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Meditations on the new space vision: the Moon as a stepping stone to Mars.

The Vision for Space Exploration invokes activities on the Moon in preparation for exploration of Mars and also directs International Space Station (ISS) research toward the same goal. Lunar missions will emphasize development of capability and concomitant reduction of risk for future exploration of Mars. Earlier papers identified three critical issues related to the so-called NASA Mars Design Reference Mission (MDRM) to be addressed in the lunar context: (a) safety, health, and performance of the human crew; (b) various modalities of mission operations ranging surface activities to logistics, planning, and navigation; and (c) reliability and maintainability of systems in the planetary environment. In simple terms, lunar expeditions build a résumé that demonstrates the ability to design, construct, and operate an enterprise such as the MDRM with an expectation of mission success. We can evolve from Apollo-like missions to ones that resemble the complexity and duration of the MDRM. Investment in lunar resource utilization technologies falls naturally into the Vision. NASA must construct an exit strategy from the Moon in the third decade. With a mandate for continuing exploration, it cannot assume responsibility for long-term operation of lunar assets. Therefore, NASA must enter into a partnership with some other entity--governmental, international, or commercial--that can responsibly carry on lunar development past the exploration phase.

Aerospace Medicine↗

Applied superconductivity and superfluidity for the exploration of the Moon and Mars.

We discuss how superconductivity and superfluidity can be applied to solve the challenges in the exploration of the Moon and Mars. High sensitivity instruments using phenomena of superconductivity and superfluidity can potentially make significant contributions to the fields of navigation, automation, habitation, and resource location. Using the quantum nature of superconductivity, lightweight and very sensitive diagnostic tools can be made to monitor the health of astronauts. Moreover, the Moon and Mars offer a unique environment for scientific exploration. We also discuss how powerful superconducting instruments may enable scientists to seek answers to several profound questions about nature. These answers will not only deepen our appreciation of the universe, they may also open the door to paradigm-shifting technologies.

Aerospace Medicine↗

Sicily or the Sea of Tranquility? Mapping and naming the moon.

In their race to provide the ultimate guide to the moon, two 17th-century astronomers proposed lunar maps and nomenclatures that they hoped would gain international currency. But the names we use today were those proposed by the Jesuit, a friend of Galileo's persecutors, in a book whose purpose was to refute the Copernican system once and for all. We now believe that Riccioli was wrong about the universe, but why do we still use his nomenclature? The keys to this foundational visual debate in astronomical image-making are the moon maps themselves.

Extraterrestrial Environment↗

The influence of the full moon on seizure frequency: myth or reality?

To investigate a possible relationship between seizure frequency and the lunar cycle, we reviewed the occurrence of seizures recorded in our epilepsy monitoring unit over a 3-year period. Analysis of the total number of seizures (epileptic plus nonepileptic) showed no significant association. A separate analysis revealed that for nonepileptic seizures, there was an increase at the full moon, and for epileptic seizures, an increase in the last quarter. We conclude that there is no "full moon" effect on seizures as a whole, although there is a possible effect on nonepileptic seizures.

Chi-Square Distribution↗

Retinal and neurologic findings in the Laurence-Moon-Bardet-Biedl phenotype.

The nosology of the Laurence-Moon and Bardet-Biedl syndromes has been controversial. Presented is a patient with polydactyly, retinopathy, ataxia, low-average intellectual function, and obesity. These features constitute a composite of both syndromes and reflect the clinical heterogeneity that may be seen. Accordingly, the authors suggest the use of the term "Laurence-Moon-Bardet-Biedl phenotype" until these syndromes can be defined in some other manner. The neuroradiologic studies document atrophy of the cerebellum that accounts for the ataxia. Electroretinograms (ERG) demonstrate the decline in retinal function over a 16-year interval and the delayed cone ERG b-wave implicit time with normal cone amplitudes to 30 Hz white flicker that can exist in the early stage of this disorder.

Adult↗

[Effect of the moon on the nocturnal postnuptial migration of the skylark Alauda arvensis L. in France].

Night-migrating skylarks (Alauda arvensis) were captured during four successive autumns in France. The study aimed at detecting a possible influence of the lunar cycle on the nocturnal migration of this species. Though nocturnal postnuptial migration of the skylarks can occur during every phase of the moon, main nocturnal movements occurred when the moon was in its waxing gibbous phase. This phase gives the best conditions for migration because from the very beginning of night, it provides the necessary horizon for individuals to navigate and its light allows the use of topographic cues. In addition it allows the species to benefit from optimal conditions of illumination for almost a week.

Animals↗

The spectrum of renal disease in Laurence-Moon-Biedl syndrome.

To determine the nature, extent, and severity of renal involvement in Laurence-Moon-Biedl syndrome (obesity, mental retardation, polydactyly, hypogonadism, and pigmented retinal dystrophy), we evaluated 20 of 30 patients with the disorder identified from ophthalmologic records in Newfoundland. The mean age was 31 years, and seven were male. All 20 patients had structural or functional abnormalities of the kidneys or both. Three had end-stage renal disease, with two requiring maintenance hemodialysis. The remaining 17 patients had normal serum creatinine values and estimated creatinine clearances. Half the subjects had hypertension. Fourteen of 17 patients could not concentrate urine above 750 mOsm per kilogram of body weight even after vasopressin, whereas all 10 normal controls could. Urinary pH decreased below 5.3 after ammonium chloride administration in all 15 normal controls, but in only 13 of 18 patients. Calyceal clubbing or blunting was evident in 18 of 19 patients studied by intravenous pyelography; 13 patients had calyceal cysts or diverticula. Seventeen of 19 patients had lobulated renal outlines of the fetal type. Four patients had diffuse renal cortical loss, but only two of these had renal insufficiency. We conclude that Laurence-Moon-Biedl syndrome includes the presence of renal abnormalities.

Adolescent↗

Why is the moon white?

Land's Retinex theory is used to explain why we perceive the colour of the moon as white. The lightness values of coloured areas are computed and the energy at the particular area (moon) is compared with the surrounding area (space-vacuum).

Color↗

World cup soccer players tend to be born with sun and moon in adjacent zodiacal signs.

The ecliptic elongation of the moon with respect to the sun does not show uniform distribution on the birth dates of the 704 soccer players selected for the 1998 World Cup. However, a uniform distribution is expected on astronomical grounds. The World Cup players show a very pronounced tendency (p = 0.00001) to be born on days when the sun and moon are in adjacent zodiacal signs.

Astrology↗

Renal histopathological changes in a child with Laurence-Moon-Biedl syndrome.

This report describes a case of Laurence-Moon-Biedl syndrome identified in a 24-month-old boy. Significant renal involvement was present with right-sided vesicoureteral reflux, cystocele, urinary tract infections, and growth arrest of the right kidney. After the development of hypertension a left renal biopsy was performed to determine if bilateral renal disease was present. Histopathological and ultrastructural changes in the left kidney are described. These changes appear to be unrelated to pyelonephritis or hypertension and to be most consistent with the nephropathy of Laurence-Moon-Biedl syndrome.

Humans↗

Glomerulonephropathy of Laurence-Moon-Biedl syndrome.

A patient with Laurence-Moon-Biedl syndrome and nephrotic range proteinuria is presented. Radiological investigation of the urinary tract revealed clubbed calyces but no evidence of obstruction or vesicoureteric reflux. Renal biopsy revealed occasional sclerotic glomeruli, extensive foot-process fusion and segmental glomerular basement membrane abnormalities with negative immunofluorescence for immunoglobulins and complement. Nephrotic proteinuria responded to steroid therapy but mild proteinuria persisted. The findings were consistent with minimal change nephropathy superimposed on the glomerular lesions of Lawrence-Moon-Biedl syndrome.

Adult↗

Moon illusion simulated in complete darkness: planetarium experiment reexamined.

In 1962, Kaufman and Rock reported that the moon illusion did not occur in the darkness of a planetarium or in a completely dark room. The present study reexamined their findings. Two pairs of light points, separated by 3.5 degrees, were presented on the dome screen of a planetarium. Subjects compared the distance between the two light points presented in the horizontal direction with the distance between the two light points at the zenith. Three illumination conditions were used: The inside of the planetarium was completely dark, was lighted, or was projected with the silhouette of a city under a starry sky. The effect of eye elevation on the illusion was also examined. Contrary to Kaufman and Rock's results, a size discrepancy comparable to the moon illusion was obtained in the horizon-and-stars condition and even in the complete-darkness condition. Little or no illusion was obtained in the lighted-room condition. The results also showed that eye elevation affected the magnitude of the illusion.

Cues↗

Lunacy revisited. The influence of the moon on mental health and quality of life.

The idea that the stars and planets may influence human health and behavior can be traced to at least Roman times, and research suggests a high proportion of health professionals continue to hold this belief. Nevertheless, evidence for the supposed influence of the moon on human behavior has proved particularly elusive, and research has tended to suffer from weaknesses in methodology and data analysis. This article reports findings drawn from a re-analysis of data from a research study into the functioning of a sample of mentally ill people living in the community. The mental health and quality of life of a sample of 100 people were assessed on four occasions during a 30-month period. Data were aggregated to represent the span of one lunar month, with scores being allocated to the relevant week of the lunar cycle during which each assessment was made. Comparison of mean values across the weeks of the lunar cycle was preformed using the ANOVA, Results showed significant change at the time of the full moon only in subjects with a diagnosis of schizophrenia (n = 56), where deterioration was observed in three areas of psychopathology and one area of quality of life. Some implications for nursing practice are discussed, and it is suggested that future research into the possibility of a lunar effect on human life should focus on the direct measurement of functioning in people with schizophrenia.

Analysis of Variance↗

W.W.W. MOON? The why, what and when of a permanent manned lunar colony.

Several reasons for going back to the Moon are listed: scientific study of our natural satellite, Earth and in general the Solar System; exploitation of the resources of Outer Space; geopolitical considerations that made Apollo possible and are still valid in the long term; advancement of manned spaceflight, as robot-based exploration is time-wise inefficient and politically negligible. Technological, organisational and legal challenges are then outlined. After a discussion of human physiology, building materials and transportation of people and goods, an underground polar location is proposed as settlement site, either within kilometre-size lava tubes or man-made caves. An analysis of spaceflight history is conducted to determine a target date for returning to the Moon to stay. In the absence of political or commercial competition, experience indicates the last decades of the XXI century. To shorten this timescale, it is recommended to focus on accomplishing the task of establishing a reliable lunar travel and settlement system, rather than developing new technologies: simplifying the goals of each single step forward (as was the case of the Clementine mission) and concentrating on production-ready (or almost-ready) equipment (compare the ill-fated X-33 to the dependable Soyuz capsules).

Astronomical Phenomena↗

[Laurence-Moon-Biedl syndrome associated with tertiary hypothyroidism. A case report].

The Laurence-Moon-Biedl syndrome is characterized by retinitis pigmentosa, obesity, psychic disturbances, polydactily and hypogonadism. Renal involvement is also a frequent finding and renal failure may be fatal for the patient. On the basis of the consanguinity and the familiarity of this syndrome. R.C., a 47 years old male, with cardiovascular failure and marked psychic sleepiness has been studied. The patient showed the full picture of this syndrome. The thyroid function has been studied and, TT4, TBG, rT3, TSH, TRH stimulation test, antimicrosomial antitireoglobulin antibodies were found within normal limit. On the other hand TT3, FT3, FT4 and 131-I thyroid captation showed a clear hypothyroidism picture. In this connection, on L-T4 administration, infect there was a complete recovery of the symptoms. This picture may confirm the hypothesis of a hypothalamic disfunction in the Laurence-Moon-Biedl syndrome.

Adult↗

Laurence-Moon-Bardet-Biedl syndrome: electrophysical and psychophysical findings.

Four cases of Laurence-Moon-Bardet-Biedl syndrome were studied through electrophysiological and psychophysical examinations, and findings were correlated with those of fluorescein angiography. In all cases the macula showed degenerative changes, including a bull's eye appearance. The fundus periphery could be devoid of clumps of pigmentation, but all cases showed profound functional abnormalities that affected the macula and the periphery, impairing both the cone and rod systems equally. Bull's eye macula associated with severe, diffuse functional abnormality of the macula and peripheral retina, along with obesity and mental retardation, help establish the diagnosis of Laurence-Moon-Bardet-Biedl syndrome.

Adolescent↗

Laurence-Moon-Biedl syndrome: report of two cases.

The Laurence-Moon-Biedl syndrome is characterized by features of familial occurrence, retinitis pigmentosa, obesity, polydactyly, hypogenitalism and mental retardation. Recently, several reports have suggested renal abnormalities as an additional cardinal feature of the syndrome. We present two cases of this syndrome from two different families. The first case was an obese eight-year-old girl with poor vision and signs of mental retardation beginning at four months of age. An intravenous urogram showed dilatation of the minor calyces of both kidneys. Genital agenesis and typical retinitis pigmentosa on fundal examination all supported the diagnosis of Laurence-Moon-Biedl syndrome. The patient's father and grandmother also had symptoms of poor vision, mental retardation and obesity. The second case was an obese 14-year-old girl with blurred vision and severe mental retardation noticed at two to three months of age. Fundi showed typical retinitis pigmentosa. She also had genital agenesis but no significant family history.

Adolescent↗

[The Laurence-Moon-Bardet-Biedl syndrome].

The Laurence-Moon-Bardet-Biedl syndrome consists of: retinitis pigmentosa, adiposo-genital dystrophy, syndactyly, mental retardation. It is presented a patient with atypical retinitis pigmentosa--unilateral, sectorial and hypopigmentary form, as part of the Laurence-Moon-Bardet-Biedl syndrome.

Adolescent↗