-O-alpha-L-rhamnopyranoside, (5) and rhodiolinin (6) by physico-chemical and spectral evidences.

Antioxidants↗
PubMed2002

Volatiles from rhizomes of Rhodiola rosea L.

Terpenes and aroma volatiles from rhizomes of Rhodiola rosea L. from Norway have been isolated by both steam distillation and headspace solid-phase micro-extraction coupled with gas chromatography and mass spectrometry analysis. The dried rhizomes contained 0.05% essential oil with the main chemical classes: monoterpene hydrocarbons (25.40%), monoterpene alcohols (23.61%) and straight chain aliphatic alcohols (37.54%). n-Decanol (30.38%), geraniol (12.49%) and 1,4-p-menthadien-7-ol (5.10%) were the most abundant volatiles detected in the essential oil, and a total of 86 compounds were identified in both the SD and HS-SPME samples. Geraniol was identified as the most important rose-like odour compound besides geranyl formate, geranyl acetate, benzyl alcohol and phenylethyl alcohol. Floral notes such as linalool and its oxides, nonanal, decanal, nerol and cinnamyl alcohol highlight the flowery scent of rose root rhizomes.

Acyclic Monoterpenes↗
PubMed2001

The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages.

In the present study, we examined the effects of the aqueous extract of Rhodiola sachalinensis root (RSE) on the expression of inducible nitric oxide (NO) synthase (iNOS) gene in RAW264.7 macrophages. RSE synergistically increased NO synthesis in interferon-gamma-primed macrophages. Reverse transcriptase polymerase chain reaction and Northern blotting analysis revealed that RSE may provide a second triggering signal for the synergistic induction of iNOS mRNA expression. Thus, iNOS-mediated NO synthesis in response to RSE may be one mechanism whereby this herbal medicine elicits its therapeutic effects.

Animals↗
PubMed1999

Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.

The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (*O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO*). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-beta-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (*O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH*). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action.

Antioxidants↗
PubMed2000

Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.

The aim of this study was to investigate the effect of repeated low-dose treatment with a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of 56 young, healthy physicians. The effect was measured as total mental performance calculated as Fatigue Index. The tests chosen reflect an overall level of mental fatigue, involving complex perceptive and cognitive cerebral functions, such as associative thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual perception. These parameters were tested before and after night duty during three periods of two weeks each: a) a test period of one RRE/placebo tablet daily, b) a washout period and c) a third period of one placebo/RRE tablet daily, in a double-blind cross-over trial. The perceptive and cognitive cerebral functions mentioned above were investigated using 5 different tests. A statistically significant improvement in these tests was observed in the treatment group (RRE) during the first two weeks period. No side-effects were reported for either treatment noted. These results suggest that RRE can reduce general fatigue under certain stressful conditions.

Adult↗
PubMed2000

A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.

The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.

Adolescent↗
PubMed1993

Polyphenols from Rhodiola crenulata.

A novel gallotannin, crenulatin ( 7), has been isolated from RHODIOLA CRENULATA. The structure was elucidated by spectral analyses (including 2D-NMR spectral measurements) and chemical methods. Also six known polyphenols have been isolated and identified.

Journal Article↗
PubMed2001

Rhodiola sachalinesis induces the expression of inducible nitric oxide synthase gene by murine fetal hepatocytes (BNL CL.2).

We have examined the effect of the aqueous extract of Rhodiola sachalinensis root (RSE), a traditional herbal medicine, on nitric oxide (NO) synthesis in murine fetal hepatocytes (BNL CL.2) by measuring the stable end-product nitrite and the mRNA of inducible NO synthase (iNOS). Interferon-gamma (IFN-gamma) by itself failed to induce NO synthesis in BNL CL.2 cells. RSE also did not elicit NO synthesis at concentrations up to 1,000 microg/ml, but dose- and time-dependently induced NO synthesis in the presence of IFN-gamma in BNL CL.2 cells. Whereas RSE or IFN-gamma failed to induce detectable levels of iNOS mRNA, a combination of RSE and IFN-gamma markedly induced iNOS mRNA in BNL CL.2 cells. Thus, we found that RSE triggered IFN-gamma-primed BNL CL.2 cells to synthesize NO by inducing iNOS gene expression. The capability of RSE to induce NO synthesis might be related to the therapeutic efficacy of RSE on the liver diseases.

Animals↗
PubMed1995

Rhodiocyanosides A and B, new antiallergic cyanoglycosides from Chinese natural medicine "si lie hong jing tian", the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey.

Two new antiallergic cyanoglycosides named rhodiocyanosides A and B were isolated from the Chinese natural medicine "Si Lie Hong Jing Tian" (Shiretsukoukeiten in Japanese), the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey., together with two new glycosides, octyl alpha-L-arabinopyranosyl(1-6)-beta-D-glucopyranoside and gossypetin 7-O-beta-D-glucopyranosyl(1-3)-alpha-L-rhamnopyranoside. Their chemical structures were determined on the basis of chemical and physicochemical evidence. Rhodiocyanosides A and B exhibited inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE. In addition, rhodiocyanoside A was found to inhibit the PCA reaction in rats.

Animals↗
PubMed1998

Oxygen transfer characteristics in the compact callus aggregates of Rhodiola sachalinensis.

The effective diffusivity of oxygen in compact callus aggregates (CCA) of Rhodiola sachalinensis was extremely small, varying from 0.34 x 10(-11) to 5.4 x 10(-9) m2/s and increasing with particle diameter. The calculated results indicated that severe oxygen limitations occurred in the CCA aggregates. However, the direct determination of the viability of the cells demonstrated that the CCA aggregates contained a high fraction of viable cells. It was suggested that the tissue differentiation or plasmodesmata within the CCA aggregates may provide capillaries for improving transport of oxygen and other nutrients.

Drugs, Chinese Herbal↗
PubMed1998

[Determination of salidroside in eight Rhodiola species by TLC-UV spectrometry].

Quantitative determination of the salidroside in eight Rhodiola species by TLC-UV spectrometry is reported. The salidroside was separated on a silica GF254 TLC plate using CHCl3-CH3OH-H2O(26:14:3) as developing solvent and determined at wavelength 223.8 nm. The results show that this method in simple and convenient.

Chromatography, Thin Layer↗