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Results for “Capripoxvirus”

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At least 91 records · Page 5Linked to original sources
PubMed2000

[Comparative study of the immunizing ability of some attenuated strains of sheep pox virus and of a sensitizing vaccine].

The authors present the results of a study designed to compare the immunogenicity of several attenuated strains of sheep pox virus and a virus/immune serum vaccine. Two of the strains studied present immunogenic characteristics that make them particularly interesting for the manufacture of a vaccine. The first, named Djelfa, confers solid immunity to animals without provoking a vaccinal reaction; the second, known as Romania, can provide protection beyond twenty-four months, but causes persistent vaccinal lesions. In a country like Algeria, these two strains could be used for immunoprophylaxis of sheep pox: the first in those regions in which prevalence is low and sheep are vaccinated on a regular basis, and the second in regions of high prevalence where herds are moved to new pastures each season.

Analysis of Variance↗
PubMed2003

Study on skin diseases in sheep from northern Ethiopia.

A study was conducted to determine the cause and prevalence of skin diseases in local sheep from northern Ethiopia. Of 520 sheep examined 174 (33%) had skin diseases of different causes. The identified causes were lice infestation due to Damalina ovis and Linognatus africanus (21%), sheep pox (8%), sarcoptic mange (Sarcoptic Scab. var. ovis) (4%), dermatophilosis due to Dermatophilus congolensis (3%), and orf (contagious ecthyma) (3%). There was no statistically significant (P > 0.05) association of any of the skin diseases with age and sex of the sheep examined. The occurrence and spread of the diseases were associated with poor management, climatic factors, feed scarcity and inadequate veterinary services. The increasing threat of skin diseases to the development of sheep production warranting an urgent control intervention is indicated.

Actinomycetales Infections↗
PubMed2004

A Vero cell-attenuated Goatpox virus provides protection against virulent virus challenge.

An Indian isolate of Goatpox virus (GTPV) was adapted and propagated in Vero cells for development of an attenuated virus. The virus was initially passaged in primary lamb testes cells and subsequently in Vero cells. At the 55th passage, the virus showed evidence of attenuation when tested for safety in seronegative goats. At this stage, the virus was found to be completely non-pathogenic. The virus was passaged further and the 60th passage was used for testing its immunogenicity in goats. The latter were inoculated with 10, 100 and 1000 TCID50 of the attenuated virus by intradermal (i.d.) route and challenged after 28 days with virulent GTPV. The attenuated virus produced no adverse reaction even at the highest dose and conferred complete protection even at the lowest dose against challenge with a high dose (2 x 10(6) of 50% skin-reactive dose SRD50) of virulent virus. Increased levels of virus-specific serum antibodies could be demonstrated by both indirect enzyme-linked immunosorbent assay (ELISA) and virus neutralization (VN) test in all the immunized goats. No horizontal transmission of the virus from the immunized to in-contact animals took place. Our results suggest that this attenuated virus could be a safe, immunogenic and potent candidate for developing a vaccine against goatpox.

Animals↗
PubMed2003

Trials for preparation of inactivated sheep pox vaccine using binary ethyleneimine.

Binary ethyleneimine (BEI) was used to inactivate the local Egyptian strain of sheep pox virus. The inactivation process was applied using final concentrations of BEI at 0.5, 1, 2 and 3% for different incubation periods at 37 degrees C. The virus was completely inactivated after 7 hours incubation with by 2% BEI final concentration; the inactivated virus was adsorbed on aluminium hydroxide gel when incubated for 6 hours in a concentration 1:1. The antibody levels were estimated by virus neutralization test and ELISA. Specific antibodies appeared from the 1st week post vaccination and remained until the 4th week post challenge. The prepared vaccine was evaluated for safety, sterility and potency. The vaccine proved to be safe, sterile and inducing protection for the vaccinated lambs when challenged by the virulent sheep pox virus up to 6 months post vaccination.

Animals↗
PubMed2004

The production and evaluation of a standard diagnostic peste des petits ruminants (PPR) hyperimmune serum prepared from the Egyptian antigen (Egypt 87).

The aim of this study was to produce a specific hyperimmune serum for diagnosis of peste des petits ruminants (PPR). Based on good laboratory practices and standard operating procedures, we produced this reagent in goats using attenuated local strain of PPRV. The quality was assured to meet the internationally required levels of potency and sterility. The titer of the product was 1024 as evaluated by virus neutralization (VN) and agar gel immunodiffusion (AGID) tests. In its final form, it is a sterile disc of a lyophilized material with a pale yellow colour, placed into an evacuated, tightly capped and capsulated vial. Local availability of such a product could be of great benefit at the time of need.

Animals↗
PubMed2005

An epidemiological study of sheep pox infection in Karnataka State, India.

Analysis of retrospective quantitative sheep pox epidemiological data from the Government Animal Husbandry Department, Karnataka, India, covering 24 years revealed significant information on sheep pox. The state has a dense sheep population including some valuable breeds. Data revealed the endemicity of the disease: there were a considerable number of outbreaks and attacks, high mortality and case fatality rates and low immunisation coverage. None of the years studied were free from infection. Temporally, the disease was most prevalent between November and May. Spatially, the disease was recorded in 19 out of 27 districts; in some of these districts sheep pox was highly endemic, in some it was endemic at low levels and in the remaining districts outbreaks occurred sporadically. Environmental factors influenced disease occurrence. Vaccine production met only one tenth of the requirement, and its peak utilisation was in the dry season.

Animals↗