Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Retraction Notice”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources

Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma.

Retraction artifact resulting in clear spaces around tumor cell nests is frequently seen in histologic material and may present difficulty in their differentiation from lymphovascular invasion. We noticed that retraction artifact seemed to be more common around groups of breast cancer cells compared with benign acini, and when extensively present, metastasis to axillary lymph nodes was often seen. Thus, we performed a study of 304 cases of stage pT1 and pT2 breast carcinomas to test our hypothesis that extensive retraction artifact in tumors correlates with lymphatic spread and outcome. Tumors were evaluated to determine the presence and extent of retraction artifact around tumor cell nests and the presence of lymphatic invasion. Lymphatic invasion was confirmed by D2-40 immunostaining. The extent of retraction artifact in tumors was correlated with clinicopathologic tumor features and patient outcome. Variable degree of retraction artifact was present in 183 of 304 (60%) invasive carcinomas, with its extent ranging from 0% to 90% (median 5%). The extent of retraction artifact showed a significant correlation with tumor size, histologic type, histologic grade, presence of lymphovascular invasion, and nodal metastasis. Further, extensive retraction artifact was significantly associated with poor overall and disease-free survival in both univariate and multivariate analyses. We propose that the apparent retraction of the stroma from cells of invasive breast carcinoma on routine histologic sections is not a phenomenon merely due to inadequate fixation as currently believed. Rather, it likely signifies important biologic changes that alter tumor-stromal interactions and contribute to lymphatic spread and tumor progression.

Artifacts↗

Role of the journal editor in sustaining integrity in research.

Editors have important but indirect roles in sustaining integrity in research, and they have major and highly visible roles in maintaining the integrity of science literature. They must publish the policies and the standards to which they will hold authors and reviewers, and then must enforce those policies. Editors cannot be responsible for the accuracy of what they publish, but they must respond thoroughly and consistently to allegations of misconduct concerning papers under consideration or already published. They must conduct appropriate inquiries and notify authors' or reviewers' institutions about possible misconduct found by those inquiries. Further, to maintain the integrity of the literature, editors must publish corrections, retractions, and notices of duplicate publication according to the standards set down by the National Library of Medicine.

Biomedical Research↗

Retraction.

Explore the source record for details and available documents.

Retraction Notice↗

Author errata.

Explore the source record for details and available documents.

Retraction Notice↗

Author errata.

Explore the source record for details and available documents.

Retraction Notice↗

Retracted article.

Explore the source record for details and available documents.

Retraction Notice↗