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Behavior of bone mass measurements. Dual energy x-ray absorptiometry total body bone mineral content, ultrasound bone velocity, and computed metacarpal radiogrammetry, with age, gonadal status, and weight in healthy women.

RATIONALE AND OBJECTIVES: Bone mass as measured by dual energy x-ray absorptiometry varies with body weight. The authors studied the behavior of bone mass measurements made by ultrasound bone velocity and metacarpal radiogrammetry in relation to body weight. METHODS: Eighty healthy women were studied: 40 post-menopausal and 40 premenopausal (mean age 60 +/- 6 and 38 +/- 8 years, respectively). The authors performed in every subject the following studies: a radiograph of the nondominant hand for metacarpal cortical thickness, a study of the 2nd to 5th proximal phalanges for ultrasound bone velocity, and total bone mineral content by dual energy x-ray absorptiometry. RESULTS: The measurements obtained with the three methods correlated significantly with each other (P < 0.0001). The only parameter related significantly with weight were total bone mineral content (P < 0.0001). In the premenopausal women, age did not correlate with any measurement. In the postmenopausal women, age correlated significantly with the three measured parameters (P < 0.0058 to P < 0.0001). CONCLUSIONS: Weight did not influence ultrasound bone velocity and metacarpal cortical thickness measurements.

Absorptiometry, Photon↗

[Relation between dietary behavior and body mass index, serum lipids and socioeconomic factors in urban residents].

The purpose of this study was to obtain basic information of factors which improve the dietary behavior of urban residents. For this reason, we studied the relation between dietary behavior and BMI, serum lipids and socioeconomic factors. We surveyed the dietary behavior of those who underwent medical examinations at a health center in the city of A. The subjects for this study were 2,627 persons aged 30 to 69 years. For purposes of analysis, the data derived in the survey was divided into two types of categories. One category is that of practicing and non-practicing group relative to specific dietary behaviors. The other is that of better dietary behaviors group and worse dietary behaviors group. (1) A comparison between the practicing and non-practicing group showed that the mean value of the total cholesterol values for the former was lower than for the latter. Similar results for the triglyceride values was obtained. The mean value of the HDL-cholesterol values for the practicing group was higher than for the non-practicing group. (2) We also compared the better dietary behaviors group with the worse group. For women, the mean value of the body mass indices in the better dietary behaviors group was lower than in worse group. We obtained similar differences for women with regard to the mean values of total cholesterol values and triglyceride values. (3) More of Breslow's health practices were followed by the better dietary behaviors group than by the worse group. (4) The number of good dietary practices was significantly related to the following socioeconomic factors: marital status, floor area of residence, steady employment, and working hours. Better dietary behaviors showed parallel correlation with better health status. Dietary behaviors of younger generations and temporary workers showed a tendency of needing to be improved.

Adult↗

'Viagra effect' - influence of mass media on patient behavior.

INTRODUCTION: The effects of modern mass media and communication on the public health system are well known. So far however, these different influences of the media have not been objectively evaluated by physician-patient contacts. PATIENTS AND METHODS: In this study we asked urologists, primary care physicians and internists in private practices in Cologne and a rural area (Erftkreis, Germany) to quantify their weekly contacts with patients suffering from erectile dysfunction (ED). The poll was conducted by four separately mailed questionnaires whereas a double counting was avoided. Between the second and third mailing, an unbelievable public attention was seen following the FDA approval of Viagra in the United States. When Viagra was available in Germany, a fourth questionnaire was sent (4 months later) to all practitioners (n = 751). RESULTS: During this time span, there was a statistically (p <or= 0.01; t test) significant increase in weekly physician-patient contacts (WPC; 13.1-19.1 WPC for urologists, 4.4-5.5 WPC for general practitioners/internists) for ED in the region of Cologne-Erftkreis. In the fourth mailing, there was a slight decrease, but overall WPC was still higher compared to the first two mailings (17 WPC for urologists, 5.2 WPC for other specialists). CONCLUSIONS: Our investigation shows that urologists are accepted as the competent advisory partners for therapy with Viagra. This was seen by the higher increase (20.1%) in patient contacts with urologists in comparison to colleagues of other medical disciplines (45.8 vs. 25.7% between mailing 1+2 and 3). In this investigation we were able to demonstrate the effects of mass media on patient behavior.

Adult↗

Possible role of the serotonergic system in the behavioral effect of massed electroconvulsive shock in rat.

Massed electroconvulsive shock (ECS) inhibited escape in a one-way avoidance system and tolerance to this effect developed in rats shocked for 4 consecutive days (1, 4, 5 and 10 ECS respectively). Chronic treatment with p-bromo-N-methylamphetamine (V-III) as well as pretreatment with pCPA antagonized the behavioral disturbing effect of massed ECS strongly supporting the idea that 5-HT plays an important role in observed behavioral effects.

5-Hydroxytryptophan↗

Study on fragmentation behavior of 5/7/6-type taxoids by tandem mass spectrometry.

The mass spectrometric behaviors of seven compounds, namely four 4beta(20),5-oxetane 5/7/6-type taxoids (i.e. taxayuntin A, taxayuntin B, taxayuntin and taxayuntin C) and three 4(20)-methylene 5/7/6-type taxoids (i.e. brevifoliol, taxchinin A and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol) have been investigated by the positive ion FAB-MS/MS technique. The fragmentation has been correlated with the types and positions of substituents of these compounds. It has been found that with the OH group at the C-10 position, taxayuntin A, taxayuntin B and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol are dominated by the loss of H2O, while with the BzO group at the C-10 position, taxayuntin, taxayuntin C, brevifoliol and taxchinin A preferentially eliminate the BzO group. In addition, C-2 is an active site, and neutral loss from the C-2 position readily occurs. The four 4beta(20),5-oxetane 5/7/6-type taxoids produce the terminal product ion with a stable conjugated system at m/z 311, while the 4(20)-methylene 5/7/6-type taxoids brevifoliol and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol produce this ion at m/z 237, and taxchinin A at m/z 253. Interestingly, characteristic fragment ions involving the loss of a 118 u group were observed for taxayuntin, and a possible fragmentation mechanism is given. The major fragmentation pathways and mechanisms of ion formation for the compounds are proposed on the basis of CID spectra and accurate mass measurements. The results of this paper will be helpful for structural analysis of analogs.

Plant Extracts↗

Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction.

PURPOSE: We examined the effects of the selective acetylcholinesterase (AChE) inhibitor TAK-802 on voiding behavior and residual urine volume in rats with partial bladder outlet obstruction (BOO) vs rats treated with the nonselective AChE inhibitor distigmine and the muscarinic agonist bethanechol. In addition, the effect of repeat doses of TAK-802 on the bladder mass increase associated with BOO was also examined. MATERIALS AND METHODS: Male rats with BOO were used. Six to 8 days after obstruction voiding behavior was observed in a metabolic cage. The animals were then treated orally with 1 drug, and voiding frequency and urine volume at each void were measured for 3 hours. Subsequently the volume of urine retained in the bladder (residual urine) was measured. In another experiment bladder weight in rats with BOO was measured after early repeat doses of TAK-802. RESULTS: BOO increased voiding frequency and decreased average voided volume. TAK-802 and distigmine increased average voided volume, while not causing any change in voiding frequency. On the other hand, bethanechol increased voiding frequency without affecting average voided volume. While all 3 drugs significantly decreased residual urine volume, TAK-802 was most efficacious. In addition, bladder weight in the control BOO group was greater (approximately 2.2-fold) than that in the sham operated group and early repeat administration of TAK-802 prevented the bladder mass increase. CONCLUSIONS: AChE inhibitors decreased residual urine volume by restoring voiding function in rats with BOO, although only the effect of TAK-802 was dose dependent. Bethanechol also decreased residual urine volume in a dose dependent manner but by increasing voiding frequency. The prevention of a bladder mass increase by TAK-802 treatment may be attributable to its effect on restoring voiding.

Administration, Oral↗

Relationship of eight basic emotions, life needs satisfaction and Type A behavior with body mass index and some biochemical characteristics in healthy blue-collar workers.

Studies of the relationship of eight basic emotion dimensions according to Plutchik, life needs satisfaction and Type A behavior with plasma cholesterol, triglyceride and glucose concentrations, and body mass index (BMI) were performed in 137 healthy blue-collar workers. Plasma cholesterol correlated positively with emotion dimensions of destruction and deprivation (r = +0.18, +0.21; p < 0.05) and negatively with the components of love in EPI (reproduction and incorporation; r = -0.24, -0.25; p < 0.01) and life needs satisfaction (family relationships, relationship with friends; r = -0.20, -0.17; p < 0.05). Triglycerides correlated negatively with satisfaction of life needs concerning health, family and friend relationships (r = -0.20, -0.20, 0.25; p < 0.05). Plasma glucose correlated positively with emotions of destruction and orientation (r = +0.22, +0.20; p < 0.05), and negatively with incorporation and reproduction (r = -0.22, -0.24; p < 0.01). BMI correlated positively with plasma cholesterol, triglyceride and glucose concentrations (r = +0.37, +0.40, +0.24; p < 0.01), and emotion of deprivation (r = +0.21; p < 0.01). Results of the study suggested the successful approach to the prevention of coronary heart disease to be related with certain basic emotions, life needs satisfaction and BMI.

Adult↗

Calcium mass balance and behavior of intact immunoreactive parathyroid hormone in acetate-free biofiltration: acute and one-year evaluation.

The present study evaluated calcium mass balance (MB) during acetate-free biofiltration (AFB) with a dialysate calcium concentration of 2 mmol/l and different ultrafiltration rates (UF; 42.5 ml/min in schedule 1 and 48.5 ml/min in schedule 3), and with a calcium concentration of 1.75 mmol/l but an UF of 43 ml/min (schedule 2). We also examined the effects of these schedules on the behavior of intact parathyroid hormone (I-PTH). AFB according to schedule 1 and 3 achieve a positive calcium MB (8.49 +/- 1.56 and 5.59 +/- 1.06 mmol, respectively), while in schedule 2 calcium MB merely balanced (0.07 +/- 2.29 mmol/l). A significant acute intradialytic I-PTH decrease was observed with all schedules; after 1 month, however, predialytic PTH values were unchanged in schedules 1 and 3, but worsening was noted in schedule 2. Subsequently, AFB was performed for 12 months employing a dialytic schedule (No. 1) involving a positive calcium balance. A year later I-PTH was significantly lower, thus proving that AFB may play an additional part in controlling secondary hyperparathyroidism.

Acetates↗

Association of depression with Body Mass Index, sedentary behavior, and maladaptive eating attitudes and behaviors in 11 to 13-year old children.

We examined the relation of different behavioral dimensions of depression with weight-related variables (BMI percentile, sedentary behavior, eating attitudes, and weight control behaviors) in children aged 11 to 13 years. Depression was assessed using the Children's Depression Inventory (CDI). Sedentary behavior was measured in 45 sixth grade students (23 boys and 22 girls) using a validated 24-hour recall instrument, the Self-Administered Physical Activity Checklist. BMI was calculated directly from measured height and weight (kg/m2). The Children's Eating Attitudes Test (ChEAT) was used to measure eating attitudes and weight control behaviors. There were not significant gender differences in reported minutes (142 vs. 91 minutes for boys vs. girls; p=0.25) of sedentary behavior (i.e., television watching and video game playing). The major finding of this study was that certain aspects of depression (i.e., interpersonal problems and feelings of ineffectiveness) were correlated with higher levels of sedentary behavior in children aged 11 to 13. A factor analysis of the study variables indicated that most dimensions of depression, sedentary behavior, and body size represent distinct but correlated behavioral dimensions. This study provides support for a link between specific aspects of depression (i.e., interpersonal problems and feelings of ineffectiveness) and sedentary behavior in children.

Adolescent↗

Mass spectral and pyrolytic behavior of the two main products of phenylbutazone degradation: simulation of unusual mass spectral fragmentation.

The two major routes of degradation of phenylbutazone (I) are oxidation and hydrolysis. Hydrolysis gives rise to n-butylmalonic acid mono(N,N'-diphenyl)hydrazide (II). Oxidation at the C-4 position yields 1,2-diphenyl-4-n-butyl-4-hydroxpyrazolidine-3,5-dione (III), which is readily hydrolyzed to n-butyltartronic acid mono-(N,N'-diphenyl)hydrazide (IV). Whereas the mass spectra of I, III, and the methyl esters of carboxylic acids II and IV all demonstrate major peaks corresponding to their respective molecular ions, the mass spectrum of II is essentially identical with that of I, suggesting facile dehydration. In the mass spectrum of IV, the peak of highest mass is found at m/e 205; no peak could be perceived corresponding to the molecular ion or to loss of water, carbon dioxide, or both of these elements from the molecular ion. Under normal pyrolytic conditions, II is decarboxylated to N-caproylhydrazobenzene (V) and IV is readily dehydrated to yield III. The mass spectral fragmentation of IV was successfully simulated in the laboratory to give an excellent yield of aniline and alpha-keto-N-caproylaniline (VI) (mol. wt. 205). The probable course of this unusual transformation was elucidated from studies of the accelerated decomposition of IV and derivatives considered as possible intermediates in the degradation process.

Carboxylic Acids↗

Psychogenic epidemics and work.

Psychogenic epidemics cover various forms of collective behavior and include mass hysteria, mass psychogenic illness, and hysterical contagion for which no physical explanation can be found. The typical course of a psychogenic epidemic at a workplace progresses from sudden onset, often with dramatic symptoms, to a rapidly attained peak that draws much publicity and is followed by quick disappearance of the symptoms. Over 90% of the affected persons are women, and the symptoms range from dizziness, vomiting, nausea, and fainting to epileptic-type seizures, hyperventilation, and skin disorders. The background mechanisms are thought to be generalized beliefs and triggering events which create a sense of threat that leads to a physiological state of arousal. This state, in turn, creates new beliefs which give meaning to the sense of arousal. The new belief spreads through sociometric channels. Predisposing factors include boredom, pressure to produce, physical stressors, poor labor-management relations, and impaired interpersonal communications, and lack of social support. It is important that a thorough investigation be carried out in all instances. Investigation is not only necessary for diagnosis, but it also reassures the management, the employees, and the press that physical factors are unlikely to be responsible for the disease.

Cultural Characteristics↗

Characterization of isomeric cationic porphyrins with beta-pyrrolic substituents by electrospray mass spectrometry: the singular behavior of a potential virus photoinactivator.

Electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (ESI-MS/MS) have been used to differentiate the 2- and 4-methylpyridyl isomers of free-base and metallated cationic beta-vinylpyridylporphyrins. The analysis by ESI-MS/MS of the deuterated analogs and semiempirical calculations of structural and electronic parameters were also undertaken. The two free-base isomers are easily differentiated by ESI-MS/MS but the presence of a metallic center renders differentiation of the metallated isomers less effective. The data acquired show that of all the studied compounds, the free-base 2-methylpyridyl isomer, which was operative in the in vitro photoinactivation of Herpes simples virus, has a different gas-phase behavior. Local distortion of the macrocycle due to the presence of the beta-vinylpyridyl substituent occurs for all the compounds, but a different electron density distribution can account for the observed gas-phase behavior of this potential virus photoinactivator.

Antiviral Agents↗