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PubMed2004

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model.

OBJECTIVE: It has been suggested that subchondral bone remodeling plays a role in the progression of osteoarthritis (OA). To test this hypothesis, we characterized the changes in the rat anterior cruciate ligament transection (ACLT) model of OA and evaluated the effects of alendronate (ALN), a potent inhibitor of bone resorption, on cartilage degradation and on osteophyte formation. METHODS: Male Sprague-Dawley rats underwent ACLT or sham operation of the right knee. Animals were then treated with ALN (0.03 and 0.24 microg/kg/week subcutaneously) and necropsied at 2 or 10 weeks postsurgery. OA changes were evaluated. Subchondral bone volume and osteophyte area were measured by histomorphometric analysis. Coimmunostaining for transforming growth factor beta (TGF beta), matrix metalloproteinase 9 (MMP-9), and MMP-13 was performed to investigate the effect of ALN on local activation of TGF beta. RESULTS: ALN was chondroprotective at both dosages, as determined by histologic criteria and collagen degradation markers. ALN suppressed subchondral bone resorption, which was markedly increased 2 weeks postsurgery, and prevented the subsequent increase in bone formation 10 weeks postsurgery, in the untreated tibial plateau of ACLT joints. Furthermore, ALN reduced the incidence and area of osteophytes in a dose-dependent manner. ALN also inhibited vascular invasion into the calcified cartilage in rats with OA and blocked osteoclast recruitment to subchondral bone and osteophytes. ALN treatment reduced the local release of active TGF beta, possibly via inhibition of MMP-13 expression in articular cartilage and MMP-9 expression in subchondral bone. CONCLUSION: Subchondral bone remodeling plays an important role in the pathogenesis of OA. ALN or other inhibitors of bone resorption could potentially be used as disease-modifying agents in the treatment of OA.

Acid Phosphatase↗
PubMed1993

Appearances of posterior osteophytes after sound anterior interbody fusion in the cervical spine: a high-definition computed myelographic study.

Whether posterior osteophytes in the cervical spine resorb after anterior interbody fusion is controversial. Previous studies have only used plain films. In order to study remodelling, a retrospective study of 53 patients using high-definition CT was performed. There was no evidence of remodelling or resorption of osteophytes and persistent osteophytes continued to deform the spinal cord for up to 12 years after fusion. The importance of this in relation to cervical spinal surgery is that every effort should be made to remove posterior osteophytes during anterior interbody fusion.

Bone Remodeling↗
PubMed1989

Anterior cervical osteophytes as a cause of progressive dysphagia.

An uncommon cause of progressive dysphagia may be large cervical osteophytes impinging upon the cervical esophagus. Dysphagia may be due to the mechanical mass effect of a large anterior osteophyte, trapping the esophagus opposite a fixed point such as the cricoid cartilage, or a local inflammatory reaction resulting in cricopharyngeal spasm. We report three patients with progressive dysphagia due to large anterior cervical osteophytes. All three patients were treated with anterior cervical approach with removal of the osteophytes without fusion. A review of the literature in addition to the specific case histories, video fluoroscopic and radiographic findings are presented.

Aged↗
PubMed1989

Dysphagia due to cervical osteophytes: a controversial entity revisited.

Although cervical osteophytes have been reported to cause dysphagia, most remain clinically silent. A case of osteophytic dysphagia is reported in which an unusually large osteophytic ridge caused marked deviation and narrowing of the cervical esophagus. The subject of osteophytic dysphagia is reviewed.

Aged↗
PubMed2006

Pattern of osteophytes and enthesophytes in the proximal ulna: an anatomic, paleopathologic, and radiologic study.

OBJECTIVE: To develop a schematic segmentation of the proximal ulna in order to detect, assess the frequency, and characterize the bony outgrowths arising from the trochlea and from the radial notch of the ulna, to enable differentiation of osteophytes from enthesophytes. MATERIALS AND METHODS: Eighty well-preserved ulna specimens from the collection of the San Diego Museum of Man were analyzed by two musculoskeletal radiologists. The trochlea and the radial notch of the ulna simulate the shape of a clock quadrant. The proximal ulna was divided into 24 anatomic areas. The relationships of the joint capsule and insertions of tendons and ligaments onto these area were assessed by the two readers, and the resulting appearances of bony outgrowths were compared at visual inspection and on Radiographs. RESULTS: The interobserver visual comparison was good in 17 areas out of 24, but poor correlation was found in 7 areas. In one case, difficulties in differentiating osteophytes originating from the brachialis muscle/ tendon (area 9) from an enthesophyte originating from the capsule insertion on the coronoid process (areas 2 or 3) occurredand between two different enthesophytes in a further case. Five cases had difficulties in defining differences in the grading system of the outgrowths. The percentage of outgrowths observed in each of the areas was globally high, especially in areas 9 and 10. On radiographs it was possible to observe irregularities in ten areas; in eight at a threshold of height of 2 mm (areas 1-4, 9, 10, 11, 14) and in two at a threshold of height of 3 mm (areas 5, 6). The two readers had the same difficulties in differentiating enthesophytes from osteophytes at radiographic and visual examination. CONCLUSION: Our segmentation scheme is reproducible and objective, and permitted the differentiation of the bony outgrowths arising from the proximal ulna into osteophytes and enthesophytes, which may be particularly useful for the in vivo assessment of abnormalities seen in elbow overuse syndromes.

Humans↗
PubMed2006

Anterior cervical osteophytes causing dysphagia and dyspnea: an uncommon entity revisited.

Large anterior cervical osteophytes can occur in degeneration of the cervical spine or in diffuse idiopathic skeletal hyperostosis (DISH). We present the case of an 83-year-old patient with progressive dysphagia and acute dyspnea, necessitating emergency tracheotomy. Voluminous anterior cervical osteophytes extending from C3 to C7 and narrowing the pharyngoesophageal segment by external compression and bilateral vocal fold immobility were diagnosed radiologically and by fiberoptic laryngoscopy. Surgical removal of all osteophytes led to the resolution of symptoms. Dyspnea with or without dysphagia caused by hypertrophic anterior cervical osteophytes is an uncommon entity. The exhaustive diagnostic workup proposed in the literature could be simplified by using fiberoptic laryngoscopy and dynamic videofluoroscopy. The causes, treatment, and outcome are discussed.

Aged, 80 and over↗
PubMed1999

Posterior decompression of the vertebral artery narrowed by cervical osteophyte: case report.

BACKGROUND: Symptomatic vertebral artery compression caused by cervical spondylosis usually is caused by compression of the artery by osteophytes arising from the uncinate process. Compression from facet joint osteophytes is seldom reported. CASE DESCRIPTION: A 69-year-old male developed symptomatic vertebral artery stenosis secondary to an osteophyte arising from the superior facet of the sixth cervical vertebra posterior to the artery. A posterior decompression of the vertebral artery with removal of the offending facet joint complex relieved the patient's transient neurologic events. CONCLUSION: Symptomatic vertebral artery stenosis may be caused by osteophytes compressing the vertebral artery anteriorly from the uncinate process or posteriorly from the facet complex.

Aged↗
PubMed2002

Osteophyte impingement of the popliteus tendon as a cause of lateral knee joint pain.

Three cases of symptomatic popliteus tendon impingement on an osteophyte are presented. In only one case did the patient complain of a painful 'snapping' on flexing and extending the knee. Diagnosis was made when tenderness was elicited on palpating the osteophyte during flexion and extension with varus stress on the knee. It may be difficult to determine whether such a prominence represents an osteophyte or an exaggerated normal lower border of the popliteus groove. Two cases were successfully treated by arthroscopic excision of the osteophyte and the remaining case by resection of the popliteus tendon.

Adult↗
PubMed2003

Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte.

OBJECTIVES: To examine the localization of bone morphogenetic protein (BMP)-2 mRNA and protein in human osteoarthritic (OA) articular cartilage and osteophyte. DESIGN: Five normal, four growing and 14 OA human cartilage samples, graded histomorphologically by Mankin Score, were studied by in situ hybridization and immunohistochemistry for the expression of BMP-2. RESULTS: BMP-2 mRNA was present in chondrocytes in neonatal growing articular cartilage, but was scarcely present in normal adult articular cartilage. In OA articular cartilage, BMP-2 mRNA and protein were detected in both clustering and individual chondrocytes in moderately or severely damaged OA cartilage. In moderately damaged OA cartilage, BMP-2 mRNA was localized in both upper and middle zone chondrocytes, but was not detected in deep layer chondrocytes. In severely damaged OA cartilage, cellular localization of BMP-2 mRNA was extended to the deep zone. In the area of osteophyte formation, BMP-2 mRNA was intensely localized in fibroblastic mesenchymal cells, fibrochondrocytes, chondrocytes and osteoblasts in newly formed osteophytic tissue. The pattern of BMP-2/4 immunolocalization was associated with that of mRNA localization. CONCLUSIONS: BMP-2 mRNA and BMP-2/4 were detected in cells appearing in OA tissues. BMP-2 was localized in cells of degenerating cartilage as well as osteophytic tissue. Given the negative localization of BMP-2 in normal adult articular cartilage, BMP-2 might be involved in the regenerating and anabolic activities of OA cells, which respond to cartilage damage occurring in osteoarthritis.

Aged↗
PubMed1997

Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis.

The formation of chondro-osteophytes in osteoarthritic joints is a unique example of adult neochondrogenesis that bears some similarities to growth plate elongation and fracture callus formation. This study uses in situ hybridization histochemistry to define the molecular phenotype of cells in active chondro-osteophytes. Chondro-osteophytes are composed of fibrocytes and osteoblasts that express type I procollagen mRNA, mesenchymal prechondrochytes that express type IIA procollagen mRNA, and maturing chondrocytes that express type IIB procollagen mRNA. Based on the spatial pattern of gene expression and cytomorphology, the neochondrogenesis associated with chondro-osteophyte formation closely resembles that of healing fracture callus.

Animals↗
PubMedDate not supplied

Lumbar spine pain originating from vertebral osteophytes.

BACKGROUND AND OBJECTIVES: Axial spine pain originates from a number of structures. Putative pain generators include facet joints, intervertebral disks, sacroiliac joints, and myofascial structures. Osteophytes originating from lumbar vertebral bodies in the area of the intervertebral disks may be a source of nociceptive low back pain which may respond to local injection. METHODS: Five patients with axial low back pain unresponsive to traditional treatment modalities were treated with fluoroscopic guided injection of local anesthetic and corticosteroid near large intervertebral osteophytes. RESULTS: All 5 patients experienced relief. CONCLUSION: Vertebral osteophytes may be a source of axial spine pain. Injection of painful osteophytes with a local anesthetic and corticosteroid solution may produce pain relief.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Mechanical stress of osteophytes in the arthritic femur head].

Osteophytes of forty femoral heads with degenerative arthritis (dissecting room material) are investigated histologically and roentgenologically. The analysis of the covering cartilage and the cancellous bone structure supports the view that osteophytes are subject to pressing forces. It is discussed that osteophytes have an influence of the degree of stress in the joint. There are no morphological indications of a traction force acting upon the osteophytes.

Aged↗
PubMed1989

Cervical osteophyte induced dysphagia.

Although cervical spondylosis is a common disorder, dysphagia induced by osteophyte formation is uncommon. Fewer than one hundred cases of cervical osteophyte induced dysphagia have been reported, with little attention to the diagnosis by barium swallow. The radiological features of two cases treated surgically with good results are described. Both cases complained of dysphagia while one had associated respiratory obstruction on forward flexion of his neck. The features on barium study of cervical osteophytes causing dysphagia include deformity at the level of osteophyte formation, in both AP and lateral projections. Tracheal aspiration due to deformity at the laryngeal inlet and interference with epiglottic retroversion may be present.

Aged↗
PubMed1993

Relationship of osteophytes to bone mineral density and spinal fracture in men.

PURPOSE: To investigate the relationship of spinal osteophytes to vertebral bone mineral density (BMD) and to spinal fracture. MATERIALS AND METHODS: This relationship was investigated in 203 men. Integral BMD was measured with dual x-ray absorptiometry, and both cortical and trabecular BMD were measured with quantitative computed tomography (QCT). RESULTS: Trabecular BMD was found to decrease with age in subjects with and without large osteophytes, while cortical and integral BMD decreased with age only in subjects without large osteophytes. Trabecular BMD in men without fracture was significantly higher than in those with fracture (P < .05 for BMD measured with single-energy QCT), while there was no significant difference between these groups in cortical or integral BMD. CONCLUSION: Measurement of trabecular BMD with QCT provides information useful in detection of age-related bone loss and of fracture in men with and without osteophytes.

Absorptiometry, Photon↗
PubMed2004

Prevalence of spondylosis deformans and estimates of genetic parameters for the degree of osteophytes development in Italian Boxer dogs.

The aim of this study was to assess the prevalence of spondylosis deformans and to investigate genetic aspects of the degree of osteophytes development (DOD) in the Italian Boxer dog population. A total of 849 Boxer dogs was radiographed on the thoracic, lumbar, and sacral regions of the spine and scored for DOD. Grading of DOD was performed for all 20 intervertebral sites comprised within the first thoracic site (site T1-T2) and the site between the seventh lumbar and the first sacral vertebra (site L7-S1). Scores for DOD ranged from 0 (no osteophytes development) to 3 (presence of a bony spur formed by osteophytes on adjoining vertebrae). The first five thoracic sites exhibited no variation for DOD and were not considered in the analysis. The prevalence of spondylosis deformans was 84%, and frequency of dogs showing at least one intervertebral site that scored 3 for DOD was 50%. Scores for DOD at different sites were analyzed as different traits. Nongenetic effects influencing DOD scores were sex, age at screening, and the kennel. Posterior densities of heritability (h2) were estimated using a univariate Bayesian analysis. Eight sites exhibited a posterior probability greater than 0.8 for h2 > 10% and were considered in a multivariate restricted maximum likelihood analysis. Estimated h2 from multivariate analysis ranged from 25 to 48% (SE from 5 to 7%). Three sites exhibited h2 estimates greater than 40%. Genetic correlations for DOD scored at different sites ranged from 0.07 to 0.96. All thoracic sites had estimated correlations larger than 0.85 with other thoracic sites. Genetic correlation between the first and the second lumbar site was 0.91. Correlations between thoracic sites and the first two lumbar sites ranged from 0.5 to 0.9. Sites L6-L7 and L7-S1 also exhibited weak relationships with all remaining sites. Breeding values of dogs for DOD at the eight sites were predicted using estimated covariance matrices. A selection index for DOD was computed from predicted breeding values and a set of relative weighting factors produced by a panel of veterinarians. The index was the most important effect influencing phenotypic differences between dogs for average DOD score, number of affected sites, and number of sites with a DOD score > 1 (P < 0.001). The degree of osteophytes development is a trait showing exploitable additive genetic variance, and breeding programs for decreasing prevalence and severity of spondylosis deformans might focus on this trait.

Age Factors↗
PubMed2000

[Experimental study on effect of qishejingkang recipe on activity of alkaline phosphatases in osteophyte formation of degenerated cervical vertebrae of rabbits].

OBJECTIVE: To study the effect of Qishejingkang recipe (QSJKR) on activity of alkaline phosphatase (ALP) in osteophyte formation of degenerated cervical vertebrae. METHODS: A model of degenerated cervical vertebrae in the rabbit was established through resection of the cervical supraspinous and interspinous ligaments from the cervical spine elicited by surgical intervention. The sites of osteophyte was observed with a light microscope. The activity of ALP of the annuls fibrosis and nucleus pulpous, end-plate in each cervical spine was assayed with biochemical method respectively. RESULTS: Osteophyte come from end-plate, the activity of ALP in the degenerated end-plate in QSJKR group declined significantly compared with model group. CONCLUSION: QSJKR could decrease the activity of ALP in end-plate of degenerated cervical vertebrae and it might inhibit the formation of osteophyte.

Alkaline Phosphatase↗
PubMed1983

Ruptures of the supraspinatus tendon. The significance of distally pointing acromioclavicular osteophytes.

The association between distally pointing osteophytes of the acromioclavicular joint and ruptures of the supraspinatus tendon was investigated by two different methods. In a radiologic study, 47 images of shoulders with arthrographically confirmed supraspinatus tendon ruptures were reviewed and compared with 50 images of shoulders without ruptures. Fifty-one percent of the shoulders with supraspinatus tendon ruptures had osteophytes, as compared with 14% of the normal shoulders. A series of 170 autopsy specimens of the shoulder were also examined in detail; partial supraspinatus tendon ruptures were found in 32 and full-thickness ruptures in 22 shoulders. Fifty-four percent of the shoulders with supraspinatus tendon ruptures had distally pointing acromioclavicular osteophytes, as compared with 10% of the normal shoulders. Bony spurs of the anterior acromial process were also encountered, but they were less frequent than the acromioclavicular osteophytes.

Acromioclavicular Joint↗
PubMed1982

The reaction of cartilage and osteophyte formation after the intraarticular injection of papain.

A histological and autoradiographical study on the reaction of chondrocytes and the growing processes of osteophyte after the intraarticular injection of papain was carried out. The degenerating processes--fibrillation, death of chondrocytes and erosion--were observed as early as 1 day after the injection, and acid mucopolysaccharide staining with safranin-O was completely lost throughout the articular cartilage 1 week after the injection. The regenerating or proliferating figures--chondrocytes mitosis, thickening of fibrous tissue--were observed as early as 3 days after the injection and chondrocyte clusters were noted after 1 week of injection. Four weeks after injection, proliferating processes were more obvious than degenerating processes, safranin-O stainability had recovered and the proliferative figures of cartilage and fibrous tissue became more obvious. As blood vessels invaded into the cartilage and thickened fibrous tissue, osteophyte began to form in these tissues. Four types of growing processes of osteophyte were observed. Hypertrophy of articular cartilage was observed, and new hyaline articular cartilage appeared to be formed through metaplasia from fibrous tissue. Including the osteophyte formation, tremendous regenerating or repairing efforts of chondrocytes and fibroblasts were observed. These results appear to indicate that cartilage has some ability to regenerate and to repair itself if it could avoid further damage.

Animals↗