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[A chromatographic method of analysis of mixtures of methylethyl ketone, n-butyl alcohol, xylene, ethylene glycol, ethylene glycol acetate, cyclohexanol, cyclohexanone and butyl glycol vapors in the air].

A gas chromatographic method for the determination of the mixture of organic solvents in air has been developed. The optimum conditions of the separation of the mixture were obtained in the column packed with 10% UCON HB 2000 coated on Chromosorb W AW DMCS 80-100 mesh. The components of the mixture are collected on activated charcoal and desorbed with CS2. A quantitative analysis is made using methyl isobutyl ketone as an internal standard. The lowest detectable limit under proposed air sampling and analysis conditions is 0.1 TLV (threshold limit value) for each component of the mixture.

Air Pollutants, Occupational

Teratologic effects of d,1-2-(o-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride (ketamine hydrochloride) in rats.

Studies were conducted of the teratologic effects of ketamine hydrochloride in rats. Ketamine treatment had no significant effect on the number of animals per litter. The histological examination of heart, liver, and kidney showed focal nuclear hypochromatosis and interfibrillary edema; diffuse hemopoietic cell infiltration, and parenchymal cell degeneration; proximal convoluted tubule degeneration. The degenerative effect is also dependent upon the dose and the duration of treatment.

Animals