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[Theoretical bases of a cardio-synchronised jet injection system into the vena cava].

Aim of this paper is to present a procedure aimed at raising the flow rate in the vena cava. To this purpose some fluid is injected at high speed in the vessel, accelerating the flow and dragging the stagnating flow upstream the catheter. In order to raise the efficiency of the system and to avoid damage to heart valves, the injection is synchronised with the diastole. A prototype of an injection system has been designed and built, in order to reach these goals. The injection times are controlled by the electrocardiogram track of the patient, in such a way that the maximum flow rate occurs when the tricuspid valve is open. A "dragging effect" index, that is the ratio between overall flow rate induced by any injection (injected flux plus dragged flux) and injected flux flow rate has been evaluated, both theoretically and experimentally. An experimental model of the lower vena cava has been built and used to measure the velocity profile in the vessel. The dragging effect at the confluence between the two iliac and the vena cava has been verified. By making the catheter sections smaller and/or raising the feeding pressure it is possible to have the injection of small volumes at high speed, capable of moving the blood in the vena cava with a minor contribution of external fluid, thus reducing risks of volume overload and overdiluition of blood.

Catheterization, Peripheral↗

[Jet injections].

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Injections, Jet↗

[JET INJECTION].

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Equipment and Supplies↗

[The use of intrapulmonary needle-jet injections of chemical preparations in the preoperative management of patients with pulmonary tuberculosis].

Among the various methods of antibacterial preparation injection for the management of pulmonary tuberculosis the intrapulmonary injection techniques with the help of a needle-stream injector (NSI-1) still remain little studied. The experience of using these techniques for treating more than 200 patients, among whom 23 patients were later operated on, showed that the early use of the method (immediately after the diagnosis was established) helped to stabilize the process in 1-1.5 months. This made it possible to perform operations within 3 months after the diagnosis was made. The method proved effective also in patients who did not present favourable dynamics during 3-6 months of the use of the traditional therapeutic methods. The results obtained allow for the use on a wide scale of needle-stream injections in the preoperative management of destructive tuberculosis patients.

Adolescent↗

[Cortisone jet injection as therapy of hypertrophic scars and keloids].

Intralesional steroid injection in the treatment of hypertrophic scars and keloids has been well known for many years. In order to determine whether this therapy can still be recommended, 57 patients with hypertrophic scars or keloids received high-pressure injections of triamcinolon acetonide (Dermojet). 50% of the cases showed significant improvement with respect to scar color, itching and scar elevation. Thus, triamcinolon acetonide therapy is indicated in particular cases.

Adolescent↗

Intradermal antitetanic-antityphoid booster by jet injection.

The immunogenicity and the reactogenicity of an unadsorbed Tetanus vaccine, intradermally administered in man as a booster immunization associated or not with lyophilized Typhoid vaccine, were comparatively studied. There were no differences in postvaccinal reactions between the Tetanus vaccine administered alone or associated with Typhoid vaccine as well as between the unadsorbed and adsorbed Tetanus vaccine. The booster inoculation carried out with Tetanus vaccine by i.d. route with doses of 10 Lf/0.1 ml proved to be effective, inducing to all the subjects a definite protective titre, maintaining for at least one year.

Adolescent↗

Intradermal antityphoid-antitetanus vaccination by jet injection.

A lyophilized, heat-killed, phenol preserved typhoid vaccine (5 x 10(8) cells) suspended in 0.1 ml unadsorbed concentrated tetanus vaccine (10 Lf) was administered in man by intradermal route. This association of the two vaccines resulted in milder postvaccinal reactions: moreover, the immunological properties of typhoid vaccine, as certified by the passive protection test of the mouse with sera of the vaccines and the H and O agglutinin titres found in these immune sera, were perfectly conserved. Consequently, the mixed typhoid-tetanus vaccination in man by intradermal route is possible and advantageous for practical and economical reasons.

Adolescent↗