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Results for “Leukemic Infiltration”

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PubMed1995

[Leukemic infiltration of the cornea in a patient with hairy-cell leukemia].

The authors describe the infiltrations of the cornea in both eyes of a patient (women) who suffered from leukaemia with "long-haired cells". The treatment was successful with 2-chlordeoxyadenosine (Leustatin). Knowledge of leucaemic infiltration in the cornea is accentuated for successful treatment in connection with basic disease.

Cornea↗
PubMed1996

[An unusual course in hairy-cell leukemia with marked abdominal lymphadenopathy, leukemic infiltration of the cornea and skin changes].

The authors describe a female patient suffering from hairy-cell leukaemia. Already at the onset of the disease, apart from marked splenomegaly, sonography revealed marked retroperitoneal lymphadenopathy. During the subsequent course skin changes developed such as vasculitis and leukaemic infiltrates of the cornea on both eyes. The patient was successfully treated with 2-chlorodeoxyadenosine (2-CdA, Leustatin).

Cornea↗
PubMed2001

Ocular manifestations of leukemia: leukemic infiltration versus infectious process.

OBJECTIVE: To determine whether specific guidelines can be developed to distinguish whether retinal infiltration in leukemia patients represents infection or neoplasia. DESIGN: Retrospective noncomparative interventional case series. PARTICIPANTS: Six patients recently seen at University of California San Francisco with retinal infiltrates in a setting of leukemia, for which adequate written and photographic information of disease course was available. INTERVENTION: Observation consisted of retrospective review of clinic charts, hospital medical records, and fundus photographs. MAIN OUTCOME MEASURES: Determination of whether retinal infiltrates represented neoplasia or infection was made by review of medical records. RESULTS: In this series, neoplastic retinal infiltrates were found in patients who had newly diagnosed leukemia and those who were in blast crisis. In contrast, the two patients who were in complete remission, but had undergone bone marrow transplantation, had retinal infiltrates attributable to infection. CONCLUSIONS: Every patient with retinal infiltrates in the setting of newly or previously diagnosed leukemia requires a systemic and central nervous system workup before the initiation of ophthalmologic treatment. The systemic status of the patient is highly informative in determining whether infection or neoplasia is responsible for the infiltration.

Adult↗
PubMedDate not supplied

Leukemic infiltration of the orbit: report of three cases and literature review.

Orbital infiltration by acute lymphoblastic leukemia is rare. The authors present 3 patients, 2 with optic nerve involvement and 1 with anterior chamber infiltration, treated by chemotherapy and radiotherapy. Two are in continuous remission at 64 and 59 months and 1 relapsed in the central nervous system 35 months after ocular relapse. Visual deterioration was prevented in two. Early diagnosis and treatment are important for preservation of vision.

Child, Preschool↗
PubMed2001

Unusual growth within a meningioma (leukemic infiltrate).

Intracranial meningiomas are generally slow-growing neoplasms. Symptoms depend on their critical intracranial location. The authors describe a case of rapidly enlarging meningioma that became symptomatic as a result of invasion by leukemic cells at the time of a blastic crisis in the context of chronic myeloid leukemia. Infiltration of an intracranial meningioma by cells from extracranial malignant neoplasms is a rare event. Even though central nervous system (CNS) or meningeal involvement is common in some hematologic malignancies, this is, to the best of our knowledge, the first report of invasion of an intracranial meningioma by leukemic cells.

Aged↗
PubMed1980

Acute leukemic infiltration of the vitreous diagnosed by pars plana aspiration.

A 30-year-old man with acute lymphoblastic leukemia, null cell, L2 type developed a unilateral dense cellular vitreous infiltrate while in apparent remission. Cytopathologic examination of material aspirated from the vitreous established the diagnosis of lymphoblastic infiltration. Prompt radiotherapy and chemotherapy rapidly reduced the vitreous infiltration and cleared cells from the cerebrospiral fluid. Intraocular involvement by the leukemic process was the initial sign of central nervous system involvement. Acute lymphoblastic leukemia should be added to the list of lymphoproliferative disorders capable of vitreous infiltration, and which can be identified by vitreous aspiration and cytopathologic examination.

Adult↗
PubMed1989

Leukemic infiltration of the eye: results of therapy in a retrospective multicentric study.

A multicentric retrospective study on leukemic ophthalmopathy (LO) is reported, including 38 patients (21 males, 17 females) with acute leukemia (AL) observed from 1976 to 1985. LO developed in four patients at the time of diagnosis of AL; ten were in first complete remission (eight off therapy), 12 in second remission, and 12 in combined relapse. The children were treated according to different schedules of systemic and intrathecal chemotherapy with or without radiotherapy (RT) of the affected eye. Ocular remission occurred in 32 of 38 patients, but with subsequent ocular relapse in six of the 32. Complete remission after LO treatment lasting for more than 24, 30, 40, and 78 months was observed in four of the ten children with isolated LO in first AL marrow remission. The authors concluded that systemic and intrathecal chemotherapy probably is associated with RT (at least 30 Gy to the affected eye). Aggressive treatment is justified because children with isolated ocular relapse can still be cured.

Adolescent↗
PubMed1987

Local application of 60Co in the treatment of leukemic infiltration of the eye.

A 20-year-old woman, who was first diagnosed as having acute lymphoblastic leukemia (ALL) at age 5 years and had several episodes of central nervous system leukemia relapse, developed leukemic involvement in the left eye. Following local application of a 60Co scleral plaque, these ocular lesions disappeared and function of the eye was restored.

Adult↗
PubMedDate not supplied

Fine needle aspiration in the evaluation of testicular leukemic infiltration.

Prior to the era of effective therapy for acute leukemia, a finding of occult testicular involvement at autopsy was not uncommon. With the advent of effective induction of remission, clinically evident testicular infiltration has been seen as a manifestation of relapse. A case is reported demonstrating the use of fine needle aspiration along with frozen section in the evaluation of testicular involvement as a manifestation of leukemic relapse.

Adult↗