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PubMedDate not supplied

[Effect of factors simulating space flight on the content of free and protein-bound forms of 11-hydroxycorticosteroids in the blood plasma].

The effect of spaceflight simulation factors (ascent to an altitude of 8,000 m, anticipation of centrifugation, psychological test, hypokinesia, and enclosure in an altitude chamber) on the content of free and protein-bound 11-hydroxycorticosteroids in plasma was studied. This exposure produced changes in the total and fractional content of the hormones. The changes depended on the simulation factor, duration of its action, and functional status of test subjects.

11-Hydroxycorticosteroids↗
PubMed1978

Improved assay of urinary total 17-hydroxycorticosteroids.

A reliable method for the quantitative determination of "total 17-hydroxycorticosteroids has been described. Urine is subjected to reduction with sodium borohydride which reduces the 17-hydroxy-20-keto-21-deoxy steroids to 17,20-dihydroxy-21-deoxy steroids and 17-ketosteroids to C19 17-hydroxysteroids. Subsequent oxidation with sodium bismuthate oxidizes all the C21 17-hydroxysteroids to the corresponding 17-ketosteroids, which are extracted with CHCl3 : Bu-OH using ammonium sulfate as the salting out agent and finally the color reaction is performed with m-dinitrobenzene and the absorbance is measured. The 17-ketosteroids originally present in the urine do not interfere, since NaBH4 reduces them to C19 17-hydroxysteroids which cannot be oxidized with sodium bismuthate and do not respond to the color reaction with m-dinitrobenzene.

17-Hydroxycorticosteroids↗
PubMed1975

[Circadian variations of 17-hydroxycorticosteroids and of tetrahydro-11-deoxycortisol in the healthy man: effect of the continuous administration of metyrapone (SU 4885)].

In eight apparently healthy young men a circadian rhythm (P less than 0,05) in urinary 17-hydroxycorticosteroids (17 OHCS) and tetrahydro-11-deoxycortisol (THS) has been demonstrated before (A), during (B) and after (C) a 36 h sustained oral administration of metyrapone (7.50 g in ten doses of 0.75 g every 4 h). Subjects synchronization: light-on 0715; light-off 2300. 17 OHCS have the acrophase phi located at 1430 (2:30 p.m.) in the three circumstances. Only traces of THS are excreted during A. During B and C when THS is excreted, a circadian rhythm is validated (p less than 0.05) with a phi at 1430.

17-Hydroxycorticosteroids↗
PubMed1976

[Effect of glucose and phenobarbital on the concentration of 11-hydroxycorticosteroids in the blood plasma of piglets].

In piglets 18 to 30 days old, the authors studied the changes of the levels of plasmatic 11-hydroxycorticosteroids (11-OHCS), the overall content of cholesterol and blood glucose two hours after oral application of glucose or phenobarbital. A dose of 0.5 g of glucose per kg of weight did not affect the parameters in question as compared with the control group which received a physiological solution. A dose of 2 g of glucose per kg of bodyweight caused glycaemia two hours after administration and an non-significant increase of the 11-OHCS level. Phenobarbital, administered at the rate of 10 mg per kg of bodyweight, markedly reduced the 11-OHCS level in the blood plasma. The level of total cholesterol showed a slight decrease in all instances. The authors discuss the mechanisms causing the changes observed. It is suggested that the effect of phenobarbital could be used for moderating the negative effects of the raised glucocorticoid level in stress situations.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

Studies on circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) in carcinoma of the breast.

Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in 25 histopathologically proved breast cancer patients pre operatively and on the 9th postoperative day and in 15 healthy women under tropical conditions. A marked rhythm in plasma 17-OHCS concentration was noticed in healthy controls. The maximal concentration occurred at 06:00 followed by a consistent decline throughout the daytime, reaching a minimum at 00:00 with an amplitude statistically significantly different from zero and an acrophase around 08:56. The plasma 17-OHCS concentration was found to be elevated at all sampling hours in breast cancer patients, irrespective of the stage of the disease. However, the degree of elevation and disruption of rhythm was more pronounced in advanced sages, preoperatively, in comparison to other groups. Moreover, the values declined markedly at all collection hours after mastectomy, approaching usual values and rhythm characteristics on the 9th postoperative day.

17-Hydroxycorticosteroids↗
PubMed1977

Selective photometric determination of betamethasone benzoate and other 21-hydroxycorticosteroids.

Condensation of the glyoxal obtained by cupric acetate oxidation of 21-hydroxycorticosteroids with acetous phenylhydrazine reagent affords a near UV chromophore. All of the tested corticosteroids, including triamicinolone acetonide, which gives low color yields in the Porter-Silber reaction and its Lewbart-Mattox modification, gave similar absorption maxima (362-370 nm) and molar absorptivities (epsilon = 17,000-20,500). Since corticosteroid 21-esters and oxidation products do not undergo the reaction, the assay method based on it is stability indicating for betamethasone benzoate and the other test compounds. Procedures are described for the assay of two topical betamethasone benzoate preparations and hydrocortisone and prednisolone tablets; recovery and precision data are given.

Betamethasone↗
PubMed1969

Plasma 11-hydroxycorticosteroid and growth hormone levels in acute medical illnesses.

Adrenal cortical response in acute medical illness has been studied by measuring the plasma 11-hydroxycorticosteroid (11-OHCS) concentration in 178 patients. Those with unbalanced diabetes, acute infections, and severe myocardial infarction had high levels. The results obtained suggest that in a patient with a severe infection and hypotension a plasma 11-OHCS level of less than 15 mug./100 ml. indicates an inadequate adrenal cortical response, and one patient with septicaemia and temporary adrenal cortical insufficiency is described. Growth hormone levels were increased in patients with severe diabetic ketosis but not in those with hyperosmolar non-ketotic diabetic coma.

Adult↗
PubMed1972

Plasma and urinary 11-hydroxycorticosteroids in differential diagnosis of Cushing's syndrome.

Morning plasma 11-hydroxycorticoids, urinary 11-hydroxycorticoids, and urinary 17-oxogenic steroids were measured before and during a dexamethasone suppression test. This consisted in the administration by mouth of 2 mg of dexamethasone daily for 48 hours, followed by 8 mg daily for 48 hours. In addition midnight plasma 11-hydroxycorticoids were measured before the start of the test. The subjects investigated were 21 patients with Cushing's syndrome, 27 obese female patients, 10 female patients with the Stein-Leventhal syndrome, and 8 female patients with idiopathic hirsutism.The results showed that the clearest distinction between the groups was made by measurement of the basal urinary 11-hydroxycorticoid excretion, where, in the group of patients with Cushing's syndrome, all the levels were well above the upper limit of normal. In addition raised midnight plasma 11-hydroxycorticoid levels were of great diagnostic value. By using these results together with those of the dexamethasone suppression tests it was possible to make a firm preoperative diagnosis of pituitary-dependent Cushing's syndrome in 90% of patients in this series.

17-Hydroxycorticosteroids↗