Epoxide hydrase activity in liver nuclei: hydration of benzo[a]pyrene-4,5-oxide and styrene oxide.
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Animals↗
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The effect of some mixed function oxidase inducers on aryl hydrocarbon hydroxylase and epoxide hydrase in nuclei and microsomes from rat liver and lung. The effect of cigarette smoke.
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Animals↗
Substrate and steric specificity of hydropyrimidine hydrase.
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Amidohydrolases↗
Epoxide hydrase activity and its relationship to development in the southern armyworm, Prodenia eridania.
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Animals↗
Interrelationships of dietary protein level, aflatoxin B metabolism, and hepatic microsomal epoxide hydrase activity.
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Aflatoxins↗
Increase in genetic activity of the polycyclic hydrocarbon benzo[a]pyrene by inhibition of the epoxide hydrase in an activation system in vitro.
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Animals↗
Improved gas chromatographic method for measuring phenylethylene glycol: application to the determination of styrene monooxygenase and epoxide hydrase activities.
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Animals↗
Purification and assay of liver microsomal epoxide hydrase.
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Animals↗
Radioactive assay of aryl hydrocarbon monooxygenase and epoxide hydrase.
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Animals↗
Epoxide hydrase: structure-activity relationships of in vitro stimulators of the microsomal activity.
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Animals↗
Plant carbonic anhydrase. Hydrase activity and its reversible inhibition.
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Acetazolamide↗
Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors.
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Alcohols↗
Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum.
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Calcium Phosphates↗
Effects of an epoxide hydrase inhibitor on in vivo binding of polycyclic hydrocarbons to DNA and on skin carcinogenesis.
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Administration, Topical↗
Molecular properties and biological functions of microsomal epoxide hydrase.
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Animals↗
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
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Animals↗
Effect of protein deficiency on the hepatic microsomal mixed function oxidase. III-Influence on aflatoxin B1 metabolism and epoxide hydrase activity.
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Aflatoxins↗
The effect of dieldrin-contaminated feed on rat hepatic microsomal epoxide hydrase and aryl hydrocarbon hydroxylase.
Adult male rats were exposed to dieldrin-contaminated rations. The hydroxylation of benzpyrene (AHH) and hydration of styrene oxide (EH) by the hepatic microsomal fraction were followed. At dieldrin levels of 5 to 25 ppm for one week, the EH activity increased from 19% to 115% above control levels respectively. Animals exposed to 25 ppm developed elevated EH activities after a few days, with a maximum increase of 2.5 times control levels after two weeks. AHH activity was not elevated over control levels at any dose or time studied. Slight but significant increases in levels of cytochrome P-450 were observed. Pentobartibal sleeping time was decreased to 61% of control levels after exposure to 20 ppm dieldrin-contaminated food for 7 days. Two days of intraperitoneal administration of technical grade dieldrin, analytical grade dieldrin and analytical grade aldrin gave similar increases in EH activity within this group. Again, no changes in AHH activity were seen.
Aldrin↗