Reactions to intravenous organic iodine compounds and their immediate treatment.
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The interaction between povidone-iodine, phagocytic cells, and microorganisms was studied. Three preparations of povidone-iodine were investigated: commercially available povidone-iodine solution Betadine, pure high-molecular-weight povidone-iodine as used in Betadine, and a low-molecular-weight povidone-iodine. Low concentrations of povidone-iodine (approximately 0.005%) have considerable activity in vitro. The concentrations used clinically (0.1 to 20%) are toxic for granulocytes and monocytes. Leukocytes reduce the in vitro microbicidal activity of povidone-iodine. No differences of any importance were found between the three preparations of povidone-iodine.
Experiments on 130 male lake frogs were made to study a combined action of SHF electromagnetic fields (microwaves) and baths KI + I2, DMSO, KI + I2 + DMSO, iodinol, iodinol + DMSO, humic acids, humic acids + KI + I2, humic acids + DMSO, sapropel + DMSO on excitability and accommodation ability of nervous and muscular tissues. The most perspective combinations (by the number of statistically significant shifts of 6 electrophysiological parameters) were selected for screening on warm-blooded animals. These were SHF microwaves + KI + I2, SHF microwaves + iodinol.
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The coupling reactions of cyclic sulfides with a silylated pyrimidine nucleobase using a hypervalent iodine reagent were investigated. The reaction of silylated uracil with cyclic sulfide 12 using PhI=O gave the desired beta-anomer 14 in moderate yield. 4'-Thiouridine (22) was obtained by deprotection of 14.