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PubMed2002

A study on the influence of calcified intervertebral disk and aorta in determining bone mineral density.

This study utilized dual-energy X-ray absorptiometry (DXA) to determine the association that age-related calcinosis of the aorta and intervertebral disks have in determining bone mineral density (BMD). Eight cadavers were chosen at random and were scanned with DXA before and after the removal of the aorta and intervertebral disks. Our results showed that the removal of sclerotic aortas decreased the vertebral BMD an average of 4.64% and the removal of two lumbar intervertebral disks further decreased BMD an average of 11.93%. These results were deemed significant at the 0.01 level using a Friedman two-way analysis of variance by ranks. It can be concluded that the presence of aortic arteriosclerotic lesions and intervertebral disk chondrocalcinosis add a significant contribution to BMD.

Absorptiometry, Photon↗
PubMed2000

Intervertebral disk disease.

Neurologic dysfunction is the most common clinical manifestation of intervertebral disk disease. This article is a comprehensive review of intervertebral disk disease emphasizing clinical features, diagnosis and treatment of cervical and thoracolumbar disk disease. Clinical signs are determined by neuroanatomic localization and severity of spinal cord injury. Myelography is most commonly used for determining the location and extent of the disk protrusion/extrusion; however, computed tomography and magnetic resonance imaging are also common adjunctive and primary diagnostic techniques. Summaries from recent studies will give the clinician an improved understanding on how to confront controversial issues regarding prophylactic and therapeutic management and prognosis.

Animals↗
PubMed2003

Correlation between bone mineral density and intervertebral disk degeneration in pre- and postmenopausal women.

The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone mineral density (BMD) in the lumbar vertebrae, radius, and calcaneus was measured by dual-energy X-ray absorptiometry for 90 women (22-74 years old). The relationship between the grade of intervertebral disk degeneration and the BMD ( Z score) was analyzed in pre- and postmenopausal women. In premenopausal women, BMD was significantly higher at all measured sites in the degenerated disk group judged at the L5-S1 level than in the normal disk group ( P < 0.05). In postmenopausal women, BMD was significantly higher at the anteroposterior L2-L4, lateral L3, and calcaneus in the degenerated disk group judged at the L2-L3 level than in the normal disk group ( P < 0.05). BMD at the anteroposterior L2-L4 and calcaneus was significantly higher in the degenerated disk group judged at the L3-L4 level than in the normal disk group ( P < 0.05). In conclusion, the BMD of not only the lumbar vertebrae but also the calcaneus and radius was mutually related to lumbar intervertebral disk degeneration from an early stage of degeneration.

Adult↗
PubMed1975

[Angioarchitechtonics of the intervertebral disks in human fetuses and newborns].

The ingrowth of the blood vessel branches into the area of the intervertebral disk takes place at the end of the second month of the intrauterine life. The primary vascular elements have a shape of stretched vascular loops, which grow into the fibrous ring of the disk from the front, from behind and from the sides. Within the fibrous tissue the blood vessels are disposed in the slit-shaped spaces between the layers of the fibrous ring. Here the vascular network is formed by anastomosing. These networks have the smaller meshes the closer to the central zones of the intervertebral disk. No blood vessel branches have been found in the jelly-like nucleus. Intraorganic vessels of the intervertebral disk do not penetrate the vertebrum body. The connection between the disk vessels and the vessels of the vertebrum body takes place in the field of the perichondrium.

Female↗
PubMed1986

Calcification of intervertebral disks in I-cell disease.

I-cell disease (ICD) is associated with skeletal dysplasia. However, changes of the intervertebral disks had not been previously reported. We describe a child with clinical and laboratory evidence of ICD who had multiple intervertebral disk calcifications. Since an excessive degeneration of the cartilage had previously been found in ICD, we propose that this process may give rise to calcification of the intervertebral disks in patients with ICD.

Calcinosis↗
PubMed1995

[Extraligamentous lumbar intervertebral disk displacement].

The preoperative assessment of sciatica secondary to a herniated intervertebral disk has been radically changed over recent years due to the development of percutaneous treatment techniques which now offer an alternative to surgery. After recalling the terminology used for the position of a herniated lumbar disk in relation to the posterior common vertebral ligament (subligamentous or transligamentous hernia) and to describe whether or not the hernia is detached from the original disk (excluded or non-excluded hernia), the authors review the current state of the art of imaging for each type of herniated lumbar intervertebral disk.

Collateral Ligaments↗
PubMed1993

Side posture manipulation for lumbar intervertebral disk herniation.

OBJECTIVES: The objective of this article is to review the status of side posture manipulation for lumbar intervertebral disk herniation. DATA SOURCES, STUDY SELECTION AND DATA EXTRACTION: The data presented in this article are from our Back Pain Clinic at the Royal University Hospital and the articles cited are those which we feel are important in reviewing this subject. CONCLUSIONS: The treatment of lumbar intervertebral disk herniation by side posture manipulation is both safe and effective. Further research is required to understand more fully the effects of this treatment on the intervertebral disk.

Chiropractic↗
PubMed2000

Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.

The temporal and spatial immunolocalization of TGF-betas and their receptors in the intervertebral disk of senescence-accelerated mouse (SAM) was examined to determine the biological roles played by TGF-betas and their receptors in the process of intervertebral disk degeneration. Ten male SAM and ICR mice aged 8, 24 or 50 weeks after birth were used for this experiment. Histological and immunohistochemical studies using specific antibodies for TGF-beta1, -beta2, -beta3, TbetaR-I, and TbetaR-II were performed. Intervertebral disks of SAM exhibited more degenerative changes than those of ICR mice. Expression of TGF-betas and TbetaRs in disk of SAM and ICR mice was observed at 8 weeks of age, and became weaker with aging. Our results suggest TGF-betas may play a role in the growth and maintenance of intervertebal disks.

Aging, Premature↗
PubMed2004

Analysis of the effect of lumbar spine fusion on the superior adjacent intervertebral disk in the presence of disk degeneration, using the three-dimensional finite element method.

The purpose of this study was to analyze the effect of lumbar spine fusion on the superior adjacent intervertebral disk in the context of disk degeneration, using a nonlinear three-dimensional finite element method. Detailed L3-L5 motion segment models of normal and degenerated intervertebral disks were developed. In fusion models, L4-L5 was fixed by either posterolateral fusion or posterior lumbar interbody fusion (PLIF). Various loading conditions such as compression loading, compression loading plus flexion moment loading, or compression loading plus extension moment loading were applied to study the corresponding stress. Tresca stress on the posterolateral part of intervertebral annulus fiber and von Mises stress on the vertebral endplate (the superior and inferior sides of L3 and L4) were reduced in all degenerated disk models compared with the normal disk models. The PLIF model showed an increase in the percentage change of stress on the vertebral endplate and on the intervertebral annulus fibrosus when flexion and extension moment loadings were applied. This finding suggests that surgeons should consider the risk of exacerbating degeneration of intervertebral disks by undertaking lumbar spine fusion, when degeneration is found in intervertebral disks adjacent to vertebrae requiring fusion.

Adult↗
PubMed2001

Correlation of diffusion in lumbar intervertebral disks with occlusion of lumbar arteries: a study in adult volunteers.

PURPOSE: To evaluate the correlation of the diffusion values in lumbar intervertebral disks with lumbar artery status and the degree of disk degeneration. MATERIALS AND METHODS: Sagittal T2-weighted images of the lumbar spine were obtained in 37 asymptomatic volunteers aged 22-68 years. The apparent diffusion coefficient (ADC) of 98 lumbar intervertebral disks was determined, and two-dimensional time-of-flight magnetic resonance angiography was performed on the corresponding 98 lumbar artery pairs (total arteries = 196). The degree of disk degeneration and the status of lumbar arteries were evaluated independently by two radiologists. ADC calculations were performed on the basis of the average signal intensities of the selected region of interest in lumbar disks. The association between ADC values of disks, the disk degeneration, and the status of lumbar arteries of the same level were analyzed with analysis of covariance, and pairwise analysis between groups (Scheffé post hoc multiple comparison) was performed with statistical software. P values less than .01 were considered significant. RESULTS: The lumbar arterial status correlated strongly with the diffusion values of intervertebral disks, and the ADC values decreased with higher degrees of arterial narrowing. The correlation between disk degeneration and diffusion was not significant. Eight severely degenerated disks with normal lumbar artery status and diffusion values were found. CONCLUSION: Impaired flow in lumbar arteries is significantly associated with decreased diffusion in lumbar disks and may play an important role in disk degeneration.

Adult↗
PubMedDate not supplied

Caudal cervical intervertebral disk disease in the small dog: role of distraction and stabilization in ventral slot decompression.

The clinical outcomes in 112 dogs weighing less than 35 pounds that were presented with cervical intervertebral disk protrusions were retrospectively evaluated. Although the second to third cervical (C2 to C3) intervertebral space was the most common site (27%) of disk protrusion, 57% of disk protrusions presented were caudal to the fourth cervical (C4) vertebra. Dogs with cranial intervertebral disk protrusions, including the C2 to C3 and C3 to C4 intervertebral disk spaces, responded favorably to ventral slot decompression. By comparison, caudal intervertebral disk protrusions (within the C4 to the seventh cervical [C7] intervertebral disk spaces) responded less favorably to ventral slot decompression, demonstrating significantly more severe clinical effects in motor function, comfort, recovery, and long-term outcome following surgery. Significant improvement in clinical results was seen in caudal disk protrusions when additional surgical distraction and stabilization were provided following ventral slot decompression.

Animals↗
PubMed1977

Intervertebral disk calcification associated with spine fusion.

Intervertebral disk calcification and spine fusion were observed in patients with Klippel-Feil syndrome, myositis ossificans progressive, juvenile rheumatoid arthritis, ankylosing spondylitis, and surgical spine fusion. The fusion appears to come first, leading to calcification. This suggests that fusion prevents the normal mechanical stresses within the disk, leading to premature degenerative changes and calcification of the nucleus pulposus.

Ankylosis↗
PubMed2006

Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds.

OBJECTIVE: To determine whether body weight, body condition score, or various body dimensions were associated with acute thoracolumbar intervertebral disk extrusion or protrusion and whether any of these factors were associated with severity of clinical signs in Dachshunds. DESIGN: Cross-sectional clinical study. ANIMALS: 75 Dachshunds with (n = 39) or without (36) acute thoracolumbar intervertebral disk extrusion or protrusion. PROCEDURES: Signalment, various body measurements, body weight, body condition score, and spinal cord injury grade were recorded at the time of initial examination. RESULTS: Mean T1-S1 distance and median tuber calcaneus-to-patellar tendon (TC-PT) distance were significantly shorter in affected than in unaffected dogs. A 1-cm decrease in T1-S1 distance was associated with a 2.1-times greater odds of being affected, and a 1-cm decrease in TC-PT distance was associated with an 11.1-times greater odds of being affected. Results of multivariable logistic regression also indicated that affected dogs were taller at the withers and had a larger pelvic circumference than unaffected dogs, after adjusting for other body measurements. Results of ordinal logistic regression indicated that longer T1-S1 distance, taller height at the withers, and smaller pelvic circumference were associated with more severe spinal cord injury. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that certain body dimensions may be associated with acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds and, in affected dogs, with severity of neurologic dysfunction.

Animals↗
PubMed1976

Postoperative infection of lumbar intervertebral disk space.

Sixteen cases of postoperative intervertebral disk space infection are reviewed. Most occurred after diskectomy, but one followed an unsuccessful attempt at a spinal anesthetic and two followed diskography. Treatment varied from aggressive surgery, either by a posterior, lateral, or anterior approach, to drain the infected disk space or spaces, to more conservative immobilization. Antibiotics were used in all cases. Needle biopsy is valuable in establishing diagnosis and identifying the organism and its antibiotic sensitivities. In some cases fusion occurred spontaneously from the infection; in others, fusion was a result of surgical fusion preceding or following the infection.

Adult↗
PubMed2006

[Clinical study on round-sharp needle therapy combined with massage for prolapse of lumbar intervertebral disk].

OBJECTIVE: To search for a better therapy for prolapse of lumbar intervertebral disk. METHODS: One hundred and sixteen cases were randomly divided into a treatment group treated with round sharp needle plus massage, and a control group with filiform needle plus massage, 58 cases in each group. Changes of symptoms and signs were observed before and after treatment. RESULTS: The effective rate was 98.2% in the treatment group and 82.8% in the control group (P < 0.01). CONCLUSION: Round sharp needle combined with massage has a better therapeutic effect on prolapse of lumbar intervertebral disk.

Humans↗
PubMedDate not supplied

[Intervertebral disk disease among oil drilling workers].

A cross-sectional study among 1,026 oil drilling workers in Northeast Brazil found a prevalence rate of 5% for intervertebral disk disease, varying from 1.8% (activities without heavy lifting) and 4.5% (occasional lifting) to 7.2% (routine lifting). Disease prevalence was 10.5% among drilling workers with more than 15 years in the industry and 11.3% among those over 40 years of age. Prevalence ratio (PR) for the association between working in oil drilling operations and intervertebral disk disease was 2.3 (95% CI: 1.3-4.0). Retrospective information about exposure was collected to minimize the healthy worker survival effect. Using information on current occupation instead of occupational life history would cause an underestimated PR of 1.1 (95% CI: 0.6-1.9). Logistic regression showed results similar to the tabular analysis. Neither confounding nor interaction was evident. Growth of the Brazilian oil industry and recent changes in the work force contract and management, involving changes in risk management and health control, indicate a need for prompt ergonomic intervention in order to control intervertebral disk disease among oil drilling workers.

Adult↗
PubMed1994

[Protrusion of thoracic intervertebral disk: report of 11 cases].

The authors reported 11 cases of thoracic intervertebral disk protrusion examined with plane film, myelography, CT and CT-myelography in 11 cases and MR imaging in 3. All of the 11, cases were confirmed by operation. There were 13 protrusions in the 11 cases with the locations of T10-11 in 4, T11-12 in 5 cases and T12-L1 in 4. 9 protrusions fell into central type, 1 into paracentral type and 1 into lateral type. The clinical symptoms were prominent with all 11 cases, however, most primary clinical diagnoses were erroneously given as lumber intervertebral disk protrusions and even the disorders of heart, lung, alimentary tract and urinary system. It was concluded that the main causes of the misdiagnosis included: (1) not easily to think of this entity for the clinic physicians due to its low incidence, (2) the untypical clinical manifestations. The authors considered that the exam method with the highest accuracy is CT-myelography.

Adult↗