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At least 91 records · Page 5Linked to original sources
PubMed1976

Testosterone and libido in holstein bulls of various ages.

Testosterone was measured by radio-immunoassay in the blood plasma collected from 197 and 195 Holstein bulls in the spring and fall seasons, respectively. Bulls ranged in age from 8 mo to 13.5 yr. The average value for spring was 8.0 ng/ml, higher than the value of 5.7 ng/ml in the fall. Also, there was a tendency for testosterone to increase with age of the bulls up to 6 to 7 yr. The concentration of circulating testosterone was unrelated to libido or semen quality.

Age Factors↗
PubMed1992

Alterations of libido in gased Iranian men.

This investigation was done on 800 Iranian men who survived the immediate hazards and lethal phase during chemical warfare exposure. At the time of interview they had gone back to their usual lives. Men injured with chemical weapons containing mustards may have impotency and loss of or decreased libido.

Chemical Warfare Agents↗
PubMed2003

[Androgens, well-being and libido in women].

Women with an androgen deficiency complain about a loss of libido and a lack of well-being. It is difficult to link these symptoms to low circulating androgen levels in blood. This is because these complaints often arise during a period of life characterized by major psychosocial changes. Furthermore, coinciding oestrogen deficiency may give rise to similar symptoms. Another problem is the assessment of androgen deficiency. The androgen assay used is designed for men presenting with levels much higher than normal. Finally, concentrations in the peripheral blood are a poor reflection of intracellular androgen receptor stimulation. Patients with complaints suggestive of a relative androgen deficiency (based on the pattern of complaints and low serum androgen concentrations) should first of all be counselled for psychosocial problems. Oestrogen deficiency should subsequently be ruled out or substituted. If the complaints still persist then androgen substitution can be considered.

Androgens↗
PubMed1989

Loss of libido.

Loss of libido is caused by unconscious anger and it can be restored if the feeling of anger is expressed. The common causes of such anger are classified and case histories suggest how the doctor/patient encounter can be used to help patients.

Adult↗
PubMed1987

Reversible sterility by cyproterone acetate plus testosterone enanthate in langur monkey with maintenance of libido.

Cyproterone acetate (1 mg/kg b.w. per day; oral) in combination with testosterone enanthate (2 mg/kg b.w. 15 days; i.m.) was administered for 60 and 90 days into adult male langur monkeys (Presbytis entellus entellus, Dufresne). Testicular weight and volume were reduced significantly. Spermatogenesis was suppressed but the interstitial cells appeared normal. Seminiferous tubules and Sertoli cell nuclear diameters were reduced significantly. The indices of testicular steroidogenesis, i.e. testicular total proteins, sialic acid, RNA and fructose showed a fall. On the contrary, cholesterol, total lipids, glycogen and phosphatases increased after treatment. Libido was not affected. Cessation of treatment resulted in a resumption of all the variables to normal levels within 90 days. The results reveal a reversible inhibition of testicular steroidogenesis which ultimately resulted in the disruption of spermatogenesis, a definite index of sterility. It is further emphasized that simultaneously administered testosterone enanthate maintains androgenicity.

Animals↗
PubMedDate not supplied

[Pharmacologic inhibition of the libido: therapy or repression? II. Clinical aspects].

Some neuroleptic medicine or hormonal by-products may--partly or fully-as to the dose--inhibit the libido of the patients who ask for it themselves causing in this way a pharmacological castration, a temporary or permanent one, but which is always reversible when the therapy is stopped. These inhibiting treatments, which essentially apply to males, are particularly useful in the case of the hypersexual patients or in the case of second offenders.

Adult↗
PubMed1983

Bromocriptine improves reduced libido and potency in men receiving maintenance hemodialysis.

Twenty-five men on maintenance hemodialysis commenced a placebo-controlled, double-blind, crossover trial of bromocriptine for erectile impotence. Eight patients on bromocriptine and one on placebo failed to complete the trial due to side-effects and 2 were withdrawn following renal transplantation. Libido or the frequency and/or quality of erections or both improved in 11 of the remaining 14 patients during bromocriptine treatment. A significant (P less than 0.01) improvement in patients' perception of sexual performance occurred on bromocriptine compared with placebo. The 3 patients in whom potency failed to improve had the lowest serum testosterone concentrations. Bromocriptine is usually effective in the management of impotence in males receiving maintenance hemodialysis provided pretreatment serum testosterone is above the lower end of the normal range, but side-effects are relatively common.

Adult↗
PubMedDate not supplied

Long-term regulation of male fertility by norethisterone enanthate 'epididymal' implants: effect on libido and fertility of rabbits.

Bilateral insertion of silastic capsules releasing 38-44 micrograms norethisterone enanthate/24 h into the epididymal fat-pads was found to induce complete azoospermia leading to infertility in adult male rabbits 8 weeks after insertion of the progestin implants. The treatment did not exert any inhibitory effects on the libido and sexual behaviour of the animals as judged by objective parameters of mating. Further, the failure of the hormone-releasing implants was not found to exert any adverse effects on the embryos and pregnancy as indicated by the delivery of normal pups to females mated with implant-bearing males 3 weeks after the insertion of 'epididymal' implants.

Animals↗
PubMed1994

[Drug modulation of libido and sexual activity. Behavior effect of GnRH analog in man].

Libido and male sexual behaviour are under the control of complex testosterone-dependent neuro-endocrine mechanisms. Better knowledge of these mechanisms has allowed to modulate sexual behaviour using drugs. Indeed, it is possible to block spontaneously uncontrollable sexual pulsions of aggressive hypersexual men by dropping testosterone secretion and consecutively decreasing androgen effects on target cells. From now, mutilating neurosurgery and treatment with either estrogens or antigonadotrophic progestagens are withdrawn. Cyproterone acetate, acting as a competitive inhibitor of testosterone action through its binding to androgen receptors, has been used with efficacy in 80% of cases studied. However, the therapeutic use of cyproterone acetate is limited by three drawbacks: i/potential side effects, ii/exclusive oral route of administration and iii/lack of available biological criteria as a control of the good observance of the treatment. We studied the efficacy of a GnRH analogue (Triptoreline), which induces a reversible hormonal castration and of which both the formulation and the route of administration avoid the inconveniences linked to a treatment with cyproterone acetate. 3.75 mg triptoreline injected intramuscularly once a month had been very effective on clinical and biological parameters in 5/6 aggressive hypersexual patients. In 3 of them a previous treatment with cyproterone acetate had been uneffective. Such a reversible hormonal castration suppressing sexual addiction, would lead to favourable conditions for psychotherapy.

Adolescent↗
PubMed1993

[Libido-related changes in the elderly].

Sexual desire can be influenced in elderly men by a number of factors such as hormonal abnormalities, socio-cultural conditions, chronic diseases, drugs. Testosterone decrease per se is not sufficient to impair sexual function in the elderly; social and psychological factors are probably of relevance as it can be observed in people living in nursing homes. Diabetes may have a major impact on sexual desire. Drugs usually associated with impairment of libido (psychotropic drugs, anti-hypertensives) are frequently used by elderly people; alcohol is a leading cause of sexual dysfunction, particularly in unfavourable social conditions.

Aged↗
PubMed1979

Testicular degeneration and libido loss in beef bulls experimentally inoculated with Anaplasma marginale.

Four sexually mature virgin beef bulls were inoculated with whole blood from a known Anaplasma marginale carrier. All four bulls became infected and experienced some degree of anemia and testicular degeneration, while uninoculated controls remained normal. Testicular degeneration was confirmed by electron microscopy, histopathology, and semen evaluation. Further observations established that the inoculated bulls exhibited a loss of libido, while controls reacted in a normal manner to a cow in estrus. Anaplasma marginale was not present in semen of inoculated bulls.

Journal Article↗
PubMed1989

Libido, menopause, and estrogen replacement therapy.

Patients may be embarrassed to communicate their concerns regarding a decrease in sexual desire to their physician, let alone request treatment. Drs Beard and Curtis recommend that patients be asked specific questions to elicit symptoms of sexual dysfunction. They outline a program of hormone replacement therapy for women who have sexual dysfunction secondary to genitourinary atrophy and for those whose loss of libido is secondary to declining levels of estrogen.

Estrogens↗
PubMed2000

Age, libido, and male sexual function.

In the last decade of the 20th century, there was a distinct reappraisal of male sexual dysfunction and its pharmaco-medical treatment. Although representative studies of sexual (dys)function in the aging male (i.e., between 60-90 years of age) are still lacking, one might assume with certainty that many men and their partners could benefit from sexological counseling and treatment. At the same time, it is obvious that many older men with erectile dysfunction do not seek or want treatment for various reasons. Nevertheless, it is obligatory that modern physicians include sexual matters in dealing with their aging patients, as an essential part of their quality of life. The doctor of today should approach the old(er) male patient with sexual dysfunction (regardless of comorbidity) in an identical manner as young(er) patients, i.e., with proper sexological history-taking, proper physical examination, and/or sexological diagnostic screening, and discussing the various available treatments. Needless to say, that they should not "create" sexual problems when patients are satisfied with their current way of life. However, with the increasing number of efficacious treatments, doctors will satisfy many of their older patients with sexual difficulties who seek treatment.

Aging↗
PubMedDate not supplied

Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women.

This study investigated the possibility of an alternative to chemical medication in the treatment of sexual dysfunction in healthy women. The efficacy of a unique herbal formulation of Muira puama and Ginkgo biloba (Herbal vX) was assessed in 202 healthy women complaining of low sex drive. Various aspects of their sex life were rated before and after 1 month of treatment. Responses to self-assessment questionnaires showed significantly higher average total scores from baseline in 65% of the sample after taking the supplement. Statistically significant improvements occurred in frequency of sexual desires, sexual intercourse, and sexual fantasies, as well as in satisfaction with sex life, intensity of sexual desires, excitement of fantasies, ability to reach orgasm, and intensity of orgasm. Reported compliance and tolerability were good. These initial findings support the strong anecdotal evidence for the benefits of Herbal vX on the female sex drive. A double-blind study is planned to further research these results.

Adult↗