Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Recovery phases”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources
PubMed1999

Mechanism of increase in anaerobic threshold during recovery phase in patients with acute myocardial infarction.

The contribution of venous return to the increase in anaerobic threshold (AT) in patients with acute myocardial infarction (AMI) was investigated. Twenty-seven patients with uncomplicated AMI underwent supine and sitting cardiopulmonary exercise testing, and 10 out of these 27 patients performed constant-workload tests in which cardiac output before and after a phase II program was measured. Data from 8 patients were eliminated because of restenosis after direct percutaneous transluminal coronary angioplasty. The increase in AT was significantly greater in the sitting position than in the supine position, 15.0+/-9.9% and 6.3+/-6.0% respectively. Average O2 pulse at AT changed non-significantly from 8.6+/-1.5 to 8.7+/-1.2 ml min(-1) beat(-1) in the supine position, but it showed a significant increase from 8.1+/-1.3 to 9.2+/-1.3 ml min(-1) beat(-1) when measured in the sitting position. In the constant-workload studies, stroke index showed a significant increase during both supine and sitting exercise. Percent increase in the stroke index from rest to exercise did not differ significantly in the supine position, but did differ significantly in the sitting position. These results strongly suggest that increased venous return as well as improvement in cardiac pump function play a major role in the mechanism of AT increase in an upright position throughout the recovery phase in AMI patients.

Acute Disease↗
PubMed1990

An unusual pattern of hemopoietic reconstitution in patients with acute myeloid leukemia transplanted with autologous recovery phase peripheral blood.

Fourteen patients with acute myeloid leukemia (AML) were autotransplanted with peripheral blood cells collected during early remission. Seven were autotransplanted in first relapse and seven in first remission. They received a median of 3.3 X 10(8) nucleated cells/kg body weight (BW) and 92 X 10(4) myeloid progenitor cell (CFU-GM) per kg BW. Rapid hemopoietic reconstitution (HR) occurred in all patients with median time to reach normal neutrophil and platelet counts 13 and 18 days post re-infusion respectively. However, in three patients neutrophil counts fell to less than 1.0 x 10(9)/l and in seven patients platelet counts fell to less than 25 x 10(9)/l between 26 and 40 days post-transplant (trough count). In all but two patients who received the lowest CFU-GM dose the counts returned to normal or near normal levels (steady count). There were significant correlations between the CFU-GM dose and the trough and the steady platelet counts (p = 0.04 and 0.01 respectively). Patients receiving more than 50 x 10(4) CFU-GM/kg BW had higher steady neutrophil and platelet counts (p = 0.011 and 0.033 respectively) although some patients receiving greater than 50 x 10(4) CFU-GM/kg still experienced thrombocytopenia during the second month post graft. There was no significant correlation between the nucleated cell dose and HR. The cause of the fall in platelet and neutrophil counts in the second month post graft is not clear but is probably a reflection of a proliferative defect in the recovery phase stem cells in AML.

Adolescent↗
PubMed1987

M-mode echocardiographs of endurance horses in the recovery phase of long-distance competition.

M-mode echocardiographic structures, and cardiac function indices, PCV, and total plasma protein values were determined for 34 endurance equine athletes before (base line) and after (after race) a 161-km endurance competition and were compared. The PCV (base-line mean, 37%; after-race mean, 46%) and total plasma protein value (base-line mean, 6.9 g/dl; after-race mean, 7.5 g/dl) increased. Compared with base-line echocardiography, after-race echocardiography indicated an increase in heart rate, as determined from the simultaneous ECG recorded on the echocardiograph (base-line mean, 41 beats/min; after-race mean, 54 beats/min), and an increase in interventricular septal diastolic thickness (base-line mean, 28 mm; after-race mean, 33 mm). The septal thickening fraction (base-line mean, 59%; after-race mean, 38%), the left atrioventricular valve E to F slope (base-line mean, 224 mm/s; after-race mean, 175 mm/s), the left ventricular diastolic dimension (base-line mean, 99 mm; after-race mean, 86 mm), the fractional shortening of the left ventricle (base-line mean, 41%; after-race mean, 37%), the aortic root dimension (base-line mean, 63 mm; after-race mean, 58 mm), the caudal aortic wall excursion (base-line mean, 19 mm; after-race mean, 11 mm) and the left atrial diastolic dimension (base-line mean, 46 mm; after-race mean, 39 mm), decreased significantly (P less than 0.05). In base-line echocardiographs, late diastolic left atrioventricular valve motion was evident in 9 horses. The aberrant left atrioventricular valve motion was not evident in after-race echocardiographs. Seemingly, central vascular volume decreased in these horses during the recovery phase of severe strenuous endurance competition.

Animals↗
PubMed1992

Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction.

The effects of physical training on hemostatic parameters were evaluated in 56 postmyocardial infarction (MI) patients before and after one month of systematic physical training and in 30 control post-MI patients, who did not undergo such training. There were no significant changes in prothrombin time (PT) and alpha 1-antitrypsin (alpha 1AT) at the beginning and end of the study in either group. Levels of fibrinogen, Factor VIII: C (VIII:C) and von Wildebrand antigen (vWf:Ag), and activities of ATIII and plasminogen (Plg) were significantly decreased in the group with physical training (p less than 0.05), while values were unchanged in the control group. Hematocrit, platelet counts, and alpha 2-plasmin inhibitor (alpha 2PI) activities also decreased in the physical training group (p less than 0.05). In contrast, these variables increased in the control group (p less than 0.05). Activated partial thromboplastin time (aPTT) tended to be prolonged in the group with physical training, while it was shortened in the control group. In a subset of 20 patients with physical training, resting levels of plasmin-alpha 2PI complex (PIC), thrombin-antithrombin III complex (TAT), protein-C (P-C:Ag), plasminogen activator inhibitor-1 (PAI-1), VII:C, and P-C activities had significantly decreased after one month of physical training (p less than 0.05), although tissue plasminogen activator activities remained unchanged. Physical training appeared to suppress coagulability as indicated by the decrease in fibrinogen, VIII:C, vWf:Ag, VII:C, and TAT, and prolongation of aPTT. The decrease in plasminogen, t-PA:Ag, alpha 2PI, PAI-1, and PIC after physical training may result from the decreased coagulability. In conclusion, physical training appears to induce a suppression of the coagulation system in patients in the recovery phase of MI.

Adult↗
PubMed2003

Severe acute respiratory syndrome (SARS): imaging findings during the acute and recovery phases of disease.

Severe acute respiratory syndrome (SARS) is a new form of atypical pneumonia, which has become a major health crisis in East Asia and Canada, with the potential for becoming the next worldwide epidemic. Until the validation of diagnostic kits is completed, clinical findings, contact history, and radiologic findings are the key to diagnosis of this disease. The imaging findings on conventional radiographs and computed tomography (CT) in the acute phase as well as during recovery are presented.

Acute Disease↗
PubMedDate not supplied

Volume transmission of dopamine may modulate light-adaptive plasticity of horizontal cell dendrites in the recovery phase following dopamine depletion in goldfish retina.

We investigated the recovery of light-adaptive spinule formation following dopamine depletion with intraocular injection of 6-hydroxydopamine (6-OHDA) and subsequent neogeneration of dopamine interplexiform cells (DA-IPC) at the marginal zone. DA-IPCs were gone by 2 weeks postinjection and appeared at the marginal zone by 6 weeks postinjection, at which time DA-IPC neurites grew toward the central retina, reaching within 0.5 mm of the central retina by 1 year. Retinas from day time, light-adapted fish at 2 weeks, 4 weeks, 3 months, and 1 year postinjection with 6-OHDA were processed for pre-embedding tyrosine hydroxylase immunoreactivity (TOH-IR) and compared to sham-injected and control retinas at the electron-microscopical (EM) level. Only 6-OHDA fish that tilted markedly toward the injected eye were used for these experiments. The tilt mimics the dorsal light reaction, indicating a 2-2.5 log unit increase in the photopic sensitivity of the 6-OHDA eye. Spinule formation was reduced by about 60% in the 2- and 4-week 6-OHDA retinas, but returned to control levels throughout the entire retina of 3-month and 1 year 6-OHDA retinas even though the central region of these retinas contained no detectable TOH-IR. Intraocular injection with 10 microM SCH 23390 (a D1 antagonist) reduced light-adaptive spinule formation by 50% both in control eyes as well as those eyes that were 3 months post 6-OHDA injected. The full return of spinule formation with only partial reinnervation of the retina with DA-IPC processes and their subsequent inhibition by SCH 23390 indicates that dopamine diffused large distances within the retina to regulate this synaptic plasticity (i.e. displayed volume transmission). Also, since all 6-OHDA injected fish displayed an increased photopic sensitivity in the injected eye when sacrificed, we suggest that horizontal cell spinules are not required for photopic luminosity coding in the outer retina.

Adaptation, Ocular↗
PubMed2003

Phase recovery from a single undersampled interferogram.

A new method of phase determination from a single undersampled interferogram is described. Two low-fringe-density synthetic interferograms corresponding to the phase differences along orthogonal directions are obtained from neighboring pixels of the aliased measured data. The only assumption is that the illumination background, the modulation intensity, and the searched phase are smooth and continuous functions. The synthetic interferograms are demodulated by use of either standard frequency or spatial-domain procedures to obtain the phase differences. The phase is then recovered by integration of the phase differences with a least-squares method. The proposed method is demonstrated to be noise tolerant.

Journal Article↗
PubMed2003

Unique phase recovery for nonperiodic objects.

It is well known that the loss of phase information at detection means that a diffraction pattern may be consistent with a multitude of physically different structures. This Letter shows that it is possible to perform unique structural determination in the absence of a priori information using x-ray fields with phase curvature. We argue that significant phase curvature is already available using modern x-ray optics and we demonstrate an algorithm that allows the phase to be recovered uniquely and reliably.

Algorithms↗
PubMed1981

The mechanism of hyperchloremic acidosis during the recovery phase of diabetic ketoacidosis.

To determine the mechanism of hyperchloremic acidosis during recovery from diabetic ketoacidosis (DKA), serial measurements were made in eight patients of serum and urinary electrolytes and organic acids, and of urinary net acid. On admission, the average decrease in serum total CO2 was 17.5 mmol/L, corresponding to the excess anion gap, 18.5 meq/L, and the serum organic acids, 17.1 meq/L. With the treatment, the anion gap and organic acids decreased by 16.1 and 14.7 meq/L, respectively, but the serum CO2 increased only by 8.4 mmol/L; serum electrolyte balance was maintained by increase in chloride concentration. Fluid retention was insufficient to explain the disparity between the increase in CO2 and the decrease in organic acids. Renal loss of bicarbonate precursors during treatment was modest and was exceeded by renal bicarbonate production. The disparity between the increase in serum CO2 and the decrease in organic acids during treatment of DKA may be explained to a large extent by a difference in volume of distribution between bicarbonate and organic anions. The renal loss of ketone anions before admission, however, is ultimately responsible for the persistence of substantial metabolic acidosis.

Acidosis↗
PubMed1998

[Recovery of respiratory parameters and oxygen consumption during the recovery phase of cardiopulmonary exercise test in patients with dilated cardiomyopathy].

OBJECTIVE: To analyse the recovery of oxygen consumption (VO2), ventilation (VE) and carbon dioxide production (VCO2) after maximal cardiopulmonary exercise testing, and to assess the possibility of recovery parameters becoming new markers of functional impairment. METHODS: Thirty-eight patients (30 males, mean age 56 +/- 11 years) with dilated cardiomyopathy performed maximal, symptom limited, treadmill exercise test with breath-by-breath respiratory gas analysis. The patients were divided in two groups, according to maximal oxygen consumption above or below 14 ml/kg/min (group I and group II, respectively). During the recovery, we analyzed the time to reach 50% of the maximal values of VO2 (T1/2 r VO2), VE (T1/2 e VE) and VCO2 (T1/2 r VCO2) in each group. RESULTS: Twenty-seven patients had a VO2max above 14 ml/kg/min (group I) and 11 had a VO2max below 14 ml/kg/min (group II). The results were as follows: T1/2 r VO2max 109 +/- 21 sec in group I versus 177 +/- 79 sec in group II (p = 0.0001). T1/2 r VCO2max 124 +/- 28 sec in group I versus 201 +/- 88 sec in group II (p = 0.0001) and T1/2 rVEmax 146 +/- 47 sec in group I versus 229 +/- 47 sec in group II (p = 0.0002). CONCLUSIONS: Patients with a poor functional capacity show a delay in the half recovery times of oxygen consumption, ventilation and carbon dioxide production. These data suggest that these parameters may be used as new markers of the level of functional impairment.

Cardiomyopathy, Dilated↗
PubMed1990

[The coronary collaterals influence in the recovery phase after exercise-induced myocardial ischemia].

The role of coronary collaterals in conditioning the recovery from exercise-induced myocardial ischaemia has not been investigated. We studied 60 patients (54 men, age 59.3 +/- 6.7 years) with low threshold effort angina and documented coronary artery disease, who underwent repeat exercise testing in 2 consecutive days. On the second day, Thallium 201 stress/rest myocardial perfusion scintigraphy was also performed. At angiography, 30 patients (Group A), had more severe disease (Gensini score: 46.9 +/- 16) and angiographically visible collaterals (grade 2-3 Cohen and Rentrop classification) perfusing the ischaemic zone; the other 30 (Group B), had lesser disease (Gensini score: 28.6 +/- 18, p less than 0.001 vs Group A) and non visible collaterals to the ischaemic areas. Maximal ST depression and total exercise duration were similar in the 2 groups (2.5 +/- 0.6 vs 2.5 +/- 0.7 mV and 6.2 +/- 1.8 vs 6.8 +/- 1.9 min, respectively) but time and rate-pressure product to 1 mm ST depression were lesser in Group A (3.5 +/- 0.8 vs 4.8 +/- 0.6 min, p less than 0.01, and 14189 +/- 2451 vs 16081 +/- 2215 b/min x mmHg, p less than 0.04). Surprisingly, in Group A, the ST segment returned to the baseline more rapidly (5.5 +/- 1.6 vs 11.7 +/- 3.3 min, p less than 0.001), and the ischaemic area [time (s) x ST (mV)], measured in the recovery period, was also smaller (301 +/- 163 vs 621 +/- 260, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1995

Collection of peripheral-blood diploid cells from chronic myelogenous leukemia patients early in the recovery phase from myelosuppression induced by intensive-dose chemotherapy.

PURPOSE: To evaluate whether intensive chemotherapy followed by peripheral stem-cell (PSC) collections during early hematopoietic recovery results in a higher percentage of diploid cell collections in patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). PATIENTS AND METHODS: Fifty-five adults with Ph-positive CML received intensive chemotherapy with daunorubicin and high-dose cytarabine (ara-C) (DAUNO-HDAC; 26 patients) or fludarabine, high-dose ara-C, and mitoxantrone (FAM; 29 patients). Collections of the peripheral mononuclear cells were initiated when the WBC count was > or = 0.8 x 10(3)/microL. Simultaneous peripheral and marrow samples were subjected to cytogenetic studies. RESULTS: Thirty-eight of 55 patients (69%) were able to undergo the PSC collections. The rate of collection was higher in chronic phase (26 of 30 patients; 87%) than in accelerated (11 of 17; 65%) and blastic phases (1 of 8; 12%). Among the 30 patients in chronic phase, cytogenetic analyses of PSC showed cytogenetic responses (Ph-positive < 95%) in 60%, which were major (Ph < 35%) in 43% and complete (Ph = 0%) in 27%. Seven of 19 patients with simultaneous studies (37%; 23% of total) had a significantly lower percentage of Ph-positive cells in the peripheral collection compared with the marrow collection; one had the reverse phenomenon (5%; 3% of total). Cytogenetic responses were modest in both peripheral and marrow collections in CML accelerated and blastic phases. Myelosuppression-associated complications were frequent, resulting in febrile episodes in 76% of patients. CONCLUSION: PSC collection during early hematopoietic recovery from intensive chemotherapy allowed the collection of diploid-rich stem cells, mostly in chronic-phase CML. The approach could be used for in vivo purging before autologous stem-cell transplantation (ASCT).

Adolescent↗
PubMed1979

Escape rhythm in complete A-V block. The recovery phase after overdrive suppression from artificial ventricular suppression from artificial ventricular pacing.

In 60 patients with third degree A-V block, recovery of escape rhythm from overdrive suppression after ventricular pacing has been studied. Implanted unipolar VVI pacemakers were inhibited by chest wall stimuli. A total of 165 rhythmograms were studied. In 37, the rate was irregular, in the other 128 the escape rate increased gradually, following an exponential curve until stabilization after 3 minutes. In 29 of these rhythmograms, a possible exit block of the first escape impulse was observed. In 99 rhythmograms without exit block, escape rhythm recovery time was an average 1.45 times basal escape RR intervals. Overdrive suppression was most marked in patients with a slow escape rhythm.

Cardiac Pacing, Artificial↗
PubMed1977

Cell cycle phase recovery from bleomycin-induced potentially lethal damage.

Mammalian cells treated during mitosis with the anticancer drug bleomycin cannot recover from potentially lethal damage. G1- and S-phase cells treated in a similar manner can recover. In synchronized G1- and S-phase cells, and in asynchronous and nondividing populations, the final survival values of recovered cells have always been found to be greater than 0.2. These data suggest that a certain fixed amount of recovery can occur, regardless of the degree of initial bleomycin-induced damage. The mechanism of this particular phenomenon is unknown.

Bleomycin↗
PubMed2006

Immunological alterations during the clinical and recovery phases of experimental swine dysentery.

The aim of this study was to examine changes in the systemic immune response during the incubation period and following the onset of clinical swine dysentery, including the recovery period. Ten healthy conventional pigs were inoculated with Brachyspira hyodysenteriae. Blood was sampled at pre-inoculation, at days 4 and 14 post-inoculation, during the first 4 days with clinical signs of dysentery and at days 1, 3, 7, 11 and 15 of the recovery period. Eight pigs developed haemorrhagic diarrhoea. Flow-cytometric analyses of lymphocyte subpopulations showed that all animals, including the two that remained healthy, had an increase in CD8alpha+ CD4- cells and gammadelta T cells at days 4 and 14 post-inoculation. In addition, an increase in CD4+ CD8alpha+ cells and CD8alpha+ CD8beta+ cells was observed at days 4 and 14 post-inoculation in animals that developed dysentery. During clinical signs of dysentery, the acute-phase protein serum amyloid A was increased. There was a two- to threefold increase in both neutrophils and monocytes during signs of dysentery and at the beginning of the recovery period. The numbers of CD8alpha+ CD8beta- CD4-, CD45RA- lymphocytes also increased during the dysentery period. Circulating CD21+ cells and CD21+ CD45RA- cells decreased at the end of the incubation period, during signs of dysentery and at the beginning of the recovery period. The dysentery-affected animals developed antibodies to B. hyodysenteriae-specific antigens (approximately 16 kDa and approximately 30 kDa) from the first day of recovery, and gammadelta T cells showed an increase during the recovery period. In comparison with pre-inoculation, increased numbers of monocytes, neutrophils, CD8alpha+ CD8beta- CD4- lymphocytes and CD45RA- lymphocytes were observed during clinical dysentery. Increased numbers of neutrophils, gammadelta T cells and specific antibodies were seen during the recovery period.

Animals↗
PubMed1994

[Comparative study of the recovery phase. Laparoscopic cholecystectomy following isoflurane, methohexital and propofol anesthesia].

Total intravenous anaesthesia (TIVA) is increasingly used in short-stay surgery such as laparoscopic cholecystectomy. TIVA may provide fast recovery of psychomotor function, thus being of benefit to both the patient's behaviour and postoperative management. The purpose of this prospective study was to compare postoperative recovery from TIVA using propofol or methohexitone as the hypnotic component and balanced anaesthesia with isoflurane. PATIENTS AND METHODS. After giving informed consent and approval by the ethical committee of our hospital, 51 patients (ASA I, II) were investigated in a prospective study. Patients were randomised to receive either isoflurane, methohexitone, or propofol. Perioperative management with regard to premedication, intraoperative analgesia, relaxation, ventilation, and postoperative analgesia was carried out identically for all groups. Postoperative vigilance, pain, and nausea scores were assessed 15, 30, 60, 120, and 360 min after extubation with a visual analogue scale (VAS). At the same points, psychomotor recovery was investigated with the following assays: sedation as shown in Table 1; orientation with ten questions as to person, time, and location; memory as expressed by the patient's ability to repeat five words; a calculation test with five subtractions of the number 7 beginning from 100; and word generation by the number of words with an initial "m" given within 1 min and with animal names. Data were analysed with Kruskal Wallis' test for multiple comparisons between the groups and with Friedman's test for repeated measurements. All values are given as medians (interquartile range) or ranges. RESULTS. There was no difference between the groups' physical condition (Table 2). All intraoperative parameters compared well between groups; the management of anaesthesia was smoother with isoflurane than with the other anaesthetics. Psychomotor recovery was somewhat faster in the propofol group than the methohexitone group, as indicated by sedation score, orientation, memory and calculation tests (Table 4), word generation tests (Fig. 4), and subjective vigilance score (Fig. 3). The difference in recovery time between the propofol and isoflurane groups was minimal and without any significance or relevance. The incidence of postoperative nausea was significantly lower after balanced anaesthesia with isoflurane (24%, P < 0.05) as compared to TIVA with either propofol (53%) or methohexitone (41%). However, there were only minor differences between the groups; the ability to cooperate and be mobilised was not limited. DISCUSSION. Each of the three techniques used in this study is suitable for anaesthesia in patients undergoing laparoscopic cholecystectomy. Since fast recovery of vigilance and psychomotor function is very important in outpatient surgery, opioid-supplemented propofol anaesthesia is well established. Inhalation anaesthesia with isoflurane in air/oxygen without adding nitrous oxide compares well to propofol TIVA for laparoscopic surgery.

Adult↗
PubMed1991

[The stress reaction in the recovery phase from halothane and isoflurane anesthesia].

This study was undertaken to investigate the influences of halothane and isoflurane as well as different extubation techniques on the endocrine stress response during recovery from general anesthesia. Forty patients scheduled for herniorrhaphy and cholecystectomy were randomly allocated to 4 groups: 20 received halothane and 20 received isoflurane anesthesia. Within the halothane and isoflurane groups, 10 patients each were extubated during anesthesia (1/2 MAC) and a further 10 had awake extubation. Premedication, induction of anesthesia, and intraoperative anesthetic management were standardized in all groups. Plasma levels of endocrine stress parameters as well as mean arterial pressure (MAP), heart rate (HR), and arterial oxygen saturation (SaO2) were measured at nine time points up to 60 min after extubation. Biometric data and duration of operation and anesthesia were comparable in all groups. In the recovery period, epinephrine levels were higher in the isoflurane groups than in the halothane groups (P = 0.02). With respect to time course, earlier and more marked increases of epinephrine, norepinephrine, and antidiuretic hormone (ADH) levels were observed in the isoflurane groups compared to the halothane groups (P less than 0.01), representing the more rapid elimination of isoflurane. The sympathoadrenergic stress response was more pronounced in patients with extubation during anesthesia than in those with awake extubation: epinephrine levels were slightly higher and group levels of norepinephrine were significantly increased (P = 0.02). No influence of the extubation techniques was observed on ADH, ACTH, and cortisol levels or on MAP, HR, or SaO2. In summary, extubation during anesthesia did not reduce the endocrine stress response. It is concluded that awake extubation should be preferred unless the operation or the patient's condition requires extubation during anesthesia.

Adult↗