Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Observation”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources

Surface orientation from texture: ideal observers, generic observers and the information content of texture cues.

Perspective views of textured, planar surfaces provide a number of cues about the orientations of the surfaces. These include the information created by perspective scaling of texture elements (scaling), the information created by perspective foreshortening of texels (foreshortening) and, for textures composed of discrete elements, the information created by the effects of both scaling and foreshortening on the relative positions of texels (position). We drive a general form for ideal observers for each of these cues as they appear in images of spatially extended textures, (e.g. those composed of solid 2-D figures). As an application of the formulation, we derive a set of 'generic' observers which we show perform near optimally for images of a broad range of surface textures, without special prior knowledge about the statistics of the textures. Using simulations of ideal observers, we analyze the informational structure of texture cues, including a quantification of lower bounds on reliability for the three different cues, how cue reliability varies with slant angle and how it varies with field of view. We also quantify how strongly the reliability of the foreshortening cue depends on a prior assumption of isotropy. Finally, we extend the analysis to a naturalistic class of textures, showing that the information content of textures particularly suited to psychophysical investigation can be quantified, at least to a first-order approximation. The results provide an important computational foundation for psychophysical work on perceiving surface orientation from texture.

Cues↗

Reactivity to home observation: a comparison of audio recorded behavior with observers present or absent.

THE STUDY COMPARED THE BEHAVIOR OF FAMILY MEMBERS AT HOME AS RECORDED BY AUDIOTAPE RECORDINGS IN TWO CONDITIONS: with an observer present or absent. Behavioral differences were expected as a function of differential reactivity to these observational procedures, but none was found, and there was no evidence of adaptation effects in either condition. In general, significant positive correlations were obtained between the rates of recorded behavior in both situations. The implications of these findings for the development of nonreactive observation procedures were discussed.

Journal Article↗

[Response uncertainty on rule learning by observation: effects of pre-experience on observational learning].

The present study was conducted to examine the hypothesis that children's feelings of uncertainty would mediate between pre-experience and rule acquisition in observational learning. After received a pretest, subjects were requested to estimate their response uncertainty concerning a task used in the pretest. Then they observed a model responding to a series of pictures each of which depicting one of four directions. The model's responses were governed by a rule consisted of two dimensions: the progression and the direction. After observing the demonstration, subjects received two post-tests which differed in the order of stimulus presentation and in terms of the reinforcement. Subjects enhancing their feelings of uncertainty in the pretest phase acquired a rule which contained a dimension of the progression, while subjects who did not enhance them acquired a rule used by the model. These findings were interpreted as generally supporting the hypothesis of response uncertainty as a mediator of rule learning.

Biofeedback, Psychology↗

A new method using medical ultrasound for measuring femoral anteversion (torsion): technique and reliability. An intra-observer and inter-observer study on dried bones from human adults.

The purpose of this study was to evaluate an ultrasound method on dried femora to decide if it is sufficiently reliable to consider its application to living subjects in health and disease. It reports the application of a standard static image B-mode ultrasound scanner to measure femoral anteversion (strictly torsion) on dried bones. The method involves creating images of bony surface contours at both the upper and the lower ends of the femur placed in a water bath. The calculation of femoral torsion involves measuring the angular difference between a head-neck line at the upper end and a transcondylar line at the lower end of the femur. This approach, using the surface contour of the bone at the upper end of the femur, is similar to that used by Lange & Pitzen (1921) and differs from conventional ways of measuring anteversion in dried bones using a central femoral head-neck axis. It is shown that in ultrasound scanning of the upper end of the dried femur to measure femoral anteversion, the head-neck line must be at, or rostral to, the base of greater trochanter. The intra- and inter-observer reliability was assessed in 10 femora, each scanned ten times by two observers. It is shown that femoral torsion can be measured by the ultrasound method to an accuracy of +/- 2 degrees (95% confidence limits) without a significant difference between the observers. The ultrasound method is compared with a new mechanical method for creating surface contours at both ends of the femur and found not to be statistically different in 37 femora. Two real-time ultrasound methods reported by other workers for measuring femoral anteversion in dried bones are reviewed. It is suggested that in applying ultrasound to measure femoral anteversion in living subjects, the B-mode static image scanner is superior to the use of real-time scanners.

Adult↗

Observations on structural features and characteristics of biological apatite crystals. 7. Observation on lattice imperfection of human tooth and bone crystals II.

In a series of studies to investigate the structural features of the biological crystal, such as the tooth and bone, using an electron microscope, we examined the ultrastructure of the human enamel, dentin, and bone crystals at near atomic resolution and showed the configuration of the hydroxyapatite structure through the cross and longitudinal sections of the enamel, dentin, and bone crystals. Subsequently, based on the results of our observations of the ultrastructure of the tooth and bone crystals, we attempted to clarify the essential structural features and characteristics of the lattice imperfections in the hydroxyapatite structure composing of the human enamel, dentin, and bone crystals from the morphological viewpoint. Therefore, using the same approach, we examined the images of the lattice imperfection of the normal human enamel, dentin, and bone crystals. In this report, following the previous observation of the lattice imperfection on the point defect structure and the dislocations appearing in the inner structure of the crystal, we describe the image of the face defect structure obtained by using the same approach from the sections of the human enamel, dentin, and bone crystals, such as the stacking fault, grain boundary, and others. The materials used for this study were the human enamel, dentin, and bone crystals. The small cubes of the material were fixed in glutaraldehyde and osmium tetroxide and embedded in epoxy resin using the routine methods. The ultrathin sections were cut with a diamond knife without decalcification. The sections were examined with the HITACHI H-800 H and H-9000 type transmission electron microscopes operated at 200 kV and 300 kV respectively. Each crystal was observed at an initial magnification of 300,000 times and at a final magnification of 10,000,000 times and over. We sincerely believe that the electron micrographs shown in this report are the first to show the images of the lattice imperfections from the sections obtained from the hydroxyapatite crystal composing of the human enamel, dentin, and bone tissue, such as the grain boundary, stacking fault, and others, at near atomic resolution.

Bone and Bones↗

Observations on structural features and characteristics of biological apatite crystals. 4. Observation on ultrastructure of human bone crystals.

In a series of studies to investigate the structural features of the biological crystals such as the tooth and bone, following the previous observations of the tooth crystal using an electron microscope, we examined the ultrastructure of the human bone crystals at near atomic resolution through the cross and longitudinal sections of the crystals. The materials used for this study were the normal bone tissue obtained from the buccal alveolar compact bone of the human mandible in the portion of the lower first molar. The small cubes of the bone tissue were fixed in glutaraldehyde and osmium tetroxide and embedded in epoxy resin using the routine methods. The ultrathin sections were cut with a diamond knife without decalcification. The sections were examined with the HITACHI H-800 type transmission electron microscope operated at 200 kV. Each crystal was observed at the initial magnification of 300,000 times and at the final magnification of 10,000,000 times and over. Using this approach, we showed the configuration of the hydroxyapatite structure in the cross and longitudinal sections of the bone crystals deposited within and between the collagen fibrils (intrafibrillar and interfibrillar crystals) in the bone tissue. Furthermore, using the same approach, we observed the crystal lattices of the hydroxyapatite structure appearing in the cross and longitudinal sections. We sincerely believe that the electron micrographs shown in this report are the first atomic images from the section obtained from the hydroxyapatite crystal from the human alveolar bone.

Alveolar Process↗

Pavlovian George Windholz (1931-2002): an exemplar of scholarly "observation and observation" and a critical contributor to psychology, and hence to behavioral neuroscience.

Although most members of the Pavlovian Society properly focus their efforts on empirical research, the scholarly, critical conceptual contributions of some individuals are also relevant to progress in psychology and behavioral neuroscience. This paper discusses the contributions of the late George Windholz (often in collaboration with Peter Lamal) as: (a) a historian of Pavlov's life and work; (b) an analyst of priority issues in psychology as a science; (c) a refuter of myths perpetrated by psychology texts. These contributions provide an example of the scholarly form of the motto "observation and observation," where the data used to test hypotheses comprise original documents (often in languages other than English) examined by the historian's critical eye.

Animals↗

The impact of observer and patient factors on the occurrence of digit preference for zero in blood pressure measurement in a hypertension specialty clinic: evidence for the need of continued observation.

BACKGROUND: Many investigators have reported unconscious over-reporting of the terminal digit zero but little literature exists on observer or patient-related factors that may predict the occurrence. This study analyzes the occurrence of zero preference in 52,827 blood pressure (BP) measurements in 8513 patients by 11 hypertension nurse specialists in the Hypertension Division at Mayo Clinic, Rochester, Minnesota. METHODS: Data from the electronic database of the Hypertension Division from April 1997 to September 2001 were analyzed for the occurrence of zero preference. Nurse-specific zero preference was stratified on four variables: number of BPs performed, years as hypertension nurse specialist, time of day BP performed (fatigue), and nursing degree. Three patient-specific factors were analyzed: age at visit (stratified by decade), type of care (continuing versus short-term), and hypertension status. RESULTS: We found significantly increased frequency of zero preference for all BPs with mean frequency of 31% v 20% expected (P < .0001). Individual nurse zero preference varied widely, 22.0% to 53.6% for systolic BP and 22.2% to 40.8% for diastolic BP). Continuing care patients had a higher zero preference than did short-term care patients for both systolic BP (34.5% v 30.2%; P < .0001) and diastolic BP (34.7% v 33.3%; P = .006). Zero preference was also more common at higher categories of hypertension (P < .001). Time of day, nursing degree, patient age, the number of BPs performed, years of service did not affect the occurrence of digit preference. CONCLUSIONS: Digit preference was demonstrated and varied significantly among well-trained hypertension nurse specialists. Further studies in a larger number of observers are required.

Adult↗

Genetic and environmental influences on observed personality: evidence from the German Observational Study of Adult Twins.

Previous behavior-genetic research on adult personality relied primarily on self-reports or peer reports that may be subject to contrast effects, resulting in biased estimates of genetic and environmental influences. In the German Observational Study of Adult Twins (GOSAT), personality traits of 168 monozygotic (MZ) and 132 dizygotic (DZ) twin pairs were rated on 35 adjective scales, largely markers of the Big 5. The ratings were provided by 120 judges who never met the twins but observed videotaped behaviors of 1 twin of each pair in 1 of 15 different settings. The aggregated video-based trait ratings were highly reliable, and substantial correlations were obtained between MZ as well as DZ twins. Model-fit analyses suggested about 40% genetic, 25% shared environmental, and 35% nonshared environmental influence. Extraversion was the only trait that seemed not to be influenced by shared environment.

Adult↗

Medullary carcinoma of the breast, proposal for a new simplified histopathological definition. Based on prognostic observations and observations on inter- and intraobserver variability of 11 histopathological characteristics in 131 breast carcinomas with medullary features.

In a previous study of 131 breast carcinomas with medullary features, we evaluated the diagnostic inter- and intraobserver variation and its prognostic implications using the criteria of typical (TMC) and atypical (AMC) medullary carcinoma of the breast put forward by Ridolfi et al. (1977). We found a considerable interobserver variation as well as intraobserver variation, with significant implication on prognosis, and concluded that the histopathological definition of MC must be sharpened and simplified in order to increase the diagnostic reproducibility. In the present study of the same population of 131 patients with breast carcinomas with medullary features we have examined inter- and intraobserver variation concerning 11 histopathological characteristics. Furthermore, we have analysed the prognostic importance of these 11 histopathological features, and the prognostic implications of the observed inter- and intraobserver variation. Based on the observations, we have eliminated criteria with poor inter-/intraobserver agreement as well as those implying no or minimal impact on the prognosis. We propose a new simplified histopathological definition of medullary carcinoma of the breast (MC), retaining reproducible, prognostically significant criteria (syncytial growth pattern and diffuse, moderate or marked mononuclear infiltration). The prognosis of MC, based on this definition, is significantly better than those of infiltrating ductal carcinomas grade II + III.

Breast Neoplasms↗

MR imaging of large multinodular goiters: observer agreement on volume versus observer disagreement on dimensions of the involved trachea.

OBJECTIVE: MR imaging and sonography are considered to be among the most reliable methods available for estimating goiter volume. Our aim was to assess the observer variability of MR imaging for estimating the volume of a large multinodular goiter and the dimensions of the related trachea. Additionally, we compared the goiter volume estimates from MR imaging with those from sonography. SUBJECTS AND METHODS: The effect of high-dose (131)I therapy on the thyroid gland and the impact on the trachea in 23 patients with a large multinodular goiter (range in volume, 100-703 mL) were monitored by observers unaware of duplicated measurements on MR imaging (n = 68) before, 1 week after, and 1 year after (131)I therapy. In goiters exclusively cervically located (n = 12), cross-sectional planimetric sonographic measurements (n = 24) were performed simultaneously with MR imaging. RESULTS: The mean intraobserver difference for the MR imaging measurements of goiter volume was 2.1 mL (1.4%, p = 0.32), and the coefficient of variation (CV) +/- SD was 3.6% +/- 2.6%. The mean interobserver difference was 0.4 mL (0.3%, p = 0.86), and the CV +/- SD was 4.1% +/- 3.5%. Compared with MR imaging, sonography underestimated goiter volume; the mean percentage difference between the volume estimates on MR imaging and those on sonography (volume estimated on MR imaging - volume estimated on sonography) was 19.5% (95% limits of agreement: -22.2% to 83.7%), and the CV +/- SD was 15.0% +/- 12.4%. The mean interobserver difference in the MR imaging measurement of tracheal volume along the goiter extension was 7.4% (95% confidence interval: 4.0-10.8%) and that of the smallest cross-sectional area of the trachea was 7.9% (95% confidence interval: 2.9-13.2%). The corresponding CV +/- SD were 8.1% +/- 6.6% and 10.3% +/- 10.3%, respectively. CONCLUSION: For the estimation of goiter volume, MR imaging has low intra- and interobserver variations. In contrast, the determination of tracheal dimensions using MR imaging has a high variability and, thus, is imprecise. Sonography significantly underestimates thyroid volume compared with MR imaging in patients with a large goiter.

Adult↗

Observation of idiopathic full-thickness macular holes. Follow-up observation.

OBJECTIVES: To evaluate the long-term follow-up observation of idiopathic full-thickness macular holes, with emphasis on the incidence and process of disappearance. METHODS: The authors followed up 97 eyes with idiopathic full-thickness macular holes for a period ranging from 2 to 182 months (average, 66 months). RESULTS: Apparent disappearance of the hole was observed in six eyes. Although improvement in visual acuity of at least 2 lines resulted in all six eyes, visual acuity improved to 20/30 or better in those eyes in which macular holes disappeared within 24 months of the initial examination. CONCLUSION: The incidence of apparent disappearance of idiopathic full-thickness macular holes was low. Improvement in visual acuity was greater in those cases in which macular holes disappeared in a relatively short period of time.

Aged↗

Sensitivity to change of the health assessment questionnaire (HAQ) and other clinical and health status measures in rheumatoid arthritis: results of short-term clinical trials and observational studies versus long-term observational studies.

To obtain evidence concerning short-term and long-term efficacy of clinical and health status measures in rheumatoid arthritis (RA), we conducted two observational studies--a 6-month study of 233 patients receiving methotrexate and a 10-year study of 157 patients receiving multiple treatments in a rheumatic disease clinic. Results of the 6-month study yielded effect sizes for treatment similar to the meta-analyses reported by Felson [corrected] et al. (Arthritis Rheum 33:1449-1461, 1990) and the controlled trials of methotrexate reported by Weinblatt et al. (Arthritis Rheum 33:330-338, 1990), suggesting that observational studies provide valid measurements of treatment effect. The effect size for the Health Assessment Questionnaire (HAQ) was 0.5. By contrast, the 10-year study suggested that standard clinical variables changed little and were not useful in assessing RA outcome, while the effect size of the HAQ was -2.39. These data continue to underscore the differences between short-term trials and the long-term outcome of RA, and suggest an important place for the HAQ or similar instruments in all phases of RA evaluation and assessment.

Arthritis, Rheumatoid↗

Autism diagnostic observation schedule: a standardized observation of communicative and social behavior.

The Autism Diagnostic Observation Schedule (ADOS), a standardized protocol for observation of social and communicative behavior associated with autism, is described. The instrument consists of a series of structured and semistructured presses for interaction, accompanied by coding of specific target behaviors associated with particular tasks and by general ratings of the quality of behaviors. Interrater reliability for five raters exceeded weighted kappas of .55 for each item and each pair of raters for matched samples of 15 to 40 autistic and nonautistic, mildly mentally handicapped children (M IQ = 59) between the ages of 6 and 18 years. Test-retest reliability was adequate. Further analyses compared these groups to two additional samples of autistic and nonautistic subjects with normal intelligence (M IQ = 95), matched for sex and chronological age. Analyses yielded clear diagnostic differences in general ratings of social behavior, specific aspects of communication, and restricted or stereotypic behaviors and interests. Clinical guidelines for the diagnosis of autism in the draft version of ICD-10 were operationalized in terms of abnormalities on specific ADOS items. An algorithm based on these items was shown to have high reliability and discriminant validity.

Adolescent↗

Observations on a model of the biology of carcinoma of the cervix: a poor fit between observation and theory.

The role of the mathematical model is to express the biological theory in the form of a set of numerical predictions which can be reconciled with data. We have fitted the model implicit in current theory, and the predictions from that do not fit the observed facts. Either the theory or the observed facts (or both) are wrong. If the facts are right, then our final model (Model II) points to the changes in the theoretical concept which are necessary. Increasing conversion from carcinoma in situ to invasive carcinoma with age must be accepted and explained. The fall in prevalence of dysplasia and carcinoma in situ before the major onset of invasive cancer must be fully appreciated and explained. The regression of carcinoma in situ to dysplasia or normal in large numbers must be accepted and explained either biologically or by error in categorization, or both.

Adult↗

The role of visual monitoring in observational learning of action patterns: making the unobservable observable.

The present experiment tested the hypothesis that concurrent visual feedback enhances observational learning of a novel action pattern that normally would be unobservable. Subjects repeatedly enacted a modeled action pattern with visual monitoring of their reproductions throughout enactments, during only early or late phases of enactment, or not at all. At periodic intervals the adequacy of their conception of the modeled pattern was also measured. Visual feedback during ongoing performance enhanced accurate reproduction of the modeled pattern; the facilitative effect was most pronounced for reproduction of complex response components. The superiority of subjects who had enacted these difficult response components with visual feedback was maintained even when both the model and feedback were withdrawn. Visual feedback did not facilitate accurate enactment of the modeled pattern before development of an adequate cognitive representation of it. The results support the social learning view that observationally-learned behaviors are cognitively represented and that visual monitoring serves to decrease discrepancies between conception and action.

Journal Article↗

The home observation assessment method (HOAM): real-time naturalistic observation of families in their homes.

The Home Observation Assessment Method (HOAM) is a new method developed to carry out objective coding of family interaction over extended time periods in a home setting. It is a computer-compatible coding system that permits on-line data reduction of interactional variables emphasizing contextual and structural dimensions of family behavior. To date, the HOAM has been applied to the study of 31 families observed for a total of over 250 sessions. Initial analysis of data from these sessions indicates that coder reliability is high and that the HOAM successfully measures dimensions of family behavior independent of architectural aspects of the home setting. Preliminary findings also indicate that although families differ dramatically along the interactional dimensions measured by the HOAM, all families studied spent remarkably little time in decision-making behavior, suggesting that behavior in the home is predominantly "maintenance-oriented."

Child↗

Observer efficiency and weights in a multiple observation task.

A sequence of seven tones, sampled from one of two distributions differing in mean frequency, is presented to observers who try to report which distribution was sampled. Estimates are obtained of the weight or importance given to each tone as a function of its temporal position. In five experiments, the reliability of the information is varied by changing the variance of the distributions; tones with high reliability are sampled from distributions with relatively small variance, whereas tones with low reliability are sampled from distributions with relatively large variance. Results show that the observations are weighted more efficiently when the tones have equal rather than unequal reliability, and when the most reliable tones have the greater intensity. Additional results show that the most intense tones often receive the greatest weight, even when those tones have the least reliability.

Adult↗