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At least 91 records · Page 5Linked to original sources
PubMed2002

Acupuncture therapy for persistent hiccups.

Persistent hiccups (singultus) is a rare but severely disabling disorder. The causes of persistent hiccups are numerous, as are the treatment options. However, none of the treatment modalities has proven to be effective by evidence-based criteria, and no treatment has been shown to be superior to another. Traditional acupuncture has not been previously reported as a modality for the treatment of persistent hiccups in the English medical literature. We describe 2 patients with persistent hiccups refractory to conventional treatments that were treated successfully using acupuncture.

Acupuncture Therapy↗
PubMed1995

Hiccups.

Hiccups result from a variety of causes and serve no known physiologic function. Although most episodes are time-limited, hiccups may become protracted, with serious consequences. Assessment of hiccups entails a focused history and physical examination coupled with selected laboratory tests. If a correctable malady is discovered, treatment should address the underlying disorder. However, if the cause remains unknown, therapeutic options include nonpharmacologic and pharmacologic measures. Since hiccups are common, this review provides a practical approach to the management of this bothersome symptom.

Female↗
PubMed2006

Metoclopramide for migraine-associated hiccup.

Persistent hiccup can be a distressing disorder. I present a case of migraine-attack-associated sustained hiccup. Metoclopramide can swiftly control both hiccup and migraine headache. Vasopressin release probably underlies migraine-aborting action of metoclopramide while restoration of oesophageal smooth muscle function involves competitive dopaminergic antagonism and a prominent cholinergic agonist activity. Episodic prolonged hiccup associated with nausea is an unusual presenting feature of migraine.

Adult↗
PubMed1989

Interactional treatment of intractable hiccups.

This article provides a comprehensive review of the literature regarding nonmedical approaches to the understanding and treatment of intractable hiccups. The author provides a rationale for an interactional view and presents a case in which post-surgical hiccups were successfully treated, using principles developed by the Mental Research Institute. Of particular interest is the manner in which the therapist managed a system that included the victim's wife, a physician, and other medical personnel who were all trying to eliminate the hiccups. Interventions were designed primarily to alter meanings attributed to the hiccups and, thus, to intervene in the system that was maintaining the problem. This article is presented as a response to Weakland's call for research and practice in family somatics.

Adult↗
PubMed1990

Nifedipine for intractable hiccups.

Seven patients with intractable hiccups were treated with a calcium channel blocker, nifedipine. A daily dose of 30 to 60 mg of this drug stopped hiccups in 4 patients and improved them in a 5th patient. In 2 patients hiccups recurred within 24 hours after stopping nifedipine. Nifedipine can be effective against intractable hiccups in some patients.

Adolescent↗
PubMedDate not supplied

[Benzodiazepine and hiccup: three case reports].

Hiccup is a sudden contraction of the inspiratory muscles, followed by an abrupt closure of the glottis, thus producing a characteristic sound. In the literature, some drugs have been reported to induce hiccup. We discuss three case reports after administration of benzodiazepine to healthy young subjects during two clinical trials. In the first study (a bioequivalence trial of two forms of lormetazepam, tablets and oral solution), 12 subjects were included in an open controlled crossover study with two periods separated by a washout of 7 days. Two subjects presented with hiccup after administration of lormetazepam (2mg oral solution). The symptom resolved in 10 and 40 minutes, respectively. In one subject, rechallenge with a tablet of lormetazepam was positive. The aim of the second study was to assess the effect of sleep deprivation and lorazepam-induced sedation on saccadic eye movements in 12 healthy subjects. Hiccup occurred in one subject 3h 15 after administration of a single oral dose of lorazepam (2mg) and resolved in 45 minutes. All cases were evaluated according to the French imputation method. These observations are discussed with regard to the drug classes mentioned most frequently in the literature.

Adult↗
PubMed2003

[The diverse etiology of hiccups].

Hiccup is a sudden contraction of the inspiratory muscles, followed by an abrupt closure of the glottis, thus producing a characteristic sound. Hiccups serve no known physiologic function. Mostly, it is a benign symptom which terminates without treatment. Persistent and intractable hiccups may indicate an organic disorder, thereby requiring evaluation based on history, physical examination, and selected laboratory tests. The treatment is based on the organic disorder, if it is found. The combination therapy with cisapride, omeprazole and baclofen is the most effective empiric treatment. We describe a number of case reports of patients with hiccups due to digitalis intoxication, ischemia of the inferior wall of the heart, peptic disease and gastroesophageal reflux disease.

Anti-Ulcer Agents↗
PubMed2004

Hiccups and multiple sclerosis.

Hiccups is a rare and unfamiliar presenting symptom of multiple sclerosis. Patients admitted to Ramathibodi Hospital from 1969 to 1992 who had a clinical diagnosis of multiple sclerosis were reviewed The presenting symptoms and neurological signs were analysed. The clinical features and course of the disease of cases who initially presented with intractable hiccups were studied in detail. There were 4 cases out of a total of 47 cases (8.5%) who presented with hiccups. These patients all had relapse and remission and two of them had a rather fulminant course of illness. Therefore, multiple sclerosis should be seriously considered as a possible cause of intractable hiccups. It may be of benign or malignant form. In the latter, the patients may develop quadriparesis within hours or days and respiratory failure may ensue. They usually respond well to high dose intravenous corticosteroids especially pulse methylprednisolone.

Adolescent↗
PubMed2005

Intractable hiccups as an unusual presentation of a uterine leiomyoma: a case report.

BACKGROUND: Hiccups, or singultus, are an abrupt, intense contraction of the inspiratory muscles accompanied by closure of the glottis and are experienced by most people. people. CASE: A 41-year-old woman with a large uterine myoma presented with recurrent and intractable hiccup boutsfor 1 year. The hiccups resolved spontaneously after hysterectomy. CONCLUSION: A uterine leiomyoma, especially the subserosal type, might become a possible etiology of hiccups when large enough to cause irritation of the vagus or phrenic nerve.

Adult↗
PubMed1991

Hiccups and related esophageal motor disorders.

The clinical course of a patient with pyrosis and intractable hiccups is presented. Hiccups persisted six years after an effective fundoplication had cured pyrosis, and the patient was eventually treated with baclofen. Esophageal function during and after hiccups was studied in detail by means of esophageal manometry and 24-hour-pH monitoring. The relationship between hiccups and gastro-esophageal reflux is discussed.

Amantadine↗
PubMed2001

Gender discrepancy observed between chemotherapy-induced emesis and hiccups.

The aim of this paper was to describe striking gender differences observed between emesis and hiccups in patients receiving cisplatin-based chemotherapy (CT) and one of two dexamethasone-containing anti-emetic regimens. Four hundred patients were evaluated in a crossover study with two arms. Patients in arm A received three doses of ondansetron 8 mg i.v. at 4-h intervals plus dexamethasone 20 mg i.v. from the start of CT, followed by dexamethasone 5 mg i.v. every 12 h, until CT was complete, after which dexamethasone was discontinued. For patients in arm B the treatment was the same as in arm A except that the three doses of ondansetron 8 mg i.v. were given at 24-h intervals. There were 363 patients in arm A and 358 patients in arm B. Vomiting/nausea/hiccups were observed in 30.3%/41.6%/23.7% of patients in arm A and 28.8%/39.1%/23.7% of patients in arm B, respectively. Comparison showed that the rates for complete control of vomiting and nausea on days 1 through 6 were significantly lower in women (P<0.0001 and =0.0004 in arm A and P<0.0001 and <0.0001 in arm B, respectively). Men had a significantly higher incidence of hiccups (P<0.0001 in both arms), but no apparent associations with age, cisplatin dose, tumor type, and the presence of vomiting and nausea during CT were found. Hiccups usually began 24 h after cisplatin administration and persisted for some days. Women had significantly higher rates of vomiting and nausea. The cause of the gender discrepancy is unknown.

Adolescent↗
PubMedDate not supplied

Persistent hiccups as an unusual manifestation of hyponatremia.

In two patients, persistent hiccups were an unusual presenting manifestation of hyponatremia. Persistent hiccups occur in a variety of serious diseases, including metabolic and electrolyte disorders. They may cause the victim significant distress and may be refractory to most treatments. Hiccups lasting more than 24 hours require investigation for an underlying organic etiology, with hyponatremia included in the differential diagnosis.

Aged↗
PubMed2005

Acupuncture for persistent hiccups in a heart and lung transplant recipient.

Hiccup is an intermittent, abrupt, involuntary contraction of the diaphragm resulting in sudden inspiration abruptly opposed by the closure of the glottis. Persistent hiccups can interfere with daily activities and cause sleep disturbance and fatigue. We report a case of persistent hiccups occurring in a heart and lung transplant recipient that was successfully treated with acupuncture.

Acupuncture Therapy↗
PubMed1991

Hiccups (singultus): review and approach to management.

Hiccups are a common, and fortunately usually transient, benign malady. Occasionally, however, hiccups fail to resolve spontaneously, resulting in patient fatigue and incapacitation and the need for the affected individual to seek medical care for resolution of the problem. The approach to the management of these patients consists of the identification and treatment of serious underlying causes of the episode as well as therapeutic interventions to achieve hiccup resolution.

Female↗
PubMed2000

Persistent hiccup as presenting symptom in medulla oblongata cavernoma: a case report and review of the literature.

A rare case of persistent intractable hiccup as presenting symptom of cavernous angioma in the medulla oblongata is reported. Pathophysiologic hypotheses about the triggering mechanism of hiccup are discussed, with special reference to the causes affecting the central nervous system. A review of the literature concerning medullary lesions presenting with persistent hiccup is also reported. Finally we have included some brief considerations about cavernous angiomas and the patterns of their clinical presentation, focusing on those located in the medulla oblongata.

Brain Neoplasms↗
PubMed1988

Sleep hiccup.

The present study is the first to prove the presence of hiccup during sleep polygraphically. Hiccup (Hc) penetrates all sleep stages; in REM sleep, it becomes randomized. The amplitude and frequency of sleep Hc have stage-dependent characteristics, and a linear regression appears with every sleep cycle. Sleep Hc may alternate, but does not coexist with, periodic leg movements. Related to inspiration, sleep Hc presents a right deviation when compared with wake Hc. The sleep pattern in persistent sleep Hc is disturbed in a nonspecific manner. Sleep Hc is not associated with sleep apnea. Sleep synchronizes the breathing rate with the hiccupping rate. During light sleep, the Hc rate exceeds the breathing rate, whereas during deep sleep, the breathing rate exceeds the Hc rate.

Adult↗
PubMed2005

A renal transplant patient with intractable hiccups and review of the literature.

Intractable hiccups in transplanted patients may be caused by various medical conditions including infections. We report a case of a 44-year-old man who suffered from intractable hiccups after cadaveric kidney transplantation. We identified 3 different hiccup periods with different causes: 1) steroid and anesthetics use, 2) severe ulcerose herpetic and mycotic esophagitis, and 3) pleuropneumonia caused by nosocomial methicillin-resistant Staphylococcus epidermidis and pulmonary abscess requiring thoracic surgery.

Adult↗
PubMed1992

Lidocaine pretreatment effectively decreases the incidence of hiccups during methohexitone administration for dilatation and curettage.

The efficacy of lidocaine 1 mg.kg-1 for prevention of methohexitone-induced hiccups was assessed in a double-blind fashion in 200 patients undergoing dilatation and curettage for pregnancy interruption. The patients were randomly assigned to receive either lidocaine 1% or saline 0.9% in a similar way (1 ml for every 10 kg of body weight). The incidence of hiccups was 16% in the control group compared to 6% in the lidocaine group. We speculate that this reduction in the methohexitone-induced hiccup ratio is related to lidocaine's membrane-stabilizing properties, which decrease the excitability of all the nervous structures involved in this reflex.

Abortion, Induced↗