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PubMed1997

Executive function of the hippocampus in social behavior in the rat.

Bilateral lesion of the fimbria resulted in a reduction of social interdependency and agonistic behavior in male-male encounters in rats. These findings are hypothesized to be consistent with J. A. Gray's (1982) supervisor model, which assigns an executive function to the septohippocampal system. To achieve this interpretation, social behavior is described in terms of relational processes (social hypothesis, behavioral sequencing, and behavioral competition). This study focused mainly on the effects of the lesion on behavioral sequencing by studying the alterations of the predictability of the behavior of a rat in terms of the behavior of its partner.

Agonistic Behavior↗
PubMed1989

Cigarette smoking, alcohol, and oral contraceptive use by type A adolescent--the Bogalusa Heart Study.

Type A behavior pattern (TABP) is an independent risk factor for cardiovascular (CV) disease and is characterized by hostile, aggressive, competitive behavior. TABP characteristics and CV risk factors have been found in children and adolescents. TABP has been correlated with adult alcohol consumption, but studies associating Type A and smoking are mixed. The purpose of this study is to investigate the smoking, alcohol use, and oral contraceptive use of Type A children and adolescents. The Hunter-Wolf Type A scale and a health habits questionnaire were evaluated for 2092 children, ages 8-17 years, within the context of a comprehensive biracial epidemiological CV screening in Bogalusa, Louisiana. Global Type A and factor components were evaluated: hostility, eagergy, desire for control, drive, and competitiveness. Correlation coefficients reflected the strongest associations between hostility and smoking and between hostility and drinking for white males. The age at menarche appeared to be correlated with the drive component.

Adolescent↗
PubMed1984

Organized dentistry and the pursuit of entry control.

Organized dentistry spent nearly a century laboring to obtain control over entry into the profession. The first attempt, the American Society of Dental Surgeons, failed because the issue of using amalgam so split the Society that collective action became impossible. The second attempt, state licensing during 1870-1900, gave preferential treatment (automatic licensing) to dental school graduates and appeared at first to be the solution to the entry problem, given the small number of schools in operation. However, dental school entrepreneurs recognized a profitable opportunity, and the supply of dental schools expanded rapidly. Thus, in the third and final attempt at obtaining entry control, organized dentistry attacked the for-profit schools. The dental practice acts were amended to require all candidates to pass a licensing examination, provided first that they were graduates of a school considered "reputable" by the state board of dental examiners. Moreover, rising costs generated by increased school standards took the profit out of for-profit operation, and by 1930 such schools ceased to exist. However, the competitive nature of the 1930s made altogether clear that entry control was a necessary, but not sufficient, condition for the maximization of dentist profits, and thus organized dentistry began its turn inward, focusing on the competitive behavior of existing dentists.

American Dental Association↗
PubMed2005

Testosterone and human aggression: an evaluation of the challenge hypothesis.

Research on testosterone-behavior relationships in humans is assessed in relation to a version of the challenge hypothesis, originally proposed to account for testosterone-aggression associations in monogamous birds. Predictions were that that testosterone would rise at puberty to moderate levels, which supported reproductive physiology and behavior. Sexual arousal and challenges involving young males would raise testosterone levels further. In turn, this would facilitate direct competitive behavior, including aggression. When males are required to care for offspring, testosterone levels will decrease. Testosterone levels will also be associated with different behavioral profiles among men, associated with life history strategies involving emphasis on either mating or parental effort. Most of these predictions were supported by the review of current research, although most studies were not designed to specifically test the challenge hypothesis.

Aggression↗
PubMed2005

Submissive behavior in mice as a test for antidepressant drug activity.

Previously, with the administration of antidepressant drugs, it has been demonstrated that the rat model of clinical depression, known as the reduction of submissive behavior model (RSBM), has considerable validity. The present study is an attempt to extend the model to mice. Several antidepressant drugs as well as a number of non-antidepressant agents were administered to mice that had been identified as submissive in a behavioral testing situation. Imipramine, desipramine, amoxapine and fluoxetine, representing three different classes of antidepressant drugs, were each able to increase competitive behavior in submissive mice and to decrease the dominance level between dominant and submissive mice in the behavioral tests. The stimulant amphetamine also reduced submissive behavior while yohimbine (also a stimulant), and the antianxiety agent diazepam had no such effect. The neuroleptic drug thiothixen had antidepressant-like effect on submissive C57BL/6J mice behavior. We conclude that like the rat model of depression from which it was developed, the mouse model responds to various antidepressants as predicted and thus may serve as a potential model of clinical depression.

Adrenergic alpha-Antagonists↗
PubMed2002

Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase.

The soluble domain of human CD38 catalyzes the conversion of NAD(+) to cyclic ADP-ribose and to ADP-ribose via a common covalent intermediate [Sauve, A. A., Deng, H. T., Angelletti, R. H., and Schramm, V. L. (2000) J. Am. Chem. Soc. 122, 7855-7859]. Here we establish that mechanism-based inhibitors can be produced by chemical stabilization of this intermediate. The compounds nicotinamide 2'-deoxyriboside (1), 5-methylnicotinamide 2'-deoxyriboside (2), and pyridyl 2'-deoxyriboside (3) were synthesized and evaluated as inhibitors for human CD38. The nicotinamide derivatives 1 and 2 were inhibitors of the enzyme as determined by competitive behavior in CD38-catalyzed conversion of nicotinamide guanine dinucleotide (NGD(+)) to cyclic GDP-ribose. The K(i) values for competitive inhibition were 1.2 and 4.0 microM for 1 and 2, respectively. Slow-onset characteristics of reaction progress curves indicated a second higher affinity state of these two inhibitors. Inhibitor off-rates were slow with rate constants k(off) of 1.5 x 10(-5) s(-1) for 1 and 2.5 x 10(-5) s(-1) for 2. Apparent dissociation constants K(i(total)) for 1 and 2 were calculated to be 4.5 and 12.5 nM, respectively. The similar values for k(off) are consistent with the hydrolysis of common enzymatic intermediates formed by the reaction of 1 and 2 with the enzyme. Both form covalently attached deoxyribose groups to the catalytic site nucleophile. Chemical evidence for this intermediate is the ability of nicotinamide to rescue enzyme activity after inactivation by either 1 or 2. A covalent intermediate is also indicated by the ability of CD38 to catalyze base exchange, as observed by conversion of 2 to 1 in the presence of nicotinamide. The deoxynucleosides 1 and 2 demonstrate that the chemical determinants for mechanism-based inhibition of CD38 can be satisfied by nucleosides that lack the 5'-phosphate, the adenylate group, and the 2'-hydroxyl moiety. In addition, these compounds reveal the mechanism of CD38 catalysis to proceed by the formation of a covalent intermediate during normal catalytic turnover with faster substrates. The covalent 2'-deoxynucleoside inactivators of CD38 are powerful inhibitors by acting as good substrates for formation of the covalent intermediate but are poor leaving groups from the intermediate complex because hydrolytic assistance of the 2'-hydroxyl group is lacking. The removal of the adenylate nucleophile required for the cyclization reaction provides slow hydrolysis as the only exit from the covalent complex.

ADP-ribosyl Cyclase↗
PubMedDate not supplied

[The inverse immunoregulation of behavior and the problem of the existence of regulatory autoantibodies].

This paper analyzes the effects of active immunization against endogenic neuromediators, neuroregulators, enzymes (catecholamines, serotonin, various regulatory peptides, alcohol dehydrogenase) on a physiological status of the body. It is indicated that such an immunization results in a decreased level (activity) of some regulatory endogenic agents and accordingly to the long-term changes in physiological functions of the body including such complex as behavior of animals. The data given in this paper on the long-term experimental immunologic correction of such the forms of pathologic states as alcoholism, increased convulsive alertness, competitive behavior, phobias are indicative of both fundamental and applied aspects of using inverse immunoregulation method.

Animals↗
PubMed1987

Competitive fixed-interval performance in humans.

Two persons responded in the same session in separate cubicles, but under a single schedule of reinforcement. Each time reinforcement was programmed, only the first response to occur, that is, the response of only one of the subjects, was reinforced. "Competitive" behavior that developed under these conditions was examined in three experiments. In Experiment 1 subjects responded under fixed-interval (FI) 30-s, 60-s, and 90-s schedules of reinforcement. Under the competition condition, relative to baseline conditions, the response rates were higher and the pattern was "break-and-run." In Experiment 2, subjects were exposed first to a conventional FI schedule and then to an FI competition schedule. Next, they were trained to respond under either a differential-reinforcement-of-low-rate (DRL) or fixed-ratio (FR) schedule, and finally, the initial FI competition condition was reinstated. In this second exposure to the FI competition procedure, DRL subjects responded at lower rates than were emitted during the initial exposure to that condition and FR subjects responded at higher rates. For all subjects, however, responding gradually returned to the break-and-run pattern that had occurred during the first FI competition condition. Experiment 3 assessed potential variables contributing to the effects of the competitive FI contingencies during Experiments 1 and 2. Subjects were exposed to FI schedules where (a) probability of reinforcement at completion of each fixed interval was varied, or (b) a limited hold was in effect for reinforcement. Only under the limited hold was responding similar to that observed in previous experiments.

Journal Article↗
PubMed1995

Home health care industry growth and change: a study of one state's experience.

Federal expenditures for home health care have been increasing at an annual rate of 30% per year since 1974, and are predicted to continue to increase more rapidly than expenditures for other health services in the future. This predication is based on: the aging population, increases in medical technology and the impact of government regulatory mechanisms which encourage growth and competition in the home health industry. In order to develop effective regulatory policies for the future it is necessary to understand the effect of past policies on home health care services. This is a descriptive study of one state's experience with a changing regulatory environment over a ten year period of time. Data from the Massachusetts Department of Public Health's Annual Reports for Home Health Agencies was used to describe industry growth and change and the effect these had on the accessibility, quality and efficiency of service delivery from 1980 to 1990. Results suggest dramatic changes in the industry, with strong evidence of agencies' competitive behaviors, improved patient access to most services, changes in staffing patterns and concerns for quality of care.

Data Collection↗
PubMedDate not supplied

The new competitive enterprise: the behavioral healthcare PHO.

The physician-hospital organization (PHO), whether in a general medical context or in the specialty of behavioral healthcare, represents an intermediate step or model in the process of integration required by current market forces in healthcare. This article describes both general medical and behavioral healthcare PHOs and analyzes the model's competitive advantages in the behavioral healthcare arena. The ways in which behavioral PHOs interface with other practice delivery models is described, along with their advantages and the factors leading to their success.

Contract Services↗
PubMed1988

Perseverative structuring of responses by schizophrenic and affective disorder patients.

Some theoretical implications from a CNS stimulation model of psychosis were tested by analysing the response patterns of schizophrenic (N = 34), affective disorder patients (N = 18), schizoid personality disorder patients (N = 9), neurotic patients (N = 9) and normal controls (N = 34) on a visual two-choice task with reinforcement. The subjects were required to press a left and right button in order to cause a cross (+) to appear on the monitor screen above one of the buttons. Certain subsequences of right and left presses were required in order for the cross to appear, and a coin-reinforcement was delivered on a variable-ratio schedule with respect to the cross condition. An analysis of structured responding in categories: one-side greater than 6, switching (RLRL), 2-1 switching (RRL) and double alternations (RRLL), revealed that the schizophrenic and affective disorder patients were significantly more perseverative in these response categories than normal controls, schizoid or neurotic patients. The last three subject groups were not significantly different from each other. The majority of the schizophrenics and all four manic patients showed the highest percentage of responding in one sided responses greater than 6, switching and 2-1 switching. Normal control subjects showed more varied response patterns with responses in double, triple and quadruple alternations and other combinations. The results are seen to support a CNS stimulation, behavioral competition model of psychosis.

Adult↗
PubMed2006

The role of personality characteristics in young adult driving.

BACKGROUND: Motor vehicle injury is the major cause of mortality among young adults. Information about the individual characteristics of those who drive dangerously could enhance traffic safety programs. The goal of this research was to examine the association between various personality-related characteristics and risky driving behaviors. METHODS: Young adults in Michigan, USA (n = 5,362) were surveyed by telephone regarding several personality factors (risk-taking, hostility, aggression, tolerance of deviance, achievement expectations) and driving behaviors (competitive driving, risk-taking driving, high-risk driving, aggressive driving, and drink/driving). Michigan driver records were obtained to examine offenses, serious offenses, driving offense points, crashes and serious crashes in the three pre-interview years. Multivariate regression analyses, adjusting for age, race, and marital status were conducted separately by sex to identify personality factors related to driving. RESULTS: For men and women, greater risk-taking propensity, physical/verbal hostility, aggression, and tolerance of deviance were significant predictors of a competitive attitude toward driving, risk-taking driving, high-risk driving, driving aggression, and drink/driving. Greater risk-taking propensity, physical/verbal hostility, aggression, and to a small degree, expectations for achievement predicted higher numbers of offenses, serious offenses, and points. CONCLUSION: Traffic safety policies and programs could be enhanced through recognition of the role personality factors play in driving behavior and the incorporation of this knowledge into the design and implementation of interventions that modify the behaviors associated with them.

Accidents, Traffic↗
PubMed2005

Effects of amphetamine on schedule-induced polydipsia.

A series of experiments examined the effects of amphetamine (AMPH) at various doses administration for different length of time on a schedule-induced polydipsia (SIP) and possible associations with behavioral activation. Two stages of a two-week AMPH treatment were introduced with interposed interval of two months. In terms of behavioral activation, AMPH induced a robust depression across stages but with less potency in the second one. As for the SIP performance, the effects manifested qualitative difference in the two stages. For the first stage, there were no differential effects of AMPH on stereotypy intensity during the facultative phase of the inter-rewarding interval. However, AMPH reduced the high frequency of licks in the adjunctive (schedule-induced) phase and increased the low frequency of nose pokes in the terminal (schedule-dependent) phase. In the second stage, AMPH had no effect on the frequency of licking whereas the efficiency of licking and the frequency of nose pokes were reduced. These results were interpreted to support the current viewpoint that the behavior of SIP displaying is relevant to the function of central dopaminergic systems. The results were further discussed in the considerations of behavioral competition, stress coping strategy, and also the impact of AMPH at different time.

Animals↗
PubMed1980

Response sensitization and depression following long-term amphetamine treatment in a self-stimulation paradigm.

The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated with saline and tested with the same dose of amphetamine. In contrast, a depression in responding was observed among animals that received long-term amphetamine administration and were tested with saline. The effects of long-term amphetamine treatment on self-stimulation could not be explained by the intrusion of drug-induced competitive behaviors such as locomotor activity and stereotypy. The results were attributed to changes in dopamine neurotransmission following prolonged exposure to amphetamine and were also discussed in terms of an animal model for 'amphetamine psychosis' and 'postamphetamine depression' in man.

Amphetamine↗
PubMed2000

Antagonist-induced intracellular sequestration of rabbit bradykinin B(2) receptor.

In a contractility assay based on the rabbit jugular vein, the structurally related drugs NPC 17731 or icatibant (1 to 3 nmol/L) were insurmountable antagonists of bradykinin (BK) B(2) receptors (B(2)Rs). After ample washing (3 hours), the antagonism exerted by these peptides was not reversible. By contrast, the antagonist LF 16. 0687 (30 to 100 nmol/L) was competitive and reversible. A rabbit B(2)R-green fluorescent protein (B(2)R-GFP) conjugate was expressed in mammalian cells. In COS-1 cells, it exhibited an affinity for [3H]BK (K(D)=1.61 nmol/L) similar to that of the wild-type rabbit B(2)R. The stably expressed construction in HEK-293 cells was functionally active (phospholipase A(2) assay), and the antagonists mentioned above retained their respective surmountable or insurmountable behavior. Competition of [(3)H]BK binding to B(2)R-GFP by the antagonists or BK was largely reversible after a 3-hour washout period at 0 degrees C; at 37 degrees C, icatibant or NPC 17731 effects were not reversible. B(2)R-GFP was visualized in the plasma membranes of HEK-293 cells and rapidly internalized in response to BK. NPC 17731 or icatibant slowly translocated B(2)R-GFP into cells over 24 hours, whereas LF 16.0687 had no effect on the subcellular distribution of B(2)R-GFP. Cell extract immunoblotting with anti-GFP antibodies revealed a 101- to 105-kDa protein that was not significantly degraded on 24 hours of cell treatment with any of the ligands but was translocated in part to the 15 000-g pellet of the extract on treatment with BK or the noncompetitive antagonists. NPC 17731 and icatibant are noncompetitive, nonequilibrium antagonists that promote the cellular sequestration of rabbit B(2)R expressed in an heterologous system.

Animals↗
PubMed1994

Competition in chemostat culture between Pseudomonas strains that use different pathways for the degradation of toluene.

Pseudomonas putida mt-2, P. cepacia G4, P. mendocina KR1, and P. putida F1 degrade toluene through different pathways. In this study, we compared the competition behaviors of these strains in chemostat culture at a low growth rate (D = 0.05 h-1), with toluene as the sole source of carbon and energy. Either toluene or oxygen was growth limiting. Under toluene-limiting conditions, P. mendocina KR1, in which initial attack is by monooxygenation of the aromatic nucleus at the para position, outcompeted the other three strains. Under oxygen limitation, P. cepacia G4, which hydroxylates toluene in the ortho position, was the most competitive strain. P. putida mt-2, which metabolizes toluene via oxidation of the methyl group, was the least competitive strain under both growth conditions. The apparent superiority of strains carrying toluene degradation pathways that start degradation by hydroxylation of the aromatic nucleus was also found during competition experiments with pairs of strains of P. cepacia, P. fluorescence, and P. putida that were freshly isolated from contaminated soil.

Biodegradation, Environmental↗
PubMed2004

Influence of substrate composition and flow rate on growth of Azospirillum brasilense Cd in a co-culture with 3 sorghum rhizobacteria.

The ability of Azospirillum brasilense Cd to colonize the niche occupied by 3 bacterial strains previously isolated from sorghum rhizosphere was studied by means of the Biolog system. The isolates were identified by different methods as strains belonging to Pseudomonas putida, Stenotrophomonas maltophilia, and Klebsiella terrigena species. Several C sources, also chosen among the constituents of sorghum root exudates, were used to evaluate the metabolic profiles of Azospirillum and the sorghum rhizobacteria. Azospirillum brasilense Cd exploited the same class of C compounds as the sorghum rhizobacteria and overlapped in their niche requirements. Since structure and functioning of a microbial community are largely affected by the flow rate of nutrient supply, the competitive behavior of A. brasilense Cd was studied in a chemostat mixed culture under C-limited conditions using disodium succinate as C source. Only at high growth rates, i.e., when the C source was highly supplied, A. brasilense Cd appeared to be a good competitor and it became the dominant species, whereas at low growth rates, it was outnumbered by the other species. However, the coexistence of all the strains was always maintained, thus suggesting that interactions other than competition or a potential cross-feeding might occur within the mixed culture.

Amino Acids↗