Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “GLOTTIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources
PubMed1991

Quantitation of DNA ploidy in squamous intraepithelial neoplasia of the laryngeal glottis.

The DNA contents in 56 laryngeal glottic biopsy specimens with a spectrum of squamous intraepithelial neoplastic (SIN) changes were evaluated by image analysis. A combination of DNA histogram features were used to define abnormal DNA-containing cell populations that were interpreted as representing intraepithelial neoplastic transformation. Eighteen biopsy specimens were classified as dysplasia/keratosis and graded SIN I, six (33%) of which were aneuploid. Eighteen (78%) of 23 biopsy specimens graded SIN II were aneuploid, and all 15 biopsy specimens graded SIN III had abnormal quantities of nuclear DNA. Twelve biopsy specimens (six of SIN II grade and six of SIN III grade) were considered to represent keratinizing forms of dysplasia, and all 12 (100%) were found to contain increased (aneuploid) quantities of DNA. We conclude that the proposed SIN-grading scheme for laryngeal epithelial abnormalities exhibits strong correlations with nuclear DNA content. In addition, aneuploidy was observed in all SIN II- and SIN III-graded biopsy specimens with prominent keratinization.

Biopsy↗
PubMed1999

Stage I (T1 N0 M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice preservation.

BACKGROUND: The therapeutic outcomes for voice preservation in Stage I (T1 N0 M0) glottic carcinoma, treated with conservation surgery, radiation therapy, and endoscopic resection, are controversial. METHODS: A retrospective tumor registry retrieval of data on patients treated with curative intent at Washington University Medical Center-Barnes Hospital between January 1971 and December 1990 for the surgical group, January 1971 to December 1985 for the low-dose radiation group, and January 1986 to January 1995 for the high-dose radiation group, was performed. RESULTS: The 659 patients with Stage I (T1 N0 M0) glottic carcinoma treated with curative intent were subdivided into four groups: (1) 90 patients received low-dose radiation (mean dose 58 Gy, range 55-65 Gy, daily fractionation 1.5-1.8 Gy); (2) 104 patients received high-dose radiation (mean dose 66.5 Gy, range 65-70 Gy, daily fractionation 2-2.25 Gy); (3) 404 patients underwent conservation surgery; and (4) 61 patients had endoscopic resection. T1A (85%) and T1B (15%) disease was equally distributed among the groups. The anterior commissure was involved in 38 patients in the radiation therapy groups and 56 patients in the surgical groups. The overall local control was 89%. The overall local salvage was 84%. The overall unaided laryngeal voice preservation was 90%. The overall 5-year disease specific and actuarial survival rates were 95% and 81%, respectively. Prevalence of 2% regional metastases, 1.2% distant metastases, and 14% second primary malignancies were documented. The cure rate was 69% for regional metastases, 13% for distant metastases, and 44% for second primary malignancies. There were 5 complication deaths (0.1%), and 38 (6%) patients died of intercurrent disease. The use and dose of tobacco products was significantly increased in patients who died of intercurrent disease (p = 0.004) or developed second primary malignancies (p = 0.024). No significant difference was observed among the four therapeutic groups in the 5-year cause-specific survival rate (p, 0.68). Actuarial survival was significantly decreased in the low-dose radiation therapy group as compared with the other three therapeutic groups (p = 0.04). Initial local control was poorer for the endoscopic (77%) and low-dose radiation (78%) groups as compared with the high-dose radiation (89%) and conservation surgery (92%) groups (p = 0.02) but significant differences were not found for ultimate local control following salvage treatment. Unaided laryngeal voice preservation was similar for high-dose radiation (89%), conservation surgery (93%) and endoscopic resection (90%), but significantly poorer for low-dose radiation (80%; p = 0.02). T1B disease (N = 94) had similar local control and voice preservation with conservation surgery (87%) and high-dose radiation (88%) but lower results with low-dose radiation and endoscopic resections (67% unaided laryngeal voice preservation; p = 0.02). CONCLUSION: (1)The four therapeutic groups achieved similar rates of disease specific survival and ultimate local control. (2) Low-dose radiation was associated with significantly lower overall actuarial survival and unaided laryngeal voice preservation. (3) Endoscopic resection was associated with a significantly lower initial local control rate, but following salvage therapy achieved equivalent results to the other treatment methods. (4) Patients with (T1 N0 M0) glottic carcinoma had similar survival, local control, and unaided laryngeal voice preservation rates with high-dose radiation, conservation surgery, and endoscopic resections, but not with low-dose radiation therapy. (c) 1999 John Wiley & Sons, Inc. Head Neck 21: 707-717, 1999.

Adult↗
PubMed2006

Analytic representation of volume flow as a function of geometry and pressure in a static physical model of the glottis.

A static physical model of the larynx (model M5) was used to obtain a large set of volume flows as a function of symmetric glottal geometry and transglottal pressure. The measurements cover ranges of these variables relevant to human phonation. A generalized equation was created to accurately estimate the glottal volume flow given specific glottal geometries and transglottal pressures. Both the data and the generalized formula give insights into the flow behavior for different glottal geometries, especially the contrast between convergent and divergent glottal angles at different glottal diameters. The generalized equation produced a fit to the entire M5 dataset (267 points) with an average accuracy of 3.4%. The accuracy was about seven times better than that of the Ishizaka-Flanagan approach to glottal flow and about four times better than that of a pressure coefficient approach. Thus, for synthesis purposes, the generalized equation presented here should provide more realistic glottal flows (based on steady flow conditions) as suitable inputs to the vocal tract, for given values of transglottal pressure and glottal geometry. Applications of the generalized formula to pulses generated by vocal fold motions typical of those produced by the Ishizaka-Flanagan coupled-oscillator model and the more recent body-cover model of Story and Titze are also included.

Glottis↗
PubMed2003

[Treatment of T1N0 glottis carcinoma with radiotherapy. Results at our center and review of the literature].

OBJECTIVE: To evaluate the results of radiotherapy in the treatment of patients with T1N0 glottic squamous cell carcinoma. MATERIAL AND METHODS: Retrospective study of a cohort of 338 patients with T1N0 glottic carcinoma treated with radiotherapy at our institution between 1985-1997. A review of the literature published during the last ten years was carried out. RESULTS: Local control with radiotherapy in our patients was 82%, reaching 97% when salvage surgery was included. The local control with radiotherapy in most of the published series ranges between 81.90%. CONCLUSIONS: Treatment with radiotherapy achieves local control in early glottic carcinomas (T1N0) in 80-90% of cases. In our centre such treatment achieved local control in 82% of cases.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Acinic cell carcinoma of the glottis: case report.

Acinic cell carcinoma is a rare tumor of the head and neck that mainly affects the parotid gland but occasionally involves the minor salivary glands of the upper aerodigestive tract. The authors present a case report of an occurrence of a low-grade acinic cell carcinoma of the true vocal fold, which they believe to be the first reported case of this type of carcinoma in this location. Laryngoscopy and laser excision was completed for what was initially thought to be a granuloma, and pathology confirmed low-grade acinic cell carcinoma of the right true vocal fold. The mass was well circumscribed and did not invade adjacent structures. After complete excision, postoperative radiation therapy was used to reduce local recurrence.

Aged↗
PubMed1998

[Improvement of glottis visualization with a McCoy blade].

Difficult intubation remains one of the major risks in anaesthetic practice. Recently, as other anaesthetic societies, the French Society for Anaesthesia and Intensive Care (SFAR) has produced algorithms for the management of a difficult intubation. New laryngoscopes and blades have been marketed in recent years, however their place in these algorithms remains unclear. In this preliminary study, we compared the laryngoscopic view in 100 consecutive patients during tracheal intubation with the McCoy laryngoscope first in its normal position and after levering the distal part of the blade. All patients were included in Mallampati classes 1 and 2. Among them, 16% were classified as Cormack and Lehane grades 3 or 4 when using the blade in the normal position. These data confirm previous observations showing that the McCoy blade in normal position performs poorly as compared with the Macintosh blade. Conversely the levering of the distal part of the blade significantly decreased the incidence of Cormack and Lehane grades of 3 or 4 (2 versus 16%, P = 0.001). It is concluded that the McCoy blade is not convenient for its routine use in patients not to be at preoperatively known risk of difficult intubation. This blade significantly improves intubating conditions. Defining the exact place of this new blade in difficult intubation algorithms requires further studies.

Adolescent↗