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PubMed1998

Evaluation of potential carcinogenicity of steroidal alkaloids from Veratrum album L. by the DC polarography method.

The presented work is devoted to the study of polarographic reduction in the series of 13 alkaloids isolated from various parts of Veratrum album subsp. lobelianum. The used compounds were evaluated from the point of view of their potential carcinogenicity in anhydrous N,N-dimethylformamide (DMF) by the method of DC polarography. All compounds were reduced during an one two-electron irreversible step. Their potential carcinogenicity characterized by a parameter tg alpha value determined in the presence of alpha-lipoic acid ranged from the highest value 0.257 obtained for the solanidane skeleton containing rubijervine to the value 0.070 for jervine. The tg alpha value determined for rubijervine (0.257) is comparable with the tg alpha of naphto-(2',1',2,3)fluoranthene (0.270)-compound classified by IARC as possible carcinogen for human. The tg alpha values determined for other alkaloids were relatively low and they do not indicate any possible carcinogenic activity.

Alkaloids↗
PubMed1976

Drugs. Differential pulse polarography of cacodylate injections.

A method was developed for the analysis of cacodylate injections, using differential pulse polarography for measuring As(III). The cacodylate molecule is decomposed to As(V) by heating with Mg(NO3)2.6H20; As(V) is then chemically reduced to As(III) and polarographed in 1M HCl supporting electrolyte. The method of standard addition is used for quantitation. Recoveries based on the analysis of synthetic cacodylic acid solutions containing approximately 9 mg arsenic/ml ranged from 99.1 to 101.7%.

Arsenic↗
PubMed1989

[Determination of heavy metals in infusion solutions using modern polarography methods].

The pharmacopoeial method of determination of heavy metals based on the formation of coloured sulphides, in comparison with instrumental methods, has relatively little sensitivity and does not provide selective determination of the individual ions. In order to determine some heavy metals in water for injection and infusion solutions, the authors employed the method of differential pulse polarography (DPP) and differential pulse anodic solvent voltammetry (DPASV) on the hanging mercury dropping (HMDE) with the use of the fast scan method (FSDPP). DPASV method proved to be particularly suitable; without any larger analytical problems the sensitivity of determination up to 8.10(-10) mol.1(-1) for copper, lead, cadmium and zinc ions was achieved. Bismuth and tin ions are also polarographically active, as well as nickel and chromium ions with the use of SPP. The medium of pH 4 achieved by adding potassium hydrogen-phthalate proved to be good. When there was an interfering effect of the access of chloride ions for copper determination, a strongly acid medium of hydrochloric acid 1 mol.1(-1) was used; an interfering effect of decomposition products of sugars on zinc determination was eliminated by performance at pH 7. Potentials of the peaks of the individual metals in various media are shown in Table I, the found values in Table II.

Infusions, Parenteral↗