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At least 91 records · Page 5Linked to original sources
PubMed1995

Evaluation of influential factors of cognitive impairments in idiopathic Parkinson's disease.

Using multivariate analysis, we investigated the influence on cognitive functions of aging, brain atrophy, incidental cerebral hyperintensities (CHs), medication, and severity, duration and the initial symptoms of the disease in 53 patients with idiopathic Parkinson's disease (PD). We semiquantitatively assessed the degree of brain atrophy and CHs based on previously established methods. Cognitive functions were significantly and diffusely impaired in PD when compared with controls who were matched for age as well as for the degree and location of CHs. Patients with PD, however, had larger ventricles. Prefrontal dysfunctions were associated with a variety of predictors such as CHs, brain atrophy, severity of PD and medication whereas dorsolateral frontal functions were related simply to age and CHs in the periventricular region. Posterior brain functions had association with severity of illness, ventricular dilatation and total CH score. Clinically observed cognitive impairments in PD may consist of cognitive defects intrinsic to the disease which are variously modified by these factors. It is essential to consider all these predictors simultaneously in any discussion of cognitive functions in PD.

Aged↗
PubMed1988

Long-term prognosis for patients with variant angina and influential factors.

Two hundred forty-five patients with variant angina were followed for an average of 80.5 months (range, 36-184 months). Survival rate at 1, 3, 5, and 10 years was 98%, 97%, 97%, and 93%, respectively. Survival rate without myocardial infarction at 1, 3, 5, and 10 years was 86%, 85%, 83%, and 81%, respectively. By univarite analysis, ST segment elevation in both the anterior and inferior electrocardiographic leads was the most important factor influencing survival, followed by use of calcium antagonists, left ventricular function, smoking, and alcohol intake. The variables that significantly correlated with survival without myocardial infarction were use of calcium antagonists, left ventricular function, extent and severity of coronary artery disease, coronary artery bypass surgery, and disease activity. Multivariate analysis using the Cox proportional hazards model showed that intake of calcium antagonists, extent and severity of coronary artery disease, and ST segment elevation in both the anterior and inferior leads were significant independent predictors of survival without myocardial infarction. We conclude that long-term prognosis for patients with variant angina is relatively good and that use of calcium antagonists improves it.

Adult↗
PubMed1983

The influential T cell in B-cell neoplasms.

Investigations of human B-cell malignancies have generally focused on the monoclonal B-cell populations. Until recently there has been little emphasis on the thymus (T) lymphocyte in these disorders. Current studies, however, suggest that quantitative and qualitative disorders of T cells are generally seen both in chronic lymphocytic leukemia and in multiple myeloma. This review will focus on two major concepts. First, it will define the quantitative and functional T-cell abnormalities in B-cell malignancies including evidence suggesting a causal link between the T-cell abnormalities and certain observed disease manifestations in chronic lymphocytic leukemia and multiple myeloma. Secondly, it will review data demonstrating that these T cells may be influenced by in vivo and in vitro manipulations and will outline some of the possible resultant clinical effects.

B-Lymphocytes↗
PubMed2002

Identification of influential cells in the analysis of ordinal square tables.

For square tables arising from ordinal categorical variables which can be considered as manifestations of underlying continuous variables, it is possible to model the underlying continuous variables in a form that facilitates the comparison of their relative locations and dispersions. An efficient estimation method for such a model is available in the literature and the object of this paper is to develop an influence analysis procedure to accompany the estimation method. The local influence approach is used to obtain the diagnostic measures, and real data sets are analysed to illustrate the practicability of the proposed measures.

Child↗
PubMed1999

[Employees' satisfaction and the influential process factors during regular health check-up by a contracted industrial health association].

This study aimed at identifying factors influencing satisfaction among employees who undergo health check-ups. Seven hundred and twenty two workers at a single working-site (669 male and 53 female) were recruited for a cross-sectional survey with a self-administered questionnaire that we newly developed through a pilot interview study. Multiple logistic regression analysis showed that overall satisfaction was significantly associated with the employee's age (p = 0.06), job type (p = 0.10), and waiting time during the examination (p < 0.01), the burden involved in filling out a check list before the examination (p = 0.06), and the courtesy of the health examination staff (p = 0.07). Our results may imply a role of satisfaction for quality assurance during work-site health check-ups.

Adult↗
PubMed1994

Assessing influential dimensions of reinforcers on choice in students with serious emotional disturbance.

We examined how reinforcer rate, quality, delay, and response effort combined to influence the choices of 6 youths with learning and behavior difficulties, and the viability of an assessment methodology derived from matching theory for determining differential responsiveness to those reinforcer and response dimensions. The students were given two concurrent sets of math problems that were equal on two dimensions but competed on two other dimensions (e.g., one set yielded higher rate and lower quality reinforcement than the other). Competing dimensions were counterbalanced across the six conditions of the initial assessment phase, permitting assessment of each dimension on time allocation. The conditions resulting in the most and least time allocated to one problem set alternative relative to the other were then replicated. Time allocated to each of the problems within sets was differentially affected by the reinforcer and/or response dimensions, with allocation patterns varying across students. The results are discussed in the context of implications for the design of treatments and extrapolations from basic research on matching and behavioral economics.

Adolescent↗
PubMed1992

The professional self-concepts of nursing undergraduates and their perceptions of influential forces.

This article explores the professional self-concepts of senior nursing undergraduates and their perceptions of the most significant forces that influenced the process. The method was qualitative; a grounded theory approach was used. The sample included 23 senior baccalaureate nursing students in their final clinical rotation prior to graduation. Audiotaped interviews were analyzed through the constant comparative method. Informants overwhelmingly perceived themselves as caring. They valued professional competence and many identified a lack of confidence in their skills. Caring qualities, caring role models, and qualities of the role models are listed.

Attitude of Health Personnel↗
PubMed1992

Retaining occupational therapists in rehabilitation settings: influential factors.

The purpose of this study was to identify the factors considered by occupational therapists in their decision to leave or to remain at a present job. Fifty-five occupational therapists practicing in freestanding rehabilitation hospitals in the Philadelphia metropolitan area were surveyed regarding general satisfaction, rewarding and stressful aspects of their current job, and personal or professional reasons to consider leaving a job. The responses were grouped by the therapists' years of experience as a framework for drawing conclusions. The results show that years of experience affects what is important to therapists at their jobs; for example, therapists who have been working for 1 year value different aspects of their jobs than therapists who have been working for over 7 years. In general, the most rewarding aspect of an occupational therapist's job was seen to be patient care; the most stressful, paperwork. In deciding to leave a job, the occupational therapists surveyed most frequently rated the following items as highly important: salary, productivity expectations, professional growth opportunities, peer relationships with other occupational therapists, and vacation time.

Adult↗
PubMed1992

[Influential factors on recurrence of renal cell carcinoma].

In order to clarify factors affecting recurrence, we reviewed 115 renal cell carcinoma patients without distant metastasis at diagnosis (Mo) treated from January 1975 to March 1990 at Sapporo Medical College Hospital. Of these 115 patients, recurrence (metastasis) was found in 23 (20.0%). The non-recurrence rate was 70.6% after the 5-year and 56.5% after the 10-year follow up. In 22 out of 23 patients, recurrence appeared within 3 years following surgery. Multivariate analysis by Cox's proportional hazard model revealed that lymph node metastasis was the most significant factor for recurrence in the 115 patients followed by stage of the primary tumor and pre-operative acute phase reactant (fever, ESR and alpha 2-globulin) in this order. When the analysis was performed in the 88 patients who was in less advanced stage (pN0pV0-1a), pre-operative acute phase reactant (fever, ESR and alpha 2-globulin) was identified as the only significant factor affecting recurrence. This result suggests that pre-operative acute phase reactant is the most important risk factor for recurrence in this group of patients.

Acute-Phase Proteins↗
PubMed2002

[Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease].

OBJECTIVE: ESWL is now widely used for the treatment of renal stone disease. Although ESWL has many advantages for patients' quality of life, few reports have demonstrated the long-term outcomes of the alterations of renal morphology after ESWL. We reported renal scarring after ESWL monotherapy in patients with renal calyceal stones. In this study, we evaluated a large series of patients' cohort treated at our institution, and assessed the causal effect of ESWL on the late occurrence of renal scar formation. PATIENTS AND METHODS: ESWL was performed with EDAP (LT-01,02) that generates shock wave energy by piezoelectric discharge. We analyzed the records of 285 kidneys treated between Dec. 1986 and Nov. 1998. Renal scarring was noted in 44 kidneys and not in 241 kidneys with periodical ultrasonography. We compared the backgrounds of the two groups using chi-square or non-parametric analysis. The Kaplan-Meier method and Cox regression model determined the analysis of renal scar formation. RESULTS: Univariate and multiple regression analysis revealed that the total amount of ESWL emission and hyperuricemia independently affected the probability of renal scar formation. CONCLUSIONS: Over-emission of ESWL (over 10,000 shots) must be care for the prevention of renal scarring in patients with renal calyceal calculi, especially when associated with hyperuricemia. After ESWL, periodical checkups with ultrasonography will provide useful information for the clinical diagnosis of renal scarring.

Adult↗