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PubMed2002

[A case of enlarged vestibular aqueduct syndrome with PDS gene mutations].

Enlarged vestibular aqueduct (EVA) is an inner ear anomaly occasionally associated with sensorineural hearing loss (SNHL) and/or dizziness. Recent genetic studies indicate that mutations in the PDS gene may cause EVA. A 10-year-old EVA patient who had undergone annual hearing tests for 7 years had an aunt and cousin who also had hearing loss and EVA, so genetic examinations were conducted for a possible genetic link. Two new PDS gene mutations, S610X and S657N, were found in all 3, including the proband. We discuss the importance of genetic analysis, which offers new insight into SNHL diagnosis and treatment in children.

Carrier Proteins↗
PubMed1990

[Ligament reinforcement with resorbable PDS cord and early functional after-care. Results of follow-up of surgically managed cruciate ligament injuries].

After operating on the injured cruciate ligaments, immediate mobilization and protection of the healing ligament are indispensible. However, no approach has yet been shown to safely provide both. Therefore, in 1984 we introduced a new technique: the repaired or reconstructed cruciate ligaments are augmented with a biodegradable material - a doubled-over PDS cord, 1.5 mm in diameter. It allows for immediate and safe mobilization. Because of its appropriate elasticity it does not cause "stress shielding." Postoperatively, the patients are mobilized on a motorized frame for 2 weeks. Subsequently, we have used a limited mobilization cast (LMC). Forty-nine out of 63 patients (78%) have now been reexamined for this follow-up study, using the score from the Hospital for Special Surgery and stress X-rays in the Lachmann, position (30 degrees flexion). The results compare favorably with a prior follow-up study of patients from our hospital without PDS augmentation and without early mobilization. The knees in the present study are more stable and have a better range of motion, particularly when the LMC was used.

Adolescent↗
PubMed1983

[Polydioxanon (PDS)--a new monofilar synthetic, absorbable suture material. Tensile strength studies in a controlled clinical trial on the large intestine of humans and physical parameters in in vitro tests].

We investigated the properties of tensile strength for the following suture materials: Polyglycolic acid (2. and 3.generation), Polyglactin 910 (3.generation) and Polydioxanon. They were situated within human large bowels for 10 to 12 days and investigated in a controlled experimental procedure. The decrease of the tensile strength in the human large bowel is significantly slower for polydioxanon suture (PDS) than for PGA (2. and 3.generation) and Polyglactin 910 (3.generation) suture. As PDS-suture are primarily less tractable than the others, there is no significant difference of tractability between all sutures after 11 days of implantation within the human colon. For PGA (3.generation) and Polyglactin 910 we found a strong loss of tractability after 10 to 12 days. In a second experimental series tensile strength, knot breaking security and knot holding capacity were tested in a tensiometer for absorbable suture materials with 3 and 6 parallel knots. The tensile strength was higher than the knot security for all sutures. Coated suture material (PGA and Polyglactin 910, both 3.generation) as well as the new monofile polydioxanon must be knotted manyfold for a secure knot position.

Adult↗
PubMedDate not supplied

Reconstruction of complete acromioclavicular separations (Tossy III) using PDS-banding as augmentation: experience in 64 cases.

Sixty-four patients with an acute type Tossy III acromioclavicular separation were treated surgically. Both the coracoclavicular ligaments and the ligaments of the acromioclavicular joint were reconstructed. An additional ligamenteous augmentation was performed, using completely resorbable 5 and 10 mm PDS bands. Thirty-nine patients (61%) were reexamined (follow-up time 2-45 months, mean 26 months). Results were good to excellent in 77% of cases. In 91% of patients, a range of motion with an abduction deficit of less than 20 degrees was obtained. Calcifications in the area of the coracoclavicular or acromioclavicular ligaments did not affect the final range of motion. Complications consisted of a subcutaneous infection in one case, a deep infection in another patient and one reluxation. PDS banding enables an early functional postoperative treatment. Implant removal is not required. Complications as breakage or migration of metal implants are avoided.

Acromioclavicular Joint↗
PubMed1993

[Therapy of humeral head fracture. Open reposition and fixation with PDS pins].

Seven patients who sustained a displaced fracture of the capitulum humeri had been treated by surgery, using a volar approach and internal fixation with PDS pins. The advantage of this method is that by using the volar approach, the displaced capitulum could be reduced properly in its exact anatomical position. The internal fixation with PDS pins was solid enough to allow early postoperative movements. A second operation to remove any material was not necessary. In all cases the clinical and x-ray results have been excellent.

Adolescent↗
PubMed1993

[Surgical management of complete acromioclavicular joint dislocation (Tossy III) with PDS cord cerclage].

29 patients out of 33 with complete acromioclavicular dislocation treated with sewing of ligaments and stabilized with a PDS-cord cerclage could be examined. The criteria of examination were subjective complaints while lifting weight, limited range of motion in the injured shoulder and radiological results after stress with 8 kp. The examination didn't show any relationship between the 3 parameters. 4 patients with poor function had partly no, partly little complaints and if any only little AC-dislocation. On the other hand 4 patients out of 6 with remaining AC-subluxation had no complaints and in no case there was a reduced range of motion greater than 10 degrees. Three patients got postoperative infection of soft tissue or bone, probably caused by incompatibility with PDS-cord, which led to a fair or poor outcome. Instead of this there can be obtained excellent and good results in 75-85% of the cases with this simple method without inserting stabilizing metals trans- or extraarticular.

Acromioclavicular Joint↗
PubMed1993

Anterior cruciate ligament reconstruction and augmentation with PDS graft.

The article briefly explains the biomechanical properties of the PDS and the most important ways of its use in anterior cruciate ligament (ACL) reconstruction. The different techniques of ACL reconstruction with gracilis and semitendinosus tendons are outlined. The authors explain their technique of ACL reconstruction with gracilis and semitendinosus plus PDS-band. The possible variations and pitfalls are pointed out. The results of this surgery are expounded.

Anterior Cruciate Ligament↗
PubMed2001

Long-term audiological feature in Pendred syndrome caused by PDS mutation.

Pendred syndrome is an autosomal recessive disorder characterized by profound deafness in childhood and goiter. We report a case of Pendred syndrome in a 27-year-old woman who had a diffuse goiter and progressive sensorineural hearing loss with fluctuation and a missense mutation (His723Arg) in the PDS gene identified in a homozygous state. Audiological findings were observed clinically over a 20-year period. Progressive hearing loss with fluctuation occurred before age 12 years. An enlarged vestibular aqueduct with enlargement of the endolymphatic duct and sac was confirmed with 3-dimensional magnetic resonance imaging hydrography.

Adult↗
PubMed1996

An improved technique for low anterior resection using a PDS endoloop.

We describe herein the results of performing a new technique of low anterior resection of the rectum using a PDS endoloop, on ten patients with rectal cancer. This technique involves first preparing the rectosigmoid colon with an anvil as in the conventional low anterior resection; then, after the stapler is inserted transanally, two endoloops are solid over the colon and rectum. The rectum is ligated by pushing the knot of the endoloop and a second knot is applied 2 cm proximal to the first. Finally, the rectum is cut and the stapler is closed and fired to make a circular end-to-end anastomosis. The level of the anastomosis ranged from 2.5 to 6 cm with a mean of 4.7 cm in the ten patients, only one of whom developed a minor anastomotic leakage postoperatively. Moreover, no patient has developed local recurrence or distant metastasis to date. In summary, this technique offers certain advantages that allow the operation to be done with more skill and safety in a narrow pelvis.

Adenocarcinoma↗
PubMed1989

A comparative study of polydioxanone (PDS) and polyglactin 910 (Vicryl) in colonic anastomoses in rats.

The use of polyglactin 910 (Vicryl) in colonic anastomoses is theoretically undesirable because its short dissolution time and multifilament structure may lead to local sepsis and anastomotic leakage. We have compared Vicryl with a newly introduced monofilament absorbable suture which has a longer dissolution time than Vicryl. In a study of 98 rat colonic anastomoses no difference was found in complication rates or cellular reaction to the suture material between Vicryl and polydioxanone (PDS). The use of monofilament suture with longer dissolution time does not necessarily imply added security for colonic anastomoses.

Anastomosis, Surgical↗
PubMed1990

[The surgical treatment of acromioclavicular joint separation with a resorbable PDS cord].

Osteosynthetic complications in surgery of acromioclavicular separations are common. Also, one more intervention is necessary for removing the metallic implants. Use of self-resorbing materials resolves such disadvantages. One more indirect surgical method is presented. After reposition of dislocated acromioclavicular joint and suture of the disrupted ligaments clavicula is fixed to the coracoid processus by a cord of polydioxanone (= PDS). Early postoperative mobilisation without risks is possible in cooperative patients. Self-resorbing implants don't modify the well known indications of conservative and operative treatment.

Absorption↗
PubMed1999

[Treatment of acromioclavicular joint separations. Central Kirschner- wire and PDS-augmentation].

Beside the basic question wether a separation of the acromioclavicular joint should be treated operatively or not, the method of operation is discussed in particular. For that reason we investigated our own method of a temporary transfixation of the joint by a centrally drilled K-wire combined with a PDS-augmentation of the coracoclavicular and a suture of the acromioclavicular ligament. Follow up examinations were possible in 57 out of 82 patients which were operated during 5 years. Patients subjective rating and objective follow up and sonographically evaluated joint conditions were scored together. Looking for the range of motion of the shoulder only 5.5% of the patients had a reduction of more than 20 degrees. Out of 12 complications in particular three infections only resulted satisfying by influencing the subjective rating negatively. In 28.1% of patients no durable anatomic reconstruction of the joint was achieved. Score achieved by these patients was significantly lower compared to those with a lasting anatomic reconstruction of the acromioclavicular joint. In conclusion the results confirm our operative regime for separations of the acromioclavicular joint. In literature survey the here described method of operation belongs to the better ones without showing a clear advantage. Nevertheless the method should be modified to decrease the rate of subluxations.

Acromioclavicular Joint↗
PubMed1987

Preclinical evaluation of PDS (polydioxanone) synthetic absorbable suture vs chromic surgical gut in urologic surgery.

A variety of suture materials are available for use in urologic surgery. Urologists have relied on absorbable suture materials which provide transient strength in anticipation that healing will occur before the suture is absorbed. Absorbable sutures thus decrease the chance of stone formation, known to occur on suture material in direct contact with the urinary stream. This report compares the breaking strength retention of polydioxanone (PDS) suture and chronic surgical gut after in vivo residence in the urinary bladder and subcutaneous tissue of the dog.

Animals↗
PubMed1988

Polydioxanone (PDS): a new material for internal suspension and fixation.

The use of the resorbable material Polydioxanone (PDS) as an alternative to stainless steel wire in the suspension and fixation of facial fractures and osteotomies is described. Evidence of the material's persistent strength in use is presented with a discussion of its advantages over stainless steel.

Bone Wires↗
PubMed2006

Clinical findings and PDS mutations in 15 patients with hearing loss and dilatation of the vestibular aqueduct.

Following systematic skull imaging of hundred and sixty seven individuals attending a medical referral centre for the deaf in Brussels, Belgium, fifteen patients (9 per cent) aged between two and 25 years were diagnosed with dilatation of the vestibular aqueduct. Careful audiological study, with a baseline assessment then longitudinal follow up, indicated mild to profound deafness with a progressive course (i.e. an average loss of 3.3 dB per year) and frequent dizziness. Sequencing of PDS was performed in all individuals. Alterations of this gene (either homozygous, heterozygous or compound heterozygous base changes) were found in 53 per cent of patients with a large vestibular aqueduct. Four new mutations (two missense, a splice site and a four base pair insertion) were described. We were unable to confirm a correlation between homozygosity, heterozygosity and a Pendred or deafness-only phenotype.

Adolescent↗
PubMed1996

Aqueous Solution Chemistry of the Mo(3)PdS(4) Cube: Substitution Reactions and the Double to Single Cube Interconversion Induced by CO, Two Phosphines, Cl(-), Br(-), and NCS(-).

The kinetics of conversion of an edge-linked double cube, in this case [{Mo(3)PdS(4)(H(2)O)(9)}(2)](8+), to the corresponding single cube [Mo(3)(PdX)S(4)(H(2)O)(9)](4+), has been studied for the first time. Reaction is induced by six reagents X = CO, two water-soluble phosphines, Cl(-), Br(-), and NCS(-), which complex at the tetrahedral Pd. The first stage of reaction is fast and is accompanied by color changes, e.g. purple to dark blue in the case of Cl(-), assigned as double to single cube conversion. With X = CO and the two phosphines, when absorbance changes are intense enough for stopped-flow monitoring with reactants at </=1 mM, rate constants 10(-)(5) k/M(-)(1) s(-)(1) at 25 degrees C are as follows: CO, 1.11; PTA, 27.8; P(C(6)H(4)SO(3))(3)(3)(-), 9.6; at I = 2.00 (Li(pts)). The reactions are independent of [H(+)] in the range 0.30-2.00 M, and no substitution at the Mo's is observed. The first stages with X = Cl(-), Br(-), and NCS(-) were too fast to monitor, but equilibrium constants K(1)/M(-)(1) were determined, Cl(-) (490), Br(-) (8040), and NCS(-) (630), by UV-vis spectrophotometry. Two subsequent kinetic stages are assigned to substitution at the Mo's. Similar behavior is observed for [Mo(3)FeS(4)(H(2)O)(10)](4+), which was selected because substitution at the Fe is also fast and there is no known double-cube formation. For both Mo(3)Pd and Mo(3)Fe the latter two stages can be explained by substitution at nonidentical (two alpha and one beta) H(2)O's on each Mo or by the presence of mixed-valent Mo(III)(2)Mo(IV) forms which are sufficiently long-lived to give a kinetic discrimination. In the case of NCS(-) an additional step, 0.015 s(-)(1), independent of [NCS(-)] is assigned to the isomerization Pd-NCS --> Pd-SCN. On removal of e.g. Cl(-) by chromatography or addition of Ag(+), the double cube re-forms.

Journal Article↗
PubMed2005

The PDS-XADS reference accelerator and its radioprotection issues.

At the start-up of the FP5 project PDS-XADS, the main initial specifications for the accelerator system (e.g. beam energy, beam intensity, beam profile, their stability and the accelerator availability and reliability) have been defined by Working Package 1 (WP1), 'Global Coherence', in connection with the other WPs of the project. From this, WP3 ('The Accelerator') has assessed the main requirements and the corresponding technical answers. A reference solution, based on a linear superconducting accelerator with its associated doubly achromatic beam line has been worked out to some detail. For high reliability, the proposed design is intrinsically fault tolerant, relying on highly modular 'de-rated' components associated with a fast digital feedback system. The proposed solution also appears to be robust in terms of operational aspects like maintenance and radioprotection. A programme for the remaining R&D required has been elaborated and is proposed within the FP6 project EUROTRANS.

Equipment Design↗
PubMed2004

Screening of SLC26A4 (PDS) gene in Pendred's syndrome: a large spectrum of mutations in France and phenotypic heterogeneity.

Sensorineural hearing defect and goiter are common features of Pendred's syndrome. The clinical diagnosis of Pendred's syndrome remains difficult because of the lack of sensitivity and specificity of the thyroid signs. The identification of PDS as the causative gene allowed molecular screening and enabled a re-evaluation of the syndrome to identify potential diagnostic characteristics. This report presents the clinical and genotypic findings of 30 French families, for whom a diagnosis of Pendred's syndrome had been made. Twenty-seven families had at least one mutated allele. Twenty-eight different mutations were identified, 11 of which had never been previously reported. The main clinical characteristics were: early hearing loss, fluctuation in terms of during deafness evolution, and the presence of an enlarged vestibular aqueduct.

Adolescent↗