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Cardiac volume.

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Cardiac Volume↗
PubMed1991

Criteria for the accurate interpretation of changes in left ventricular ejection fraction and cardiac volumes as assessed by rest and exercise gated radionuclide angiography.

Although serial left ventricular ejection fraction and volumetric measurements using gated radionuclide angiography are commonly used to evaluate clinical changes and therapeutic outcomes in individual patients, criteria are not available for accurately interpreting whether a change in any of these hemodynamic measurements is clinically meaningful. Accordingly, the magnitude of inherent variability among sequential measurements of hemodynamic variables assessed by gated radionuclide angiography was investigated in a double-blind placebo-controlled fashion in 39 patients during two placebo periods separated by 6 weeks. All patients analyzed had remained clinically stable during the study period. Although the mean values for all hemodynamic variables between the two placebo periods were minimally changed, the differences in individual patients were striking. Criteria were developed to allow meaningful interpretation of changes in hemodynamic variables by estimating the likelihood that an observed change is due to variability alone. On the basis of this analysis of placebo radionuclide angiographic data, variation due to chance alone is unlikely to account for all variability if a change observed between the two rest gated studies in a patient is greater than or equal to 7% units for left ventricular ejection fraction, greater than or equal to 45 ml/m2 for end-diastolic volume index, greater than or equal to 35 ml/m2 for end-systolic volume index, greater than or equal to 20 ml/m2 for stroke volume index and greater than or equal to 1.25 liters/min per m2 for cardiac index. An observed 4% unit change in left ventricular ejection fraction (increase or decrease) after a medical intervention in an individual patient occurs by random variation greater than 25% of the time.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiac Volume↗
PubMed1975

[A modification of the Roher-Kahlstorf method for estimating rapid changes in cardiac volume].

A simple roentgenological procedure is described, by which it is possible to measure the heart volume and its alteration during early orthostatic adaptation.--Long distance films are taken in the p.a.-projection using a 70-mm-camera with a frequency of 2 to 4 exposures per second. The length and width and there by the plane of the heart are determined from these films. The mean horizontal depth diameter, that is necessary to calculate the volume of the heart can be gained by indirect means. There is no statistically significant difference between the heart volumes, that have been determined in 12 test persons by the method described, and the commonly used method. -- The alteration of the heart volume in 10 test persons were investigated during acute orthostatic stress. The heart volume, which was 693 +/- 24,8 ml before the orthostatic stress, decreased within 6,9 +/- 1,6 sec statistically significant by 16,5% An influence of the movements of the diaphragm on the heart volume determination could be excluded.

Angiocardiography↗