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PubMedDate not supplied

[Immunologic tests in the prognosis of solid malignant tumors].

Survival at 6, 12 and 24 months was studied in relation to the immunological findings before treatment and its variations after treatment in 600 patient and its variations after treatment in 600 patients with solid malignant tumours. Any change in any of these tests is a sign of poor prognosis proportional to the degree of this change. The most precise prognosis is given by an association of these tests. These two year survival rate for tumours without apparent spread was 87% if the tests were normal, 43% if one group of tests was disturbed and 11% if two groups of tests were abnormal. With local or regional spread, the survival was 52% in cases with normal tests, 12% if one group was disturbed, and 4% if both groups of tests were abnormal. With multiple metastases, the survival rates were respectively 24%, 4% and 0%. Thus the prognosis is less unfavourable for a tumour with general spread and normal immunological tests (24%) than for a localised tumour with a disturbance of two groups of immunological tests (11%). These immunological tests carried out before any treatment are thus very valuable in prognosis, independant of the apparent extension of the tumour. This indications are important in deciding on treatment.

Follow-Up Studies↗
PubMed1978

Epidemiology of poly-parasitism. III. Effects on the diagnostic capacity of immunological tests.

The paper describes some effects of interaction between different types of parasitic infections on the diagnostic capacity of immunological tests for parasitic diseases. Examples shown include an analysis of association for anergy to tuberculin in skin tests of individuals with and without skin manifestations of onchocerciasis; skin tests with P. westermani and C. sinensis antigens to detect double infections in patients harbouring both trematodes; geographical evaluation of the sensitivity of the complement fixation (CF) test for schistosomiasis with S. mansoni antigen between different communities in Chad; reduced sensitivity of the CF test for schistosomiasis in patients with confirmed schistosomiasis who have also onchocerciasis; studies on the specificity of the slide flocculation (SF) test for schistosomiasis in relation to specified intestinal parasites and to the presence of antibodies to E. granulosus and T. spiralis in villages of Afghanistan; and a study of association between poly-parasitism and anticomplementary activity in the sera of population samples from the African Savannah. The combined investigations indicate that there are large dissimilarities in test performance between communities with different disease spectra and nutritional status. The findings suggest that polyparasitism interferes with immunodiagnostic tests both directly through cross-reactions with antigens and antibodies and indirectly through its effects on nutrition and on mechanisms affecting the complement system. Large scale screening for parasitic diseases with immunodiagnostic tests in areas in which the medical problems are not well-known should be prededed by a small, well-planned pilot study in which the relative sensitivity and specificity of the test can be determined before its use in extensive population studies.

Afghanistan↗
PubMed1994

Assessment of the new immunological test Hemoblot for detecting occult blood in faeces.

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening.

Adult↗
PubMedDate not supplied

Advances in pre- and posttransplant immunologic testing in kidney transplantation.

Pre- and posttransplant risk estimation in kidney transplantation is important for the selection of appropriate treatment strategies. Recently, using new immunologic tests, we made observations within the framework of the Collaborative Transplant Study that may influence clinical practice. Complement-dependent lymphocytotoxic panel reactivity as a measure of anti-HLA sensitization, although criticized for its low sensitivity, is a useful indicator of an increased risk of rejection. Using the more sensitive complement-independent ELISA methodology, which utilizes solubilized HLA molecules instead of lymphocytes, we found that recipients with preformed complement-dependent anti-HLA antibodies showed a decreased graft survival only if their antibodies were directed against both HLA class I and class II, whereas isolated reactivity only against HLA class I or class II was of no clinical consequence. Pretransplant serum-soluble CD30 (sCD30) was found to be an independent and highly predictive factor of immunologic risk. The effects of sCD30 and anti-HLA antibodies were additive. Importantly, even patients without anti-HLA antibodies showed a strong HLA matching effect if their pretransplant serum contained high levels of sCD30. Although the role of anti-HLA antibody formation after transplantation remains uncertain, ELISA-detected sCD30 was shown to indicate impending graft rejection as early as on posttransplant days 3 to 5. Another very sensitive indicator of impending rejection is provided by posttransplant monitoring of the cytotoxic T-lymphocyte effector genes, perforin and granzyme B, in peripheral blood using real-time PCR.

Antigens, CD↗
PubMed1989

The use of three immunologic tests in detection of antibodies against Trichinella spiralis.

Human sera (330 from patients with manifestations suggestive trichinosis) were examined for antibodies. The immunologic tests used were counter current immunoelectrophoresis (CEP), enzyme linked immunosorbent assay (ELISA) and immunoflourescence (IF). Seropositive reactions were demonstrated in 2.7%, 5.4% and 2.4% of the sera by the 3 tests respectively. However, 2.4% of the sera were seropositive by the three tests. It seems that the use of two of these tests is valuable in diagnosis when muscle biopsy is unproductive.

Animals↗
PubMed1997

Medical devices; reclassification of tumor-associated antigen immunological test system--FDA. Final rule.

The Food and Drug Administration (FDA) is announcing that it is codifying the reclassification of tumor-associated antigen immunological test systems intended as an aid in monitoring patients for disease progression or response to therapy or for the detection of recurrent or residual disease from class III (premarket approval) to class II (special controls). FDA is also announcing that it has issued an order in the form of a letter to Centocar, Inc., reclassifying serum tumor markers into class II. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 and the Safe Medical Devices Act of 1990.

Antigens, Neoplasm↗
PubMed1977

[Enzyme-immunological tests: determination of the activity of peroxidase with the aid of the "Trinder reagent" (author's transl)].

Most of the currently used enzyme-immunological tests employ horse radish peroxidase as a marker enzyme. A new method is described for the determination of extremely small quantities of peroxidase. This largely prevents the inactivation of the peroxidase by H2O2 and thereby permits a much longer incubation time. In the presence of 25 mmol/l phenol, 2 mmol/l 4-amino-antipyrin and 0.8 mmol/l H2O2, peroxidase catalyses the formation of a red quinonimine, whose increase in adsorption is directly proportional to the enzyme concentration.

Aminopyrine↗
PubMed1975

[Use of immunologic tests in periodic preventive examinations of workers involved in benzidine production].

In 95 workers engaged in benzidine production the results of the cutaneous delayed hypersensitivity response to the injection of tissue embryonal antigen were studied, 76 of them were additionally examined for application of 2,4-dinitrochlorobenzene (DNCB). Studies on the state of the immune response of the workers' organism were conducted in association with clinical and cytoscopic findings. The immunological tests applied during prophylactic examinations revealed, according to objective signs, a group of persons with immunological defects. And just in this group pretumor conditions and occupational vesical tumors were detected. The results of the authors' observations made it possible to recommend an application of the tests reflecting the state of cell immunity, to determine immunological defects in such workers as adjuvant methods for periodic prophylactic examinations.

Adult↗
PubMed1996

[Immunologic tests in patients with idiopathic uveitis--preliminary reports].

AIM: This study aimed to evaluate the immune system function in patients with uveitis of unknown aetiology. METHODS: The clinical material comprised 19 patients with endogenous uveitis. In all cases the following immunological tests were performed: serum immunoglobulins A, G, M, total IgE, circulating immune complexes, complement components C3c and C4-all determined by laser nephelometry; antinuclear antibodies assessed with indirect immunofluorescence method using HEp-2 cell lines; and antineutrophil cytoplasmic antibodies using indirect immunofluorescence test. In 4 cases lupus anticoagulant was measured with APTT and dRVVT assays. RESULTS: Among our 19 examined patients immunological abnormalities were found in 12 cases. Changes in immunoglobulin concentrations were found in 8 cases. In 4 patients abnormalities of the complement system were observed. Antinuclear antibodies with speckled pattern in indirect immunofluorescence were present in 7 cases. CONCLUSION: In a proportion of patients with endogenous uveitis mild immunological abnormalities were present, suggesting an autoimmune background of the disease. Studies of the immunological profile can therefore help in better evaluation of the patients. It remains to be determined whether the observed immunological alterations are of any importance in the pathogenesis of the studied disease.

Adolescent↗
PubMed1980

[Immunological tests as guide-lines for the treatment of systemic lupus erythematosus (author's transl)].

Sixty-five patients with systemic lupus erythematosus were followed up for periods of 8 to 48 months. Sixty-six clinical exacerbations of the disease were observed and treated with various, non-randomized therapeutic regimens. The relationship between the results of immunological tests (DNA binding rate, serum levels of C3 and C4, presence of immune complexes and number of E rosettes) and the clinical and histological changes detected during treatment with corticosteroids or immunosuppressants was studied. In most cases a correlation was found between clinical and histological activities and the intensity of immunological reactions. Immunological abnormalities usually preceded clinical exacerbations but were rarely seen in patients with stable remission. However, exceptions occurred, which limit the value of these tests as sole therapeutic guide-lines in systemic lupus erythematosus.

Adolescent↗
PubMed1982

[Hypotheses on the tumoral nature of fibrocystic mastopathy. Review of bibliographic data and experimental immunologic tests].

The literature on fibrocystic mastopathy has been reviewed and it is noted that, if considered to be a dyplasia pure and simple, it is hard to fit the disease into the biphasic framework of cancer growth; its histopathological picture and development are very suggestive of cancer, it has the same experimental models as breast cancer; there are episodic contradictory results when it is submitted to immunological testing. On these bases, 16 cases of fibrocystic mastopathy have been put through the LAI test according to Thompson. It was found that the disease is antigenic in its clear stage, and that the pictures preceding and following it have a typical immunological index (NAI). With these and reported data, it is concluded that there are sound experimental bases for hypothesising that in its clear stage, fibrocystic mastopathy is a benign tumour of the breast.

Animals↗
PubMed1992

Morbidity study of extruder personnel with potential exposure to brominated dioxins and furans. I. Results of blood monitoring and immunological tests.

The potential for exposure of employees to polybrominated dibenzofurans (PBDFs) and dibenzo-p-dioxins (PBDDs) during extrusion blending of resins containing decabromodiphenyl ether was established through previous air monitoring (area samples) and biomonitoring studies. The findings presented herein are further biomonitoring results for 42 employees and immunological tests for exposed and referent employees. Among potentially exposed men, 2,3,7,8-TBDF and 2,3,7,8-TBDD concentrations in blood lipid ranged from non-detectable to 112 parts per trillion (ppt) and from non-detectable to 478 ppt respectively. Biomonitoring results correlated well with assignments in the extruder work area when adjusted for process changes and engineering improvements and provided biological half life estimates of between 1.1 and 1.9 years for 2,3,7,8-TBDF and between 2.9 and 10.8 years for 2,3,7,8-TBDD. Results for 16 measures of the immune system were examined in relation to exposure (exposed v referent group) and in relation to the biomonitoring data. Some individual trends in immunological parameters with exposure and covariates such as age and cigarette smoking were found (for example, an increase in complement C4 with increasing concentrations of PBDFs and PBDDs, increased lymphocyte subpopulation counts with cigarette smoking); however, the overall clinical assessment was that the immune system of exposed employees was not adversely impacted at these burdens of PBDFs and PBDDs.

Adult↗
PubMed1979

Immunologic testing of patients with genitourinary malignancies.

The discipline and techniques of immunology have been an important part of recent advances in genitourinary oncology. Although the initial promise of tumor immunology has not been realized in man, discoveries in the laboratory are revitalizing the expectation that this field will yet be of significant assistance in the diagnosis and treatment of cancer. Already tumor immunology studies along with new immunologic assay techniques have produced clinically important tumor markers, such as alpha-fetoprotein, human chorionic gonadotropin, and prostatic acid phosphatase, and have intensified the search for other markers. Finally, research activity is increasingly focusing on the tumor cell itself, again often using immunologic methods. Although most of this activity is still experimental, analysis of blood-group antigens in transitional cell carcinoma has produced sufficient data to suggest that such an approach will soon be a part of the urologist's clinical armamentarium in his efforts to treat patients with bladder tumors.

ABO Blood-Group System↗