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PubMed1986

Differential effect of common snack foods on caloric intake, growth and obesity in weanling male and female rats with hypothalamic obesity.

In order to see whether weanling normophagic rats with hypothalamic obesity (VMNL rats) become hyperphagic and more obese than when fed lab chow, and to see in addition whether there is a possible sex difference in whatever response is found, male and female VMNL rats were fed lab chow for 14 days after lesion production and then, for the following 42 days, they received Hostess HoHos, potato chips, marshmallows and french fries in addition to lab chow. At termination, body weights were similar among the groups, but VMNL rats were fatter and shorter than controls. Also, female VMNL rats were fatter and shorter than male VMNL rats and layed down more fat per unit of food energy. Total caloric intake was greater in controls than in VMNL rats and in males than in females. However, the females showed a decrease in intake and the males an increase over time. Males ate more lab chow and french fries than females. Lab chow was the only food that VMNL rats ate more of than controls. The VMNL rats ate less french fries, HoHos and potato chips than controls, but similar amounts of marshmallows. There was no sex difference in macronutrient intake and per cent macronutrient intake. Moreover, controls ate as much carbohydrate and less per cent carbohydrate than VMNL rats, more fat than VMNL rats, but normal per cent fat and normal protein and per cent protein. Sex X lesion interactions indicated that female VMNL rats ate more per cent carbohydrate than female controls and male VMNL rats, ate more protein than male controls. The greater degree of obesity in the females despite the lower caloric intake may be due to enhanced food energy utilization. The data also show that weanling VMNL rats do not exhibit the great preference for palatable diets that have been reported for mature rats with ventromedial hypothalamic area lesions and that the only sex difference in intake is with french fries, which have neither the highest fat nor the highest carbohydrate content of the foods tested.

Animals↗

PubMed1999

Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates.

Caloric restriction (CR) increases maximum life span in rodents while attenuating the development of age-associated pathological and biological changes. Although nearly all of the rodent studies have initiated CR early in life (1-3 months of age), CR, when started at 12 months of age, also extends maximum life span in mice. Two main questions face investigators of CR. One concerns the mechanisms by which CR retards aging and diseases in rodents. There is evidence that CR may act, at least in part, by reducing oxidative stress. A CR-induced decrease in oxidative stress appears to be most profound in post-mitotic tissues and may derive from lower mitochondrial production of free radicals. The second issue is whether CR will exert similar effects in primates. Studies on CR in rhesus monkeys (maximum life span approximately 40 years) support the notion of human translatability. We describe the University of Wisconsin Study of rhesus monkeys subjected to a 30% reduction of caloric intake starting at either 1989 or 1994 when they were approximately 10 years old. The data from our study and from other trials suggest that CR can be safely carried out in monkeys and that certain physiological effects of CR that occur in rodents (e.g., decreased blood glucose and insulin levels, improved insulin sensitivity, and lowering of body temperature) also occur in monkeys. Whether oxidative stress in monkeys is reduced by CR will be known by the year 2000, while effects on longevity and diseases should be clearly seen by, appropriately, 2020.

Aging↗

PubMed1975

Satiety: a graded behavioural phenomenon regulating caloric intake.

Rhesus monkeys inhibited their feeding in response to intragastric nutrient preloads, so as to maintain a constant caloric intake. There is a definite dose- response relationship to calories which does not depend on the volume, caloric concentration, or nature of the nutrient. This accurate control is accomplished even though some of the preload remains in the stomach throughout the feeding period.

Animals↗

PubMed1994

The diurnal rhythm in adrenocorticotropin responses to restraint in adrenalectomized rats is determined by caloric intake.

There is a diurnal rhythm in ACTH responses to stressors that peaks, in nocturnally feeding rats, at the time of lights on, in the morning (AM). To determine whether this rhythm is subordinate to the rhythm in food intake, we tested the effects of removing food during the night or the day on ACTH responses in the AM or evening (PM) to the stimulus of restraint in 5-day-adrenalectomized rats. An overnight fast reduced the ACTH response to restraint with tail blood sampling in the AM to the low magnitude observed in the PM in rats fed ad libitum; by contrast, a fast of equivalent duration imposed during the day had no effect on the ACTH response to the stressor in the PM. Short term fasts did not alter the normal AM-PM rhythm in basal ACTH levels. The fasts did, however, significantly decrease the pituitary ACTH concentration at both times of day, suggesting that lack of food had stimulated ACTH secretion during the preceding 14 h. Providing calories by either gavage or manipulation of food presentation increased ACTH responses to restraint in fasted adrenalectomized rats in both the AM and PM. Although four of four experiments showed that provision of calories to fasted rats resulted in increased ACTH responses to the stimulus of restraint, none of the manipulations of caloric intake fully restored ACTH responses in fasted rats to the high amplitude observed in ad libitum fed rats in the AM. We conclude that 1) unlike the circadian rhythm in basal activity in the hypothalamic-pituitary-adrenalocortical (HPA) system, the diurnal rhythm in ACTH responsiveness to stimuli is tightly coupled to the endogenous rhythm in energy intake; and 2) caloric deprivation per se appears to activate the HPA system at some time during the 14- to 17-h fast, but does not produce the normal facilitation in the AM response to acute restraint that is induced by chronic or prior stimulation of the HPA axis.

Adrenalectomy↗

PubMed1997

Cultural factors, caloric intake and micronutrient sufficiency in rural Nepali households.

This study examined the allocation of food within 105 Nepali households using a combination of recall and observation methods. While a relationship exists between caloric intake and sufficiency of intake of several key micronutrients (i.e., beta carotene, vitamin C and iron) for the study population as a whole this relationship is weaker for certain subgroups. In particular, micronutrient intakes of adolescent girls and adult women are much less likely to be tried to total caloric consumption when compared with the intakes of other household members. This gender differential appears linked in part to specific food beliefs and practices that tend to reduce women's consumption of micronutrient-rich foods, such as dietary restrictions during menstruation, pregnancy and lactation. Overlapping with these beliefs and practices, an overall pattern of disfavoritism of females in the intrahousehold allocation of food is evident in the study communities. While staple food items (i.e. rice, lentil soup, bread, etc.) are distributed fairly equally, side dishes usually containing a higher proportion of micronutrients (i.e. vegetables, meat, yogurt, ghee, etc.) are often preferentially allocated to valued household members, including adult males and small children (of both sexes).

Adolescent↗

PubMed2001

Epidemiologic data on the relationships of caloric intake, energy balance, and weight gain over the life span with longevity and morbidity.

Animal experiments have shown that calorically restricted (CR) animals weigh less and live longer than their ad libitum-fed peers. Are these observations applicable to human beings? This is an important question because the prevalence of obesity in America has increased markedly over recent years. We examine whether there are physiologic effects that occur with CR in humans that could plausibly explain the observed longevity of laboratory animals associated with CR. We also review epidemiologic data from observational and interventional studies on the relationships of caloric intake, energy balance, and weight gain with age-related diseases and longevity. Additionally, data on whether long-term, sustained maintenance of weight loss is feasible, as well as the degree of CR achieved in clinical trials, are summarized. Finally, we provide recommendations regarding further epidemiologic research that will help clarify unanswered questions in these areas.

Energy Intake↗

PubMed1996

The effects of short-term food deprivation on caloric intake in eating-disordered subjects.

The primary aim of this experimental investigation was to examine the effects of short-term dietary restriction on caloric consumption in eating disordered subjects. Subjects with bulimia nervosa, binge eating disorder, and overweight non-eating disordered subjects, attended a laboratory experiment during which they were randomly assigned to either a 1 h or a 6 h food deprivation condition prior to being served a multi-item buffet. The primary measure of interest was calories consumed during the laboratory experiment. Subjects deprived of food for 6 h consumed significantly more calories at the buffet compared to subjects in the 1 h food deprivation condition. However, caloric intake during the entire laboratory day was not affected by the experimental manipulation. Subjects in the longer deprivation condition apparently compensated at the buffet for the caloric restriction, but did not overcompensate.

Adult↗

PubMed2000

[Pre-eclampsia: role of excessive caloric intake].

OBJECTIVE: To compare the average daily diet of women having physiologic pregnancy versus patients presenting preeclampsia (PE) in order to evaluate if increased caloric intake is associated with preeclampsia. METHODOLOGY: The macronutrients and kilocalories in measurements obtained from diaries filled in over a seven day period by 147 pregnant women (30 preeclamptics, 117 with physiologic pregnancy were compared (the proportion of about 1/4 between the two groups was chosen to increase the statistical efficacy, because this pathology is rather unfrequent). RESULTS: The analysis of the diaries shows that the preeclamptic women consume, every day a greater quantity (p < 0.05) of kilocalories, proteins and lipids than the physiologic pregnancy. No statistically significant difference was found for fibres and carbohydrates (the last ones recorded without distinguish mono and disaccharides from polysaccharides). Physiologic pregnancy mean Body Mass Index is 21.6 versus 26.4 of PE women (p < 0.05). CONCLUSION: Intake of energy, protein and lipid were positively associated with risk of PE. Overweight patients are highly at risk of contracting PE. These data, according to others trials confirm the advisability: 1) to analyse the diet of pregnant women; 2) to reduce nutritional intake, if in excess, first of all, in women at risk of PE; 3) to suggest loosing weight to overweight patients before initiating a pregnancy.

Energy Intake↗

PubMed2000

Influence of caloric intake on gastric emptying of solids assessed by 13C-octanoic acid breath test.

BACKGROUND: The 13C-octanoic breath test (13C-OBT), a recently developed technique to evaluate gastric emptying of solids, has been validated in comparison to scintigraphy with low caloric meals (250 kcal). However, there is consensus that for clinical studies total caloric load should be in excess of 300 kcal, but studies comparing 13C-OBT results after low and medium caloric meals are lacking. METHODS: Ten healthy subjects were given a 250-kcal and a 550-kcal meal in randomized order. Gastric emptying was assessed simultaneously by ultrasonography and 13C-OBT. Breath samples were taken according to both classic (21 samples over 5 h) and simplified (11 samples) schedules. RESULTS: Increasing the meal energy content resulted in significantly longer half emptying time (T(1/2)) estimates by both ultrasonography (P < 0.01, Wilcoxon test) and 13C-OBT (P < 0.05). T(1/2) estimates by the two methods significantly correlated for both the 250 (r(s) = 0.733, P = 0.018) and the 550 (r(s) = 0.637, P = 0.035) kcal meal. However, differences between T(1/2) estimates by 13C-OBT and ultrasonography were greater after the 550- than the 250-kcal meal (median 172.5 versus 76.5 min, P < 0.05). Interindividual variability was also 2-fold greater for indexes estimated by 13C-OBT with the 550-kcal meal compared with the 250-kcal meal. For both meals 13C-OBT yielded similar results with the classic and simplified schedules. CONCLUSIONS: In healthy subjects caloric intake is a major determinant of gastric emptying rate. However, after a medium caloric meal 13C-OBT shows some inaccuracy, which raises questions about its routine clinical application. Nevertheless, when using 13C-OBT one must take into account that the simplified schedule is just as effective as the classic one, and is far lower in cost.

Adult↗

PubMedDate not supplied

Influence of caloric intake on gastric inhibitory polypeptide, VIP and gastrin release in man.

Blood glucose, gastric inhibitory polypeptide (GIP), vasoactive intestinal polypeptide (VIP) and gastrin secretions were measured over a three-hour period following the ingestion by normal subjects of a mixed meal with two different caloric levels (1055 Kcal and 1192 Kcal). No VIP secretion was observed after either meal. Gastrin release was not modified by the increase of caloric intake (mainly carbohydrates and lipids), whereas GIP secretion was significantly more important after the meal with the highest caloric value (peak at 30 mm: 499.5 +/- 250.4 vs. 273.4 +/- 128.7 pg/ml and integrated response 53.3 +/- 20.5 vs. 28.2 +/- 9.9 ng X ml-1 X 180 min-1-p less than 0.05). This difference could not be attributed to glucose since the blood glucose levels were not significantly different. It is more probably related to the total amount of ingested food. This suggests the existence of rapid mechanisms of adaptation to the incoming load of the GIP-producing cells.

Adult↗

PubMed1983

The assessment of physical activity in older women: analysis of the interrelationship and reliability of activity monitoring, activity surveys, and caloric intake.

The interrelationship and reliability of three different activity measures were examined in 76 postmenopausal women. The women wore Large Scale Integrated (LSI) activity monitors, completed the Paffenbarger Activity Survey, and completed 3-day food logs for determination of caloric intake/expenditure. The Paffenbarger survey was assessed twice, a year apart. The results indicated that caloric intake was a very poor index of activity. The LSI activity monitoring and Paffenbarger survey were both effective, reliable measures of physical activity. However, they appeared to measure somewhat different aspects of physical activity. The LSI measured physical activity associated with movement, whereas the surveys measured the intensity component of energy expenditure. The research indicated that it is important to evaluate the characteristics of the activity of interest in order to select a physical activity tool for assessing activity patterns in older women.

Aged↗

PubMed1989

Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers.

Patients with bulimia (binge-purge syndrome) frequently complain that they consume a very restrictive diet to avoid gaining weight. To investigate this claim, 23 hospitalized bulimic patients were assessed daily for body weight, caloric intake, macronutrient diet content, activity measures, and body composition estimates during weight-stable periods. Bulimic patients ate fewer kilocalories per kilogram body weight (22.1 +/- 4.6 kcal/kg) than did age-matched normal women (29.7 +/- 6.5 kcal/kg) but had similar activity levels and body composition. Clinical variables, such as history of laxative abuse, anorexia, or obesity, and physiological characteristics, such as body weight, activity level, or dietary content, could not account for this difference in caloric consumption. Bulimic patients tended to eat a diet lower in fat and higher in protein than did control subjects. These results agree with observations of increased efficiency of caloric utilization in obese patients and support patient complaints of a tendency to gain weight easily.

Adolescent↗

PubMed1984

Association between malnutrition and caloric intake, emesis, psychological depression, glucose taste, and tumor mass.

A nutritional evaluation was performed in 72 patients with advanced solid tumors receiving chemotherapy: 35 patients (49%) were considered malnourished and 37 (51%) were considered normal. The malnourished group showed a significantly lower caloric intake than the normal group (1214 +/- 360 vs 2088 +/- 607; P less than 0.001) and a higher incidence of severe depression (16 of 27 patients [59%] vs six of 30 [20%]; P = 0.026). No significant difference was found between the normal and malnourished patients in reference to emesis, glucose tasting threshold, or tumor burden.

Adult↗

PubMed1980

Hypophosphatemia and neurological changes secondary to oral caloric intake: a variant of hyperalimentation syndrome.

Previous reports have described a syndrome of paresthesias, weakness, seizures and hypophosphatemia in patients and animals receiving intravenous hyperalimentation. In this report we describe a group of five patients who developed this syndrome while on oral caloric intake and three patients who received only modest amounts of hyperalimentation therapy. As an experimental corollary, studies were performed in starved and normal dogs with calories infused via an intragastric catheter. The serum inorganic phosphorus (Pi) fell slightly in normal animals from 4.8-2.5 mg. %. In the starved dogs with diarrhea or vomiting the Pi fell gradually from 4.8-1.6. In starved dogs without gastrointestinal symptoms the Pi fell precipitously from 3.7-1.4 mg % on the first day of infusion and remained at that level. Approximately 50% of the starved animals developed the neurological syndrome; none of the normal animals had neurological symptoms.

Adult↗

PubMedDate not supplied

Effect of fenfluramine on caloric intake and macronutrient selection in Lou/c rats during aging.

Previous studies have shown a shift of preferences from carbohydrate to fat and a decrease in protein intake in self-selected Lou/c rats with advancing age. This study investigated a potential neurochemical mechanism underlying age-related modifications by evaluating the effects of fenfluramine (dl-F), a drug that enhances 5-HT release and blocks its re-uptake by presynaptic terminals, on macronutrient selection. The drug dl-F (1.5 and 3mg/kg s.c.) induces a dose-related hypophagia with the oldest animals being the most sensitive. The main decrease is in fat consumption with minor changes in carbohydrate and protein consumptions. Young, but not old animals, compensate during the day the nocturnal intake decrease induced by dl-F. The plasma concentration of dexfenfluramine (d-F) was higher as the rats aged. The icv administrations of dl-F induced a caloric intake decrease in the oldest groups and a differential effect on protein intake between old and young rats. Metergoline induced a partial reversion of dl-F effect on food intake but this effect was not age related. These data suggest a possible implication of serotoninergic system in modifications of food behavior during aging. However, further studies are needed.

Aging↗

PubMed1991

Acute effects of nicotine on hunger and caloric intake in smokers and nonsmokers.

The inverse relationship between smoking and body weight may be due in part to nicotine's effects on reducing hunger and eating. Male smokers and nonsmokers (n = 10 each), abstinent overnight from smoking and food, participated in four sessions, involving consumption of a liquid caloric load or water followed by nicotine (15 micrograms/kg) or placebo via nasal spray every 20 min for 2 h. Hunger and satiety ("fullness") ratings were obtained prior to each dose presentation. At the end of the two sessions involving the caloric load (simulating breakfast), subjects were also presented with typical lunch/snack food items varying in sweet taste and fat content for ad lib consumption. Results indicated that, for both smokers and nonsmokers, the hunger-reducing effects of nicotine occurred only following caloric load consumption, and there was no effect of nicotine on hunger afer water consumption. Smokers unexpectedly reported greater satiation than nonsmokers following the caloric load regardless of nicotine or placebo condition. Nicotine also resulted in less caloric intake during the meal, and the decrease was not specific to consumption of sweet, high-fat foods. These results indicate that nicotine reduces appetite, possibly helping to explain the influence of smoking on body weight.

Adult↗

PubMed1997

Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake.

Both cholecystokinin (CCK), a short-term meal-related satiety signal, and the ob protein leptin, a postulated long-term adiposity hormone, are thought to be important signals in the multiple interacting systems that control appetite and adiposity. We hypothesized that these hormones may synergistically interact to suppress feeding. Following IP administration of leptin (two doses of 50 micrograms each) and CCK (2, 4, 8, or 16 micrograms) total daily caloric intake was significantly reduced by leptin and CCK compared to leptin alone. These results support the hypothesis that CCK and leptin may synergistically interact to control long-term feeding.

Animals↗

PubMed1976

[Modification of the caloric intake as a function of energy expenditure in patients with diarrhea].

UNLABELLED: We have compared, using non protein RQ method, energy expenditures of diarrheic patients with intraperitoneal or intraluminal suppuration and feed enterally (group II) or intravenously (group III). Five non suppurative diarrheic patients feed enterally were studied as control (group I). Carbohydrate, protein and fat intakes were not significantly different in the 3 groups of patients. Patients of group II metabolized significantly less of carbohydrate (p less than 0.01) and more of fat (P less than 0.01) than groups I and III patients. Carbohydrate and fat expenditures of patients of groups I and III were not significantly different. CONCLUSION: 1) There is a possible trouble of carbohydrate absorption in suppurative diarrheic patients. 2) Therefore caloric intake must be preferably parenteral in these patients.

Adolescent↗