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PubMed1985

[Malignant transformation of cutaneous cylindromas. 2 case reports and a review of the literature].

We report on two female patients (age 78 and 81) suffering from multiple hereditary cylindromas which had grown, changed in color towards a bluish note, and partly exulcerated. The lesions were widely excised; plastic surgical reconstruction resulted in satisfactory healing. Histological examination showed similar features in both patients: We observed decreased differentiation of structures otherwise typical for cylindromas, polymorphism of cells and nuclei, mitoses, and beginning infiltration of the galea. Although there were no metastases found, malignant transformation was deduced from sudden growth, exulceration, as well as dedifferentiation of histological structures in combination with infiltrative expansion.

Aged↗
PubMed1987

[Adenoid cystic carcinoma or cylindroma of the cervix uteri. Review of the literature apropos of a personal case].

The authors report on a case of cylindroma of the cervix combined with a carcinoma in situ. Reviewing the literature which helped them, they studied the anatomo-pathological characteristics as well as the histogenesis and the therapy for cylindromas, which are more often found in other parts of the body. In particular, they are found in the salivary glands. There the origin is still uncertain and the evolution from the same stage is worse than in epidermoid carcinoma of the cervix.

Adult↗
PubMedDate not supplied

[Clinical and evolutive considerations on rhinosinus cylindromas].

With reference to 7 cases of rhinosinusal cylindroma, rarely, encountered at this level (approximately 3% of all malignant rhinosinusal tumours), the authors discuss the evolution of the tumour and its treatment in the light of recent published data and their own experience in cases followed up over a long interval. In contrast to the pathohistologic aspect according to which these tumours are relatively benign, cylindromas appear to be malignant tumours with a slow, infiltrative evolution and a marked tendency to recurrence. After many years they may be transformed into carcinomas. They seldom give metastasis to the regional lymph nodes, but often generalize in the end stage by haematogenic route (with localizations in the lungs, pleura, brain, spinal column, ribs, long bones). As they are radioresistant, initial broad surgical excision is compulsory followed--when surgery is performed in the advanced stages--by complementary radiotherapy (intracavitary cobalt, intracavitary contact roentgentherapy, telecobalt, teleradiumtherapy, electron therapy).

Adult↗
PubMedDate not supplied

Benign dermal eccrine cylindroma. A pitfall in the cytologic diagnosis of adenoid cystic carcinoma.

Aspiration cytology from four benign dermal eccrine cylindromas and five adenoid cystic carcinomas were compared. These two lesions were found to have so much in common morphologically that they may be indistinguishable on a purely cytologic basis. Accordingly, we recommend a restricted excision to obtain a histopathologic diagnosis before more extensive surgery is performed whenever a lesion is cytologically consistent with adenoid cystic carcinoma but clinically shows a picture that does not exclude dermal eccrine cylindroma.

Biopsy, Needle↗
PubMed1977

Membranous basal cell adenoma of parotid gland, dermal cylindromas, and trichoepitheliomas. Comparative histochemistry and ultrastructure.

A basal cell adenoma of parotid, eccrine dermal cylindromas and trichoepitheliomas occurring in the same patient were examined by light and electron microscopy and histochemistry. The eccrine and parotid adenomas were similar both structurally and histochemically except for the presence of Langerhans cells in the cutaneous adenoma and well differentiated mucinous cells in the parotid tumor. The three different hamartomas found in this individual may represent the effect of a single pleiotropic gene acting on ontogenetically related stem cells.

Adenoma↗
PubMed1980

Management of adenoid cystic carcinoma of the uterine cervix (cylindroma): report of six cases and reappraisal of all cases reported in the medical literature.

We report 6 new cases of adenoid cystic carcinoma (cylindroma) of the uterine cervix (5, invasive cancer and 1, in situ cancer). All 6 patients were elderly women and 5 were hypertensive. Additionally, 3 (Patients 1, 2, and 4) were obese and 1 (Patient 3) had diabetes mellitus. Three patients were seen because of postmenopausal vaginal bleeding and 3 were found to have malignant cells on routine exfoliative cytologic examination. Histologically, the tumor cells were relatively uniform, with scanty cytoplasms and a palisading pattern at the periphery of the tumor masses. Round cystic spaces were found in all 6 cases and hyaline nodules were present in some of the cyclic spaces in 2. The tumors were found in Stages IA, IB, IIB, IIB, and IIIB (cases 1-4 and 6 respectively), and were treated with irradiation only. There have been only 38 cases of invasive adenoid cystic carcinoma of the cervix reported in the world medical literature. We review the treatment and survival for all 38 cases previously reported and add 5 new cases.

Aged↗
PubMed2004

[Treatment of recalcitrant wounds with autologous epidermal equivalents. After excision of multiple cylindromas of the scalp].

A 63 year old man developed non-healing ulcerations after en-bloc resection of multiple cylindromas of the scalp. After excision and granulation-stimulating local therapy, the wound was covered with mesh grafts from the thighs. He developed widespread tension blisters with superficial ulcerations in the occipital region which did not heal despite adequate topical therapy. We then treated him successfully with EpiDex, a tissue engineered fully differentiated epidermal equivalent derived from keratinocytes of the outer root sheath of plucked anagen hair follicles. We introduce this treatment modality as a non-invasive effective option in treating non-healing ulcers.

Carcinoma, Adenoid Cystic↗
PubMed1982

Familial dermal cylindroma with involvement of the parotid gland.

The association of turban tumour with other dermal cylindromas in the parotid gland is very rare. Another case is reported in which the hereditary nature of the disease is discussed and certain aspects of the treatment and management of these cases are considered.

Adenoma↗
PubMed1990

Dermal eccrine cylindroma (turban tumour).

Dermal eccrine cylindroma, or turban tumour, is a rare benign tumour of the eccrine sweat glands. Despite its histologically benign behaviour, the disease process is distressing for the patients. We present our experience of this condition, with a review of the literature, and recommend a treatment protocol for the disease.

Adult↗
PubMed1986

Cylindroma of the nasopharynx: a chronic disease.

From March 1958 to October 1984, 10 patients with cylindroma (cystic adenoid epithelioma) arising in the nasopharynx were treated in our hospital. The presenting symptoms of these patients ranged in duration for 2 weeks to 8 years, with an average of 25 months. Eighty percent of the patients had destruction of the base of skull and 60% had cranial nerve involvement. Of these 10 patients, two had Stage II disease, two had Stage III, and six had Stage IV. Response was seen in this tumor at tissue doses between 5000-8000 rad. Of the seven patients at risk for 5 years, 86% survived, yet 36% of the patients died of tumor between the fifth to tenth year. Fifty percent of the patients lived beyond 10 years. Based on this experience, a dose of more than 8000 rad is advised for the primary lesion. For the neck region, radiation is indicated only when there are lymph node metastases; prophylactic radiation of the neck is not necessary. Local recurrence or single distant metastasis is amenable to radiation therapy. Among the six patients who failed in the course of follow-up, three had local recurrences, two had pulmonary metastases, and one died of cerebral vascular accident.

Adult↗
PubMed2004

Nd:YAG laser for effective treatment of multiple cylindroma of the scalp.

The case presented illustrates the successful effect of the Nd:YAG laser in the treatment of multiple giant scalp tumours in a patient who would not accept surgical excisions. A 60-year-old woman with multiple cylindroma covering the whole scalp area was treated with a Nd:YAG laser in a cutting continuous mode. Postoperative healing by second intention within 3-4 weeks left limited superficial scars. No tendency to relapse was noted during a follow-up of 4 years.

Carcinoma, Adenoid Cystic↗
PubMed1977

Tracheal cylindroma: anaesthetic management.

A tracheal cylindroma in a lady aged 56 yr was excised. The problems of tracheal and carinal resection, and an anaesthetic technique which obviates the use of cardiopulmonary bypass are described.

Anesthesia, General↗
PubMed1990

Malignant degeneration of dermal cylindroma.

Dermal cylindroma is a rare tumor of the cutaneous appendage system, which can undergo aggressive malignant transformation. Clinically this change can manifest as ulceration. The histological features of malignant degeneration are well defined. When these changes occur, prompt excisional biosy or reexcision with clear surgical margins is indicated.

Aged↗
PubMed1996

Transcranial erosion of a benign dermal cylindroma.

Dermal eccrine cylindroma is a benign adnexal tumor that commonly affects the scalp, neck, and face. Malignant transformation is rare and has resulted in several cases of intracranial invasion. There have been no previously reported cases of a benign lesion eroding through the skull vault. We report the development of such a lesion in a woman who had undergone total scalp excision and resurfacing with a split skin graft some 23 years earlier. Details of the case and its management are presented.

Adenoma↗
PubMed2004

Cylindroma of the breast of skin adnexal type: a study of 4 cases.

Four cases of solitary cylindroma of the breast of skin adnexal type are described. The tumors were morphologically and immunophenotypically identical to their dermal counterparts. They arose in close proximity to the nipple, such as the retroareolar area of the breast and in intimate association with the lactiferous ducts, suggesting an origin from the latter structures. One case occurred in a woman with hereditary multiple cylindromatosis (Brooke-Spiegler syndrome). This is the second reported case of this hereditary syndrome with extracutaneous manifestations and the first case in which the breast is involved.

Adult↗
PubMed1984

Basement membrane components outline the tumour islands in cylindroma.

The main histological feature of cylindroma is the deposition of sheaths of a 'hyalinized' material contiguous to the tumour cell clusters. Although ultrastructural studies of this material have revealed a basement membrane-like structure, its exact nature has remained unclear. Using immuno-staining with affinity-purified antibodies directed against distinct basement membrane components, we have shown that type IV collagen and laminin are major constituents of this zone. In addition, cell culture studies indicated that both proteins are synthesized by the tumour cells. The immunohistological data make it clear that the tumour matrix between the tumour cell islands is composed not only of basement membrane components, but also is composed of other connective tissue constituents, i.e. type I and III collagen and fibronectin.

Basement Membrane↗