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[Antidromic reciprocating rhythm in Wolff-Parkinson-White syndrome precipitated by a ventricular extrasystole arising at the emergence of the preexcitation pathway].

A 9 year old child was investigated for attacks of wide QRS complex tachycardia occurring exclusively during the daytime and favoured by exercise or stress, with ventricular extrasystoles of the same form occurring between attacks. Endocavitary investigation showed a concealed atrioventricular accessory pathway during sinus rhythm with anterograde 1/1 conduction up to 270/min; retrograde conduction was not so good with block occurring at 175/min. The spontaneous tachycardia was reproduced by catecholamine infusion: it was an antidromic reciprocating rhythm triggered by a ventricular extrasystole of identical form to that of a pure preexcitation complex and to that of the tachycardia complexes. Spontaneous termination of attacks always occurred when conduction from the ventricle to the atria stopped. The attacks could be induced by ventricular extrastimuli when they caused an increment in retrograde conduction time resulting from retrograde conduction up the nodohisian pathway and not the Kent bundle. The tachycardia could also be initiated by atrial extrastimuli providing pure pre-excitation could be obtained. In both cases, retrograde conduction of the nodohisian pathway had to be improved by catecholamines. When the patient was given betablocker therapy the attacks of tachycardia completely disappeared. The association of ventricular extrasystoles and antidromic reciprocating rhythm and their morphological identity suggest that these extrasystoles were in fact automatic activity of the Kent bundle. Escape phenomena as signs of passive automatism have been described in this conditions but, to our knowledge, extrasystoles suggesting an active automatic process have not been previously reported.

Cardiac Complexes, Premature↗

Interdependent extrasystoles in a patient with a biventricular bypass heterotopic cardiac homograft.

This report describes the induction of atrial extrasystoles in the donor heart by preceding ventricular extrasystoles in the recipient heart of a patient with a biventricular bypass heterotopic cardiac homograft. Timing of the ventricular extrasystoles of the recipient heart in relationship to the preceding donor heart systole was critical to the production of donor heart atrial extrasystoles. The mechanism is thought to be a mechanical one resulting from an acute pressure rise in the atrium of the donor heart due to increased mitral regurgitation from the recipient heart resulting from the ventricular extrasystoles.

Blood Pressure↗

[Significance of ST segment and R wave changes in exercise-induced supraventricular extrasystole].

In a retrospective study the importance of ST segment and R wave changes in sinus beats and in supraventricular extrasystoles was examined in 23 patients who had exhibited supraventricular extrasystoles during exercise testing and who had undergone coronary arteriography in 1993 and 1994. Significant coronary artery disease was detected in 18 patients (group A), whereas 5 subjects (group B) had no demonstrable obstructive lesions. In every patient the authors measured the ST depression and R wave amplitude of the supraventricular extrasystole (STe and Re, respectively), and of the preceding sinus beat (STs and Rs, respectively), and than they calculated the difference between the two [ST(e-s) and R(e-s), respectively]. The ST(e-s) + R(e-s) value was higher than zero mV in 13 patients in group A, and in neither case in group B. Among the 4 patients in group A with false negative results of exercise tests, 3 had a positive ST(e-s) + R(e-s) value, whereas the only patient in group B with false positive exercise test result had a negative ST(e-s) + R(e-s) value. In patients with exercise induced supraventricular extrasystoles, the changes of ST depression and R wave amplitude in the extrasystoles and in the preceding sinus beats, may supplement the criterions of a positive examination.

Arrhythmia, Sinus↗

Concealed his bundle extrasystoles in congenital heart disease.

His bundle electrograms were recorded in two children with cardiac conduction disturbances. In the surface electrocardiograms of one patient His bundle extrasystoles mimicked atrial nonconducted bigeminal rhythms; in the other, they simulated second degree atrioventricular (A-V) block and conducted junctional extrasystoles. In both instances the conduction disturbance was a result of concealed conduction of the His bundle extrasystole into the A-V junction. We conclude that the surface electrocardiogram is suggestive but not definitive in diagnosing His bundle extrasystoles and that His bundle recordings are indispensable for correct diagnosis and treatment.

Bundle of His↗

Decreases in repetitive extrasystole threshold in the conscious pig with myocardial infarct were reversed by tyrosine.

Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham operated (intact) pigs. Mean arterial pressure and heart rate were measured via chronically implanted aortic catheters. The repetitive extrasystole threshold (defined as the energy in milliamperes (ma) needed to cause a spontaneous ventricular beat following a premature beat induced by an electrical impulse), was measured via a bipolar pacing catheter placed during instrumentation surgery in the apex of the right ventricle. One week after infarct, the myocardial infarct group was studied before and ninety minutes after the administration of tyrosine (8 mg/kg iv). Before tyrosine, the myocardial infarct group had a significantly lower repetitive extrasystole threshold (12 +/- 1 ma) compared to the intact group (19 +/- 2 ma). Ninety minutes after tyrosine, the repetitive extrasystole threshold in the myocardial infarct group was 17 +/- 1 ma. The availability of tyrosine did not alter the repetitive extrasystole threshold in the intact group. Thus, vulnerability to ventricular arrhythmia was enhanced in pigs with recent myocardial infarction. Tyrosine, which can be nutritionally manipulated, may reduce myocardial vulnerability to arrhythmia after infarct.

Animals↗

T-wave alternans phase following ventricular extrasystoles predicts arrhythmia-free survival.

OBJECTIVE: The purpose of this study was to assess the value of T-wave alternans (TWA) following ventricular extrasystoles in predicting arrhythmia-free survival. BACKGROUND: Stratifying risk for sudden death in patients with coronary disease and moderate left ventricular (LV) dysfunction remains a challenge. We hypothesized that, in such patients, a discontinuity in beat-to-beat T-wave alternation (TWA phase reversal) following single ventricular extrasystoles reflects transiently exaggerated repolarization dispersion, and predicts spontaneous ventricular arrhythmias. METHODS: We studied 59 patients with ischemic LV dysfunction (mean LV ejection fraction 38.7 +/- 5.3%) and nonsustained ventricular tachycardia undergoing programmed stimulation. TWA was computed spectrally from the ECG during ventricular pacing, and TWA phase reversal was reflected by a discontinuity in T-wave oscillation after single ventricular extrasystoles. RESULTS: Patients induced into ventricular arrhythmias (n = 36) had greater TWA magnitude (V(alt): 6.60 +/- 6.46 microV vs 2.61 +/- 1.97 microV; P = .001) and more frequent TWA phase reversal (62.1% vs 44.4%; P = .02) than those who were not (n = 23). During a mean follow-up of 36 +/- 12 months, positive TWA (V(alt) > or =1.9 microV) and TWA phase reversal both (P < .05) predicted events (all-cause mortality, ventricular tachycardia, ventricular fibrillation). Univariate predictors of arrhythmia-free survival were TWA phase reversal (P < .005), positive TWA (P < .05), age (P = .008), and LV mass index (P = .043). On multivariate analysis, only TWA phase reversal and age predicted events; if TWA phase was excluded, only positive TWA and age predicted events. CONCLUSION: Phase reversal in TWA following ventricular extrasystoles predicts spontaneous ventricular arrhythmias and all-cause mortality in patients with moderate ischemic LV dysfunction and was a better predictor than positive TWA or programmed ventricular stimulation.

Aged↗

Within-breath modulation of the triggering of extrasystoles in man.

Sufficient isolated extrasystoles were recorded during a period of quiet breathing in nine patients to test the null hypothesis that there is no within-breath influence of respiration on the triggering of extrasystoles. In five patients a highly significant respiratory modulation of the firing of extrasystoles was seen. The frequency distribution of extrasystoles during the respiratory cycle appeared to be approximately sinusoidal. The phase relations varied with respiratory frequency, and the peak incidence occurred relatively later in the cycle when breaths were shorter: always at about 2 s after the start of inspiration. An autonomatic reflex mechanism, equivalent to that causing sinus arrhythmia, appears to be the most likely explanation.

Adult↗

[Supraventricular tachycardia of the fetus in the 3d trimester of pregnancy following persistent supraventricular extrasystole].

Persistent supraventricular extrasystoles are antepartally, intrapartally and postpartally the most frequent form of arrhythmias, and do not cause fetal congestive heart failure (hydrops fetalis). The premature beats often disappear spontaneously prenatally, but in most cases within the first two weeks of life. The extremely rare observation of the occurrence of a supraventricular tachycardia in the 37th week of gestation in a fetus with persistent supraventricular extrasystoles from the 20th week of gestation onward and with a postnatally diagnosed Wolff-Parkinson-White syndrome is described. Because of the importance of this complication of supraventricular extrasystoles (a supraventricular tachycardia of the fetus can cause a cardiac failure with hydrops fetalis and eventually intrauterine death), it is important that all fetuses with supraventricular extrasystoles be closely monitored by frequent observation of the fetal heart rate using ultrasound (M-mode-echocardiography), cardiotocography and auscultation. Postpartally a cardiologic examination of these newborn infants is necessary, particularly in order to exclude the presence of a preexcitation.

Cardiac Complexes, Premature↗

Rate dependence of ventricular extrasystoles: computer identification and quantitative analysis.

A new computer program was designed to identify and quantify the rate dependence of arrhythmias using 24 hour Holter tape recordings. The program was used in 10 untreated apparently healthy patients with fixed, coupled, isolated monomorphic ventricular extrasystoles. The second cycles of two consecutive sinus cycles were grouped according to whether or not they were followed by a ventricular extrasystole. Each of these sinus cycles was further analysed by cycle length during successive one hour periods. From the number of cycles in each cycle length class, identification and quantification of an upper or lower limit, or both, of cycle length beyond which ventricular extrasystoles disappeared were possible. Upper and lower limits were observed in 10 and eight of the 10 patients respectively. An upper and a lower limit were identifiable (mean(SD) 9.3(5.1) and 8.4(5.8) times per recording respectively). Values of both types of limits varied throughout tape recording. A positive significant correlation was found between the values of upper and lower limits and the mean sinus cycle length during the corresponding hour in nine of the 10 and eight of the eight patients respectively. The type of relation observed suggests that heart rate directly alters limits or that heart rate and limits are under the same influence of the autonomic nervous system. It is concluded (a) that identification and quantification of the rate dependence of arrhythmias is possible using this computer program; and (b) that, in patients with ventricular extrasystoles and apparently normal hearts, upper and lower limits vary and are related to heart rate.

Adolescent↗

Localization of the accessory pathway in the Wolff-Parkinson-White syndrome from the ventriculo-atrial conduction time of right ventricular apical extrasystoles.

In 18 consecutive patients with the Wolff-Parkinson-White syndrome undergoing electrophysiologic study, the ventriculo-atrial conduction time of right ventricular apical extrasystoles which advanced atrial activation during circus movement tachycardia was studied in relation to accessory pathway location. Accessory pathway location was determined by delta wave morphology during maximal pre-excitation, mapping of atrial activation during circus movement tachycardia and ventricular pacing, the effect of bundle branch block on ventriculo-atrial conduction time during circus movement tachycardia, and the effect of pacing from different sites in the atria on the stimulus-to-delta wave interval. In 7 patients with septal accessory pathways, ventriculo-atrial conduction time was similar during circus movement tachycardia and following right ventricular apical extrasystoles (mean difference 0 +/- 6 ms, range -5 to +10 ms). In contrast, in 11 patients with a left free wall accessory pathway, ventriculo-atrial conduction time increased by 46 +/- 15 ms (range 15 to 65 ms) following right ventricular apical extrasystoles. Therefore, measurement of the ventriculo-atrial conduction time of right ventricular extrasystoles during circus movement tachycardia provides an easy way to distinguish between septal and left free wall accessory pathways. This finding may be of particular use in determining the location of concealed bypass tracts.

Adolescent↗

Q waves and ventricular extrasystoles in resting electrocardiograms. A 16 year follow up in Busselton study.

Isolated abnormalitites in the resting electrocardiograms of 1546 Busselton people with no history of angina or past myocardial infarction were examined in relation to 16 year mortality. Multivariate discriminate analysis in men showed significant independent relationship for Q waves with coronary heart disease and for ventricular extrasystoles with cardiovascular disease. In women multivariate analysis showed significant relations for ventricular extrasystoles with total mortality and coronary heart disease. There were higher trends in mortality for both men and women with frequent ventricular extrasystoles compared with those with infrequent ventricular extrasystoles.

Adult↗

QT dispersion in sinus beats and ventricular extrasystoles in normal hearts.

OBJECTIVE: Recent studies have suggested that QT interlead variability (dispersion) on the surface electrocardiogram may have potential as a measure of recovery time dispersion. To test this hypothesis further QT dispersion occurring in sinus beats was compared with that in ventricular extrasystoles. DESIGN: Simultaneous electrocardiograms were recorded at 50 mm/s during sinus rhythm in a drug free state while ventricular extrastimuli were introduced by programmed right ventricular stimulation at different coupling intervals. QT dispersion, defined as the difference between the maximum and minimum QT, was calculated separately for the extrasystoles and preceding and following sinus complexes. To correct for the influence of the number of measurable leads on QT dispersion, an "adjusted" QT dispersion calculated as QT dispersion/square root of the number of measurable leads, was used to compare sinus complexes and extrasystoles. PATIENTS: Nine patients were studied who were undergoing electrophysiological study for investigation of palpitation and were found to have electrically normal ventricles. RESULTS: At all coupling intervals tested "adjusted" QT dispersion was significantly greater in the ventricular extrasystoles than in either the preceding or following sinus complexes. For the coupling interval 350 ms, the 95% confidence intervals for the difference between means was 52 to 78 ms (preceding sinus complex) and 56 to 82 ms (following sinus complex) (p less than 0.00001). There was no correlation between the coupling interval and the magnitude of the "adjusted" QT dispersion. CONCLUSION: These results accord fully with expected differences in ventricular recovery time dispersion and offer further support for the hypothesis that QT dispersion reflects regional variation in ventricular recovery. If substantiated by invasive studies, these findings have wide implications for both the usefulness and the method of QT measurement.

Cardiac Complexes, Premature↗

Reappraisal of the coupling interval of ventricular extrasystoles as an index of ectopic mechanisms.

OBJECTIVE: A mathematical model of modulated ventricular parasystole based on the relation between the coupling interval and the preceding RR interval was developed in an attempt to distinguish between parasystolic automaticity and other mechanisms. MATHEMATICAL MODEL: The relation between the coupling interval and the preceding RR interval was examined by plotting the coupling interval of each extrasystole against the preceding RR interval (coupling interval/RR diagram). The coupling interval/RR diagrams obtained from simulations with various modulation modes suggested that the parasystolic mechanism was likely when the dots representing extrasystoles appeared as discrete clusters. In contrast, a linear horizontal accumulation of dots indicated a non-parasystolic mechanism. CLINICAL OBSERVATION: To verify the validity of the simulations, 24 hour electrocardiographic recordings from 60 patients with frequent ventricular extrasystoles (> 1000/day) were analysed to determine whether the extrasystoles showed intrinsic periodicity. Intrinsic periodicity indicative of a parasystolic mechanism was seen in 14 (93%) of 15 patients in whom the coupling interval/RR diagram was characteristic of a parasystolic mechanism. When the coupling interval did not change (variability < 200 ms) over a wide range of RR intervals (> 700 ms) intrinsic periodicity was never identified (0/17). Parasystolic automaticity was the likely mechanism in 11 of the remaining 28 patients (39.3%) in whom coupling interval/RR diagrams were not definitive. CONCLUSION: These data indicate that definite patterns of coupling interval/RR diagrams can be used to distinguish between parasystolic and non-parasystolic mechanisms.

Adolescent↗

Spectral analysis of fetal heart rate variability in fetuses with supraventricular extrasystoles.

OBJECTIVE: Fetal heart rate (FHR) variability is an important indicator of fetal well-being. In fetal tachyarrhythmias, however, visual analysis of FHR variability is limited. We therefore applied power spectral analysis of FHR to evaluate the fetal state. METHODS: Fetal R-R intervals were detected by means of an external ECG in 3 fetuses with supraventricular extrasystoles after cardiac malformations had been excluded by fetal echocardiography. Using an autoregressive model, power spectral densities were calculated from 20 consecutive 256-beat segments for the following frequency bands: <0.03 Hz (very low frequency), 0.03-0.069 Hz (low frequency; LF), 0.07-0.129 Hz (mid-frequency) and 0.13-1.0 Hz (high frequency; HF). RESULTS: The FHR variability in fetal supraventricular extrasystoles mainly resulted from the HF component (63.91 +/- 6.97%). The sympatho-vagal balance (LF/HF) was decreased in the tracings with extrasystoles (0.13). CONCLUSION: The analysis of FHR variability in fetal supraventricular extrasystoles revealed an imbalance between sympathetic and parasympathetic regulation.

Adult↗

Type A alternating Wenckebach periodicity in the reentrant pathway of interpolated ventricular extrasystoles.

A 67-year-old man with interpolated ventricular extrasystoles is reported in whom alternate sinus QRS complexes were followed by interpolated ventricular extrasystoles with progressively lengthening coupling intervals until one of these alternate sinus complexes failed to be followed by an extrasystole. This is the first report to suggest the presence of type A alternating Wenckebach periodicity in the reentrant pathway of interpolated ventricular extrasystoles. It is suggested that 2:1 block occurred at a proximal level in the reentrant pathway, while Wenckebach block occurred at a distal level in the pathway.

Aged↗

[Post-extrasystolic potentiation in chronic Chagas' heart disease. A radiologic contrast ventriculography study].

OBJECTIVE: To determine the existence and frequency of the phenomenon of post-extrasystolic potentiation in dyssynergic myocardial areas of patients with chronic Chagas' heart disease studied by use of radiologic contrast ventriculography. METHODS: This study is a semiquantitative retrospective analysis of radiologic contrast ventriculography in patients with chronic Chagas' disease, who were consecutively studied to assess the mechanisms of ventricular tachycardia. RESULTS: Of the 72 patients initially included, in only 20 patients was possible the ventriculographic analysis for the purposes of this study. The phenomenon of post-extrasystolic potentiation was observed in 11 (55%) of these patients, and a 15.31% improvement was observed in the contractility score from the baseline to the post-extrasystole condition (P=0.0001). That phenomenon occurred even in ventricular segments with an intense deficit in contractility. CONCLUSION: The phenomenon of post-extrasystolic potentiation is observed in a significant proportion of patients with chronic Chagas' heart disease, in whom the phenomenon could be angiographically analyzed, indicating the existence of potentially recruitable contractile reserve in ventricular regions, showing marked dyssynergy. Additional studies for clarifying the underlying mechanisms are required.

Chagas Disease↗

Concealed ventricular extrasystoles. A family of premature ventricular complexes with high spontaneous variability.

BACKGROUND: The term concealed ventricular extrasystoles defines a phenomenon in which premature beats have a cyclical distribution and manifest after a predictable number of intervening sinus beats. The extent of its spontaneous variability as well as the stability of its orderly distribution, however, have not been defined yet. The aim of this study was to assess whether there is any difference between the variability of concealed ventricular extrasystoles and their allorhythmic patterns. METHODS: The distribution of premature ventricular complexes (PVCs) was evaluated in 39 patients with frequent monomorphic PVCs (> 1000/die) during a baseline 24-hour ambulatory monitoring electrocardiogram. Patients were divided into two groups: group A had evidence of concealed ventricular extrasystoles, while in group B PVCs were randomly distributed. All patients underwent a second ambulatory monitoring electrocardiogram within 30-360 days. RESULTS: The overall number of PVCs did not differ between the groups. Patients of group A showed a very high spontaneous variability (p = 0.006) between the first and the second ambulatory monitoring electrocardiogram, whereas significant differences were not observed among patients of group B. CONCLUSIONS: Concealed ventricular extrasystoles are not casual and transient, but should be regarded as a marker of a "family" of PVCs that have the tendency either to maintain their orderly distribution for long periods or to disappear suddenly.

Adolescent↗

[Analysis of cases with fetal extrasystole coexisting with cardiac and extracardiac pathology].

OBJECTIVE: The paper presents a review of cases with fetal extrasystole coexisting with different cardiac and extracardiac pathology. DESIGN: The aim of the study is to analyse the results of echocardiographic examinations of fetuses with premature atrial contractions (PAC) quantitatively significant (bigeminy, trigeminy) or coexisting with other abnormal findings in fetal heart or other extracardiac pathologies. MATERIAL AND METHOD: Selected group of 33 (24%) fetuses from 135 with fetal extrasystole was analyzed. The mean gestational time of diagnosis was 29.2 + 4.1 weeks. RESULTS: Quantitatively significant arrhythmia (bigeminy, trigeminy) was diagnosed in 14 fetuses. Blocked PAC (2:1) occurred in two cases causing fetal bradycardia. Premature atrial extrasystole coexisting with different type of arrhythmias were diagnosed in 10 cases (4 x with SVT, 4 x with sinus bradycardia, 2 x with ventricular extrasystole). Heart defects in the analyzed group with PAC were recognized in two fetuses (1 x d-TGA, 1 x heterotaxy syndrome--common a-v canal). Myocarditis was diagnosed in 3 (9%) cases. From the group of 33 fetuses 6 newborns died (1 x d-TGA, 1 x T18, 1 x myocarditis, 1 x circulatory centralization). Mortality in the analyzed group was 18.2%. CONCLUSION: In cases of fetal arrhythmias echocardiography should be widely applied in order to evaluate the kind of arrhythmia, sufficiency of circulation and coexistence of heart defects, extracardiac malformations or functional abnormalities with arrhythmia in fetal circulation.

Arrhythmias, Cardiac↗