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Inhibitory effects of sexual steroidal hormones on the responses of the isolated guinea-pig lleum to acetylcholine and histamine.

Six sexual steroidal hormones (progesterone, pregnenolone, testosterone, ethinyl-oestradiol, oestriol and oestrone) inhibit acetylcholine- and histamine-induced contractions of the isolated guinea-pig ileum. Different degrees of inhibitory capacity were found. High concentrations of PGE1 and F2alpha reverse some of these inhibitions. This reversal seems to be non-specific and probably related to sensitization of the ileal smooth muscle by prostaglandins. The inhibitory action of sexual steroids might be non-specific as well. But a "corticoid-like" effect cannot be excluded.

Acetylcholine↗

Androstenedione metabolism in patients with endometrial cancer.

The plasma concentration of androstenedione and the instantaneous conversion of androstenedione to estrone was increased in patients with endometrial cancer as compared to postmenopausal control subjects. Moreover, the per cent of estrone derived from androstenedione was increased in the cancer group.

Androstenedione↗

Urinary oestrogen excretion, oestrous behaviour and ovulation in heifers treated with prednisolone during pro-oestrus and oestrus.

The purpose of the trial was to investigate the effect of prednisolone treatment during pro-oestrus and oestrus on the ovarian function in heifers. Four heifers were treated daily with 30 mg prednisolone i.m. per 100 kg body weight from pro-oestrus until ovulation was palpated. Treatment with prednisolone did not appear to have any effect on the length of the follicular phase or on ovulation. In three of the treated heifers, the urinary excretion of oestrous behaviour was normal but in the remaining heifer the excretion of oestrogen was found to be lower and oestrous behaviour weakly expressed. The effects of corticosteroids on the follicular phase, ovulation and oestrous behaviour in different species are discussed.

Animals↗