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Protocol management of dysuria, urinary frequency, and vaginal discharge.

A proctocol to be administered by nurses for the management of dysuria, frequent urination, and vaginal discharge was validated. In a randomized, controlled trial, 146 women were seen by both nurse and physician and then assigned to either the nurse-proctocol treatment plan or the physician treatment plan. The clinical data collected by the nurse showed no important differences from the physicians' data. The protocol recommended that 89 percent of the patients be sent home without seeing the physician. The physicians agreed with the protocol-recommended disposition in all but two cases. All patients with complications were appropriately referred to the physician. In follow-up, more than 95 percent of both groups reported symptomatic improvement, and repeat urine cultures were negative. We conclude that the protocol can be accurately administered, makes sound recommendations, is safe, and efficiently saves physician time.

Adolescent↗

[Treatment of persistent dysuria in women].

Sixty female patients with chronic cystitis and persistent dysuria (PD) were divided into two groups according to their treatment. Group 1 (n = 38) patients have received combined conservative treatment; group 2 (n = 22) received the above treatment plus have undergone transurethral resection (TUR) of the urinary bladder mucosa. For control, urodynamic tests were made (uroflowmetry, sphincterometry, electromyography of the urinary bladder muscles); microcirculation was studied at laser doppler flowmetry. It was found that PD females with chronic cystitis develop microcirculatory disorders registered at laser doppler flowmetry. They consist in congestion of blood in the microvessels, vascular spasm, red cell aggregation with sludge-syndrome and combine with urodynamic disorders manifesting as weak detrusor contractivity and evacuation function. The above urodynamic and microcirculatory disorders are treated conservatively (antibacterial therapy, transcutaneous laser irradiation of the suprapubic region using intravesical methods). To eradicate PD in long-term inflammation in the urinary bladder and development of squamous cell metaplasia of the urothelium, TUR of the affected area and intramural nerves with partial denervation of the urinary bladder is indicated.

Adult↗

Comparative efficacy and tolerability of cephradine and cefuroxime axetil in the treatment of acute dysuria and/or frequency in general practice.

One hundred and thirteen patients with dysuria and/or frequency were treated randomly with either 500 mg cephradine 12-hourly or 125 mg cefuroxime axetil 12-hourly, for seven days. A total of 71 patients were found to have urinary infection: bacteriological cure rates were 97% one week post-treatment, and 96% five weeks post-treatment, for both antibiotics. On direct questioning, adverse events were reported by eight patients out of 59 taking cephradine and by three of 54 who had received cefuroxime axetil. However, only three and one respectively stopped taking the antibiotic due to the adverse event. Analysis of diary cards, completed by 109 patients, showed a significantly higher incidence of increased frequency of bowel movements in those taking cefuroxime axetil. It is concluded that both antibiotics are of equal value in the treatment of simple acute urinary infections in general practice.

Adolescent↗

[A case of atresia hymenalis in a pubescent girl with complaint of dysuria].

A 12-year-old girl was referred to the National Hospital Organization Nara Hospital complaining of dysuria and lower abdominal pain. On examination of the external genitalia, vaginal opening was closed completely. Ultrasonography and magnetic resonance imaging revealed atresia hymenalis with hematocolpos. Hymenal incision was carried out and clinical symptoms were improved. Seventy-eight cases of atresia hymenalis reported in the Japanese literature since 1987 are reviewed. It is necessary to include atresia hymenalis in diagnosis of voiding difficulty in pubescent girls.

Child↗

[A decision analysis model in laboratory medicine--appropriate usage of microbiological examination in women with dysuria].

Decision analysis is a noteworthy methods to solve complex medical problems and select best alternative under uncertainty, and its practical applications in laboratory medicine are anticipated for appropriate usage of laboratory resources. From the view of classical microbiology, it is necessary to identify bacteria causing an infection and select sensitive antibiotics to this pathogen. Decision analysis was used to estimate the clinical and economic implications of microbiological testing for urinary tract infections at the initial visit for all women with acute dysuria. A strategy of initial culture was compared with a strategy involving the use of culture only for patients with symptoms persisting 3 days after initial therapy (wait 3 days strategy). Expected direct cost and medical care days were 10,748 yen and 7.12 days for initial culture strategy and 6872 yen and 7.24 days for wait 3 days strategy. Sensitivity analysis showed that initial culture strategy was not cost effective when the frequency of antibiotics resistant organisms would be increased or required days to obtain microbiological tests results would be decreased.

Algorithms↗

[The dysuria syndrome. Significance of urethral diameter for recurrent bacterial cystitis in the female].

Internal urethrotomy is still used in female patients for the prophylactic treatment of recurrent bacterial cystitis as well as for sterile dysuric voiding disorders. 72% of the bacterial cystitis group (n = 18) remained uninfected during the 1st year after the treatment. 60% of the women with sterile dysuria complaints reported a significant improvement after the surgical procedure. The success is most possibly due to improved urodynamic conditions. The necessity of urethrotomy in patients with recurrent bacterial cystitis is discussed. The etiology of sterile dysuric voiding disorders however remains unclear.

Adult↗

[Dysuria in women and bladder hypocontractibility].

Urodynamic tests used to analyze 120 cases of non-neurogenic and non-iatrogenic dysuria in women provided data to which the following criteria were applied: maximum output less than 15 ml/s and/or residue greater than 100 ml. Clinical examination, including endoscopy, established a possible obstructive cause in 60 cases (36 patients with prolapse, 12 with urethral stenosis and 12 with cervical disease) the 60 other cases remaining unexplained. The frequency of reduced or absent contractility, 68% in the total population, is still 58% when a cervico-urethral obstruction exists.

Adolescent↗

Dysuria in general practice.

An analysis of 98 clinical consultations for dysuria in an urban general practice revealed that only 60 percent of patients had proven urinary tract infections. Two percent had gonorrhoea and the rest had an urethral syndrome. Most of the urinary tract infections were caused by Escherichia coli and Streptococcus epidermidis. Proteus mirabilis was the next commonest infecting organism. Among the commonly used urinary antimicrobials, nitrofurantoin was found to be the cheapest and most effective agent. The aetiology of the urethral syndrome was obscure and apart from a small minority of patients who had thrush (16 percent) no obvious cause could be found.

Bacterial Infections↗

A case of dysuria as a result of a communication between the urinary bladder and corpus uteri in a Cairn Terrier.

A 61/2-month-old Cairn Terrier, considered to be a bilateral cryptorchid male, was presented with dysuria and urinary incontinence. This was found to be due to a congenital communication between the urinary bladder and corpus uteri and resulted in distention of the uterus with urine which could not be voided. An ovariohysterectomy was performed. The dog was found to be a gentic female with what resembled external male genitalia, i.e. a female pseudohermaphrodite.

Animals↗

[Experience of a double Malecot polyurethane intraurethral catheter in patients with dysuria].

We reviewed our experience of using double Malecot polyurethane intraurethral catheters (IUC). Ten patients with dysuria were treated between April 1991 and April 1993. Seven patients with benign prostatic hypertrophy (BPH) were judged as in a high risk group for operation. The three other patients had neurogenic bladder (two had underactive bladder and 1 had overactive bladder). Under local anesthesia, 150 ml of 0.1% Povidone iodine solution was infused into the bladder through a Nelaton catheter. Under guidance by ultrasonography, an IUC was placed into the bladder neck and posterior urethra using the specially designed introduction set. An long-term follow up of the BPH patients, two IUCs were removed for operation and one was exchanged for an indwelling catheter because of deterioration in general condition. In the neurogenic bladder patients, all IUC were removed because of the increase of residual urine, formation of a pseudourethra, or dislocation into the bladder. Side effects were observed in 6 patients such as, urethral bleeding and stone formation in the stent. Erosion and bleeding tendency in the urethral mucosa were shown in the prolonged duration cases. We conclude that a urethral stent is an effective devise for a high risk patient with benign prostatic hypertrophy but we must keep each patient under strict observation for complications during IUC placement.

Aged↗

Single dose of ofloxacin treatment in women with dysuria and frequency.

The efficacy of single dose ofloxacin in lower urinary tract infections was investigated in this study. Fifty-one women with complaints of dysuria and frequency were treated with a single dose of 400 mg ofloxacin orally. The results of urinalysis and urine culture which were performed 4-7 days after the administration of the drug were evaluated. Thirty-eight of the 47 evaluable patients (80.85%) were asymptomatic with normal urinalysis and sterile urine, thus cured. The data of the study suggest that single dose ofloxacin may be the first treatment option in the particular group of women with uncomplicated urinary tract infection.

Administration, Oral↗

[Labial adhesion presenting as urinary incontinence and dysuria in a postmenopausal woman: a case report].

A 68-year-old woman admitted to our hospital complaining of urinary incontinence and dysuria. On examination, the labia were found to be fused extensively, with a pinhole opening at the midline. Under spinal anesthesia, the adhesion was clearly separated with the Hegar's dilator. There remains no recurrence in this patient following therapy. The labial adhesion was considered to be an acquired disease caused by infection, trauma in the genitalia, or sexless life, according to hypoestrogenism.

Aged↗

Symptomatology and development of urolithiasis in children with frequency-dysuria syndrome associated with hypercalciuria.

To investigate the long-term outcome of the frequency-dysuria syndrome (FDS) with hypercalciuria (HCU), 19 children (15 girls and 4 boys; age range 15 months to 10 years) who presented with FDS alone (N=9) or with other associated clinical features (N=10; 6 with gross hematuria, 3 with microscopic hematuria and 1 with abdominal pain) were followed-up over 720 patient-months. Calcium loading test indicated absorptive HCU in 12 patients, renal HCU in 2, and in 5 the test was inconclusive. All patients were treated with a standard protocol after diagnosis. During follow-up, FDS recurred in 4 children, gross hematuria in 3, lumbar pain in 5, and 7 children developed urolithiasis within 3 to 60 months. The latter 7 children (4 with absorptive HCU and 1 with renal HCU) tended to be older than the other 12 (7.14 vs 5.08 years; p=0.11) and required a longer time to normalize urinary calcium excretion (16 vs 7 months; p <0.01). The initial urinary calcium excretion was similar between the patients with and those without stones (5.53 vs 5.6 mg/kg/d). In all other parameters measured, there were no statistically significant differences between the patients who initially presented with FDS alone and those with FDS accompanied with other urinary symptoms. We conclude that HCU and FDS in children can vary considerably in the clinical mode of presentation as well as its sequels. Significant risk for urolithiasis burdens the children who require a longer time (>12 months) to normalize their hypercalciuria.

Calcium↗