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[Farber disease: a cause of hoarseness of the voice in children].

Farber's disease (disseminated lipogranulomatosis) is an autosomal recessive disease characterized by deposition of glycolipid ceramide in different tissues due to deficiency of lysosomal acid ceramidase. The disease starts to manifest at the age of four months by a hoarse cry or swollen tender joints followed by subcutaneous nodules. This disease is fatal in the first years of life and no treatment is known until now. This study presents four cases of Farber's disease who all presented by hoarseness of voice, polyarthritis and subcutaneous nodules. After clinical examination, the diagnosis was confirmed by fiberoptic flexible nasopharyngolaryngoscopy which showed the presence of vocal folds thickening in all patients and affection of the cricoarytenoid joint in one patient and biopsy from the subcutaneous nodules which showed infiltration of the deep dermis and subcutaneous tissues by fibroblasts and large foamy histiocytes.

Acid Ceramidase↗

[Clinical analysis of hoarseness after thyroidectomy].

The present paper reports 86 cases of hoarseness after thyroidectomy. In 37 cases, glottic paralysis was confirmed. Among them the injury of recurrent laryngeal nerve were 89.91% (33/37). In 33(36 side) cases of recurrent laryngeal nerve paralysis, left injury was 20 and right was 16. Referring to the literature author consider that: 1. the recurrent laryngeal nerve was injured easy by thyroidectomy because that thyroid gland was located closely with recurrent laryngeal nerve in neck; 2. recurrent laryngeal nerve injury after thyroidectomy was related to the character of thyroid gland tumor and times of operations; 3. incidence of superior laryngeal nerve injure in thyroidectomy was rare; 4. following up 16 cases of glottic paralysis, most of all (13/16) hoarseness was improved with the health side vocal cords overcompensation.

Adolescent↗

[An eye on the vocal cords: family practitioner and hoarseness].

In four patients with hoarseness, men aged 53 and 67 years, and women aged 8 and 37 years, indirect laryngoscopy revealed, respectively, a squamous cell carcinoma of the vocal cord, recurrent nerve paralysis due to pulmonary carcinoma, irritative noduli due to forced use of the voice, and psychic stress as the cause. In a patient with existing hoarseness over a period of 3 to 6 weeks, the vocal cords will have to be examined with indirect laryngoscopy. Where the general practitioner is not equipped to handle this procedure, he can make a referral to an ear, nose and throat specialist. It would, however, be to the benefit of the patient and the general practitioner if the latter were to master the technique of indirect laryngoscopy. This would enable the patient to be treated without further delay, and it might also make selective referral possible.

Adult↗

[79 cases: a clinical analysis of hoarseness in children].

OBJECTIVE: To research the clinical characters of the hoarseness in children. METHOD: 79 cases are analysed retrospectively. RESULT AND CONCLUSION: Age for this disease is usually 3 years old. People with irritable character are more easy to get it. Vocal nodule is the main cause to chronic hoarseness in children. Conservative treatment is important.

Adolescent↗

[Hoarseness in a recent visitor to the tropics through infection of the larynx by Histoplasma capsulatum].

A 58-year-old man presented with hoarseness and a sore throat for the previous 3 months, which were caused by a laryngeal infection with the fungus Histoplasma capsulatum. He had been infected during a stay in Indonesia. Both his hoarseness as well as the Histoplasma antigen titres in serum responded to therapy with itraconazol. H. capsulatum is found in tropical and subtropical areas worldwide, but infections are most commonly reported from the south of the United States of America. If not asymptomatic, the disease most often presents with pulmonary symptoms. A histoplasmosis presenting as a laryngeal infection is relatively uncommon and can be mistaken for papillomatosis or carcinoma. The diagnosis can be made by microscopy and culture of the fungus; an antigen test is available in the United States.

Antifungal Agents↗

Hoarseness as imminent symptom of aortic aneurysm rupture (Ortner's syndrome).

Ortner's syndrome (cardiovocal syndrome) is the clinical entity of hoarseness due to left recurrent laryngeal nerve palsy caused by cardiovascular disease. We present a case of an 86-year-old woman with hoarseness as a prominent symptom due to a large painless aneurysm of the thoracic aorta, which soon ruptured. Cardiovocal syndrome can be a rare but an important and probably the only major clinical finding of a painless aortic rupture.

Aged, 80 and over↗

Ambulatory esophageal and hypopharyngeal pH monitoring in patients with hoarseness.

Ten patients referred by an otolaryngologist for ambulatory esophageal pH monitoring for suspected reflux-induced hoarseness were monitored with a dual ambulatory pH system in which probes were simultaneously placed 5 cm above the lower esophageal sphincter and 2 cm above the upper esophageal sphincter (laryngeal inlet). All were nonsmokers. Hypopharyngeal reflux (pH drop less than 4 in upper electrode preceded by pH drop less than 4 in esophageal electrode) was conclusively demonstrated in 7 of 10 patients. Three of these seven patients had normal frequency and duration of esophageal reflux and would have been classified as normal, yet demonstrated acid reflux into the hypopharynx. As a group, these patients were high frequency, short duration, upright refluxers. Combined hypopharyngeal and esophageal pH monitoring is useful in the diagnosis of reflux-induced hoarseness.

Adult↗

[Investigation of the mechanism of hoarseness after thyroidectomy].

Electromyography of the intrinsic laryngeal muscles and laryngeal function measurements were performed on 34 patients with hoarseness after thyroidectomy. It is believed that mild laryngeal nerve paralysis might not give rise to disturbances in vocal cord movement. Causes of hoarseness after thyroidectomy could be mild recurrent superior laryngeal or combined nerve paralysis. During recovery, the vocal cord moved from paramedian position to middle position. Normal vocal cord movements did not mean complete recovery from paralysis, since electromyogram still showed abnormal potentials. It is suggested that vocal cord paralysis be divided into three types: severe, moderate and mild.

Adenoma↗

Hoarse voice.

Various causes of hoarse voice are briefly discussed in this article. As it is not possible to give a detailed account of all the causes of this important condition affecting the larynx, any patient with persistent hoarseness of more than four weeks' duration should have his larynx thoroughly examined. The head mirror, suitable light source, laryngeal mirror, spirit lamp, pierce of gauze and a local anaethetical spray is all that is required to carry out a mirror examination of the larynx.

Hoarseness↗

[A case of sarcoidosis presenting with hoarseness and dysphagia due to glossopharyngeal and vagus nerve paresis].

The patient was a 20-year-old female who complained of hoarseness and dysphagia. Chest X-ray showed bilateral hilar lymphadenopathy. Sarcoidosis was diagnosed histologically on the basis of granuloma without necrosis, by transbronchial lung biopsy (TBLB). Bronchofiberscopic findings revealed no granuloma of the vocal cords. Examination of the central nervous system with MRI identified no abnormalities. Hoarseness and dysphagia were thought to have been caused by glossopharyngeal and vagus nerve paresis. These signs improved markedly after two weeks of steroid therapy. This is a rare case of sarcoidosis associated with glossopharyngeal & vagus nerve paresis.

Adult↗

Hoarseness. From viral laryngitis to glottic cancer.

Hoarseness indicates an abnormality at the level of the glottis. This symptom may result from either structural or physiologic disorders. The differential diagnosis is lengthy and includes both benign and malignant diseases. History taking and physical examination, particularly laryngeal visualization, provide key clues. Careful and complete examination is always recommended, because airway obstruction can in some situations quickly follow hoarseness.

Hoarseness↗

[Diagnosis and therapy of hoarseness].

A patient consulting his physician because of hoarseness often suffers from viral laryngitis. This infectious disease usually heals within one or two weeks. If the hoarseness persists for more than three weeks, the patient should be examined by laryngoscopy to exclude a laryngeal cancer. The differential diagnosis includes other organic or functional lesions. Voice therapy is the treatment of choice for functional voice disturbances and for disorders of pubertal mutation, which very rarely are due to hormonal changes. Organic lesions are usually treated by surgery.

Acute Disease↗

[Tuberculous mediastinal lymphadenitis presenting as hoarseness].

A 70 year-old woman was admitted to our hospital complaining of hoarseness. Bronchoscopic examination revealed that the left vocal cord was fixed in the paramedian position, and therefore left recurrent nerve paralysis was suspected. Although a chest X-ray film showed no abnormal findings, a chest computed tomogram showed that pretracheal (#3) and subaortic (#5) lymph nodes were swollen (1 to 2 cm in diameter). An open biopsy was done. Histological examination of the resected mediastinal lymph nodes revealed an accumulation of Langhans giant cells and epithelioid cells in caseous necrosis. An acid-fast bacillus was seen after Ziehl-Neelsen staining. This was a rare case of mediastinal tuberculous lymphadenitis in which hoarseness was useful for early diagnosis. Fifty-three cases of tuberculous mediastinal lymphadenitis have been reported in Japan.

Aged↗

Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus.

Otolaryngologic involvement is rarely a manifestation of drug-induced systemic lupus erythematosus (SLE). Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months. Histopathologic study of an epiglottic "pseudotumor" disclosed necrotizing vasculitis. To our knowledge, this is the first reported case of laryngeal involvement as a complication of hydralazine-induced SLE.

Epiglottis↗

Hoarseness as the initial clinical presentation of anomalous left coronary artery from the pulmonary artery.

Anomalous origin of the left coronary artery from the pulmonary artery is a rare congenital anomaly that, if left untreated, will most often result in severe myocardial ischemia and significant morbidity and mortality. We report an unusual presentation of this defect in a 2-month-old infant who had an initial complaint of a "hoarse cry." We theorize that impingement of the recurrent laryngeal nerve due to dilatation of the pulmonary artery was the most likely etiology of the patient's symptoms. This case serves as an important reminder that serious congenital heart disease may present with any number of complaints and unusual findings.

Blood Vessel Prosthesis Implantation↗

Evaluation of the patient with hoarseness.

Hoarseness has a broad range of etiologies, and in most cases a diagnosis can be made by recording an accurate history and by conducting a thorough physical examination. This paper will present an overview of the more common voice disorders and explain in which cases imaging studies such as computed tomography or magnetic resonance imaging are necessary. The essential imaging features will be discussed.

Adult↗